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Displaying drugs 2776 - 2800 of 9713 in total

Mebendazole

A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of microtubules. [PubChem]
Approved
Vet approved
Matched Description: … A benzimidazole that acts by interfering with carbohydrate metabolism and inhibiting polymerization of …
Matched Products: … MEBENDAL (R) TABLETAS …

Dopamine

One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action.
Approved
Matched Description: … One of the catecholamine neurotransmitters in the brain. ... A family of receptors (receptors, dopamine) mediate its action. ... Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating …
Matched Products: … CARDIOPAL(R) 200 MG …

Insulin glargine

Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched International brands: … Lantus R …
Matched Description: … , with a goal of avoiding any periods of hypoglycemia. ... Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type ... B31 and 32) of the B-chain. …

Plant-based virus-like particles, recombinant, adjuvanted COVID-19 vaccine

The Covifenz COVID-19 vaccine (plant-based virus-like particles (VLP), recombinant, adjuvanted) is a plant-based vaccine developed in partnership by Medicago and GlaxoSmithKline which is approved in Canada for the prevention of COVID-19. It is composed of VLPs expressing SARS-CoV-2 spike protein trimers (stabilized in a pre-fusion conformation) and is mixed with...
Approved
Matched Description: … speed and ease of manufacturing and increased immunogenicity. ... [L40694] It is composed of VLPs expressing SARS-CoV-2 spike protein trimers (stabilized in a pre-fusion ... developed in partnership by Medicago and GlaxoSmithKline which is approved in Canada for the prevention of …

Doravirine

Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg). Doravirine is formally indicated for the treatment of...
Approved
Investigational
Matched Description: … treatments available for the management of HIV-1 infection. ... [L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), ... [L4562] Doravirine is formally indicated for the treatment of HIV-1 infection in adult patients with …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Fluorescein

A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs...
Approved
Matched Categories: … Diagnostic Uses of Chemicals …

Nifurtimox

Chagas disease, caused by a parasite known as Trypanosoma cruzi (T.cruzi), is a vector-transmitted disease affecting animals and humans in the Americas. It is commonly known as American Trypanosomiasis. The CDC estimates that approximately 8 million people in Central America, South America, and Mexico are infected with T. cruzi, without...
Approved
Investigational
Matched Description: … L15366] Nifurtimox, developed by Bayer, is a nitrofuran antiprotozoal drug used in the treatment of ... [L15361] A convenient feature of Bayer's formulation is the ability to divide the scored tablets manually …

Davesomeran

Davesomeran is a mRNA vaccine used in conjunction with elasomeran as part of the Moderna Bivalent COVID-19 vaccine. Similar to the previous Moderna COVID-19 vaccine, Moderna Bivalent vaccine encodes the full-length pre-fusion stabilized spike (S) protein to elicit an immune response.[L43882,L28026] However, with the addition of davesomeran, Moderna Bivalent vaccine...
Approved
Investigational
Matched Description: … [L43882] A phase 2 and 3 open-label study in participants 18 years or older who had previously received ... 3rd 2022, Health Canada also approved the Moderna Bivalent Vaccine as a booster shot in individuals 18 ... years of age or older. …

Esketamine

Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, esketamine, also known as Spravato (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression. Esketamine is the s-enantiomer of Ketamine. Ketamine...
Approved
Investigational
Matched Description: … Esketamine is the s-enantiomer of [Ketamine]. ... Ketamine is a mixture of two enantiomers (mirror image molecules). ... Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness …

Lotilaner

Lotilaner is an ectoparasiticide that is a member of the isoxazoline family of compounds. Lotilaner has largely been used for veterinary uses as an antiparasitic agent to treat flea and tick infestations in animals.[A260746, L47556] Lotilaner consists of two enantiomers: the S-enantiomer is active in vivo, while the R-enantiomer is...
Approved
Vet approved
Matched Description: … the R-enantiomer is reported to exhibit low biological activity. ... Lotilaner is an ectoparasiticide that is a member of the isoxazoline family of compounds. ... The active ingredient found in drug products of lotilaner is the S-enantiomer. …

Gallium nitrate

Gallium nitrate is a nitrate salt of DB14524, a heavy metal that has been used as a diagnostic agent. Gallium nitrate is reported to possess antiresorptive and hypocalcemic effects on bone. GANITE, a product of gallium nitrate previously used to treat cancer-related hypercalcemia, was discontinued from marketing in the US...
Approved
Investigational
Matched Description: … Gallium nitrate is a nitrate salt of [DB14524], a heavy metal that has been used as a diagnostic agent ... [A17097] GANITE, a product of gallium nitrate previously used to treat cancer-related hypercalcemia, …

Mosunetuzumab

Mosunetuzumab is a humanized anti-CD20/CD3 bispecific antibody. It can recognize and bind two different targets simultaneously, CD20 on cancer B-cells and CD3 on T-cells, allowing it to redirect T-cell cytotoxic activity to cancer cells. The standard of care for patients with B-cell lymphoma includes an anti-CD20 monoclonal antibody, such as...
Approved
Investigational
Matched Description: … patients with relapsed or refractory (R/R) FL who have received at least two prior systemic therapies ... leukemia (CLL) or aggressive B-cell lymphoma, have a high probability of relapse or recurrence after ... [A249320] The standard of care for patients with B-cell lymphoma includes an anti-CD20 monoclonal antibody …

