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Displaying drugs 226 - 250 of 8039 in total

Everolimus

Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and...
Approved
Matched Description: … target of rapamycin) inhibitor. ... It is currently used as an immunosuppressant to prevent rejection of organ transplants. ... Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian …
Matched Categories: … Mammalian target of rapamycin (mTOR) kinase inhibitors …

Prasterone

Prasterone, also known as dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. In...
Approved
Investigational
Nutraceutical
Matched Description: … Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. ... States, DHEA or DHEAS have been advertised with claims that they may be beneficial for a wide variety of ... treat women experiencing moderate to severe pain during sexual intercourse (dyspareunia), a symptom of …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Lorcaserin

Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is...
Approved
Withdrawn
Matched Description: … This decision was based on the results of a clinical trial assessing the risk of heart-related problems ... that found that patients treated with lorcaserin may have a higher risk of cancer. ... Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Probenecid

The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Approved
Investigational
Matched Description: … It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. ... been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of …
Matched Categories: … combinations of sulfonamides …

Tenofovir disoproxil

Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name Viread, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs for the management of HIV infection as well as for...
Approved
Investigational
Matched Description: … Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name ... _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase ... This drug is prescribed in combination with other drugs for the management of HIV infection as well as …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Megestrol acetate

17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Approved
Investigational
Vet approved
Matched Description: … It has also been used in the palliative treatment of breast cancer. …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Moclobemide

A reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder. Most meta-analyses and most studies indicate that in the acute management of depression, moclobemide is more efficacious than placebo medication and similarly efficacious as tricyclic antidepressants (TCA) or selective serotonin reuptake inhibitors (SSRIs)....
Approved
Investigational
Matched Description: … Most meta-analyses and most studies indicate that in the acute management of depression, moclobemide …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

St. John's Wort

Approved
Investigational
Nutraceutical
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Zuclopenthixol

Zuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Major brands of zuclopenthixol are Cisordinol, Acuphase, and Clopixol. This drug is a liquid. This compound...
Approved
Investigational
Matched Description: … Major brands of zuclopenthixol are Cisordinol, Acuphase, and Clopixol. This drug is a liquid. ... Known drug targets of zuclopenthixol include 5-hydroxytryptamine receptor 2A, D(1B) dopamine receptor …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Zonisamide

Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of...
Approved
Investigational
Matched Description: … uptake of the excitatory neurotransmitter glutamate. ... to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. ... This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the …
Matched Categories: … combinations of sulfonamides …

Rifapentine

Rifapentine is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.
Approved
Investigational
Matched Description: … Rifapentine is an antibiotic drug used in the treatment of tuberculosis. …
Matched Categories: … Drugs for Treatment of Tuberculosis …

Chloramphenicol

An antibiotic first isolated from cultures of Streptomyces venezuelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)...
Approved
Vet approved
Withdrawn
Matched Description: … fatal aplastic anemia associated with this specific route of administration. ... An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically ... p106) The FDA has withdrawn all oral drug products containing chloramphenicol, due to the high risk of …
Matched Categories: … Antiinfectives for Treatment of Acne …

Ondansetron

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. Having been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has...
Approved
Withdrawn
Matched Description: … than 16 mg of ondansetron hydrochloride in a single dose, due to a high risk of QT prolongation. ... It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including ... orally soluble films that are both discreet in administration and less of a burden in comparison to …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Metoclopramide

Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to...
Approved
Investigational
Matched Description: … [L8417] One unique property of this drug is that it does not increase gastric acid secretion. ... gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Yohimbine

A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Approved
Investigational
Vet approved
Matched Description: … Yohimbine has been used as a mydriatic and in the treatment of impotence. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Iloperidone

Iloperidone is a benzisoxazole and an atypical antipsychotic agent that was first approved by the FDA on May 6, 2009. It is considered to be a second-generation antipsychotic drug with multiple receptor binding profile, although it shows high affinity towards 5-HT2A and dopamine D2 receptors. Iloperidone is currently used to...
Approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Voxilaprevir

Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat ... nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of ... Vosevi is approved for the treatment of adult patients with chronic HCV infection with genotype 1, 2, …
Matched Categories: … Antivirals for treatment of HCV infections …

Cabergoline

Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Oxcarbazepine

Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of carbamazepine and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate...
Approved
Matched Description: … [L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of ... Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was ... via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood - a pro-drug of …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Aminophylline

Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma,...
Approved
Matched Description: … Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as ... The majority of aminophylline medications are discontinued and the remaining medications on the market …
Matched Categories: … combinations of xanthines …

Temsirolimus

Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agency (EMEA) on November 2007.
Approved
Matched Description: … Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). …
Matched Categories: … Mammalian target of rapamycin (mTOR) kinase inhibitors …

Carbamazepine

Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1....
Approved
Investigational
Matched Description: … [A180301] Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. …
Matched Categories: … Inducers of Drug Clearance ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Erythromycin

Erythromycin is a bacteriostatic antibiotic drug produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the macrolide group of antibiotics which consists of Azithromycin, Clarithromycin, Spiramycin and others. It was originally discovered in 1952. Erythromycin is widely used for treating a variety of infections, including those...
Approved
Investigational
Vet approved
Matched Description: … (formerly Streptomyces erythraeus) and belongs to the macrolide group of antibiotics which consists of ... Erythromycin is a bacteriostatic antibiotic drug produced by a strain of Saccharopolyspora erythraea ... [L5245] Erythromycin is widely used for treating a variety of infections, including those caused by gram-positive …
Matched Categories: … Antiinfectives for Treatment of Acne …

Mirtazapine

Mirtazapine is a tetracyclic piperazino-azepine antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6157] The effects of this...
Approved
Matched Description: … tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of ... [T595, L6157] The effects of this drug may be observed as early as 1 week after beginning therapy. ... This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Lamivudine

A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Approved
Investigational
Matched Description: … reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …
Displaying drugs 226 - 250 of 8039 in total