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Displaying drugs 176 - 200 of 14551 in total
Oprelvekin, the active ingredient in Neumega®, is recombinant Interleukin-11 (IL-11), which is produced in Escherichia coli (E. coli) by recombinant DNA technology. With a molecular mass of approximately 19,000 daltons, the non-glycosylated protein is 177 amino acids in length in comparison to the natural IL-11, which is 178 amino acid...
Approved
Investigational
Matched Description: … With a molecular mass of approximately 19,000 daltons, the non-glycosylated protein is 177 amino acids ... in Escherichia coli (E. coli) by recombinant DNA technology. ... in length in comparison to the natural IL-11, which is 178 amino acid long. …
Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotarix is a live attenuated vaccine containing the...
Approved
Matched Description: … Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. ... [L1116] Rotarix is a live attenuated vaccine containing the 89-12 human strain. ... [L1117] Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq …
Matched Salts name: … Human Rotavirus A type G1P(8) strain RIX4414 live antigen ... Human Rotavirus A type G1P7(5) strain WI79 live antigen ... Human Rotavirus A type G2P7(5) strain SC2 live antigen ... Human Rotavirus A type G4P7(5) strain BRB live antigen ... Human Rotavirus A type G3P7(5) strain WI78 live antigen …
Matched Products: … ROTARIX ORAL SÜSPANSIYON HAZIRLAMAK IÇIN LIYOFILIZE TOZ IÇEREN FLAKON, 1 ADET …
Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss . Progesterone is used in various contraceptive preparations to prevent ovulation...
Approved
Vet approved
Matched Iupac: … [a]phenanthren-7-one ... (1S,3aS,3bS,9aR,9bS,11aS)-1-acetyl-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta …
Matched Description: … , embryo implantation, and the successful establishment of pregnancy. ... Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity ... to progesterone of human ovarian origin [FDA label]. …
Matched Categories: … Sex Hormones and Modulators of the Genital System …
Matched Products: … N/A ... Gesterol In Oil-liq Im 50mg/ml ... PROGESTOGEL 1% …
Tepotinib is a MET tyrosine kinase inhibitor intended to treat a variety of MET-overexpressing solid tumors. It was originally developed in partnership between EMD Serono and the University of Texas M.D. Anderson Cancer Center in 2009 and has since been investigated in the treatment of neuroblastoma, gastric cancers, non-small cell...
Approved
Investigational
Matched Iupac: … 3-{1-[(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}phenyl)methyl]-6-oxo-1,6-dihydropyridazin …
Matched Description: … [A228058] MET is a desirable target in the treatment of certain solid tumors as it appears to play a ... (NSCLC) with _MET_ alterations, and was subsequently granted accelerated approval by the US FDA in February ... overexpressed and/or mutated. …
Matched Categories: … MATE 1 Inhibitors ... Heterocyclic Compounds, 1-Ring …
Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to ibandronic acid, minodronic acid, and risedronic acid. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone.[L13712,L13715,L13721] Zoledronic acid...
Approved
Matched Synonyms: … (1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid ... (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid …
Matched Iupac: … [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid …
Matched Description: … [L13712,L13715,L13721] Zoledronic acid was first described in the literature in 1994. ... Zoledronic acid, or CGP 42'446,[A203120] is a third generation, nitrogen containing bisphosphonate similar ... of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Drugs for Treatment of Bone Diseases …
Matched Products: … N/A ... Zoledronic Acid - A ... Zoledronic Acid Injection A
C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibition of several target proteases within...
Approved
Investigational
Matched Description: … C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase ... Down-stream effects of the lack of enzyme inhibition by C1 esterase inhibitor results in swelling due ... Additionally, C4 and C2 cleavage occurs resulting in auto-activation of the complement system. …
Matched Categories: … Drugs Used in Hereditary Angioedema …
Matched Products: … RUCONEST 2100 U IV ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ İÇEREN FLAKON, 1 ADET …
Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals. It received FDA approval on February 27, 2020 for the acute treatment migraine headache, and was subsequently approved by the European Commission in April 2022 for both the treatment and prevention of migraines. While several parenteral antagonists...
Approved
Investigational
Matched Iupac: … yl}piperidine-1-carboxylate ... 2,3-difluorophenyl)-5H,6H,7H,8H,9H-cyclohepta[b]pyridin-9-yl 4-{2-oxo-1H,2H,3H-imidazo[4,5-b]pyridin-1- …
Matched Description: … ] and was subsequently approved by the European Commission in April 2022 for both the treatment and prevention ... Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals. ... that possessed oral bioavailability[A189207] until the approval of [atogepant] in 2021. …
Matched Categories: … MATE 1 Inhibitors ... Heterocyclic Compounds, 1-Ring ... Calcitonin Gene-Related Peptide (CGRP) Antagonists ... Calcitonin Gene-Related Peptide Receptor Antagonists …
Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately .
Approved
Matched Iupac: … 4-[(1R)-1-hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]benzene-1,2-diol …
Matched Description: … diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately ... to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in ... Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Adrenergic beta-1 Receptor Agonists …
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid...
