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Displaying drugs 1876 - 1900 of 13977 in total
A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra...
Approved
Matched Iupac: … methyl(2-methyl-1-phenylpropan-2-yl)amine …
Matched Categories: … Adrenergic and Dopaminergic Agents …
Fluciclovine is a [18F]-tagged synthetic analog of the amino acid L-leucine. It presents excellent diagnostic properties to be used in positron emission tomography (PET) imaging. The structure of fluciclovine allows it to be uptaken by the tumoral cells by its amino acid transporter without incorporating in the metabolism within the...
Approved
Matched Description: … Fluciclovine is a [18F]-tagged synthetic analog of the amino acid L-leucine. ... [A31385] Fluciclovine was developed by Blue Earth Diagnostics, Ltd. and FDA approved in May 27, 2016. …
Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate.
Approved
Matched Description: … as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and
Matched Mixtures name: … Kaolin and Pectin Susp …
Matched Categories: … Alimentary Tract and Metabolism …
The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in...
Approved
Investigational
Matched Description: … photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Bicisate, also known as ethyl cysteinate dimer (ECD), is a N,N'-1,2-ethylene-di-yl-bis-L-cysteinate diethyl ester. It is used in conjunction with technetium Tc99m as a tracer to measure cerebral blood flow with single-photon emission computed tomography (SPECT). The complex of bicisate and technetium Tc99m as a kit was developed by Lantheus Medcl...
Approved
Investigational
Matched Description: … [A32374] The complex of bicisate and technetium Tc99m as a kit was developed by Lantheus Medcl and FDA-approved …
Pibrentasvir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS5A inhibitor that targets the the viral RNA replication and viron assembly. In combination with DB13879, pibrentastiv is a useful therapy for patients who experienced therapeutic failure from other NS5A inhibitors. In cell cultures, the emergence of amino...
Approved
Investigational
Matched Iupac: … methyl N-[(2S,3R)-1-[(2S)-2-{5-[(2R,5R)-1-{3,5-difluoro-4-[4-(4-fluorophenyl)piperidin-1-yl]phenyl}-5 …
Matched Description: … the the viral RNA replication and viron assembly. ... Pibrentasvir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS5A inhibitor that targets ... resistance-associated positions in HCV genotype 1a, 2a or 3a replicons led to reduced susceptibility and
Matched Categories: … glecaprevir and pibrentasvir …
Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as Roflumilast and Crisaborole.[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July 2019, apremilast was granted...
Approved
Investigational
Matched Description: … It belongs to the same drug class as [Roflumilast] and [Crisaborole]. ... associated with Behcet's disease, an autoimmune condition that causes recurrent skin, blood vessel, and
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Cocoa butter is an edible natural fat obtained from the Theobroma cocoa seeds that is predominantly found in dark chocolate . It is a rich source of monounsaturated and saturated fatty acids that mainly contains approximately 33% DB04224, 25% DB03796, and 33% DB03193 but does not contain caffeine or theobromine....
Approved
Matched Description: … Cocoa butter is included in chocolate and other food products, and can also be found in over-the-counter ... skin products such as lotions, creams, and bars intended to maintain skin softness. ... Oftentimes cocoa butter is used in over-the-counter pharmaceutical products and suppositories. …
Matched Mixtures name: … Up and Up Hemorrhoidal …
Matched Categories: … Diet, Food, and Nutrition ... Antipruritics and Local Anesthetics …
Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands. The pancrelipase lipase is an enzyme secreted by the pancreas that is responsible for the hydrolysis of dietary fat molecules in the human digestive system....
Approved
Matched Description: … Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and ... mixture, including pancrelipase lipase, was developed by Ortho-McNeil-Janssen Pharmaceuticals, Inc and
Matched Mixtures name: … Pancreatin and Enzyme Formula - Tablet …
Matched Categories: … Enzymes and Coenzymes …
Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter acetylcholine (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its...
Approved
Matched Description: … [A19054] It has been widely used for over 50 years,[A299] most commonly in its chloride salt form, as ... Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and ... a means of neuromuscular blockade during intubation and surgical procedures. …
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Approved
Investigational
Matched Iupac: … 5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazoline-2,4-diamine …
Matched Description: … It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …
Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.
Approved
Investigational
Matched Description: … After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases …
Matched Categories: … Ganciclovir and prodrug ... Nucleosides and Nucleotides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. In clinical trials, acemetacin exhibits a better gastric tolerability compared to its active metabolite indometacin. It was developed by...
Approved
Investigational
Matched Iupac: … 2-({2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)acetic acid …
Matched Description: … Merck and Company in Germany as an attempt to provide a safer drug but other than the amelioration on ... the gastrointestinal effects, the metabolism of acetamicin led to the formation of indomethacin and
Matched Categories: … Acetic Acid Derivatives and Related Substances ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Acetarsol, with the molecular formula N-acetyl-4-hydroxy-m-arsanilic acid, is a pentavalent arsenical compound with antiprotozoal and antihelmintic properties. It was first discovered in 1921 by Ernest Fourneau at the Pasteur Institute. It was developed by Neolab Inc, and approved by Health Canada as an antifungal on December 31, 1964. It has...
