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Displaying drugs 1426 - 1450 of 2401 in total

Blinatumomab

Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostly expressed on the surface of...
Approved
Investigational
Matched Description: … promotes tumor cell lysis and apoptosis. ... acute lymphoblastic leukemia (ALL) in relapsed and refractory patients. ... recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … BLINCYTO POWDER FOR INFUSION 35 MCG/VIAL ... BLINCYTO (Blinatumomab) for injection 35 mcg/vial …

Etacrynic acid

A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop...
Approved
Investigational
Matched Description: … Henle, but also in the proximal and distal tubules. ... A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of ... This pharmacological action results in excretion of these ions, increased urinary output, and reduction …
Matched Products: … Ethacrynate Sodium for Injection ... Ethacrynate Sodium for Injection USP …

Peginterferon alfa-2b

Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most...
Approved
Matched Description: … 41% for genotype 1 and 75% for genotypes 2-6 after 48 weeks of treatment. ... development of endocrine and autoimmune disorders, retinopathies, cardiovascular and neuropsychiatric ... -2b for the treatment of Hepatitis C [A19593]. …
Matched Categories: … Treatments for Hepatitis C ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …
Matched Products: … PEG-INTRON CLEARCLICK FOR INJECTION 80 mcg/0.5 ml ... PEG-INTRON CLEARCLICK FOR INJECTION 100 mcg/0.5 ml ... PEG-INTRON CLEARCLICK for Injection 50 mcg/0.5 ml …

Remdesivir

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends on an RNA-dependent RNA polymerase...
Approved
Investigational
Matched Description: … the related SARS-CoV and MERS-CoV,[A222398] and has been investigated in multiple COVID-19 clinical ... disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and ... , A222393] Broad antiviral activity of remdesivir is suggested by its mechanism of action,[A222398] and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Nucleosides and Nucleotides ... Antivirals for Systemic Use ... Antiinfectives for Systemic Use ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Products: … COVIFOR (REMDESIVIR FOR INJECTION 100MG/VIAL) ... VEKLURY® LYOPHILIZED POWDER FOR IV INFUSION 100MG/VIAL …

Risankizumab

Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and Europe in April 2019. Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease.[L39885,L44191,L44231] Risankizumab...
Approved
Investigational
Matched Description: … It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and ... [A254716] Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease. ... [L39885,L44191,L44231] Risankizumab is being investigated for atopic dermatitis.[A254716] …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Skyrizi 75 mg solution for injection in pre-filled syringe ... SKYRIZI SOLUTION FOR INJECTION IN PRE-FILLED PEN 150MG/ML ... SKYRIZI SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 150MG/ML …

Thyrotropin alfa

Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of...
Approved
Vet approved
Matched Description: … similarity with the alpha subunit of human chorionic gonadotropin (hCG), luteinizing hormone (LH), and ... linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and ... Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Anterior Pituitary Lobe Hormones and Analogues ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … Thyrogen 0.9 mg Powder for Solution for Injection …

Idarucizumab

Idarucizumab is a humanized monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype molecule that binds to and inactivates the oral anticoagulant dabigatran, thereby reversing its anticoagulant effect. As a direct acting oral anticoagulant (DOAC), one of the risks associated with the use of dabigatran includes bleeding, espeically when...
Approved
Matched Description: … monoclonal antibody fragment (Fab) derived from an immunoglobulin G1 isotype molecule that binds to and ... Its use is associated with immediate, complete and sustained reversal of the anticoagulant effects of ... Approved under the tradename Praxbind (FDA), idarucizumab is indicated for the emergency treatment of …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … PRAXBIND Solution for Injection/Infusion 50 mg/ml ... PRAXBIND SOLUTION FOR INJECTION/INFUSION 50 MG/ML …

Radium Ra 223 dichloride

Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was...
Approved
Investigational
Matched Description: … As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas ... It was first approved by the FDA in May 2013 and is currently marketed under the brand name Xofigo, which ... indicated in patients who have metastatic bone cancer that is symptomatic with no visceral metastases and …
Matched Products: … XOFIGO SOLUTION FOR INJECTION 1100kBq/ML ... Xofigo (Radium-223 Dichloride) 1100 kBq/mL Solution for Injection …

Granisetron

A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
Approved
Investigational
Matched Iupac: … 1-methyl-N-[(1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]-1H-indazole-3-carboxamide …
Matched Description: … A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant ... for cancer chemotherapy patients. …
Matched Categories: … Alimentary Tract and Metabolism ... Antiemetics and Antinauseants …
Matched Products: … Granisetron Kabi concentrate for solution for infusion 1mg/ml ... KYTRIL FOR INFUSION 1MG/ML ... KYTRIL FOR INFUSION 3 mg/3ml …

