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Displaying drugs 301 - 325 of 15017 in total

Eliglustat

Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher disease, the accumulation of glucosylceramide leads to...
Approved
Investigational
Matched Description: … [A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase ... [L41404,A7634] Eliglustat was approved by the FDA in August 2014 as an oral substrate reduction therapy ... This leads to complications such as anemia and thrombocytopenia. …
Matched Categories: … Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …

Rucaparib

Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the genetically-mutated cancer...
Approved
Investigational
Matched Description: … [A249240] The drug was later approved by the European Commission in May 2018. ... Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. ... [L42185] It is currently used to treat recurrent ovarian and prostate cancer in adults. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Fluticasone propionate

Fluticasone propionate is a synthetic glucocorticoid[F4355,F4358][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358][FDA Label]. Fluticasone propionate was first approved in 1990 .
Approved
Matched Description: … Fluticasone propionate was first approved in 1990[L5962]. ... These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory …
Matched Mixtures name: … Fluticasone Propionate and Salmeterol ... Fluticasone Propionate and Salmeterol ... Fluticasone Propionate and Salmeterol …
Matched Products: … Up and Up Allergy Relief Nasal ... Up and Up allergy relief nasal ... Berkley and Jensen Allergy Relief …

Ondansetron

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. Having been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has...
Approved
Withdrawn
Matched Description: … Having been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ... A competitive serotonin type 3 receptor antagonist. ... cisplatin, and has reported anxiolytic and neuroleptic properties. …
Matched Categories: … Antiemetics and Antinauseants …
Matched Products: … Ondansetron and Dextrose ... Ondansetron Hydrochloride and Dextrose ... Ondansetron hydrochloride and dextrose …

Sulfadimethoxine

Sulfadimethoxine is a sulfonamide antibiotic. Sulfadimethoxine is used to treat many infections, including treatment of respiratory, urinary tract, enteric, and soft tissue infections. It is most frequently used in veterinary medicine, although it is approved in some countries for use in humans. Sulfadimethoxine inhibits bacterial synthesis of folic acid (pteroylglutamic...
Approved
Vet approved
Withdrawn
Matched Description: … Sulfadimethoxine is approved in Russia for use in humans, including children, and has been successfully ... acid. ... Sulfadimethoxine inhibits bacterial synthesis of folic acid (pteroylglutamic acid) from para-aminobenzoic …
Matched Categories: … Sulfonamides and trimethoprim ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

DaxibotulinumtoxinA

DaxibotulinumtoxinA is an acetylcholine release inhibitor and neuromuscular blocking agent. It is a botulinum toxin without accessory proteins purified from the bacterium Clostridium botulinum type A, the gram-positive anaerobic bacterium primarily present in soil. C. botulinum is known to produce toxins that can cause botulism in humans.[A261075, L47860] DaxibotulinumtoxinA was...
Approved
Matched Description: … DaxibotulinumtoxinA is an acetylcholine release inhibitor and neuromuscular blocking agent. ... is a botulinum toxin without accessory proteins purified from the bacterium _Clostridium botulinum_ type ... [L47865] On August 14, 2023, the drug was also approved for the treatment of cervical dystonia. …
Matched Categories: … Botulinum Toxins, Type A …

Interferon alfacon-1

Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional amino acid changes were made to facilitate the...
Approved
Investigational
Matched Description: … Four additional amino acid changes were made to facilitate the molecular construction, and a corresponding ... natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding ... Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. …
Matched Categories: … Interferon Type I ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …

Metronidazole

Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several decades , with added antiparasitic properties that set...
Approved
Matched Description: … It is available in capsule form, tablet form, and topical form, and suppository preparations for the ... , and amebiasis which are parasitic infections. ... [L3754] It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis …
Matched Mixtures name: … Bismuth Subcitrate Potassium, Metronidazole and Tetracycline Hydrochloride ... Bismuth Subcitrate Potassium, Metronidazole, and Tetracycline Hydrochloride …
Matched Categories: … Drugs for Acid Related Disorders ... Alimentary Tract and Metabolism ... metronidazole and diloxanide ... spiramycin and metronidazole ... cefuroxime and metronidazole …

