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Displaying drugs 2976 - 3000 of 15149 in total
Nedosiran is an RNA interference targeting hepatic lactate dehydrogenase, the enzyme responsible for the conversion of glyoxylate to oxalate. Oxalate, particularly calcium oxalate, precipitation is the main cause of kidney stones formation; therefore, blocking the production of oxalate can help alleviate renal symptoms. Nedosiran was approved by the FDA on...
Approved
Investigational
Matched Synonyms: … DCR-PHXC free acid
Matched Description: … older and adults with primary hyperoxaluria type 1 (PH1) and relatively preserved kidney function. ... sup>, 2023, under the brand name RIVFLOZA to lower urinary oxalate levels in children 9 years of age and ... This approval is based on the favorable results from the pivotal phase 2 PHYOXTM2 and interim …
Methyl nicotinate is the methyl ester of DB00627 that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation. For veterinary purposes, methyl nicotinate is used to...
Approved
Matched Synonyms: … Nicotinic acid, methyl ester ... 3-pyridinecarboxylic acid methyl ester …
Matched Description: … muscle and joint pains [F64]. ... an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and ... methyl nicotinate is used to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and
Tarlatamab is a first-in-class T-cell engager used to treat extensive-stage small cell lung cancer. It is a bispecific monoclonal antibody that targets CD3 expressed on the surface of T-cells and delta-like ligand 3 (DLL3), an inhibitory ligand that suppresses Notch signaling and is highly expressed across various SCLC disease stages...
Approved
Investigational
Matched Synonyms: … Immunoglobulin scfv-scfv-scfc, anti-(homo sapiens dll3 (delta-like ligand 3)) and anti-(homo sapiens …
Matched Description: … across various SCLC disease stages and treatment statuses. ... L50748] It is a bispecific monoclonal antibody that targets CD3 expressed on the surface of T-cells and ... delta-like ligand 3 (DLL3), an inhibitory ligand that suppresses Notch signaling and is highly expressed …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. It...
Approved
Vet approved
Matched Synonyms: … 2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid ... 4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid ... 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid
Matched Iupac: … 4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid
Matched Description: … It is an anthranilic acid derivative. ... Furosemide has a fast onset and short duration of action and has been used safely and effectively in ... both pediatric and adult patients. …
Matched Categories: … furosemide and potassium ... furosemide and potassium-sparing agents ... High-Ceiling Diuretics and Potassium-Sparing Agents …
An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris;...
Approved
Investigational
Matched Synonyms: … 9(Z)-Retinoic acid ... 9-cis-retinoic acid ... (7E,9Z,11E,13E)-retinoic acid
Matched Iupac: … (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
Matched Description: … Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth ... An important regulator of gene expression during growth and development, and in neoplasms. ... ; and embryonic development. …
Matched Categories: … Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …
A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Approved
Investigational
Vet approved
Matched Synonyms: … Yohimbic acid methyl ester ... 17α-hydroxyyohimban-16α-carboxylic acid methyl ester ... (16α,17α)-17-hydroxyyohimban-16-carboxylic acid methyl ester …
Matched Description: … Yohimbine has been used as a mydriatic and in the treatment of impotence. …
Matched Categories: … Genito Urinary System and Sex Hormones …
Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the...
Approved
Matched Synonyms: … 1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin …
Matched Description: … The active ingredient in most formulations is desmopressin acetate. ... Nocdurna, or desmopressin acetate, was approved by the FDA on June 21st, 2018 for the treatment of nocturia ... solution, intravenous solution, oral tablet and oral lyophilisate [A31662]. …
Matched Salts name: … Desmopressin acetate anhydrous ... Desmopressin acetate
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Vasopressin and Analogues ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … Desmopressin Acetate ... Desmopressin acetate
An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease . Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical...
Approved
Matched Synonyms: … 5-aminosalicylic acid ... m-Aminosalicylic acid
Matched Iupac: … 5-amino-2-hydroxybenzoic acid
Matched Description: … drugs like acetylsalicylic acid, which is active in inflammatory bowel disease [A174022]. ... An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory ... Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine …
Matched Products: … Ntp-5-aminosalicylic Acid
A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin.
Approved
Matched Synonyms: … 1-Methyl-5-p-toluoylpyrrole-2-acetic acid ... 5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid ... 1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid
Matched Iupac: … 2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetic acid
Matched Categories: … Acetic Acid Derivatives and Related Substances ... Heteroaryl acetic acid NSAIDS ... Antiinflammatory and Antirheumatic Products ... Topical Products for Joint and Muscular Pain ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Aglucosidase alfa consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the degradation of glygogen to glucose in lysosomes. It is encoded by the most predominant of nine observed haplotypes of this gene. Aglucosidase alfa is produced by recombinant DNA technology in a Chinese hamster ovary cell...
Approved
Matched Synonyms: … Acid maltase ... Acid-alpha glucosidase ... Human acid precursor alpha-glucosidase, recombinant …
Matched Description: … Aglucosidase alfa consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the ... It is used for the treatment of Pompe disease (GAA deficiency) in infants and pediatric patients. ... glycoprotein with a calculated mass of 98,008 daltons for the 883 residue mature polypeptide chain, and
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.
Approved
Matched Synonyms: … meso-dimercaptosuccinic acid ... meso-2,3-dimercaptosuccinic acid
Matched Iupac: … (2R,3S)-2,3-disulfanylbutanedioic acid
Matched Description: … A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates …
Potassium alum is considered by the FDA as a generally recognized as safe (GRAS) substance. It is an inorganic salt, also called potassium aluminum sulfate with a formula of AlK(SO4)2 that is predominantly produced in the dodecahydrate form (AlK(SO4)2 * 12H2O). Potassium alum is formed by large, transparent crystals that...