Artesunate

Artesunate is indicated for the initial treatment of severe malaria. The World Health Organization recommends artesunate as first line treatment for severe malaria. Artesunate was developed out of a need for a more hydrophilic derivative of artemisinin. Artesunate was granted FDA approval on 26 May 2020.
Approved
Investigational
Matched Description: … Artesunate is indicated for the initial treatment of severe malaria. ... [L890] Artesunate was developed out of a need for a more hydrophilic derivative of [artemisinin]. ... [L14099] The World Health Organization recommends artesunate as first line treatment for severe malaria …
Matched Categories: … Artemisinin and derivatives ... artesunate and mefloquine ... artesunate and amodiaquine ... artesunate and pyronaridine ... artesunate, sulfalene and pyrimethamine …
Matched Products: … ARTESUNATE FOR INJECTION ... ARTESUN POWDER FOR INJECTION 60 MG …

Osugacestat

Osugacestat (BMS-906024) has been used in trials studying the treatment of Cancer, Lymphoblastic Leukemia, Acute T-cell, and Precursor T-Cell Lymphoblastic Lymphoma.
Investigational
Matched Synonyms: … Butanediamide, N1-((3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3- ... (2R,3S)-N1-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl …
Matched Iupac: … (2R,3S)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl …
Matched Description: … 906024) has been used in trials studying the treatment of Cancer, Lymphoblastic Leukemia, Acute T-cell, and …

Izencitinib

Izencitinib is under investigation in clinical trial NCT03920254 (TD-1473 Long-term Safety (LTS) Ulcerative Colitis (UC) Study).
Investigational
Matched Synonyms: … 3-((1r,3s,5s)-3-((7-((5-methyl-1h-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo(3.2.1 ... 8-azabicyclo(3.2.1)octane-8-propanenitrile, 3-((7-((5-methyl-1h-pyrazol-3-yl)amino)-1,6-naphthyridin- …
Matched Iupac: … 3-[(1R,3S,5S)-3-({7-[(5-methyl-1H-pyrazol-3-yl)amino]-1,6-naphthyridin-5-yl}amino)-8-azabicyclo[3.2.1 …

Human immunoglobulin G

Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human plasma via Cohn fractionation. The purification process includes cold alcohol fractionation, polyethylene glycol precipitation, and ion exchange chromatography. IVIg contains the same distribution of IgG antibody subclasses as is found in the general human population....
Approved
Investigational
Matched Description: … Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human ... The purification process includes cold alcohol fractionation, polyethylene glycol precipitation, and ... IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … GAMMAGARD S/D FOR INJECTION ... -C SOLUTION FOR INFUSION 10% ... OCTAGAM 5% SOLUTION FOR INFUSION …

Dexamethasone acetate

Commonly known as decadron, dexamethasone acetate is a glucocorticosteroid previously marketed in the USA for the treatment of inflammatory respiratory, allergic, autoimmune, and other conditions.[T797,L10695,L14348] Developed in 1957, dexamethasone is structurally similar to other corticosteroids such as hydrocortisone and prednisolone. Dexamethasone acetate has largely been replaced by dexamethasone phosphate and...
Approved
Investigational
Vet approved
Matched Synonyms: … 16alpha-Methyl-9alpha-fluoroprednisolone 21-acetate …
Matched Description: … to be administered for a large variety of inflammatory conditions. ... the treatment of inflammatory respiratory, allergic, autoimmune, and other conditions. ... one-third in patients on oxygen therapy and mechanical ventilation, respectively. …

Berdazimer

Berdazimer is a polymeric substance consisting of a polysiloxane backbone (Si-O-Si bonds) with covalently bound N-diazeniumdiolate nitric oxide (NO) donors. It releases NO through exposure to proton donors like water, which will degrade the N-diazeniumdiolate entity. Berdazimer was previously investigated as a potential treatment for molluscum contagiosum, a viral cutaneous...
Approved
Matched Synonyms: … Silsesquioxanes, 3-(2-hydroxy-1-methyl-2-nitrosohydrazinyl)propyl 3-(methylamino)propyl, polymers with …
Matched Description: … of adult and pediatric molluscum contagiosum, and it is the first drug to be approved for this condition ... it poses challenges such as repeated doctor visits, post-surgical scarring and skin discoloration, and ... fear and anxiety in the pediatric population. …

Choriogonadotropin alfa

Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical...
Approved
Matched Description: … O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER ... -121, SER-127, SER-132 and SER-138 (on beta subunit). ... human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gonadotropins and Antigonadotropins ... Sex Hormones and Modulators of the Genital System …
Matched Products: … Ovidrel Solution for Injection 250 mcg ... OVIDREL 250MCG/0.5ML SOLUTION FOR INJECTION …

