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Displaying drugs 2426 - 2450 of 14950 in total

Tilmanocept

Tilmanocept is under investigation in clinical trial NCT03241446 (Pharmacokinetics and Dosimetry of Tc 99m Tilmanocept Following a Single Intravenous Dose Administration in Male and Female Subjects Diagnosed With Rheumatoid Arthritis (RA)).
Approved
Investigational
Matched Description: … Tilmanocept is under investigation in clinical trial NCT03241446 (Pharmacokinetics and Dosimetry of Tc ... 99m Tilmanocept Following a Single Intravenous Dose Administration in Male and Female Subjects Diagnosed …

Siponimod

Siponimod, also known as Mayzent, by Novartis, is a new drug formulated for the management of Multiple Sclerosis (MS). It was approved by the FDA on March 26, 2019 and by Health Canada on February 20, 2020. This drug is considered a sphingosine-1-phosphate (S1P) receptor modulator and is thought to...
Approved
Investigational
Matched Iupac: … cyclohexyl-3-(trifluoromethyl)phenyl]methoxy}imino)ethyl]-2-ethylphenyl}methyl)azetidine-3-carboxylic acid …
Matched Description: … , disrupting communication between the brain and other parts of the body. ... It was approved by the FDA on March 26, 2019 [L5792] and by Health Canada on February 20, 2020. ... [L12171] This drug is considered a _sphingosine-1-phosphate (S1P) receptor modulator_ and is thought …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Crotalus scutulatus antivenin

Crotalus scutulatus antivenin is derived and purified immunoglobulin fragments obtained from other domestic animals such as sheep previously immunized with Crotalus scutulatus (also known as the Mojave rattlesnake ). The final purified antivenin product is obtained by mixing other different monospecific snake antivenins and isolating the antivenin of interest through...
Approved
Experimental
Matched Description: … isolating the antivenin of interest through fractionation and chromatography techniques. ... Crotalus scutulatus antivenin is derived and purified immunoglobulin fragments obtained from other domestic ... Mojave rattlesnakes inhabit desert areas of the southwestern United States and central Mexico. …

Metaxalone

Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous system depression. Metaxalone...
Approved
Matched Description: … Metaxalone is associated with few side effects and is available as a 800 mg scored tablet. ... muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and …

Amantadine

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and...
Approved
Matched Description: … It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic ... effects in movement disorders are not well understood but probably reflect an increase in synthesis and …

Bithionol

Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the NDA's for bithionol drug products were withdrawn on October 24, 1967 (see the Federal Register of October 31, 1967 (32...
Approved
Withdrawn
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …

Fludeoxyglucose (18F)

Fludeoxyglucose F 18 Injection is a positron emitting radiopharmaceutical containing no-carrier added radioactive 2-deoxy-2-[18F]fluoro-D-g1ucose, which is used for diagnostic purposes in conjunction with Positron Emission Tomography (PET). It is administered by intravenous injection.
Approved
Investigational
Matched Categories: … Indicators and Reagents …

Methylchloroisothiazolinone

Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties. It is found within many commercially available cosmetics, lotions, and makeup removers. It is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness,...
Approved
Experimental
Matched Description: … It is found within many commercially available cosmetics, lotions, and makeup removers. ... scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area. ... Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and …

Selexipag

Selexipag was approved by the United States FDA on December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce risk of hospitalization. PAH is a relatively rare disease with usually a poor prognosis requiring more treatment options to prolong long-term outcomes. Marketed by...
Approved
Matched Description: … December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and ... Marketed by Actelion Pharmaceuticals under brand name Uptravi, selexipag and its active metabolite, ACT ... act as agonists of the prostacyclin receptor to increase vasodilation in the pulmonary circulation and …
Matched Categories: … Blood and Blood Forming Organs …

Iodoform

Iodoform is an organoiodine compound with the formula CHI3 and a tetrahedral molecular geometry. It is a relatively water-insoluble yellow solid that is chemically reactive in free-radical reactions . Due to its antimicrobial properties following topical administration, minimal levels of iodoform may be found in disinfectants and it is more...
Approved
Experimental
Vet approved
Matched Description: … Iodoform is an organoiodine compound with the formula CHI3 and a tetrahedral molecular geometry. ... dressing or powder for wounds and sores, however such clinical use to this date is limited. ... Since the beginning of the 20th century, iodoform has been commonly used as a healing and antiseptic …

Phenytoin

Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as...
Approved
Vet approved
Matched Description: … Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one ... [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market. ... has also been investigated for several other indications such as bipolar disorder, retina protection, and …
Matched Categories: … Medications that reduce magnesium levels ... Phenytoin and Prodrugs ... Metabolic Side Effects of Drugs and Substances …

Carvedilol

Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as...
Approved
Investigational
Matched Description: … , and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. ... Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker ... [L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension …
Matched Categories: … carvedilol and ivabradine ... Alpha and Beta Blocking Agents ... Calcium-Regulating Hormones and Agents …

Etrasimod

Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that targets the S1P1,4,5 with no detectable activity on S1P2 and S1P3 receptors. S1P receptors are membrane-derived lysophospholipid signaling molecules that are involved in the sequestration of circulating peripheral lymphocytes in lymph nodes. Therefore, S1P receptor modulators like etrasimod...
Approved
Matched Iupac: … 3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1H,2H,3H,4H-cyclopenta[b]indol-3-yl]acetic acid …
Matched Description: … 26% remission rate observed in UC 52 and UC 12 trials respectively. ... receptor modulator that targets the S1P1,4,5 with no detectable activity on S1P2 and ... obtained from Pfizer’s Elevate UC Phase III registrational program, consisting of the Elevate UC 52 and …

