Displaying drugs 126 - 150 of 2454 in total
Chloral hydrate
A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication.
Approved
Illicit
Investigational
Vet approved
Matched Synonyms: … chloral monohydrate …
Matched Description: … A hypnotic and sedative used in the treatment of insomnia. …
Matched Categories: … Hypnotics and Sedatives ... Miscellaneous Anxiolytics Sedatives and Hypnotics …
Matched Description: … A hypnotic and sedative used in the treatment of insomnia. …
Matched Categories: … Hypnotics and Sedatives ... Miscellaneous Anxiolytics Sedatives and Hypnotics …
Menthol
Approved
Matched Mixtures name: … Sunset Pain Relief Heating Camphor and Amino Acids ... Menthol and Zinc Oxide ... Menthol and Zinc Oxide …
Matched Products: … Nice Citrus ... Lactic Acid Free M Synergy for male ... Highpothecary Therapeutics CBD Zing …
Matched Products: … Nice Citrus ... Lactic Acid Free M Synergy for male ... Highpothecary Therapeutics CBD Zing …
Norepinephrine
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is...
Approved
Matched Description: … Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic ... It is also found in plants and is used pharmacologically as a sympathomimetic. ... Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse …
Matched Categories: … Epinephrine and similars ... Adrenergic and Dopaminergic Agents ... Alpha-and Beta-adrenergic Agonists …
Matched Products: … NOREPINEPHRINE BITARTRATE MONOHYDRATE ... LEVOPHED SULFITE FREE CONCENTRATE SOLUTION FOR IV INFUSION 1MG/ML …
Matched Categories: … Epinephrine and similars ... Adrenergic and Dopaminergic Agents ... Alpha-and Beta-adrenergic Agonists …
Matched Products: … NOREPINEPHRINE BITARTRATE MONOHYDRATE ... LEVOPHED SULFITE FREE CONCENTRATE SOLUTION FOR IV INFUSION 1MG/ML …
Lidocaine
Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local...
Approved
Vet approved
Matched Description: … Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an ... , it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and …
Matched Mixtures name: … Hyaluronic Acid 60mg and Lidocaine 2% PF ... Fluocinolone Acetonide 0.025% / Lidocaine HCl Monohydrate 1% ... Cimetidine 10% / Lidocaine 5% / Salicylic Acid 40% …
Matched Categories: … Analgesics and Anesthetics ... Antipruritics and Local Anesthetics ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …
Matched Products: … Zingo ... BENGAY Ginger Citrus ... LIDOCAINE HCL MONOHYDRATE …
Matched Mixtures name: … Hyaluronic Acid 60mg and Lidocaine 2% PF ... Fluocinolone Acetonide 0.025% / Lidocaine HCl Monohydrate 1% ... Cimetidine 10% / Lidocaine 5% / Salicylic Acid 40% …
Matched Categories: … Analgesics and Anesthetics ... Antipruritics and Local Anesthetics ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …
Matched Products: … Zingo ... BENGAY Ginger Citrus ... LIDOCAINE HCL MONOHYDRATE …
Codeine
The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease...