Approved
Matched Synonyms: … Aluminum potassium sulfate anhydrous
Matched Mixtures name: … Gingibraid W Epineph and Alum 1e ... Gingibraid W Epineph and Alum 2e ... Gingibraid W Epineph and Alum 3e …
Omega-3 fatty acids are polyunsaturated fatty acids (PUFAs) with a double bond at the third carbon atom from the end of the carbon chain. The three types of omega-3 fatty acids involved in human physiology are α-linolenic acid (ALA) (found in plant oils), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)...
Approved
Nutraceutical
Matched Synonyms: … Omega-3 acid ... Omega-3 fatty acid ... Omega-3 acid triglycerides …
Matched Description: … in plant oils), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) (both commonly found in ... Therapeutic products containing omega-3 fatty acid and its derivatives for treatment of hypertriglyceridemia ... Omega-3 fatty acids play a critical role in metabolism and cellular function and they are available as …
Matched Mixtures name: … Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA …
Matched Categories: … Bile and Liver Therapy ... Alimentary Tract and Metabolism …
Sulbactam is a beta (β)-lactamase inhibitor and a derivative of the basic penicillin nucleus. When given in combination with β-lactam antibiotics, sulbactam produces a synergistic effect as it blocks the enzyme responsible for drug resistance by hydrolyzing β-lactams.
Approved
Matched Synonyms: … Penicillanic acid sulfone ... Penicillanic acid 1,1-dioxide ... (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide …
Matched Iupac: … (2S,5R)-3,3-dimethyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Matched Description: … Sulbactam is a beta (β)-lactamase inhibitor and a derivative of the basic penicillin nucleus. …
Matched Mixtures name: … Ampicillin and Sulbactam ... Ampicillin and Sulbactam ... Ampicillin and Sulbactam …
Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] .
Approved
Matched Synonyms: … Phosphoric acid, calcium salt …
Matched Mixtures name: … Multiple Vitamins and Minerals ... Multiple Vitamins and Minerals ... Multivitamins and Minerals for Men …
Matched Categories: … ascorbic acid (vit C) and calcium ... Alimentary Tract and Metabolism …
A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Approved
Matched Synonyms: … Indinavir anhydrous
Matched Description: … A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. …
Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, hydroxyurea...
Approved
Matched Synonyms: … Carbamohydroxamic acid ... Carbamohydroximic acid
Matched Description: … adherence, the need for therapeutic monitoring, and serious side effects of secondary cancer and birth ... conditions exists, hydroxyurea is used sparingly in clinical settings, largely due to lack of knowledge and
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... Antineoplastic and Immunomodulating Agents …
Phenylalanine is an essential aromatic amino acid that is a precursor of melanin, dopamine, noradrenalin (norepinephrine), and thyroxine.
Approved
Investigational
Nutraceutical
Matched Synonyms: … (S)-2-Amino-3-phenylpropionic acid ... (S)-alpha-Amino-beta-phenylpropionic acid
Matched Iupac: … (2S)-2-amino-3-phenylpropanoic acid
Matched Description: … ] (norepinephrine), and [thyroxine]. ... Phenylalanine is an essential aromatic amino acid that is a precursor of melanin, [dopamine], [noradrenalin …
Matched Mixtures name: … Aminosyn II and Dextrose ... Aminosyn II and Dextrose ... Travasol Amino Acid Inj 8.5% …
Matched Categories: … Amino Acids, Peptides, and Proteins …
A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
Approved
Illicit
Matched Synonyms: … 5-ethyl-5-isoamylbarbituric acid ... 5-ethyl-5-isopentylbarbituric acid ... 5-ethyl-5-(3-methylbutyl)barbituric acid
Matched Description: … A barbiturate with hypnotic and sedative properties (but not antianxiety). ... Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with …
Matched Categories: … Hypnotics and Sedatives …
Approved
Experimental
Investigational
Matched Synonyms: … Fumaric acid monomethyl ester …
Matched Iupac: … (2E)-4-methoxy-4-oxobut-2-enoic acid
Cefalotin is a cephalosporin antibiotic.
Approved
Investigational
Vet approved
Matched Synonyms: … 7-(2-Thienylacetamido)cephalosporanic acid ... 7-(2'-thienylacetamido)cephalosporanic acid ... 3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid
Matched Iupac: … acetyloxy)methyl]-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.
Approved
Investigational
Matched Synonyms: … bosentan anhydrous
Matched Description: … blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Rifampin, also known as rifampicin, is a broad-spectrum antimicrobial that was first discovered in 1965 and clinically used in 1968. Rifampin is used to treat tuberculosis and works by inhibiting the microbial DNA-dependent RNA polymerase (RNAP).
Approved
Matched Synonyms: … piperazinyl)formimidoyl]-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione 21-acetate
Matched Iupac: … -8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate
Matched Description: … rifampicin, is a broad-spectrum antimicrobial [A263748] that was first discovered in 1965 [A263753] and ... [A263768] Rifampin is used to treat tuberculosis and works by inhibiting the microbial DNA-dependent …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... dapsone and rifampicin ... rifampicin and isoniazid ... dapsone, rifampicin and clofazimine ... rifampicin, ethambutol and isoniazid …
A covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
Approved
Nutraceutical
Matched Synonyms: … L-alpha-Diamino-beta-dithiolactic acid ... (R,R)-3,3'-dithiobis(2-aminopropanoic acid) …
Matched Iupac: … (2R)-2-amino-3-{[(2R)-2-amino-2-carboxyethyl]disulfanyl}propanoic acid
Matched Description: … A covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Mucor circinelloides f. lusitanicus allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Molds, rusts and smuts, mucor circinelloides f. lusitanicus …
Displaying drugs 2976 - 3000 of 15149 in total