Mequinol

Mequinol is a phenol used in various applications. It is used as an inhibitor for acrylic monomers and acrylonitirles, as a stabilizer for chlorinated hydrocarbons and ethyl cellulose, as an ultraviolet inhibitor, as a chemical intermediate in the manufacture of antioxidants, pharmaceuticals, plasticizers, and dyestuffs . It is found as...
Approved
Matched Description: … , pharmaceuticals, plasticizers, and dyestuffs [L993]. ... It is used as an inhibitor for acrylic monomers and acrylonitirles, as a stabilizer for chlorinated hydrocarbons ... and ethyl cellulose, as an ultraviolet inhibitor, as a chemical intermediate in the manufacture of antioxidants …

Xenon-133

Xenon-133 is an inhaled radionuclide used for lung imaging, imaging blood flow in the brain, and to assess pulmonary function.
Approved
Matched Description: … Xenon-133 is an inhaled radionuclide used for lung imaging, imaging blood flow in the brain, and to assess …

Sea salt

Sea salt is the salt obtained from the evaporation of seawater or water from saltwater lakes. Sea salt production is subject to little processing which leaves certain trace minerals and elements behind. In comparison, table salt is mined from underground sedimentary deposits and is more heavily processed to eliminate minerals....
Approved
Matched Description: … Sea salt production is subject to little processing which leaves certain trace minerals and elements ... In comparison, table salt is mined from underground sedimentary deposits and is more heavily processed ... Unlike sea salt, table salt usually contains an additive to prevent clumping and involves addition of …

Nuvaxovid

SARS-CoV-2, the causative agent of COVID-19, relies on the interaction between its trimeric spike (S) glycoprotein and angiotensin-converting enzyme 2 (hACE2) expressed on host cells in order to establish a productive infection in humans. Antibodies directed against the S protein are capable of blocking S-hACE2 interactions and neutralizing viral particles...
Approved
Investigational
Matched Description: … neutralizing viral particles and are present in convalescent patients and those who have been inoculated ... of inducing productive cellular and humoral immune responses in humans and across a wide range of animal ... causative agent of COVID-19, relies on the interaction between its trimeric spike (S) glycoprotein and …

Primidone

Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954.
Approved
Vet approved
Matched Description: … [L11112] Primidone was developed by J Yule Bogue and H C Carrington in 1949. ... Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and …
Matched Categories: … Barbiturates and Derivatives ... Hypnotics and Sedatives ... Phenobarbital and similars …

Risdiplam

Risdiplam is an orally bioavailable mRNA splicing modifier used for the treatment of spinal muscular atrophy (SMA). It increases systemic SMN protein concentrations by improving the efficiency of SMN2 gene transcription. This mechanism of action is similar to its predecessor nusinersen, the biggest difference being their route of administration: nusinersen...
Approved
Investigational
Matched Description: … substantially cheaper than other available SMA therapies,[L15351] risdiplam appears to provide a novel and …

Foscarbidopa

Foscarbidopa is under investigation in clinical trial NCT04379050 (Extension Study to Evaluate Safety and Tolerability of 24-hour Daily Exposure of Continuous Subcutaneous Infusion of ABBV-951 in Adult Participants With Parkinson's Disease).
Approved
Investigational
Matched Iupac: … (2S)-2-hydrazinyl-3-[3-hydroxy-4-(phosphonooxy)phenyl]-2-methylpropanoic acid …
Matched Description: … Foscarbidopa is under investigation in clinical trial NCT04379050 (Extension Study to Evaluate Safety and …

Voretigene neparvovec

Voretigene Neparvovec-rzyl (VN-rzyl) is an adeno-associated virus vector-based gene therapy. An adeno-associated virus is a small virus that infects humans and other primates. It is not pathogenic and it causes a very mild immune response. This type of virus is vastly used as vectors for gene therapy because they can...
Approved
Matched Description: … It is not pathogenic and it causes a very mild immune response. ... [L1094] An adeno-associated virus is a small virus that infects humans and other primates. ... [A31478] VN-rzyl was developed by Spark Therapeutics Inc. and FDA approved on December 19, 2017. …

Iron isomaltoside 1000

Iron isomaltoside 1000 is under investigation in Iron Deficiency Anaemia. Iron isomaltoside 1000 has been investigated for the treatment and basic science of Anemia, Gastric Cancer, Esophageal Cancer, Chronic Kidney Disease, and Anemia, Iron-Deficiency, among others.
Approved
Investigational
Matched Description: … , Esophageal Cancer, Chronic Kidney Disease, and Anemia, Iron-Deficiency, among others. ... Iron isomaltoside 1000 has been investigated for the treatment and basic science of Anemia, Gastric Cancer …

Alimemazine

A phenothiazine derivative that is used as an antipruritic.
Approved
Vet approved

Periciazine

Periciazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine...
Approved
Investigational
Matched Description: … It also has adrenolytic, anticholinergic, metabolic and endocrine effects and an action on the extrapyramidal ... It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while ... medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and …

Flibanserin

Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder...
Approved
Investigational
Matched Description: … the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters. ... Flibanserin's mechanism of action is attributed to its high affinity for 5-HTA1 and 5-HTA2 receptors, ... displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in …
Matched Categories: … Genito Urinary System and Sex Hormones …
Displaying drugs 2426 - 2450 of 14950 in total