Carvedilol

Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as...
Approved
Investigational
Matched Description: … racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R( ... of moderate hypertension. ... of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the treatment …

Oxiconazole

Oxiconazole is an antifungal agent that is commonly found in topical formulations. It is marketed under the brand names Oxistat and Oxistat, and is used in the treatment of various skin infections such as athlete's foot, jock itch and ringworm.
Approved
Matched Description: … It is marketed under the brand names Oxistat and Oxistat, and is used in the treatment of various skin …
Matched Categories: … combinations of imidazole derivatives …

Sulfanilamide

Sulfanilamide is a molecule containing the sulfonamide functional group attached to an aniline.
Approved
Matched Categories: … combinations of sulfonamides …

Remifentanil

Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depression and analgesia.
Approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Velmanase alfa

Velmanase alfa is a recombinant human lysosomal alpha-mannosidase developed for enzyme replacement therapy to treat alpha-mannosidosis. Alpha-mannosidosis is a rare autosomal recessive lysosomal storage disorder. Patients with alpha-mannosidosis have a genetic mutation that causes a deficiency in the lysosomal enzyme alpha-mannosidase, which is an enzyme responsible for breaking down complex...
Approved
Investigational
Matched Description: … The resulting accumulation of sugars in the body leads to an array of clinical manifestations leading ... alpha-mannosidase for the treatment of alpha-mannosidosis. ... Commission in March 2018 under the market name Lamzede [L39754] as the first human recombinant form of …

Dextromethorphan

Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997]
Approved
Matched Description: … is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of …
Matched Mixtures name: … Regular Strength Cold Medication(daytime R.) ... Hot Lemon Relief for Symptoms Of Cough and Cold ... Hot Liquid Relief for Symptoms Of Cold and Cough …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sulfamethoxazole

Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with trimethoprim, which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps in the biosynthesis of nucleic acids and...
Approved
Matched Description: … [L11830] In this combination, sulfamethoxazole is useful for the treatment of a variety of bacterial ... infections, including those of the urinary, respiratory, and gastrointestinal tracts. ... acid synthesis - these agents work synergistically to block two consecutive steps in the biosynthesis of …
Matched Mixtures name: … SOLASTEM(R) TABLETAS ... MEDIPRIM F (R) TABLETA ... MEDIPRIM F (R) TABLETA …
Matched Categories: … combinations of sulfonamides ... Drugs for Treatment of Tuberculosis …

Somatotropin

Human growth hormone (HGH), also known as somatotropin, is a peptide hormone that is synthesized and secreted by the somatotropic cells of the anterior pituitary gland. Growth hormone plays an essential role in growth regulation during childhood as well as other basal metabolic functions, muscle and fat mass regulation, blood...
Approved
Investigational
Matched Description: … that contains 191 amino acid residues with a molecular weight of 22 kDa. ... known as somatotropin, is a peptide hormone that is synthesized and secreted by the somatotropic cells of ... [A228183] Growth hormone therapy is approved for various disorders of growth hormone deficiency, …
Matched Products: … HUMATROPE 18 IU (6 MG) LIYOFILIZE TOZ ICEREN KARTUS, 1 ADET …

Zileuton

Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Zileuton relieves such symptoms through its...
Approved
Investigational
Withdrawn
Matched Description: … Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro ... the formation of leukotrienes from arachidonic acid. ... The immediate release tablet of Zileuton has been withdrawn from the US market. …

Ivermectin

Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of Streptomyces avermitilis. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A1a (22,23-dihydroavermectin B1a) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A1a (22,23-dihydroavermectin B1b). Ivermectin is mainly used in...
Approved
Investigational
Vet approved
Matched Iupac: … (1'R,2R,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)- ... 2R,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'-{ ... trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1^{4,8}.0^{20,24}]pentacosane]-10',14',16',22'-tetraen-2'-one; (1'R, …
Matched Description: … blocks of patient records. ... Due to a number of factors - for example, the relatively low number of patients per trial and the speed ... in favour of thoroughly-vetted therapies (e.g. …

Avibactam

Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime (Avycaz). This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and the treatment of complicated urinary tract infections, including pyelonephritis caused by antibiotic resistant-pathogens,...
Approved
Matched Description: … As there is limited clinical safety and efficacy data, Avycaz should be reserved for patients over 18 ... infections in combination with metronidazole, and the treatment of complicated urinary tract infections ... This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal …

Flibanserin

Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder...
Approved
Investigational
Matched Description: … It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of ... Flibanserin's mechanism of action is attributed to its high affinity for 5-HTA1 and 5-HTA2 receptors, ... displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Tocofersolan

D-Alpha-tocopheryl polyethylene glycol 1000 succinate (Tocofersolan, Vedrop), has been developed in Europe as an orally bioavailable source of vitamin E in children suffering from cholestasis . Cholestasis is the reduction or stoppage of bile flow, either to impaired secretion by hepatocytes (liver cells) or obstruction , . Tocofersolan is a...
Approved
Matched Description: … of [DB11251]. ... 1000 succinate (Tocofersolan, Vedrop), has been developed in Europe as an orally bioavailable source of ... Cholestasis is the reduction or stoppage of bile flow, either to impaired secretion by _hepatocytes_ …
Displaying drugs 2776 - 2800 of 9713 in total