Approved
Withdrawn
Matched Description: … It has been canceled and withdrawn from the market since August 12, 1997.[L1113] ... formula N-acetyl-4-hydroxy-m-arsanilic acid, is a pentavalent arsenical compound with antiprotozoal and ... It was developed by Neolab Inc, and approved by Health Canada as an antifungal on December 31, 1964. …
Matched Categories: … Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Agents Against Leishmaniasis and Trypanosomiasis ... Gynecological Antiinfectives and Antiseptics ... Antiparasitic Products, Insecticides and Repellents …
Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.
Approved
Matched Description: … Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular …
Matched Categories: … Hypnotics and Sedatives …
Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibition prevents the integration of HIV-1 DNA into the host genome and thereby blocks the formation of the...
Approved
Matched Iupac: … 6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline …
Matched Description: … On September 24, 2014, the FDA approved the single pill form of elvitegravir. ... Elvitegravir was first licensed from Japan Tobacco in 2008 and developed by Gilead Sciences. ... thereby blocks the formation of the HIV-1 provirus and resulting propagation of the viral infection. …
Matched Categories: … emtricitabine, tenofovir disoproxil, elvitegravir and cobicistat ... emtricitabine, tenofovir alafenamide, elvitegravir and cobicistat …
Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15...
Approved
Matched Iupac: … 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide …
Matched Description: … Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. ... The 15 mg and 20 mg tablet should be taken with food. FDA approved on July 1, 2011. …
Matched Categories: … Blood and Blood Forming Organs …
Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Approved
Matched Iupac: … 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide …
Matched Description: … It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Trimetazidine is a piperazine derivative indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies. Trimetazidine has been studied as a treatment for angina pectoris since the late 1960s.[A233255,A233260] Acidic conditions, caused by anaerobic metabolism and fatty acid oxidation, in response...
Approved
Investigational
Matched Iupac: … 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine …
Matched Description: … to myocardial ischemia, activate sodium-hydrogen and sodium-calcium antiport systems. ... [A233255,A233260] Acidic conditions, caused by anaerobic metabolism and fatty acid oxidation, in response …
Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues
Approved
Withdrawn
Matched Description: … Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatropin and Somatropin Agonists ... Anterior Pituitary Lobe Hormones and Analogues …
Ganaxolone is the 3β-methylated synthetic analog of allopregnanolone, a metabolite of progesterone. Ganaxolone belongs to a class of compounds referred to as neurosteroids. Endogenous neurosteroids, which comprise certain metabolites of progesterone and deoxycorticosterone, bind potently and specifically to GABAA receptors to enhance their inhibitory effects, and are thus known to...
Approved
Investigational
Matched Description: … Ganaxolone is the 3β-methylated synthetic analog of [allopregnanolone],[L41130] a metabolite of [progesterone ... , bind potently and specifically to GABAA receptors to enhance their inhibitory effects, and ... [A3197] Endogenous neurosteroids, which comprise certain metabolites of progesterone and deoxycorticosterone …
Phenylbutyric acid is a fatty acid and a derivative of butyric acid naturally produced by colonic bacteria fermentation. It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting as a chemical chaperone. It is used to treat genetic metabolic syndromes, neuropathies, and urea cycle disorders.[L386,L42105]
Approved
Investigational
Matched Description: … It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting ... [A249035] It is used to treat genetic metabolic syndromes, neuropathies, and urea cycle disorders. ... Phenylbutyric acid is a fatty acid and a derivative of [butyric acid] naturally produced by colonic bacteria …
Matched Categories: … Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …
Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes.
Approved
Investigational
Matched Iupac: … -hydroxyphenyl)ethyl]carbamoyl}-2-hydroxypropyl]carbamoyl}ethyl]carbamoyl}-2-hydroxyethyl]carbamoyl}methyl ... ,13S,16S,19R)-16-(carbamoylmethyl)-19-[(2S)-2,6-diaminohexanamido]-7,13-bis[(1R)-1-hydroxyethyl]-10-methyl ... methylpropyl]carbamoyl}ethyl]carbamoyl}-2-hydroxypropyl]carbamoyl}pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-4-methyl
Matched Description: … Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metabolism. Alpelisib was designed to target...
Approved
Investigational
Matched Iupac: … (2S)-N1-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine …
Matched Description: … Alpelisib is marketed under the trade name Piqray and is available as oral tablets. ... that plays a role in various biological processes, including proliferation, survival, differentiation, and ... To initiate alpelisib therapy, it is required that the presence of a PIK3CA mutation in the tissue and
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Nalmefene, a 6-methylene analogue of naltrexone, is an opioid receptor antagonist. It acts as an antagonist at the mu (μ)-opioid and delta (δ)-opioid receptors and a partial agonist at the kappa (κ)-opioid receptor. In Europe, nalmefene oral tablets are used to reduce alcohol consumption in adults with alcohol dependence. Nalmefene...
Approved
Investigational
Withdrawn
Matched Description: … [L40684] It acts as an antagonist at the mu (μ)-opioid and delta (δ)-opioid receptors and a partial agonist ... partial reversal of opioid drug effects, including respiratory depression, induced by either natural or synthetic
Displaying drugs 1876 - 1900 of 13977 in total