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Displaying drugs 226 - 250 of 10408 in total

Remestemcel-L

Remestemcel-L is a third-party, off-the-shelf suspension of ex-vivo cultured adult human mesenchymal stem cells intended for intravenous infusion. The mesenchymal stem cells are derived from the bone marrow of unrelated and human leukocyte antigen (HLA)–unmatched healthy adult donors and have the ability to differentiate into different tissue cells. It was...
Approved
Investigational
Matched Description: … It was approved for use in Canada in May 2012 as Prochymal for the management of refractory acute Graft ... In clinical studies, patients treated with remestemcel-L demonstrated an improvement in their aGvHD and ... While systemic corticosteroids and other immunosuppressive agents are commonly used as first-line treatments …
Matched Categories: … Antiviral Agents ... Anti-Infective Agents ... Anti-Inflammatory Agents …

Tacrolimus

Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis...
Approved
Investigational
Matched Description: … Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant …
Matched Categories: … Agents causing hyperkalemia ... Nephrotoxic agents ... Agents Causing Muscle Toxicity ... QTc Prolonging Agents ... Myelosuppressive Agents …

Sodium borate

Approved
Experimental
Matched Categories: … Anti-Infective Agents …

Dostarlimab

Dostarlimab is an IgG4 humanized monoclonal antibody targeted against the human programmed death receptor-1 (PD-1). PD-1 receptors are found on T-cells and, when activated, serve to inhibit immune responses - some cancers leverage this system by overexpressing PD-1 ligands, thereby effectively inhibiting the anti-tumor immune response that would typically attempt...
Approved
Investigational
Matched Description: … Dostarlimab is an IgG4 humanized monoclonal antibody targeted against the human programmed ... [L33340] A companion diagnostic device - the VENTANA MMR RxDx Panel - was also approved alongside this ... [A234379] Agents acting on the PD-1 pathway, such as [nivolumab] and [pembrolizumab], facilitate endogenous …
Matched Categories: … Antineoplastic Agents ... Antineoplastic and Immunomodulating Agents …

Terconazole

Terconazole is an anti-fungal drug that is mainly used to treat vaginal yeast infections (or vaginal candidiasis). It is classified as a triazole ketal derivative. Terconazole was initially approved by the FDA in 1987.[FDA label] This drug is available in cream and suppository forms and both have demonstrated high levels...
Approved
Matched Description: … [A178096] Terconazole was initially approved by the FDA in 1987. ... Terconazole is an anti-fungal drug that is mainly used to treat vaginal yeast infections (or vaginal …
Matched Categories: … Antifungal Agents ... Anti-Infective Agents ... Antifungal Agents (Vaginal) …

Pyridoxine

Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally present in many foods. As its classification as a vitamin implies, Vitamin B6 (and pyridoxine) are essential nutrients required for normal functioning of many biological systems within the body. While many plants and microorganisms are...
Approved
Investigational
Nutraceutical
Vet approved
Matched Description: … It's important to note that Vitamin B6 is the collective term for a group of three related compounds, ... Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally ... More specifically, pyridoxine is converted to pyridoxal 5-phosphate in the body, which is an important …
Matched Mixtures name: … PLASVIT AN INYECTABLE ... Kanga-B Vitamin B Group + C …

Tropisetron

Tropisetron is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. Tropisetron appears to be well tolerated with the most frequently reported adverse effect being headache. Extrapyramidal...
Approved
Investigational
Matched Description: … Tropisetron is an indole derivative with antiemetic activity. …
Matched Categories: … Antidepressive Agents ... Autonomic Agents ... Antiarrhythmic agents ... Serotonin Agents ... Gastrointestinal Agents …

Nylidrin

Nylidrin, also known as buphenine belongs to the category of drugs called vasodilators, which relax blood vessels and increase blood flow. Nylidrin is a peripheral vasodilator. Some studies show the evidence of improving cognitive impairment in selected individuals, such as geriatric patients with mild to moderate symptoms of cognitive, emotional...
Approved
Matched Description: … Nylidrin, also known as _buphenine_ belongs to the category of drugs called _vasodilators_, which relax …
Matched Categories: … Adrenergic Agents ... Autonomic Agents ... Tocolytic Agents ... Antiarrhythmic agents ... Cardiovascular Agents …

Estetrol

Naturally or synthetically produced steroid estrogens have a wide range of pharmaceutical uses ranging from hormonal contraception to the treatment of menopausal symptoms. Estetrol (E4) is a native estrogen occurring naturally during pregnancy, but can be synthesized from a plant source and used for contraception. It is more potent and...
Approved
Investigational
Matched Description: … [L33184] On April 15 2021, Mayne Pharma Group Limited and Mithra Pharmaceuticals were granted FDA ... [L33179] In Canada, Nextstellis was approved for use in March 2021; it was developed by Mithra and is ... Estetrol is the first new estrogen introduced to the USA in over 50 years and is the first approved estetrol …

Cimetidine

A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Approved
Investigational
Matched Categories: … Anti-Ulcer Agents ... Histamine Agents ... Agents Causing Muscle Toxicity ... Gastrointestinal Agents ... Neurotransmitter Agents …