Approved
Illicit
Matched Description: … agent, and is also recommended in certain diseases with incessant coughing. ... The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for ... Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease …
Matched Mixtures name: … C T Acetylsalicylic Acid Codeine and Caf Tab ... Acetylsalicylic Acid, Caffeine and 8 Mg Codeine Phosphate ... Acetylsalicylic Acid, Caffeine & 8 Mg Codeine Phosphate Tablets …
Matched Salts name: … Codeine monohydrate ... Codeine sulfate ... Codeine sulfate anhydrous …
Matched Categories: … codeine and acetylsalicylic acid ... Cough and Cold Preparations ... codeine and ibuprofen ... codeine and paracetamol ... Opium Alkaloids and Derivatives …
Matched Products: … Codeine Sulfate ... Codeine sulfate …
Matched Mixtures name: … C T Acetylsalicylic Acid Codeine and Caf Tab ... Acetylsalicylic Acid, Caffeine and 8 Mg Codeine Phosphate ... Acetylsalicylic Acid, Caffeine & 8 Mg Codeine Phosphate Tablets …
Matched Salts name: … Codeine monohydrate ... Codeine sulfate ... Codeine sulfate anhydrous …
Matched Categories: … codeine and acetylsalicylic acid ... Cough and Cold Preparations ... codeine and ibuprofen ... codeine and paracetamol ... Opium Alkaloids and Derivatives …
Matched Products: … Codeine Sulfate ... Codeine sulfate …
N-acetyl-beta-D-galactosamine 6-sulfate
Experimental
Matched Synonyms: … N-Acetyl-D-galactosamine 6-sulfate ... N-acetyl-β-D-galactosamine 6-sulfate …
Matched Name: … N-acetyl-beta-D-galactosamine 6-sulfate …
Matched Iupac: … {[(2R,3R,4R,5R,6R)-5-acetamido-3,4,6-trihydroxyoxan-2-yl]methoxy}sulfonic acid …
Matched Name: … N-acetyl-beta-D-galactosamine 6-sulfate …
Matched Iupac: … {[(2R,3R,4R,5R,6R)-5-acetamido-3,4,6-trihydroxyoxan-2-yl]methoxy}sulfonic acid …
Albuterol
Salbutamol (Albuterol [USAN]) is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formulated as a...
Approved
Vet approved
Matched Description: … Salbutamol is formulated as a racemic mixture of the R- and S-isomers. ... USAN]) is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and ... The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer …
Matched Mixtures name: … Ipratropium Bromide and Albuterol Sulfate ... Ipratropium Bromide and Albuterol Sulfate ... Ipratropium Bromide and Albuterol Sulfate …
Matched Salts name: … Albuterol sulfate …
Matched Categories: … salbutamol and beclometasone ... salbutamol and sodium cromoglicate ... salbutamol and ipratropium bromide …
Matched Products: … Albuterol Sulfate ... Albuterol sulfate ... Albuterol Sulfate ER …
Matched Mixtures name: … Ipratropium Bromide and Albuterol Sulfate ... Ipratropium Bromide and Albuterol Sulfate ... Ipratropium Bromide and Albuterol Sulfate …
Matched Salts name: … Albuterol sulfate …
Matched Categories: … salbutamol and beclometasone ... salbutamol and sodium cromoglicate ... salbutamol and ipratropium bromide …
Matched Products: … Albuterol Sulfate ... Albuterol sulfate ... Albuterol Sulfate ER …
SP1049C
SP1049C is a novel anthracycline chemotherapeutic agent containing doxorubicin and two nonionic pluronic block copolymers. It is designed to overcome drug resistance in a number of cancers. It has successfully completed Phase 1 trials. Phase 2 results are currently under final review. Preliminary data, in its first clinically tested indication,...
Investigational
Matched Synonyms: … doxorubicin with pluronics F-127 and L-61 ... Doxorubicin HCl with pluronic L-61 and pluronic F-127 …
Matched Description: … Median survival is encouraging and correlates strongly with dose levels.[A260416] ... SP1049C is a novel anthracycline chemotherapeutic agent containing [doxorubicin] and two nonionic pluronic …
Matched Description: … Median survival is encouraging and correlates strongly with dose levels.[A260416] ... SP1049C is a novel anthracycline chemotherapeutic agent containing [doxorubicin] and two nonionic pluronic …
Carglumic acid
Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl glutamate synthase. This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and cause neurologic problems, cerebral edema, coma, and death. Carglumic acid was...
