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Displaying drugs 226 - 250 of 8055 in total

Apomorphine

Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884. Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.[A203597,A203618] Apomorphine...
Approved
Investigational
Matched Description: … Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Metamfetamine

Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potential for addiction and abuse. The...
Approved
Illicit
Withdrawn
Matched Description: … group of sympathomimetic amines. ... Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine ... The FDA withdrew its approval for the use of all parenteral drug products containing methamphetamine …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Paritaprevir

Paritaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … Lack of significant side effects and short duration of therapy is a considerable advantage over older ... reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma ... Paritaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic …
Matched Categories: … Antivirals for treatment of HCV infections …

Indapamide

The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a number of lifestyle changes (ie. reduced...
Approved
Matched Description: … an estimated 25% of adults globally. ... [A204155] Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts ... [A204155] Treatment for hypertension should include a number of lifestyle changes (ie. reduced sodium …
Matched Categories: … combinations of sulfonamides …

Maprotiline

Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used...
Approved
Investigational
Matched Description: … Maprotiline is effective at reducing symptoms of anxiety associated with depression. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Hydrocodone

Hydrocodone is a synthetic opioid derivative of codeine. It is commonly used in combination with acetaminophen to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by dextromethorphan in current cough and cold formulations. Hydrocodone's more potent metabolite, hydromorphone...
Approved
Illicit
Investigational
Matched Description: … The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of ... Hydrocodone is a synthetic opioid derivative of codeine. ... metabolite, [hydromorphone] has also found wide use as an analgesic and is frequently used in cases of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Clindamycin

Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bacilli and gram-negative bacilli. Interestingly,...
Approved
Vet approved
Matched Description: … Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious ... [L11593] It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as ... and has largely replaced, [lincomycin], a naturally occurring lincosamide and the eponymous member of …
Matched Categories: … Antiinfectives for Treatment of Acne …

Everolimus

Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and...
Approved
Matched Description: … target of rapamycin) inhibitor. ... It is currently used as an immunosuppressant to prevent rejection of organ transplants. ... Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian …
Matched Categories: … Mammalian target of rapamycin (mTOR) kinase inhibitors …

Prasterone

Prasterone, also known as dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. In...
Approved
Investigational
Nutraceutical
Matched Description: … Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. ... States, DHEA or DHEAS have been advertised with claims that they may be beneficial for a wide variety of ... treat women experiencing moderate to severe pain during sexual intercourse (dyspareunia), a symptom of …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Lorcaserin

Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is...
Approved
Withdrawn
Matched Description: … This decision was based on the results of a clinical trial assessing the risk of heart-related problems ... that found that patients treated with lorcaserin may have a higher risk of cancer. ... Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Probenecid

The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Approved
Investigational
Matched Description: … It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. ... been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of …
Matched Categories: … combinations of sulfonamides …

Tenofovir disoproxil

Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name Viread, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs for the management of HIV infection as well as for...
Approved
Investigational
Matched Description: … Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name ... _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase ... This drug is prescribed in combination with other drugs for the management of HIV infection as well as …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Megestrol acetate

17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Approved
Investigational
Vet approved
Matched Description: … It has also been used in the palliative treatment of breast cancer. …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Moclobemide

A reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder. Most meta-analyses and most studies indicate that in the acute management of depression, moclobemide is more efficacious than placebo medication and similarly efficacious as tricyclic antidepressants (TCA) or selective serotonin reuptake inhibitors (SSRIs)....
Approved
Investigational
Matched Description: … Most meta-analyses and most studies indicate that in the acute management of depression, moclobemide …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

St. John's Wort

Approved
Investigational
Nutraceutical
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Zuclopenthixol

Zuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Major brands of zuclopenthixol are Cisordinol, Acuphase, and Clopixol. This drug is a liquid. This compound...
Approved
Investigational
Matched Description: … Major brands of zuclopenthixol are Cisordinol, Acuphase, and Clopixol. This drug is a liquid. ... Known drug targets of zuclopenthixol include 5-hydroxytryptamine receptor 2A, D(1B) dopamine receptor …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Zonisamide

Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of...
Approved
Investigational
Matched Description: … uptake of the excitatory neurotransmitter glutamate. ... to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. ... This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the …
Matched Categories: … combinations of sulfonamides …

Rifapentine

Rifapentine is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.
Approved
Investigational
Matched Description: … Rifapentine is an antibiotic drug used in the treatment of tuberculosis. …
Matched Categories: … Drugs for Treatment of Tuberculosis …

Chloramphenicol

An antibiotic first isolated from cultures of Streptomyces venezuelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)...
Approved
Vet approved
Withdrawn
Matched Description: … fatal aplastic anemia associated with this specific route of administration. ... An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically ... p106) The FDA has withdrawn all oral drug products containing chloramphenicol, due to the high risk of …
Matched Categories: … Antiinfectives for Treatment of Acne …

Ondansetron

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. Having been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has...
Approved
Withdrawn
Matched Description: … than 16 mg of ondansetron hydrochloride in a single dose, due to a high risk of QT prolongation. ... It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including ... orally soluble films that are both discreet in administration and less of a burden in comparison to …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Metoclopramide

Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to...
Approved
Investigational
Matched Description: … [L8417] One unique property of this drug is that it does not increase gastric acid secretion. ... gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Yohimbine

A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Approved
Investigational
Vet approved
Matched Description: … Yohimbine has been used as a mydriatic and in the treatment of impotence. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Iloperidone

Iloperidone is a benzisoxazole and an atypical antipsychotic agent that was first approved by the FDA on May 6, 2009. It is considered to be a second-generation antipsychotic drug with multiple receptor binding profile, although it shows high affinity towards 5-HT2A and dopamine D2 receptors. Iloperidone is currently used to...
Approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Voxilaprevir

Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat ... nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of ... Vosevi is approved for the treatment of adult patients with chronic HCV infection with genotype 1, 2, …
Matched Categories: … Antivirals for treatment of HCV infections …

Cabergoline

Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Displaying drugs 226 - 250 of 8055 in total