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Displaying drugs 376 - 400 of 15350 in total

Tirzepatide

Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Dual GIP/GLP-1 agonists gained increasing attention as new therapeutic agents for glycemic and weight control as they demonstrated better glucose control and weight loss compared to selective GLP-1 receptor agonists in preclinical and clinical trials....
Approved
Investigational
Matched Description: … agonists in preclinical and clinical trials. ... only GIP and GLP-1 receptor agonist for this indication. ... Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Cholestyramine

Cholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water.
Approved
Investigational

Etanercept

Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1....
Approved
Investigational
Matched Description: … [L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region ... variety of inflammatory conditions including rheumatoid arthritis (RA), ankylosing spondylitis (AS), and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Thiosulfuric acid

Thiosulfuric acid is available in its salt forms sodium thiosulfate and sodium thiosulfate pentahydrate. Sodium thiosulfate is part of the World Health Organization’s list of essential medicines, and it has a variety of industrial uses, including food preservative, water de-chlorinator and paper pulp bleaching agent. Sodium thiosulfate is rapidly degraded...
Approved
Investigational
Matched Description: … it is frequently used in conjunction with sodium nitrite (a salt form of [nitrous acid]). ... Thiosulfuric acid is available in its salt forms sodium thiosulfate and sodium thiosulfate pentahydrate ... Sodium thiosulfate is part of the World Health Organization’s list of essential medicines, and it has …
Matched Mixtures name: … Sodium polysulthionate and folic acid ... Sodium Polysulthionate and Folic Acid …

Silver nitrate

Silver nitrate is an inorganic compound with the chemical formula AgNO3. In its solid form, silver nitrate is coordinated in a trigonal planar arrangement. It is often used as a precursor to other silver-containing compounds. It is used in making photographic films, and in laboratory setting as a staining agent...
Approved
Investigational
Matched Description: … In its solid form, silver nitrate is coordinated in a trigonal planar arrangement. ... in PAGE gels and in scanning electron microscopy. ... It is used in making photographic films, and in laboratory setting as a staining agent in protein visualization …
Matched Categories: … Antiseptics and Disinfectants …

Valoctocogene roxaparvovec

Valoctocogene roxaparvovec is an adeno-associated virus serotype 5 (AAV5) based gene therapy vector that expresses the B-domain deleted SQ form of human coagulation factor VIII (hFVIII-SQ). The expression of hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein and increase the levels of active...
Approved
Investigational
Matched Description: … adeno-associated virus serotype 5 (AAV5) based gene therapy vector that expresses the B-domain deleted SQ form ... [L43282,A252807] Valoctocogene roxaparvovec was approved by EMA in September 2022 and is indicated for ... hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein and …
Matched Categories: … Cellular and Gene Therapy ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Ocriplasmin

Ocriplasmin is a recombinant truncated form of human plasmin with a molecular weight of 27.2 kDa produced by recombinant DNA technology in a Pichia pastoris expression system. Ocriplasmin is a protein made up of 249 amino acids and has two peptide chains. Agent for pharmacologic vitreolysis; thrombolytic agent. FDA approved...
Approved
Matched Description: … Ocriplasmin is a protein made up of 249 amino acids and has two peptide chains. ... Ocriplasmin is a recombinant truncated form of human plasmin with a molecular weight of 27.2 kDa produced …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …

Erenumab

Erenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and antagonize the calcitonin gene-related peptide receptor (CGRPR) as a means to prevent migraines. Aimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the first and only...
Approved
Investigational
Matched Description: … Aimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the ... Erenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and ... first and only FDA approved treatment specifically developed to prevent migraine by blocking the CGRP …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Hyaluronic acid

Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and neural tissues; it was first isolated in 1934. Karl Meyer and John Palmer obtained glycosaminoglycan (GAG) from the bovine eye, giving it the name “hyaluronic acid”. HA is involved in many important physiological processes, including but not...
Approved
Vet approved
Matched Description: … oral, topical, and injectable forms. ... Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and ... Karl Meyer and John Palmer obtained glycosaminoglycan (GAG) from the bovine eye, giving it the name “ …
Matched Mixtures name: … Hyaluronic Acid 60mg and Lidocaine 2% PF ... ELDEEN AGE TWENTY ONE MifitPatch and Serum ... ELDEEN AGE TWENTY ONE MifitPatch and Serum …
Matched Categories: … Preparations for Treatment of Wounds and Ulcers …

Vemurafenib

Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann...
Approved
Matched Description: … [A31270] Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Baloxavir marboxil

Baloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.[A39895, A251755] It is a prodrug of baloxavir with an improved absorption profile than its active metabolite due to the addition of a phenolic hydroxyl...
Approved
Investigational
Matched Iupac: … methyl carbonate ... 3,5,7,11,13-hexaen-2-yl]-9,12-dioxo-5-oxa-1,2,8-triazatricyclo[8.4.0.0^{3,8}]tetradeca-10,13-dien-11-yl]oxy}methyl …
Matched Categories: … Baloxavir and prodrugs …

Manidipine

Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.
Approved
Investigational
Matched Iupac: … 3-{2-[4-(diphenylmethyl)piperazin-1-yl]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine …
Matched Description: … It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages …
Matched Categories: … delapril and manidipine ... ACE Inhibitors and Calcium Channel Blockers ... Calcium-Regulating Hormones and Agents …

Doxorubicin

Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed...
Approved
Investigational
Matched Description: … terminates with a primary alcohol group compared to the methyl group of daunorubicin. ... Hodgkin’s lymphoma, multiple myeloma, sarcoma, and pediatric cancers. ... [A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain …
Matched Categories: … Anthracyclines and Related Substances ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …

Trypsin

Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of the amino acids lysine or arginine....
Approved
Vet approved
Matched Description: … converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form ... residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form ... Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Preparations for Treatment of Wounds and Ulcers …

Selenious acid

Selenious acid is the acid form of sodium selenite, a form of selenium . Selenium is an essential trace element and antioxidant. It is a cofactor metabolic enzyme regulation. It also plays an important role in maintaining the general health of tissue and muscle and has antioxidant properties. Selenium is...
Approved
Investigational
Matched Description: … Selenious acid is the acid form of sodium selenite, a form of selenium [L1910]. ... It also plays an important role in maintaining the general health of tissue and muscle and has antioxidant ... Selenium is an essential trace element and antioxidant. …
Matched Mixtures name: … Vitamin and Mineral Drink Mix ... Multivitamins and Minerals Tablets ... Golf Vitamin and Mineral Supplement …
Matched Categories: … Diet, Food, and Nutrition ... Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …

Aluminum chloride

Aluminum chloride is a chemical compound with the chemical formula AlCl3. When contaminated with iron chloride, it often displays a yellow color compared to the white pure compound. It is used in various chemical applications as a Lewis base, with anhydrous aluminium trichloride being the most commonly used Lewis acid....
Approved
Investigational
Matched Description: … , in an aqueous solution nonaerosol dosage form [L2012]. ... approves the use of aluminum chloride as an active ingredient up to 15%, calculated on the hexahydrate form …
Matched Categories: … Astringents and Deodorants …

Flupentixol

Flupentixol is an antipsychotic drug of the thioxanthene group. It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. Flupentixol decanoate is one of the active ingredients found in injectable drug formulations: it is produced by esterification of cis(Z)‐flupentixol with decanoic acid. Flupentixol is an antagonist of...
Approved
Investigational
Withdrawn
Matched Description: … [A229083] Flupentixol is an antagonist of both D1 and D2 dopamine receptors. ... It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. ... It is approved for use in Canada and other countries around the world, but not in the US. …

Methscopolamine

Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be effective...
Approved
Matched Description: … Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products ... Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh ... The oral tablets are used as an adjunct therapy for the treatment of peptic ulcer and is shown to be …
Matched Categories: … Alimentary Tract and Metabolism ... Mydriatics and Cycloplegics ... Belladonna and Derivatives, Plain ... methylscopolamine and psycholeptics …

Estrone sulfate

Estrone sulfate (as estropipate) is a form of estrogen. It has several uses such as: alleviate symptoms of menopause as hormone replacement therapy, treatment some types of infertility, treatment of some conditions leading to underdevelopment of female sexual characteristics, treatment of vaginal atrophy, treatment of some types of breast cancer...
Approved
Matched Iupac: … [(3aS,3bR,9bS,11aS)-11a-methyl-1-oxo-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Estrone sulfate (as estropipate) is a form of estrogen. ... postmenopausal women), treatment of prostate cancer and prevention of osteoporosis. ... characteristics, treatment of vaginal atrophy, treatment of some types of breast cancer (particularly in men and …
Matched Mixtures name: … Esterified Estrogens and Methyltestosterone ... Esterified Estrogens and Methyltestosterone …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Adalimumab

Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor.[A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. This drug is frequently known as Humira. It is produced...
Approved
Experimental
Matched Description: … This drug is available in a prefilled syringe form and convenient pen form for subcutaneous self-administered ... a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and ... [A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Hydroxyethyl cellulose

Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as...
Approved
Matched Iupac: … 1-{[3,4,5-tris(2-hydroxypropoxy)-6-{[4,5,6-tris(2-hydroxypropoxy)-2-[(2-hydroxypropoxy)methyl]oxan-3- …
Matched Description: … non-ionic and water-soluble nature. ... It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its ... cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and …

Octreotide

Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also occur. Acromegaly is...
Approved
Investigational
Matched Description: … [L14501] Octreotide is a long-acting drug with pharmacologic activities that mimic those of the natural ... Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also ... , including carcinoid tumors and vasoactive intestinal tumors (VIPomas). …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatostatin and Analogues …

Methenamine

Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine).
Approved
Vet approved
Matched Description: … In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate …
Matched Mixtures name: … Methenamine and Sodium Salicylate ... Methenamine and Sodium Salicylate (nsaid) ... Disinfectant(Model III)Sanitizer Hand And Surface …
Matched Categories: … sodium salicylate and methenamine ... Genito Urinary System and Sex Hormones …

Cetuximab

Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor (EGF). EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour cells; it is responsible...
Approved
Matched Description: … neck cancer and metastatic, KRAS wild-type colorectal cancer, and metastatic colorectal cancer with ... EGFR overexpression has been linked to more advanced disease and poor prognosis. ... cells; it is responsible for regulating epithelial tissue development and homeostasis. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Aripiprazole lauroxil

Aripiprazole lauroxil is a long-acting injectable atypical antipsychotic drug used in the treatment of schizophrenia in adult patients. It is a prodrug of aripiprazole, which acts as a partial agonist at the D2 and 5-HT1A receptors, and as an antagonist at the 5-HT2A receptors . Affecting about 1% of the...
Approved
Investigational
Matched Iupac: … (7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-2-oxo-1,2,3,4-tetrahydroquinolin-1-yl)methyl dodecanoate …
Matched Description: … It is a prodrug of [aripiprazole], which acts as a partial agonist at the D2 and 5-HT1A receptors, and ... catanoia, and negative symptoms that include social withdrawal, anhedonia, and flattening of emotional ... patients are faced with social stigma and discriminations. …
Matched Categories: … Aripiprazole and prodrugs …
Displaying drugs 376 - 400 of 15350 in total