Approved
Matched Synonyms: … Carglumic acid ... Acide carglumique ... Acidum carglumicum …
Matched Name: … Carglumic acid …
Matched Iupac: … (2S)-2-(carbamoylamino)pentanedioic acid …
Matched Description: … Carglumic acid was approved by the U.S. Food and Drug Administration (FDA) on 18 March 2010. ... cause neurologic problems, cerebral edema, coma, and death. ... disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and …
Matched Categories: … Amino Acids and Derivatives ... Amino Acids, Peptides, and Proteins ... Alimentary Tract and Metabolism ... Amino Acids, Acidic ... Amino Acids …
Matched Products: … Carglumic Acid ... Carglumic acid ... ACIDO CARGLUMICO WAYMADE …
Matched Name: … Carglumic acid …
Matched Iupac: … (2S)-2-(carbamoylamino)pentanedioic acid …
Matched Description: … Carglumic acid was approved by the U.S. Food and Drug Administration (FDA) on 18 March 2010. ... cause neurologic problems, cerebral edema, coma, and death. ... disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and …
Matched Categories: … Amino Acids and Derivatives ... Amino Acids, Peptides, and Proteins ... Alimentary Tract and Metabolism ... Amino Acids, Acidic ... Amino Acids …
Matched Products: … Carglumic Acid ... Carglumic acid ... ACIDO CARGLUMICO WAYMADE …
PlasmaCord
PlasmaCord is platelet-poor plasma that is derived by fractionation from sterile umbilical cord and placental blood. It is developed by Cellpraxis and is currently being investigated against severe acute respiratory syndrome (SARS).
Investigational
Matched Synonyms: … Human umbilical cord and placental blood plasma …
Matched Description: … PlasmaCord is platelet-poor plasma that is derived by fractionation from sterile umbilical cord and placental ... [L27581] It is developed by Cellpraxis and is currently being investigated against severe acute respiratory …
Matched Description: … PlasmaCord is platelet-poor plasma that is derived by fractionation from sterile umbilical cord and placental ... [L27581] It is developed by Cellpraxis and is currently being investigated against severe acute respiratory …
RP-72
Investigational
Matched Synonyms: … 72 amino acid proprietary recombinant protein antagonist for the CXCR1 and CXCR2 receptors of interleukin ... CXC chemokine receptor types 1 and 2 inhibitor RP72 …
Tolevamer
Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, HIV.
Approved
Investigational
Matched Synonyms: … Polystyrene sulfonate ... polystyrenesulfonic acid ... Polystyrene sulfonic acid …
Matched Description: … Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. ... It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among ... It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines …
Matched Categories: … polystyrene sulfonate ... Drugs for Treatment of Hyperkalemia and Hyperphosphatemia ... Acids ... Sulfur Acids ... Acids, Noncarboxylic …
Matched Products: … Sodium Polystyrene Sulfonate ... CALCIUM POLYSTYRENE SULFONATE ... PMS-sodium Polystyrene Sulfonate …
Matched Description: … Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. ... It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among ... It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines …
Matched Categories: … polystyrene sulfonate ... Drugs for Treatment of Hyperkalemia and Hyperphosphatemia ... Acids ... Sulfur Acids ... Acids, Noncarboxylic …
Matched Products: … Sodium Polystyrene Sulfonate ... CALCIUM POLYSTYRENE SULFONATE ... PMS-sodium Polystyrene Sulfonate …
L-serine O-sulfate
Experimental
Matched Synonyms: … Serine O-sulfate …
Matched Name: … L-serine O-sulfate …
Matched Iupac: … (2S)-2-amino-3-(sulfooxy)propanoic acid …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Neutral …
Matched Name: … L-serine O-sulfate …
Matched Iupac: … (2S)-2-amino-3-(sulfooxy)propanoic acid …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Neutral …
Cupric Chloride
Cupric chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).
