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Displaying drugs 451 - 475 of 1990 in total

Protamine sulfate

Since it's earliest discovery in salmon rine sperm heads in the late 1800's to its formal introduction via US FDA approval in 1939, protamine sulfate has occupied an important therapeutic niche as perhaps the only viable option for reversing the anticoagulant effect of heparin use for over 77 years [A174778,...
Approved
Matched Description: … kidney tissue damage, and anaphylactic reaction, amongst others [A174778, L5371]. ... reversal predominantly via the formation of an inactive complex between the anionic nature of heparin and ... potential range in reversing all parenteral anticoagulants are sometimes considered high and limited …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Perfluorohexyloctane

Perfluorohexyloctane is a semifluorinated alkane that contains six perfluorinated carbon atoms and eight hydrogenated carbon atoms. It is an inert, slightly amphiphilic compound. Because it is a completely non-aqueous liquid, microbial growth is not possible; therefore, its drug products do not need to be combined with any preservative.[A259746, A259751] Perfluorohexyloctane...
Approved
Matched Description: … Perfluorohexyloctane is a semifluorinated alkane that contains six perfluorinated carbon atoms and eight …
Matched Categories: … Ophthalmological and Otological Preparations …

Maraviroc

Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Maraviroc name...
Approved
Investigational
Matched Description: … company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and …

Tezepelumab

Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling.[A243764, A243769] Thymic stromal lymphopoietin (TSLP), an innate pleiotropic IL-2-family cytokine, has emerged as a key upstream regulator of chronic inflammation across asthma endotypes. Blocking the...
Approved
Investigational
Matched Description: … [A243764, A243769, A243774] Tezepelumab is a human monoclonal IgG2λ antibody directed against TSLP ... including eosinophil counts and IgE, FeNO, IL-5, and IL-13 levels. ... endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Omeprazole

Originally approved by the FDA in 1989, omeprazole is a proton-pump inhibitor, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class,...
Approved
Investigational
Vet approved
Matched Description: … Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults ... These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases ... This drug was the first clinical useful drug in its class, and its approval was followed by the formulation …
Matched Mixtures name: … Omeprazole and Sodium Bicarbonate ... Omeprazole and Sodium Bicarbonate ... Omeprazole and Sodium Bicarbonate …
Matched Categories: … Alimentary Tract and Metabolism ... Omeprazole and enantiomer ... omeprazole, amoxicillin and rifabutin ... omeprazole, amoxicillin and metronidazole ... omeprazole, amoxicillin and clarithromycin …
Matched Products: … Up and Up Omeprazole ... Berkley and Jensen Omeprazole ... Foster and Thrive Omeprazole …

Pertuzumab

Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. It was first approved by the FDA in...
Approved
Matched Description: … humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human ... It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. ... It was first approved by the FDA in 2012 for use with [docetaxel] and another HER2-targeted monoclonal …
Matched Categories: … HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors ... Amino Acids, Peptides, and Proteins ... pertuzumab and trastuzumab ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Anistreplase

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived...
Approved
Matched Description: … A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human ... Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. ... derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Capivasertib

Hormone receptor (HR) positive, especially estrogen receptor-positive, HER2-negative breast cancer is the most common subtype of metastatic breast cancer, resulting in more than 400,000 deaths annually. Although endocrine-based therapy is the first line of treatment, resistance eventually emerges, leaving chemotherapy the only but often ineffective treatment left. Therefore, significant research...
Approved
Investigational
Matched Description: … based on favorable results obtained from the CAPItello-291 trial, where the combination of capivasertib and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Eribulin

Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for use in the treatment of...
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Trastuzumab

Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal...
Approved
Investigational
Matched Description: … Trastuzumab binds to HER2 and suppresses cancer cell growth, proliferation, and survival directly and ... [L14015] It is used as a treatment of human epidermal growth factor receptor (HER)-2+ metastatic breast ... selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human …
Matched Categories: … HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors ... Amino Acids, Peptides, and Proteins ... pertuzumab and trastuzumab ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Neratinib

Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer.
Approved
Investigational
Matched Description: … Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitors …

Estradiol dienanthate

Estradiol Dienanthate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol benzoate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Description: … pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously within the human ... a chance to enter systemic circulation and exert its estrogenic effects [A12102]. ... Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Delavirdine

A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.
Approved
Matched Categories: … Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor …

Capromab pendetide

Capromab is a Murine IgG1 monoclonal 7E11-C5.3 antibody that recognizes prostate specific membrane antigen (PSMA – also known as glutamate carboxypeptidase 2) from prostate cancer cells and normal prostate tissue. When linked to pendetide, capromab is used as a chelating agent for the radionuclide Indium In-111 during imaging to evaluate...
Approved
Matched Description: … specific membrane antigen (PSMA – also known as glutamate carboxypeptidase 2) from prostate cancer cells and …
Matched Categories: … Indicators and Reagents ... Amino Acids, Peptides, and Proteins …

Phenylacetic acid

Phenylacetic acid is an organic compound containing a phenyl functional group and a carboxylic acid functional group. It is a white solid with a disagreeable odor. Because it is used in the illicit production of phenylacetone (used in the manufacture of substituted amphetamines), it is subject to controls in countries...
Approved
Matched Description: … Phenylacetic acid is an organic compound containing a phenyl functional group and a carboxylic acid functional ... manufacture of substituted amphetamines), it is subject to controls in countries including the United States and …
Matched Mixtures name: … Sodium Phenylacetate and Sodium Benzoate ... Sodium Phenylacetate and Sodium Benzoate ... Sodium Phenylacetate and Sodium Benzoate …
Matched Categories: … Alimentary Tract and Metabolism ... sodium benzoate and sodium phenylacetate ... Various Alimentary Tract and Metabolism Products …