Approved
Investigational
Matched Iupac: … methyl 3-[(7S)-12-bromo-3-methyl-9-(pyridin-2-yl)-2,5,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14), …
Matched Description: … [A214857] These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/ ... was approved for use by the FDA in July 2020 under the brand name Byfavo. ... Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation …
Varenicline is a prescription medication used to treat smoking addiction. This medication is the first approved nicotinic receptor partial agonist. Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine receptor. In addition it acts on alpha3/beta4 and weakly on alpha3beta2 and alpha6-containing receptors. A full...
Approved
Investigational
Matched Description: … Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine ... The FDA said it is keeping the black box in place at least until the results of the trial are announced ... Pfizer is conducting an additional safety study of the drug, results of which are expected in late 2015 …
Matched Mixtures name: … CHAMPIX 0,5 MG 11 + 1 MG 42 FILM KAPLI TABLET ... CHAMPIX 0,5 MG 11 + 1 MG 42 FILM KAPLI TABLET ... CHAMPIX 0,5 MG 1 MG FILM KAPLI TABLET, 11 VE 14 ADET …
Matched Categories: … Drugs Used in Addictive Disorders ... Drugs Used in Nicotine Dependence …
Matched Products: … และ 1 มก.) ... แชมปิกซ์ (1 มก.) ... CHAMPIX 1 MG FILM KAPLI TABLET, 28 ADET …
A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amino acids. This leads...
Approved
Investigational
Matched Description: … This leads to excretion of these amino acids and a decrease in ammonia levels. ... It is conjugated to GLYCINE in the liver and excreted as hippuric acid. ... Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia …
Matched Salts cas: … 532-32-1
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … S Panax All In One Mist …
Live attenuated zoster vaccine is available as two products: Zostavax for the prevention of shingles in immunocompetent people over the age of 50, and Varivax for the prevention of chickenpox in individuals 12 months of age and older. While the two vaccines contain the same immunological components and provide protection...
Approved
Matched Description: … by only 51% and the risk of post-herpetic neuralgia by 67% [A31349]. ... First approved in May 2006 by the Food and Drug Administration, Zostavax was the first vaccine available ... virus, Zostavax contains a higher dose and is used in older adults to prevent the development of shingles …
Matched Mixtures name: … Priorix - Tetra Pulver in einer Durchstechflasche und Lösungsmittel in einer Fertigspritze zur Herstellung ... ENJEKSIYONLUK SÜSPANSIYON HAZIRLAMAK IÇIN LIYOFILIZE TOZ IÇEREN FLAKON VE ÇÖZÜCÜ IÇEREN ENJEKTÖR , 1 ... PRIORIX-TETRA 0.5 ML SC ENJEKSIYON IÇIN LIYOFILIZE TOZ IÇEREN FLAKON VE ÇÖZÜCÜ IÇEREN KULLANIMA HAZIR ENJEKTÖR, 1
Matched Products: … SUSPANSIYON HAZIRLAMAK ICIN LIYOFILIZE TOZ ICEREN FLAKON VE COZUCU ICEREN KULLANIMA HAZIR ENJEKTOR, 1 ... VARIVAX Pulver und Lösungsmittel zur Herstellung einer Injektionssuspension in einer Fertigspritze ... Varilrix Pulver und Lösungsmittel zur Herstellung einer Injektionssuspension in einer Fertigspritze …
Oxybuprocaine (also known as Benoxinate) is a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.
Approved
Investigational
Matched Description: … Oxybuprocaine (also known as Benoxinate) is a local anesthetic, which is used especially in ophthalmology ... Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases …
Matched Products: … Benoxinat 1% - Lösung zur Anästhesie in der Oto-Rhino-Laryngologie …
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939.
Approved
Matched Iupac: … 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol …
Matched Description: … [A187370] The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s ... Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate ... the pupil,[L9413] and induce local vasoconstriction. …
Matched Salts cas: … 1416-03-1
Matched Mixtures name: … Doc in the Box All Day Supply ... Meds on the Go ... Day Time Cold Multi-Symptom Cool Blast
Matched Categories: … Compounds used in a research, industrial, or household setting ... Adrenergic alpha-1 Receptor Agonists ... Monoamine Oxidase A Substrates …
Matched Products: … Help I Have the Sniffles ... Help I Have a Stuffy Nose ... PHENYLALPHA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 50MCG/ML …
Theobroma cacao, whole, allergenic extract is used in allergenic testing.
Approved
Matched Description: … Theobroma cacao, whole, allergenic extract is used in allergenic testing. …
Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as...
Approved
Matched Iupac: … 1-{[3,4,5-tris(2-hydroxypropoxy)-6-{[4,5,6-tris(2-hydroxypropoxy)-2-[(2-hydroxypropoxy)methyl]oxan-3- …
Matched Description: … and adjunct agent in topical drug formulations to facilitate the delivery of drugs with hydrophobic ... It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its ... Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming …
Matched Salts name: … Hydroxyethyl cellulose (1500 MPa.s at 1%) ... Hydroxyethyl cellulose (2000 MPa.s at 1%) ... Hydroxyethyl cellulose (3000 MPa.s at 1%) ... Hydroxyethyl cellulose (4000 MPa.s at 1%) ... Hydroxyethyl cellulose (5000 MPa.s at 1%) …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and...