Lapatinib

Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a...
Approved
Investigational
Matched Description: … Lapatinib is a human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor ... It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer ... anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Alvimopan

Alvimopan is a peripherally acting μ opioid antagonist. It is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period.
Approved
Investigational
Matched Iupac: … 2-[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanamido]acetic acid …
Matched Description: … It is used to avoid postoperative ileus following small or large bowel resection and accelerates the …
Matched Categories: … Alimentary Tract and Metabolism …

Insulin pork

Insulin isolated from pig pancreas. Composed of alpha and beta chains, processed from pro-insulin. Forms a hexameric structure.
Approved
Matched Description: … Composed of alpha and beta chains, processed from pro-insulin. Forms a hexameric structure. …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Insulins and Analogues for Injection, Fast-Acting ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Peginesatide

Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of the structure itself. Peginesatide...
Approved
Investigational
Matched Description: … iminodiacetic acid and β-alanine. ... FDA approved March 27, 2012. ... The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Cupric oxide

Cupric oxide, or copper (II) oxide, is an inorganic compound with the chemical formula CuO. Cupric oxide is used as a precursor in many copper-containing products such as wood preservatives and ceramics. Cupric oxide may be found in over-the-counter vitamin-mineral supplements as a source of DB09130. The mean daily dietary...
Approved
Matched Description: … Cupric oxide poses potential health and environmental concern due to toxic and mutagenic particles generating ... paints, and catalysts in organic synthesis [A32656]. ... The mean daily dietary intake of copper in adults ranges between 0.9 and 2.2 mg [L2422]. …
Matched Mixtures name: … Iron Polysaccharides Folic Acid DHA ... Multivitamin and Mineral ... Multiple Vitamins and Minerals …
Matched Categories: … Diet, Food, and Nutrition …

Elafibranor

Elafibranor (code name GFT505) is a multimodal and pluripotent medication for treatment of atherogenic dyslipidemia for an overweight patient with or without diabetes. It is an oral treatment that acts on the 3 sub-types of PPAR (PPARa, PPARg, PPARd) with a preferential action on PPARa. As of February 2016, elafibranor...
Approved
Investigational
Matched Iupac: … 2-{2,6-dimethyl-4-[(1E)-3-[4-(methylsulfanyl)phenyl]-3-oxoprop-1-en-1-yl]phenoxy}-2-methylpropanoic acid …
Matched Description: … Elafibranor (code name GFT505) is a multimodal and pluripotent medication for treatment of atherogenic ... As of February 2016, elafibranor has completed 8 clinical trials and a phase III is in progress. …
Matched Categories: … Bile and Liver Therapy ... Alimentary Tract and Metabolism …

Cerliponase alfa

Cerliponase alfa is an enzyme replacement treatment for a specific form of Batten disease. It was the first FDA-approved treatment to slow loss of walking ability (ambulation) in symptomatic pediatric patients 3 years of age and older with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), also known as tripeptidyl...
Approved
Investigational
Matched Description: … patients 3 years of age and older with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), ... Cerliponase alfa was approved in April, 2017 (as Brineura). ... It was the first FDA-approved treatment to slow loss of walking ability (ambulation) in symptomatic pediatric …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Vonoprazan

Vonoprazan is a potassium-competitive acid blocker (PCAB) that inhibits H+, K+-ATPase-mediated gastric acid secretion. PCABs represent an alternative to proton-pump inhibitors for the treatment of acid-related disorders. Unlike proton-pump inhibitors, PCABs are not affected by CYP2C19 genetic polymorphisms and do not require acid-resistant formulations. Furthermore, vonoprazan is 350-times more potent...
Approved
Investigational
Matched Description: … [A253702] In May 2022, the FDA approved the use of vonoprazan in a co-packaged product containing amoxicillin ... acid-resistant formulations. ... ATPase-mediated gastric acid secretion. …
Matched Categories: … Gastric Acid Lowering Agents ... Drugs for Acid Related Disorders ... Potassium-competitive Acid Blockers ... Alimentary Tract and Metabolism ... vonoprazan and amoxicillin …

