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Displaying drugs 4651 - 4675 of 10619 in total
EVT 201 is a novel partial positive allosteric modulator of the GABAA receptor complex which is being developed as a treatment for insomnia. It is being developed by Evotec Inc.
Investigational
Matched Description: … EVT 201 is a novel partial positive allosteric modulator of the GABAA receptor complex which is being …
Experimental
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Dalcetrapib is under investigation for the treatment of Acute Coronary Syndrome.
Investigational
Matched Description: … Dalcetrapib is under investigation for the treatment of Acute Coronary Syndrome. …
Cositecan is the novel camptothecin derivative which is also known as Karenitecin. It has been developed for superior oral bioavailability and increased lactone stability. It is used to treat cancer.
Investigational
Phenoxypropazine is a non-selective and irreversible monoamine oxidase enzyme inhibitor (MAOI), belonging to the hydrazine chemical class. It was marketed as an antidepressant in 1961 but was later withdrawn in 1966 because of its hepatotoxic potential.
Withdrawn
Matched Description: … It was marketed as an antidepressant in 1961 but was later withdrawn in 1966 because of its hepatotoxic …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity...
Experimental
Matched Description: … released into the cytoplasm where it releases calcium ions from internal stores within the cell's ... , which is one of the phospholipids that make up the cell membrane. ... These calcium ions stimulate the activity of B kinase or calmodulin. …
Investigational
Matched Iupac: … 3-[(1E)-2-[(2R)-1,2-dimethylpyrrolidin-2-yl]ethenesulfonyl]-1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)urea …
AVI-4557 is an oral antisense compound that selectively inhibits the metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown of approximately half of currently marketed drugs. Studies indicate that AVI-4557 can successfully reduce the rate of metabolism for certain drugs, therefore allowing greater and...
Investigational
Matched Description: … approximately half of currently marketed drugs. ... anxiety, cancer, and a number of other serious conditions. ... metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown of
Thymidine is a pyrimidine deoxynucleoside. Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to synchronize the cells in S phase.
Experimental
Investigational
Matched Description: … In cell biology it is used to synchronize the cells in S phase. …
Ty800 is a vaccine designed to offer rapid, oral, single-dose protection against Salmonella typhi, the cause of typhoid fever. The Ty800 vaccine was developed using genetic techniques to delete specific genes known to be essential to the virulence of S. typhi. It is being developed by AVANT Immunotherapeutics, Inc.
Investigational
Matched Description: … S. typhi. ... vaccine designed to offer rapid, oral, single-dose protection against Salmonella typhi, the cause of ... developed using genetic techniques to delete specific genes known to be essential to the virulence of
Gestonorone is often mistaken for gestonorone capproate which has a different chemical structure.
Experimental
Matched Categories: … Sex Hormones and Modulators of the Genital System …
A narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem]
Experimental
Illicit
Matched Description: … A narcotic analgesic with a long onset and duration of action. ... It is used mainly in the treatment of narcotic dependence. [PubChem] …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Chlorine is a stongly oxidizing agent and the third most electronegative element which belongs to the group of halogens with the atomic number 17 and symbol Cl. Being a yellow-green gas at room temperature, chlorine is the second most abundant halogen on Earth. It is commonly used in sanitation, disinfection...
Experimental
Matched Description: … is a stongly oxidizing agent and the third most electronegative element which belongs to the group of
Matched Categories: … Weapons of Mass Destruction …
Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S. miltiorrhiza . Protocatechualdehyde possesses antiproliferative and pro-apoptotic properties against human breast cancer cells and colorectal cancer cells by reducing the expression of pro-oncogenes...
Experimental
Matched Description: … the herb S. miltiorrhiza [A27224]. ... properties against human breast cancer cells and colorectal cancer cells by reducing the expression of ... naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of
Seletracetam is a pyrrolidone derivative and with a structural similarity to newer generation antiepileptic drug levetiracetam. It binds to the same target as levetiracetam but with higher affinity and has shown potent seizure suppression in models of acquired and genetic epilepsy with high CNS tolerability. It is predicted to have...
Investigational
Matched Description: … its development had been put on hold in July 2007. ... As of 2010, its production was further halted due to the investigation of a newer antiepileptic agent ... Seletracetam was in Phase II clinical trials under the supervision of the U.S. …
Aminopterin is an amino derivative of folic acid, which was once used as an antineoplastic agent in the treatment of pediatric leukemia. In the 1950's its production was discontinued in favor of methotrexate, which is less potent but less toxic. Off label, aminopterin has also been used in the treatment...
Investigational
Withdrawn
Matched Description: … In the 1950's its production was discontinued in favor of methotrexate, which is less potent but less ... treatment of pediatric leukemia. ... Clinicians need to be aware of the characteristic teratologic effects of aminopterin and methotrexate …
Investigational
Matched Categories: … Preparations for Treatment of Wounds and Ulcers …
A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)
Illicit
Withdrawn
Matched Description: … It has properties similar to those of dextroamphetamine. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Benmoxin is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine class. It was first synthesized in 1967 and rapidly used in Europe as an antidepressant. However, this agent is no longer marketed.
Withdrawn
Matched Description: … Benmoxin is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine class …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Mebanazine, also known as Actomol, is a monoamine oxidase inhibitor (MAOI) belonging to the hydrazine class of chemicals. It was used in the past as an antidepressant in the 1960s, but has since been discontinued because of its hepatotoxic potential.
Withdrawn
Matched Description: … also known as _Actomol_, is a monoamine oxidase inhibitor (MAOI) belonging to the _hydrazine_ class of ... It was used in the past as an antidepressant in the 1960s, but has since been discontinued because of
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Pheniprazine is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s. In addition, it was used for the treatment of other conditions, such as angina pectoris and schizophrenia. Pheniprazine was withdrawn by its manufacturer due to its...
Withdrawn
Matched Description: … Pheniprazine is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine ... In addition, it was used for the treatment of other conditions, such as angina pectoris and schizophrenia …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Experimental
Matched Categories: … EGF Family of Proteins …
Tertomotide is under investigation in clinical trial NCT01223209 (A Study, Combination, Immunologic Study of LTX-315 as adjunct to tertomotide in Patients Following Curative Surgery for Carcinoma). It is a peptide vaccine that activates the immune system so that it recognizes and kills cancer cells. It is being developed by Pharmexa...
Investigational
Matched Description: … It is being developed by Pharmexa A/S. ... Tertomotide is under investigation in clinical trial NCT01223209 (A Study, Combination, Immunologic Study of
Experimental
Matched Iupac: … (1R,3R)-N-[1-(4-bromophenyl)ethyl]-2,2-dichloro-1-[(S)-methanesulfinyl]-3-methylcyclopropane-1-carboxamide …
Displaying drugs 4651 - 4675 of 10619 in total