Approved
Investigational
Matched Iupac: … (3S)-N-{5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}-3-hydroxypyrrolidine ... -1-carboxamide …
Matched Description: … kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important ... both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress ... [L49821] Larotrectinib was granted accelerated approval by the FDA in November 2018 for the treatment …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. It is derived from cephamycin C, which is produced by Streptomyces lactamdurans.
Approved
Matched Synonyms: … (6R,7S)-4-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(thiophen-2-enyl)acetamido]-5-thia-1-azabicyclo[4.2.0 …
Matched Iupac: … (6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0 …
Matched Description: … It is derived from cephamycin C, which is produced by Streptomyces lactamdurans. ... Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. …
Triclocarban, with the chemical formula C13H9Cl3N2O is an antibacterial agent that is particularly effective against Gram-positive bacteria such as Staphylococcus aureus. It is a bacteriostatic compound that has been found in antibacterial soaps and other personal care products. In 2017, the US FDA prohibited the marketing of over-the-counter (OTC) consumer...
Approved
Matched Synonyms: … 1-(3',4'-dichlorophenyl)-3-(4'-chlorophenyl)urea …
Matched Iupac: … 3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea …
Matched Description: … In 2017, the US FDA prohibited the marketing of over-the-counter (OTC) consumer antiseptic wash products ... It is a bacteriostatic compound that has been found in antibacterial soaps and other personal care products ... Triclocarban, with the chemical formula C13H9Cl3N2O [L2675] is an antibacterial agent that is particularly …
Matched Products: … NEXT 1 Anti-bacterial ... Next 1 Anti-Bacterial Sport ... Cuticura Medicated Soap Unscented 1% …
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated)....
Approved
Illicit
Matched Description: … It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia ... (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Meprobamate is a controlled substance in the ... but has largely been superseded by the benzodiazepines. …
Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. Often the result of long-term myocardial ischemia, cardiomyopathy, or other cardiac insults, heart failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and metabolites, resulting in complex systemic pathologies. Heart...
Approved
Matched Description: … Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. ... , resulting in complex systemic pathologies. ... Winthrop Research Institute in the 1980s. …
Matched Mixtures name: … Milrinone Lactate in Dextrose …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Heterocyclic Compounds, 1-Ring …
Matched Products: … Milrinone Lactate in Dextrose ... Milrinon Hikma 1 mg/ml Injektionslösung ... Milrinon Tillomed 1 mg/ml Injektions-/Infusionslösung …
Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of...
Approved
Vet approved
Withdrawn
Matched Iupac: … N-(4-chlorophenyl)-1-{N'-[6-(N-{[N'-(4-chlorophenyl)carbamimidamido]methanimidoyl}amino)hexyl]carbamimidamido …
Matched Description: … [L11518,L11512,A190453] Chlorhexidine was developed in the UK by Imperial Chemical Industries in the ... practice for the treatment of inflammatory dental conditions caused by microorganisms. ... biguanide groups joined by a central hexamethylene chain. …
Matched Salts cas: … 56-95-1 ... 3697-42-5 …
Matched Mixtures name: … Cathejell Diphenhydramin 1 % / Chlorhexidin 0,05 % - Gel (in Tuben) ... QUIRUCIDAL NF ... easyangin Spray zur Anwendung in der Mundhöhle …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Chlorhexamed 1% - Gel zur Anwendung in der Mundhöhle ... Chlorhexamed Direkt 1 % - Gel zur Anwendung in der Mundhöhle ... Alsoft A Hand Disinfectant 0.2% w/v …
Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it...
Approved
Matched Description: … Although approved for the treatment of rheumatoid arthritis, Repligen has entered a slightly different ... Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated ... of 92,300 Da and it is a homodimer of two homologous polypeptide chains of 357 amino acids each. …
Matched Products: … ORENCIA Injection 125mg/ml in Prefilled Syringe …
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is...
Approved
Investigational
Matched Synonyms: … 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one …
Matched Iupac: … 4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one …
Matched Description: … elongation of DNA chains, thus resulting in the termination of viral DNA growth. ... A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by ... The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector therapy. Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of wounds associated with dystrophic epidermolysis bullosa (DEB). DEB is caused by mutations in the COL7A1 gene that...
Approved
Matched Synonyms: … Dna (recombinant herpes simplex virus type 1 strain kos plasmid vector kb103 human collagen col7a1-specifying …
Matched Description: … [L46916] DEB is caused by mutations in the _COL7A1_ gene that encodes collagen VII (COL7), a major component ... Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of ... Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector …
Matched Categories: … Cellular and Gene Therapy …
Displaying drugs 176 - 200 of 14551 in total