Displaying drugs 476 - 500 of 9423 in total
Flavin adenine dinucleotide
A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
Flavin adenine dinucleotide is approved for use in Japan under the trade name Adeflavin as an ophthalmic treatment for vitamin B2 deficiency.
Approved
Matched Description: … in Japan under the trade name Adeflavin as an ophthalmic treatment for vitamin B2 deficiency. ... (Lehninger, Principles of Biochemistry, 1982, p972)
Flavin adenine dinucleotide is approved for use …
Corifollitropin alfa
Corifollitropin alfa, also known as Elonva is used in women undergoing fertility treatment to stimulate the development of more than one mature egg (oocyte) at a time in the ovaries. This drug used together with a gonadotropin-releasing hormone (GnRH) antagonist, a type of medicine also used in fertility treatments. Elonva...
Approved
Investigational
Matched Description: … the elevated effectiveness of this drug, however, warns at the same time against the possibility of an ... increased risk of ovarian hyperstimulation in the high responder study group of women [L2276], [A32526 …
Doripenem
Doripenem is a broad-spectrum, carbapenem antibiotic marketed under the brand name Doribax by Janssen. Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal infections. In a clinical trial of doripenem treatment in ventilator associated pneumonia (vs. imipenem and cilastatin), it was found that...
Approved
Investigational
Matched Description: … ventilator associated pneumonia (vs. imipenem and cilastatin), it was found that doripenem carried an ... Doripenem injection was approved by the FDA in 2007 to treat complicated urinary tract and intra-abdominal ... warning against use in ventilator-associated pneumonia and to reiterate its safety and efficacy for its approved …
Manganese citrate
Approved
Experimental
Dalfopristin
Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis.
Approved
Sibutramine
Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the...
Approved
Illicit
Investigational
Withdrawn
Matched Description: … orally administered agent for the treatment of obesity. ... USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an …
Matched Categories: … Antidepressive Agents …
Matched Categories: … Antidepressive Agents …
Nilutamide
Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Nilutamide blocks the action of androgens of adrenal and testicular origin that stimulate the growth of...
Approved
Investigational
Matched Description: … Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. …
Atezolizumab
Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers.[A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based chemotherapy, or whose tumors do not respond to platinum-based chemotherapy. Atezolizumab was granted...
Approved
Investigational
Matched Description: … voluntarily withdrew the use of atezolizumab for the treatment of urothelial carcinoma, previously approved …
Latanoprost
Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998. Latanoprost is the first topical prostaglandin F2 alpha analog used for glaucoma treatment. It has been found to be well-tolerated and its use...
Approved
Investigational
Matched Description: … It was initially approved by the FDA in 1998. …
Clomifene
A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Approved
Investigational
Matched Description: … A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the …
Trimipramine
Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.
Approved
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Tricyclic ... Antidepressive Agents Indicated for Depression …
Ceftobiprole
Ceftobiprole is a fifth-generation semisynthetic cephalosporin antibacterial which is available commercially as the prodrug ceftobiprole medocaril. Ceftobiprole is a broad-spectrum agent with demonstrated activity against both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains of Staphylcoccus aureus (methicillin-resistant Staphylococcus aureus; MRSA).
The EMA's Committee for Medicinal Products for Human Use (CHMP)...
Approved
Investigational
Matched Description: … Ceftobiprole is a broad-spectrum agent with demonstrated activity against both Gram-positive and Gram-negative ... in October 2017 for use in certain patients with bacterial pneumonia,[L50472] and was subsequently approved …
Quinidine
Quinidine is a D-isomer of quinine present in the bark of the Cinchona tree and similar plant species. This alkaloid was first described in 1848 and has a long history as an antiarrhythmic medication.[A38016,A250050] Quinidine is considered the first antiarrhythmic drug (class Ia) and is moderately efficacious in the acute...
Approved
Investigational
Matched Description: … This alkaloid was first described in 1848 and has a long history as an antiarrhythmic medication. …
Upadacitinib
Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage damage...
Approved
Investigational
Matched Description: … Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic ... [A189165]
The FDA approved upadacitinib in August 2019 and it is used for the treatment of active ... [L10896] In December 2019, it was additionally approved by the European Commission and Health Canada. …
Tropisetron
Tropisetron is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.
Tropisetron appears to be well tolerated with the most frequently reported adverse effect being headache. Extrapyramidal...
Approved
Investigational
Matched Description: … Tropisetron is an indole derivative with antiemetic activity. …
Matched Categories: … Antidepressive Agents …
Matched Categories: … Antidepressive Agents …
Tezacaftor
Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator class. It was developed by Vertex Pharmaceuticals and FDA approved in combination with ivacaftor to manage cystic fibrosis. This drug was approved by the FDA on February 12, 2018. Cystic Fibrosis is an autosomal recessive disorder caused...
Approved
Investigational
Matched Description: … [L6814] This drug was approved by the FDA on February 12, 2018. ... [L1595] It was developed by Vertex Pharmaceuticals and FDA approved in combination with [ivacaftor] to ... in the gene for the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, an ion channel …
Naldemedine
Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of DB00704 to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and...
Approved
Investigational
Matched Description: … Naldemedine is an opioid receptor antagonist [FDA Label]. ... Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opioid-induced Constipation …
Sulfathiazole
Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination with sulfabenzamide and sulfacetamide.
Except for those formulated for vaginal use, the FDA withdrew its approval for the use of...
Approved
Vet approved
Withdrawn
Influenza A virus A/Christchurch/16/2010 NIB-74XP (H1N1) antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an …
Phosphoric acid
Phosphoric Acid is a colorless, odorless phosphorus-containing inorganic acid. Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++, and Mg++.
Approved
Matched Description: … Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++ …
Rabies virus inactivated antigen, A
Rabies virus inactivated antigen, A is an inactivated virus vacine for the intramuscular injection. It is an active immunization against rabies that can be administered pre- or post-exposure to the rabies virus.
Approved
Investigational
Matched Description: … Rabies virus inactivated antigen, A is an inactivated virus vacine for the intramuscular injection. ... It is an active immunization against rabies that can be administered pre- or post-exposure to the rabies …
Imipramine
Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, imipramine exerts...
Approved
Matched Description: … They contain a tricyclic ring system with an alkyl amine substituent on the central ring. …
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Tricyclic ... Antidepressive Agents Indicated for Depression …
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Tricyclic ... Antidepressive Agents Indicated for Depression …
Ethionamide
A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Approved
Matched Description: … A second-line antitubercular agent that inhibits mycolic acid synthesis. …
Dapsone
A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of...
Approved
Investigational
Tecovirimat
The World Health Organization declared smallpox, a contagious and sometimes fatal infectious disease, eradicated in 1980. However, there have been longstanding concerns that smallpox may be used as a bioweapon.[A35133,L3614] Tecovirimat is an antiviral drug that was identified via a high-throughput screen in 2002. It is effective against all orthopoxviruses,...
Approved
Investigational
Matched Description: … [A35133,L3614] Tecovirimat is an antiviral drug that was identified via a high-throughput screen in 2002 ... [A35131,A35143]
Tecovirimat was approved by the FDA in July 2018 as the first drug ever approved to ... [L3626, L3614] Tecovirimat was later approved by Health Canada in December 2021,[L39397] followed by …
Displaying drugs 476 - 500 of 9423 in total