Tazarotene

Tazarotene, commonly marketed as Tazorac®, Avage®, and Zorac®, is member of the acetylenic class of retinoids. It is a prodrug that is found in topical formulations used in the treatment of various conditons, such as psoriasis, acne, and sun damaged skin (photodamage).
Approved
Investigational
Matched Description: … Tazarotene, commonly marketed as Tazorac®, Avage®, and Zorac®, is member of the acetylenic class of retinoids ... found in topical formulations used in the treatment of various conditons, such as psoriasis, acne, and …
Matched Mixtures name: … Hyaluronic Acid Sodium Salt 0.5% / Tazarotene 0.1% ... Hyaluronic Acid Sodium Salt 0.5% / Tazarotene 0.05% …
Matched Categories: … tazarotene and ulobetasol ... Skin and Mucous Membrane Agents …

Valsartan

Valsartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes telmisartan, candesartan, losartan, olmesartan, and irbesartan. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis of aldosterone...
Approved
Investigational
Matched Iupac: … (2S)-3-methyl-2-(N-{[2'-(2H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}pentanamido)butanoic acid …
Matched Description: … type 2 diabetes and in nondiabetic patients diagnosed with chronic kidney disease. ... Valsartan is commonly used for the management of hypertension, heart failure, and Type 2 Diabetes-associated ... Shortly after, in 1997, this drug was approved in the United States. …
Matched Mixtures name: … AMLODIPINE and VALSARTAN ... Amlodipine and Valsartan ... Amlodipine and Valsartan …
Matched Categories: … Angiotensin II Type 1 Receptor Blockers ... Angiotensin II Type 2 Receptor Blockers ... valsartan and nebivolol ... valsartan and diuretics ... valsartan and aliskiren …

Trametinib

Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 inhibitor.[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. It was later approved by Health Canada on July 18, 2013 and by the European Commission on June 30, 2014. Trametinib...
Approved
Matched Description: … [A258298] It was later approved by Health Canada on July 18, 2013 [L45588] and by the European Commission ... [A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. ... Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Interferon beta-1a

Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta.
Approved
Investigational
Matched Description: … The amino acid sequence is identical to that of natural human interferon beta. …
Matched Categories: … Interferon Type I ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …

Clopidogrel

Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral...
Approved
Matched Description: … Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and ... with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and ... be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and …
Matched Mixtures name: … Clopidogrel/acetylsalicylic Acid Mylan ... Clopidogrel/acetylsalicylic Acid Mylan ... Clopidogrel/acetylsalicylic Acid Mylan …
Matched Categories: … Blood and Blood Forming Organs …

Zonisamide

Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of...
Approved
Investigational
Matched Description: … The US and Europe approved it in 2000 and 2005, respectively.[A1379,A1383] ... may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type ... In 1989, it was approved for commercial use in Japan. …
Matched Categories: … Calcium-Regulating Hormones and Agents …

Efavirenz

Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with...
Approved
Investigational
Matched Description: … virus (HIV) type 1. ... Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI ... For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with …
Matched Mixtures name: … Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate ... Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate ... Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... Metabolic Side Effects of Drugs and Substances ... lamivudine, tenofovir disoproxil and efavirenz ... emtricitabine, tenofovir disoproxil and efavirenz …

Hesperidin

Hesperidin is a flavan-on glycoside found in citrus fruits.
Approved
Investigational
Matched Mixtures name: … KORDEL`S C TIME ACID FREE C 1000MG TABLET ... VENAFIX (Diosmin and Hesperidin Tablet) …

Danazol

A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Approved
Matched Description: … Danazol has been used in the treatment of endometriosis and some benign breast disorders. ... A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary …
Matched Categories: … Antigonadotropins and Similar Agents ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Displaying drugs 301 - 325 of 15017 in total