Racecadotril

Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
Investigational
Matched Iupac: … benzyl 2-{2-[(acetylsulfanyl)methyl]-3-phenylpropanamido}acetate …
Matched Description: … Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …
Matched Products: … Hidrasec Infants 10mg Granules for Oral Suspension ... Hidrasec Children 30mg Granules for Oral Suspension ... Hidrasec Infants Granules for Oral Suspension 10mg …

Venetoclax

Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types...
Approved
Investigational
Matched Synonyms: … 4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro ... -4-{[(oxan-4-yl)methyl]amino}benzene-1-sulfonyl)-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide ... 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-(3-nitro …
Matched Iupac: … 4-yl)methyl]amino}benzenesulfonyl)-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzamide ... 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(3-nitro-4-{[(oxan- …
Matched Description: … Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lymphocytic ... Previously, this drug was indicated only for patients with 17p gene deletion [F2130]. ... A new indication was approved in 2018 for the treatment patients with chronic lymphocytic leukemia (CLL …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Isavuconazonium

Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it...
Approved
Investigational
Matched Iupac: … [3-({[2-(methylamino)acetyl]oxy}methyl)pyridin-2-yl]carbamoyl}oxy)ethyl]-1H-1,2,4-triazol-4-ium ... 1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4-[1-({methyl …
Matched Description: … [A38834] It is the prodrug form of isavuconazole, the active moiety, and it is available in oral and ... 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed ... This formulation also avoids the use of a cyclodextrin vehicle for solubilization required for intravenous …
Matched Categories: … Isavuconazole and Prodrugs …
Matched Products: … CRESEMBA POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 200MG …

Eribulin

Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for use in the treatment of...
Approved
Investigational
Matched Iupac: … 14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33S,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl …
Matched Description: … Eribulin is also being investigated for use in the treatment of advanced solid tumors [A7439]. ... Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer ... who have previously received at least two chemotherapeutic regimens for the treatment of metastatic …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … HALAVEN 0.5 mg/ml solution for injection ... Halaven Solution for Injection 0.5mg/mL …

Ranibizumab

Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment directed against human vascular endothelial growth factor A (VEGF-A), which is a glycoprotein implicated in the pathophysiology of age-related macular degeneration.[A2301, L38978] Ranibizumab is used to treat various ocular disorders with abnormal growth of blood vessels, such as neovascular...
Approved
Matched Description: … , and Health Canada respectively. ... In order to improve drug delivery to the target organ, ranibizumab is available for intravitreal use. ... used in the off-label treatment of neovascular age-related macular degeneration for intravenous injection …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Lucentis 10mg/ml Solution for Injection ... ACCENTRIX 10MG/ML SOLUTION FOR INJECTION ... LUCENTIS 10 MG/ML SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE …

Belimumab

Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A251495, L42705] By binding to...
Approved
Matched Description: … Belimumab was first approved by the FDA on March 9, 2011,[A251495] making it the newest drug to be approved for ... [A251520] It is currently used to treat SLE and lupus nephritis.[L42630] ... antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Benlysta Powder for Solution for Infusion 120mg ... Benlysta Powder for Solution for Infusion 400mg …

Ixekizumab

Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflammatory conditions. In particular, IL-17A has...
Approved
Investigational
Matched Description: … heavy chain polypeptides of 445 amino acids each, and has a molecular weight of 146,158 Daltons for ... for systemic therapy or phototherapy. ... using standard technology for bioprocessing. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Taltz 80mg solution for injection in pre-filled pen ... Taltz 80mg solution for injection in pre-filled syringe ... TALTZ SOLUTION FOR INJECTION IN PRE-FILLED PEN 80 mg/ml …

Propofol

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness,...
Approved
Investigational
Vet approved
Matched Description: … for induction and/or maintenance of anaesthesia prior to and during surgeries. ... Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia ... effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. …
Matched Categories: … Hypnotics and Sedatives …
Matched Products: … FRESOFOL 2% MCT/LCT EMULSION FOR INJECTION OR INFUSION ... Recofol N 10mg/ml Emulsion for injection or infusion ... Recofol N 20mg/ml Emulsion for injection or infusion …

Dacarbazine

An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Approved
Investigational
Matched Description: … Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Dacarbazine for Injection BP ... DAC POWDER FOR INJECTION 200 mg/vial ... DBL DACARBAZINE FOR INJECTION 200 mg …
Displaying drugs 1426 - 1450 of 2401 in total