Peginterferon alfa-2a

Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most...
Approved
Investigational
Matched Description: … Peginterferon alfa-2a is derived from the alfa-2a moeity of recombinant human interferon and acts by ... binding to human type 1 interferon receptors. ... development of endocrine and autoimmune disorders, retinopathies, cardiovascular and neuropsychiatric …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …

Cefepime

Cefepime is a fourth-generation cephalosporin antibiotic developed in 1994. Cefepime is active against Gram-positive and Gram-negative bacteria, and has greater activity against both compared to third-generation antibiotics.[A2457,A249050] Cefepime is normally used to treat severe nosocomial pneumonia and infections caused by multi-resistant microorganisms such as Pseudomonas aeruginosa, and is also indicated...
Approved
Investigational
Matched Description: … Cefepime is active against Gram-positive and Gram-negative bacteria, and has greater activity against ... [A2457,A249050] Cefepime is normally used to treat severe nosocomial pneumonia and infections caused ... by multi-resistant microorganisms such as _Pseudomonas aeruginosa_, and is also indicated for the empirical …
Matched Categories: … cefepime and amikacin …
Matched Products: … Cefepime Hydrochloride and Dextrose …

Calcium lactate

Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is...
Approved
Investigational
Vet approved
Matched Description: … as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and …
Matched Categories: … Alimentary Tract and Metabolism …

Riboflavin

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and...
Approved
Investigational
Nutraceutical
Vet approved
Matched Description: … in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. ... Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. ... It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms …
Matched Mixtures name: … Multi Vitamin and Mineral vitamin ... Vitamin and Mineral Drink Mix ... Multiple Vitamins and Minerals …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …

Besilesomab

Besilesomab is a mouse monoclonal antibody labelled with the radioactive isotope technetium-99m for determining the location of inflammation/infection in peripheral bone in adults with suspected osteomyelitis [FDA Label]. Utilised only as a diagnostic agent, besilesomab is currently approved by the EMEA for marketing and use in various European countries like...
Approved
Matched Description: … Utilised only as a diagnostic agent, besilesomab is currently approved by the EMEA for marketing and ... various European countries like Italy, France, Germany, Spain, Portugal, Norway, Sweden, the Netherlands, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Lansoprazole

Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD) along with other pathologies...
Approved
Investigational
Matched Description: … Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally ... [A177065] It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective ... at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD) along …
Matched Mixtures name: … Lansoprazole, Amoxicillin, and Clarithromycin ... Lansoprazole, Amoxicillin and Clarithromycin ... Lansoprazole, Amoxicillin and Clarithromycin …
Matched Categories: … Alimentary Tract and Metabolism ... lansoprazole, amoxicillin and levofloxacin ... lansoprazole, clarithromycin and tinidazole ... lansoprazole, amoxicillin and metronidazole ... lansoprazole, tetracycline and metronidazole …
Matched Products: … Up and Up Lansoprazole ... Berkley and Jensen Lansoprazole ... Foster and Thrive Acid Reducer …

Benzalkonium

Benzalkonium is a quaternary ammonium compound used as a biocide, a cationic surfactant, and as a phase transfer agent [FDA Label]. Benzalkonium is more commonly contained in consumer products in its salt form, benzalkonium chloride [FDA Label]. This salt is used in a great variety of international pharmaceutical products such...
Approved
Investigational
Matched Description: … Benzalkonium is a quaternary ammonium compound used as a biocide, a cationic surfactant, and as a phase ... This salt is used in a great variety of international pharmaceutical products such as eye, ear, and nasal ... When used as an ingredient in antiseptic and disinfectant products however, it is an active antimicrobial …
Matched Mixtures name: … First aid and Burn ... Small Cuts and Burns ... Small Cuts and Burns …
Matched Categories: … Antiseptics and Disinfectants …
Matched Products: … Port and Co ... Lucas and Zoe ... Amber and Black …

Lactose

A disaccharide of glucose and galactose in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.
Approved
Experimental
Investigational
Matched Description: … A disaccharide of glucose and galactose in human and cow milk. ... It is used in pharmacy for tablets, in medicine as a nutrient, and in industry. …
Matched Categories: … Diet, Food, and Nutrition …

Irinotecan

Irinotecan is a topoisomerase inhibitor used for chemotherapy. It is a water-soluble analogue of camptothecin, which is extracted from the Chinese tree Camptotheca acuminate. The bis-piperidine side chain in the structure of irinotecan bestows enhanced water solubility. As an anticancer drug, irinotecan was first commercially available in Japan in 1994...
Approved
Investigational
Matched Description: … Both irinotecan and SN-38 mediate antitumor activity by forming a complex with topoisomerase I and blocking ... This leads to the arrest of the cell cycle in the S-G2 phase and cancer cell death.[A263376] ... [A263376] Approved by the FDA in 1996,[A263366] irinotecan is used to treat colorectal cancer and pancreatic …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Tositumomab

Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).
Approved
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins …
Displaying drugs 451 - 475 of 1990 in total