Omadacycline

Omadacycline has been used in trials studying the treatment of Bacterial Pneumonia, Bacterial Infections, Community-Acquired Infections, and Skin Structures and Soft Tissue Infections. Omadacycline represents a significant advance over the well-known tetracycline family, and has been shown to be highly effective in animal models at treating increasingly problematic, clinically prevalent...
Approved
Investigational
Matched Categories: … Anti-Bacterial Agents …

Diflunisal

Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the...
Approved
Investigational
Matched Categories: … Antirheumatic Agents ... Nephrotoxic agents ... Agents causing hyperkalemia ... Anti-Inflammatory Agents ... Sensory System Agents …

Lumiracoxib

Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in Australia due to concerns that it may cause liver failure. New Zealand and Canada have also followed suit in recalling...
Approved
Investigational
Matched Categories: … Nephrotoxic agents ... Antirheumatic Agents ... Agents causing hyperkalemia ... Anti-Inflammatory Agents ... Sensory System Agents …

Viloxazine

Viloxazine is a selective norepinephrine reuptake inhibitor. For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant. It was first approved in the UK in 1974; however, the immediate-release formulation was discontinued due to business reasons unrelated to drug safety and efficacy. In the US,...
Approved
Investigational
Withdrawn
Matched Description: … In April 2021, an extended-release formulation of viloxazine under the brand name QELBREE was approved ... [L41685] For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant ... It was first approved in the UK in 1974; however, the immediate-release formulation was discontinued …
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Second-Generation ... Adrenergic Agents ... Anticholinergic Agents ... Neurotransmitter Agents …

Imatinib

Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated with...
Approved
Matched Description: … [L42220] Imatinib was approved on February 1st ,2001 by the FDA and November 7th, 2001 by the EMA ... The discovery of imatinib also established a new group of therapy called "targeted therapy", since treatment …
Matched Categories: … Antineoplastic Agents ... QTc Prolonging Agents ... Myelosuppressive Agents ... Photosensitizing Agents ... Immunosuppressive Agents …

Efalizumab

Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It was later withdrawn...
Approved
Investigational
Withdrawn
Matched Description: … The FDA approved efalizumab in 2003. …
Matched Categories: … Immunosuppressive Agents ... Antineoplastic and Immunomodulating Agents …

Triclocarban

Triclocarban, with the chemical formula C13H9Cl3N2O is an antibacterial agent that is particularly effective against Gram-positive bacteria such as Staphylococcus aureus. It is a bacteriostatic compound that has been found in antibacterial soaps and other personal care products. In 2017, the US FDA prohibited the marketing of over-the-counter (OTC) consumer...
Approved
Matched Description: … Triclocarban, with the chemical formula C13H9Cl3N2O [L2675] is an antibacterial agent that is particularly …
Matched Categories: … Anti-Infective Agents ... Anti-Infective Agents, Local …

Bivalirudin

Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important to monitor changes in...
Approved
Investigational
Matched Categories: … Hematologic Agents …

Guanadrel

Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent.
Approved
Matched Description: … Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent. …
Matched Categories: … Cardiovascular Agents ... Antihypertensive Agents …

Buspirone

Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. Unlike many drugs used to treat anxiety, buspirone does...
Approved
Investigational
Matched Description: … Buspirone was first approved in 1986 by the FDA [A181751] and has been used to treat anxiety disorders …
Matched Categories: … Antidepressive Agents ... Serotonin Agents ... Tranquilizing Agents ... Agents that produce hypertension ... Neurotransmitter Agents …

Phenyl salicylate

Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in DB00945 ). Phenyl salicylate may...
Approved
Matched Description: … Phenyl salicylate may also be found in some antiseptic agents [L2467]. ... It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing ... that is either a polyphenolic compound composed of two or more monocyclic aromatic units linked by an …
Matched Categories: … Anti-Infective Agents, Local …

Tetrofosmin

Tetrofosmin was developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines. Tetrofosmin is used in conjunction with technetium Tc-99m as a radiopharmaceutical.
Approved
Matched Description: … Tetrofosmin is part of the group of diphosphines. …

Methenamine

Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine).
Approved
Vet approved
Matched Categories: … Anti-Bacterial Agents ... Anti-Infective Agents ... Urinary Acidifying Agents ... Anti-Infective Agents, Urinary …

Daprodustat

Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK.[A254167,A254162] Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces...
Approved
Investigational
Matched Description: … in patients with CKD undergoing dialysis, daprodustat was non-inferior to erythropoiesis-stimulating agents ... [A254172] In June 2020, daprodustat was first approved in Japan for the treatment of renal anemia. ... [L43857] On February 1, 2023, daprodustat was fully approved by the FDA as the first oral treatment for …

Hydroxyzine

Hydroxyzine is a first-generation histamine H1-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus. The active metabolite of hydroxyzine,...
Approved
Matched Description: … [L9677] The active metabolite of hydroxyzine, [cetirizine], is also available as an active ingredient …
Matched Categories: … Anti-Anxiety Agents ... Histamine Agents ... QTc Prolonging Agents ... Neurotransmitter Agents ... Potential QTc-Prolonging Agents …
Displaying drugs 226 - 250 of 10408 in total