Advanced Filter

Filter by Group

Filter by Market Availability

Clear
Displaying drugs 326 - 350 of 11546 in total

Minaprine

Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.
Approved
Matched Description: … Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …

Linezolid

Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the initiation of bacterial protein synthesis - more specifically,...
Approved
Investigational
Matched Description: … Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive ... [A233425] A second member of this class, [tedizolid], was approved by the FDA in 2014 and is considered …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …

Ruxolitinib

Ruxolitinib, formerly known as INCB018424 or INC424, is an anticancer drug and a Janus kinase (JAK) inhibitor. It is a potent and selective inhibitor of JAK1 and JAK2, which are tyrosine kinases involved in cytokine signalling and hematopoiesis. Myeloproliferative neoplasms, such as myelofibrosis and polycythemia vera, are often characterized by...
Approved
Matched Description: … It is a potent and selective inhibitor of JAK1 and JAK2,[A229698] which are tyrosine kinases involved ... Ruxolitinib, formerly known as INCB018424 or INC424, is an anticancer drug and a Janus kinase (JAK) inhibitor ... [A229708] Due to a large number of patients with myeloproliferative neoplasms who have JAK2 mutations …
Matched Categories: … Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Chlormerodrin

Chlormerodrin is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs.
Approved
Withdrawn
Matched Description: … Chlormerodrin is a mercurial compound with toxic side effects that was previously used as a diuretic. ... The radiolabeled form has been used as a diagnostic and research tool. …

Degarelix

Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH) which ultimately causes testosterone suppression. Reduction in...
Approved
Matched Description: … Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) ... Chemically, it is a synthetic linear decapeptide amide with seven unnatural amino acids, five of which …

Meglumine

Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …

Gadoversetamide

Gadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver.
Approved
Investigational
Matched Description: … Gadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Ceftriaxone

Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges , eyes , and inner ear . Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone...
Approved
Matched Description: … Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. ... [A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the ... Ceftriaxone is a commonly used antimicrobial due to its good activity against multi-drug resistant Enterobacteriaceae …
Matched Products: … CEFTRIAXONA 1000 MG POLVO ESTERIL PARA RECONSTITUIR A SOLUCION INYECTABLE. …

Setmelanotide

Setmelanotide is the first available treatment for patients with pro-opiomelanocortin, proprotein subilisin/kexin type 1, or leptin deficiencies. It is an agonist of the melanocortin 4 receptor. Earlier attempts at agonizing MC4R (such as LY2112688) lead to successful weight loss, but also an increase in blood pressure and heart rate. Other...
Approved
Investigational

Motixafortide

Motixafortide is a cyclic peptide hematopoietic stem cell mobilizer used to improve stem cell collection prior to autologous transplantation. Hematopoietic stem cell transplantation (HSCT) is commonly employed in the context of hematologic cancers - high-dose chemotherapy regimens destroy cancerous blood cells, which are then replaced via infusion of the patient's...
Approved
Investigational
Matched Description: … Motixafortide is a cyclic peptide hematopoietic stem cell mobilizer used to improve stem cell collection ... previously approved [plerixafor], motixafortide is an inhibitor of C-X-C Motif Chemokine Receptor 4 (CXCR4), a …

Nylidrin

Nylidrin, also known as buphenine belongs to the category of drugs called vasodilators, which relax blood vessels and increase blood flow. Nylidrin is a peripheral vasodilator. Some studies show the evidence of improving cognitive impairment in selected individuals, such as geriatric patients with mild to moderate symptoms of cognitive, emotional...
Approved
Matched Description: … Nylidrin is a peripheral vasodilator. …

Cholesterol

The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Approved
Investigational
Matched Iupac: … 11a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …

Magnesium cation

Magnesium hydroxide is used primarily in "Milk of Magnesia", a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate constipation, but can also be used to relieve indigestion and heartburn. When taken internally by mouth as a laxative, the...
Approved
Nutraceutical
Matched Description: … Magnesium hydroxide is used primarily in "Milk of Magnesia", a white aqueous, mildly alkaline suspension ... When taken internally by mouth as a laxative, the osmotic force of the magnesia suspension acts to draw …

Betaine

Betaine is a methyl group donor that functions in the normal metabolic cycle of methionine. It is a naturally occurring choline derivative commonly ingested through diet, with a role in regulating cellular hydration and maintaining cell function.[A252235,A252240] Homocystinuria is an inherited disorder that leads to the accumulation of homocysteine in...
Approved
Investigational
Nutraceutical
Matched Description: … It is a naturally occurring choline derivative commonly ingested through diet, with a role in regulating ... Betaine is a methyl group donor that functions in the normal metabolic cycle of methionine. …

Tacrolimus

Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis...
Approved
Investigational
Matched Description: … Tacrolimus is chemically known as a macrolide. ... It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory ... It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …

Sunitinib

Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally available as an orally administered formulation....
Approved
Investigational
Matched Description: … Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …

Trimipramine

Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.
Approved
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index …

Sevelamer

Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel.
Approved
Matched Description: … Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Ethanolamine oleate

Ethanolamine oleate is a mild sclerosing agent. It is composed of ethanolamine, a basic substance, which when combined with oleic acid forms a clear, straw to pale yellow colored, deliquescent oleate.
Approved
Matched Description: … It is composed of ethanolamine, a basic substance, which when combined with oleic acid forms a clear, ... Ethanolamine oleate is a mild sclerosing agent. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Argatroban

Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients...
Approved
Investigational
Matched Description: … Argatroban is a direct, selective thrombin inhibitor. ... Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT ... Parental anticoagulants must be stopped and a baseline activated partial thromboplastin time must be …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …

Ergosterol

A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ERGOCALCIFEROL.
Approved
Experimental
Matched Iupac: … 5,6-dimethylhept-3-en-2-yl]-9a,11a-dimethyl-1H,2H,3H,3aH,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably ... AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in …

alpha-Arbutin

Approved
Experimental

Cortisone acetate

Cortisone acetate was first isolate in 1935 and became more widely researched in 1949. Since then, glucocorticoids such as cortisone acetate have been used to treat a number of inflammatory conditions such as endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, and gastrointestinal diseases and disorders.[A226300,L13203] Cortisone acetate...
Approved
Investigational
Matched Iupac: … -hydroxy-9a,11a-dimethyl-7,10-dioxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … [A226295] Since then, glucocorticoids such as cortisone acetate have been used to treat a number of inflammatory …

Azelastine

Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic conjunctivitis.[L8240,L8270] It is a racemic mixture, though there is no noted difference in pharmacologic activity between enantiomers, and was first...
Approved
Matched Description: … Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment ... [L8240,L8270] It is a racemic mixture, though there is no noted difference in pharmacologic activity ... [L8240,L8270] Azelastine is also available in combination with fluticasone propionate as a nasal spray …

Amoxapine

Amoxapine, the N-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation....
Approved
Matched Description: … In depressed individuals, amoxapine exerts a positive effect on mood. ... See toxicity section below for a complete listing of side effects. ... They contain a tricyclic ring system with an alkyl amine substituent on the central ring. …
Matched Categories: … Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index …
Displaying drugs 326 - 350 of 11546 in total