Approved
Investigational
Matched Synonyms: … Cupric chloride anhydrous …
Matched Name: … Cupric Chloride …
Matched Description: … Cupric chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to …
Matched Salts name: … Cupric chloride dihydrate …
Matched Products: … Cupric Chloride …
Matched Name: … Cupric Chloride …
Matched Description: … Cupric chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to …
Matched Salts name: … Cupric chloride dihydrate …
Matched Products: … Cupric Chloride …
Cimetidine
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Approved
Investigational
Matched Description: … It inhibits gastric acid secretion, as well as pepsin and gastrins output. …
Matched Mixtures name: … Cimetidine 10% / Lidocaine 5% / Salicylic Acid 40% ... Cimetidine 5% / Ibuprofen 2% / Salicylic Acid 17% …
Matched Categories: … Alimentary Tract and Metabolism ... Acid Reducers ... Metabolic Side Effects of Drugs and Substances ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) ... Gastric Acid Lowering Agents …
Matched Products: … Up and Up Acid Reducer ... Acid Reducer ... Equaline Acid Reducer …
Matched Mixtures name: … Cimetidine 10% / Lidocaine 5% / Salicylic Acid 40% ... Cimetidine 5% / Ibuprofen 2% / Salicylic Acid 17% …
Matched Categories: … Alimentary Tract and Metabolism ... Acid Reducers ... Metabolic Side Effects of Drugs and Substances ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) ... Gastric Acid Lowering Agents …
Matched Products: … Up and Up Acid Reducer ... Acid Reducer ... Equaline Acid Reducer …
VA-MENGOC-BC®
VA-MENGOC-BC is a meningococcal B and C vaccine and an outer membrane vesicle (OMV)-based vaccine. The OMVs contain over 100 proteins, and are derived from meningococcal group B and capsular polysaccharide of meningococcal group C. As there already exists a polysaccharide-based vaccine against meningococcal disease originating from serogroups A,C,W135, and...
Investigational
Matched Synonyms: … Meningococcal polysaccharide vaccine groups B and C …
Matched Description: … VA-MENGOC-BC is a meningococcal B and C vaccine and an outer membrane vesicle (OMV)-based vaccine. ... The OMVs contain over 100 proteins, and are derived from meningococcal group B and capsular polysaccharide ... Y, this vaccine was created for use against serogroups B and C. …
Matched Description: … VA-MENGOC-BC is a meningococcal B and C vaccine and an outer membrane vesicle (OMV)-based vaccine. ... The OMVs contain over 100 proteins, and are derived from meningococcal group B and capsular polysaccharide ... Y, this vaccine was created for use against serogroups B and C. …
Ethanol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages.
Approved
Matched Description: … It has bactericidal activity and is used often as a topical disinfectant. ... A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout ... It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as …
Matched Mixtures name: … MARINA AND DEMME HAPPY HANDS Hand Sanitizer Set UNSCENTED FRESH CITRUS COCONUT VANILLA ... MARINA AND DEMME HAPPY HANDS Hand Sanitizer Set UNSCENTED FRESH CITRUS COCONUT VANILLA ... MARINA AND DEMME HAPPY HANDS Hand Sanitizer Set UNSCENTED FRESH CITRUS COCONUT VANILLA …
Matched Categories: … Antiseptics and Disinfectants …
Matched Products: … Hyalolex Hand Sanitizer with Lemon and Zinc ... Hyalolex Hand Sanitizer with Lavender and Zinc ... Zing Hand Sanitizer …
Matched Mixtures name: … MARINA AND DEMME HAPPY HANDS Hand Sanitizer Set UNSCENTED FRESH CITRUS COCONUT VANILLA ... MARINA AND DEMME HAPPY HANDS Hand Sanitizer Set UNSCENTED FRESH CITRUS COCONUT VANILLA ... MARINA AND DEMME HAPPY HANDS Hand Sanitizer Set UNSCENTED FRESH CITRUS COCONUT VANILLA …
Matched Categories: … Antiseptics and Disinfectants …
Matched Products: … Hyalolex Hand Sanitizer with Lemon and Zinc ... Hyalolex Hand Sanitizer with Lavender and Zinc ... Zing Hand Sanitizer …
