Displaying drugs 4676 - 4700 of 10732 in total
AVI-4557
AVI-4557 is an oral antisense compound that selectively inhibits the metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown of approximately half of currently marketed drugs. Studies indicate that AVI-4557 can successfully reduce the rate of metabolism for certain drugs, therefore allowing greater and...
Investigational
Matched Description: … approximately half of currently marketed drugs. ... anxiety, cancer, and a number of other serious conditions. ... metabolic enzyme cytochrome P450 3A4 (CYP), a liver enzyme responsible for the metabolism or breakdown of …
Thymidine
Thymidine is a pyrimidine deoxynucleoside. Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to synchronize the cells in S phase.
Experimental
Investigational
Matched Description: … In cell biology it is used to synchronize the cells in S phase. …
Gestonorone
Gestonorone is often mistaken for gestonorone capproate which has a different chemical structure.
Experimental
Matched Categories: … Sex Hormones and Modulators of the Genital System …
Methylestrenolone
Experimental
Matched Categories: … Sex Hormones and Modulators of the Genital System …
EVT 201
EVT 201 is a novel partial positive allosteric modulator of the GABAA receptor complex which is being developed as a treatment for insomnia. It is being developed by Evotec Inc.
Investigational
Matched Description: … EVT 201 is a novel partial positive allosteric modulator of the GABAA receptor complex which is being …
Dalcetrapib
Dalcetrapib is under investigation for the treatment of Acute Coronary Syndrome.
Investigational
Matched Description: … Dalcetrapib is under investigation for the treatment of Acute Coronary Syndrome. …
Cositecan
Cositecan is the novel camptothecin derivative which is also known as Karenitecin. It has been developed for superior oral bioavailability and increased lactone stability. It is used to treat cancer.
Investigational
Chlorine
Chlorine is a stongly oxidizing agent and the third most electronegative element which belongs to the group of halogens with the atomic number 17 and symbol Cl. Being a yellow-green gas at room temperature, chlorine is the second most abundant halogen on Earth. It is commonly used in sanitation, disinfection...
Experimental
Matched Description: … is a stongly oxidizing agent and the third most electronegative element which belongs to the group of …
Matched Categories: … Weapons of Mass Destruction …
Matched Categories: … Weapons of Mass Destruction …
Ty800
Ty800 is a vaccine designed to offer rapid, oral, single-dose protection against Salmonella typhi, the cause of typhoid fever. The Ty800 vaccine was developed using genetic techniques to delete specific genes known to be essential to the virulence of S. typhi. It is being developed by AVANT Immunotherapeutics, Inc.
Investigational
Matched Description: … S. typhi. ... vaccine designed to offer rapid, oral, single-dose protection against Salmonella typhi, the cause of ... developed using genetic techniques to delete specific genes known to be essential to the virulence of …
Protocatechualdehyde
Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S. miltiorrhiza . Protocatechualdehyde possesses antiproliferative and pro-apoptotic properties against human breast cancer cells and colorectal cancer cells by reducing the expression of pro-oncogenes...
Experimental
Matched Description: … the herb S. miltiorrhiza [A27224]. ... properties against human breast cancer cells and colorectal cancer cells by reducing the expression of ... naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of …
Fluoroazomycin arabinoside F-18
Fluoroazomycin arabinoside F-18 is under investigation in clinical trial NCT03257150 (A Study of the Use of Irreversible Electroporation in Pancreatic Ductal Cancer).
Investigational
Matched Description: … Use of Irreversible Electroporation in Pancreatic Ductal Cancer). ... Fluoroazomycin arabinoside F-18 is under investigation in clinical trial NCT03257150 (A Study of the …
Matched Categories: … Diagnostic Uses of Chemicals …
Matched Categories: … Diagnostic Uses of Chemicals …
Aminopterin
Aminopterin is an amino derivative of folic acid, which was once used as an antineoplastic agent in the treatment of pediatric leukemia. In the 1950's its production was discontinued in favor of methotrexate, which is less potent but less toxic. Off label, aminopterin has also been used in the treatment...
Investigational
Withdrawn
Matched Description: … In the 1950's its production was discontinued in favor of methotrexate, which is less potent but less ... treatment of pediatric leukemia. ... Clinicians need to be aware of the characteristic teratologic effects of aminopterin and methotrexate …
Chlorphentermine
A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)
Illicit
Withdrawn
Matched Description: … It has properties similar to those of dextroamphetamine. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Benmoxin
Benmoxin is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine class. It was first synthesized in 1967 and rapidly used in Europe as an antidepressant. However, this agent is no longer marketed.
Withdrawn
Matched Description: … Benmoxin is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine class …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Mebanazine
Mebanazine, also known as Actomol, is a monoamine oxidase inhibitor (MAOI) belonging to the hydrazine class of chemicals. It was used in the past as an antidepressant in the 1960s, but has since been discontinued because of its hepatotoxic potential.
Withdrawn
Matched Description: … also known as _Actomol_, is a monoamine oxidase inhibitor (MAOI) belonging to the _hydrazine_ class of ... It was used in the past as an antidepressant in the 1960s, but has since been discontinued because of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Pheniprazine
Pheniprazine is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s. In addition, it was used for the treatment of other conditions, such as angina pectoris and schizophrenia. Pheniprazine was withdrawn by its manufacturer due to its...
Withdrawn
Matched Description: … Pheniprazine is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine ... In addition, it was used for the treatment of other conditions, such as angina pectoris and schizophrenia …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
2,2-Dichloro-1-methanesulfinyl-3-methyl-cyclopropanecarboxylic acid [1-(4-bromo-phenyl)-ethyl]-amide
Experimental
Matched Iupac: … (1R,3R)-N-[1-(4-bromophenyl)ethyl]-2,2-dichloro-1-[(S)-methanesulfinyl]-3-methylcyclopropane-1-carboxamide …
Tertomotide
Tertomotide is under investigation in clinical trial NCT01223209 (A Study, Combination, Immunologic Study of LTX-315 as adjunct to tertomotide in Patients Following Curative Surgery for Carcinoma). It is a peptide vaccine that activates the immune system so that it recognizes and kills cancer cells. It is being developed by Pharmexa...
Investigational
Matched Description: … It is being developed by Pharmexa A/S. ... Tertomotide is under investigation in clinical trial NCT01223209 (A Study, Combination, Immunologic Study of …
Iodohippuric acid
Iodohippuric acid is under investigation in clinical trial NCT02599844 (Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults).
Investigational
Matched Description: … Iodohippuric acid is under investigation in clinical trial NCT02599844 (Impact of Pediatric Acute Renal …
Matched Categories: … Diagnostic Uses of Chemicals …
Matched Categories: … Diagnostic Uses of Chemicals …
Etretinate
Etretinate is a medication used to treat severe psoriasis. It is a synthetic aromatic retinoid. The mechanism of action of etretinate is still incompletely understood although, like retinoic acid, it is thought to interfere with the terminal differentiation of keratinocytes. It is thought to bind to the retinoic acid receptors....
Withdrawn
Matched Description: … The mechanism of action of etretinate is still incompletely understood although, like retinoic acid, ... Etretinate is also believed to enhance the binding of cAMP to the regulatory RI subunit of cAMP dependent ... it is thought to interfere with the terminal differentiation of keratinocytes. …
Matched Categories: … Retinoids for Treatment of Psoriasis …
Matched Categories: … Retinoids for Treatment of Psoriasis …
Displaying drugs 4676 - 4700 of 10732 in total