4-(Hydrogen sulfate)-beta-D-galactopyranose
Experimental
Matched Synonyms: … 4-(Hydrogen sulfate)-beta-D-galactopyranose …
Matched Name: … 4-(Hydrogen sulfate)-beta-D-galactopyranose …
Matched Iupac: … [(2R,3R,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxidanesulfonic acid …
Matched Name: … 4-(Hydrogen sulfate)-beta-D-galactopyranose …
Matched Iupac: … [(2R,3R,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxidanesulfonic acid …
Carbazochrome sulfonic acid
Experimental
Matched Name: … Carbazochrome sulfonic acid …
Matched Iupac: … (5Z)-5-[(carbamoylamino)imino]-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-indole-2-sulfonic acid …
Matched Salts name: … Carbazochrome sodium sulfonate …
Matched Products: … CARBAZOCHROME SODIUM SULFONATE …
Matched Iupac: … (5Z)-5-[(carbamoylamino)imino]-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-indole-2-sulfonic acid …
Matched Salts name: … Carbazochrome sodium sulfonate …
Matched Products: … CARBAZOCHROME SODIUM SULFONATE …
NeuroCell-PD
Investigational
Matched Synonyms: … Porcine fetal neural dopaminergic cells and/or precursors aseptically prepared and coated with anti-MHC …
Tretinoin
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant,...
Approved
Investigational
Nutraceutical
Matched Synonyms: … Retinoic acid ... Retionic acid ... Acide retinoique …
Matched Iupac: … (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid …
Matched Description: … Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin ... activates nuclear receptors to regulate epithelial cell growth and differentiation. ... [A257689] Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging …
Matched Mixtures name: … Clindamycin 1% / Sodium Sulfacetamide Monohydrate 5% / Tretinoin 0.025% ... Clindamycin Phosphate and Tretinion ... OLIVIA QUIDO FIRM and FADE I …
Matched Categories: … Cell Stimulants and Proliferants ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Vitamin A Acid ... ACIDO RETINOICO ... Vitamin A Acid 0.1% Cream …
Matched Iupac: … (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid …
Matched Description: … Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin ... activates nuclear receptors to regulate epithelial cell growth and differentiation. ... [A257689] Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant, and free radical-scavenging …
Matched Mixtures name: … Clindamycin 1% / Sodium Sulfacetamide Monohydrate 5% / Tretinoin 0.025% ... Clindamycin Phosphate and Tretinion ... OLIVIA QUIDO FIRM and FADE I …
Matched Categories: … Cell Stimulants and Proliferants ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Vitamin A Acid ... ACIDO RETINOICO ... Vitamin A Acid 0.1% Cream …
Glycolic acid
Approved
Investigational
Matched Synonyms: … Glycollic acid ... 2-Hydroxyacetic acid ... Hydroxyacetic acid …
Matched Name: … Glycolic acid …
Matched Iupac: … 2-hydroxyacetic acid …
Matched Mixtures name: … CREMA CON ACIDO GLICOLICO AL 8% …
Matched Categories: … Acids, Acyclic ... Hydroxy Acids ... Carboxylic Acids …
Matched Products: … Glycolic Acid ... ACIDO GLICOLICO OVOCELL …
Matched Name: … Glycolic acid …
Matched Iupac: … 2-hydroxyacetic acid …
Matched Mixtures name: … CREMA CON ACIDO GLICOLICO AL 8% …
Matched Categories: … Acids, Acyclic ... Hydroxy Acids ... Carboxylic Acids …
Matched Products: … Glycolic Acid ... ACIDO GLICOLICO OVOCELL …
Lonoctocog alfa
Approved
Investigational
Matched Products: … AFSTYLA POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 250IU/VIAL ... AFSTYLA POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500IU/VIAL ... AFSTYLA 250IU powder and solvent for solution for injection …
AFM-13
Investigational
Matched Synonyms: … Recombinant antibody construct against human CD30 and CD16A …
Displaying drugs 126 - 150 of 2454 in total