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Displaying drugs 501 - 525 of 13963 in total

Rezafungin

Rezafungin is an echinocandin antifungal drug.[A258393,L45633] Unlike other echinocandins such as caspofungin and micafungin, rezafungin has long‐acting pharmacokinetics and a high stability that allows for it to have long dosing intervals maintaining high plasma exposure. Rezafungin has a half-life higher than 130 hours and can be administered once a week...
Approved
Investigational
Matched Description: … [A258403] In March 2023, the FDA approved rezafungin for injection for the treatment of candidemia and ... Rezafungin has a half-life higher than 130 hours and can be administered once a week instead of daily ... invasive candidiasis in adults with limited or no alternative treatment options. …

Nabilone

Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as...
Approved
Investigational
Matched Description: … for such a wide variety of medical conditions. ... It is also approved for use in treatment of anorexia and weight loss in patients with AIDS. ... It was approved in 1985 by the United States FDA for treatment of chemotherapy-induced nausea and vomiting …

Pyrantel

Pyrantel is a pyrimidine-derivative anthelmintic agent for the oral treatment of various parasitic worm infections including ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis . Pyrantel was initially described in 1965 by researchers from Pfizer who sought cyclic amidines with suitable pharmacokinetic properties (specifically, duration of action) for use...
Approved
Vet approved
Matched Description: … Pyrantel is mainly available in formulations for dogs and cats as the embonate salt, containing a 34.7% ... Pyrantel is a pyrimidine-derivative anthelmintic agent for the oral treatment of various parasitic worm ... pharmacokinetic properties (specifically, duration of action) for use as an anthelmintic drug. …
Matched Mixtures name: … Heartgard Plus Chewable Tablet for Dogs - Up to 25 lbs ... Heartgard Plus Chewable Tablet for Dogs - 26 - 50 lbs ... Heartgard Plus Chewable Tablet for Dogs - 51 - 100 lbs …

Cefixime

Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs). β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of essential PBPs, result in impaired cell wall homeostasis,...
Approved
Investigational
Matched Description: … [A263026] However, cefixime is not recommended as a first-line of treatment for uncomplicated urogenital ... [A263031] Cefixime was first approved in the United States in 1986.[L49293] ... Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Phenyl salicylate

Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in DB00945 ). Phenyl salicylate may...
Approved
Matched Description: … It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing ... Phenyl salicylate is used as a food additive in the USA [L2479]. ... salicylate (found in [DB00945] ). …

Oxyquinoline

Oxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and pesticide properties. It is used as a stabilizer for hydrogen peroxide, where it is sometimes added in cosmetic products.
Approved
Vet approved
Matched Description: … It is used as a stabilizer for hydrogen peroxide, where it is sometimes added in cosmetic products. ... Oxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and …
Matched Mixtures name: … INDIO (111-IN) OSSINA CURIUM NETHERLANDS …
Matched Categories: … Antiinfectives and Antiseptics for Local Oral Treatment …

Magnesium hydroxide

Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used commercially...
Approved
Investigational
Matched Description: … It can also be used topically as a deodorant or for the relief of canker sores (aphthous ulcers). ... Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable ... magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used commercially as a …
Matched Mixtures name: … One-A-day Advance Men's ... Maalox oral suspension in sachet …
Matched Categories: … Drugs for Acid Related Disorders …

Cortisone acetate

Cortisone acetate was first isolate in 1935 and became more widely researched in 1949. Since then, glucocorticoids such as cortisone acetate have been used to treat a number of inflammatory conditions such as endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, and gastrointestinal diseases and disorders.[A226300,L13203] Cortisone acetate...
Approved
Investigational
Matched Iupac: … -hydroxy-9a,11a-dimethyl-7,10-dioxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … Cortisone acetate was first isolate in 1935 and became more widely researched in 1949. ... [A226295] Since then, glucocorticoids such as cortisone acetate have been used to treat a number of inflammatory …
Matched Categories: … Corticosteroids for Systemic Use …

Chromium nicotinate

Approved
Experimental

Remimazolam

Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid...
Approved
Investigational
Matched Description: … [A214857] These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/ ... A214857] Remimazolam was the first "soft" benzodiazepine analog to be developed[A214862] and was approved for ... use by the FDA in July 2020 under the brand name Byfavo. …

Sotagliflozin

Sotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind, which is approved for use in the EU, in combination with insulin, to improve glycemic control in patients with type 1 diabetes mellitus (T1DM) and a BMI ≥27 kg/m2. Its potency in inhibiting SGLT2 is similar...
Approved
Investigational
Matched Description: … for use in the EU, in combination with insulin, to improve glycemic control in patients with type 1 ... [L39734] A similar approval has also been sought in the US, but the FDA has since published a proposal ... and colon, thereby reducing post-prandial glucose levels. …
Matched Categories: … Drugs Used in Diabetes …

Remestemcel-L

Remestemcel-L is a third-party, off-the-shelf suspension of ex-vivo cultured adult human mesenchymal stem cells intended for intravenous infusion. The mesenchymal stem cells are derived from the bone marrow of unrelated and human leukocyte antigen (HLA)–unmatched healthy adult donors and have the ability to differentiate into different tissue cells. It was...
Approved
Investigational
Matched Description: … It was approved for use in Canada in May 2012 as Prochymal for the management of refractory acute Graft ... a risk for poor outcomes and creating a significant clinical challenge [A31818]. ... stem cells intended for intravenous infusion. …

Thrombin

Also known as coagulation factor II, thrombin is a serine protease that plays a physiological role in regulating hemostasis and maintaining blood coagulation. Once converted from prothrombin, thrombin converts fibrinogen to fibrin, which, in combination with platelets from the blood, forms a clot. Medical thrombin is a protein substance produced...
Approved
Investigational
Matched Description: … Also known as coagulation factor II, thrombin is a serine protease that plays a physiological role in ... Medical thrombin is a protein substance produced through a conversion reaction in which prothrombin of ... Thrombin requires no intermediate physiological agent for its action. …
Matched Mixtures name: … Artiss Solutions for Sealant, Deep Frozen …

Omaveloxolone

Omaveloxolone (RTA-408) is a semisynthetic oleanane triterpenoid with antioxidant and anti-inflammatory properties.[A257534,A257539] Omaveloxolone acts as an activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor that mitigates oxidative stress. In patients with Friedreich's ataxia, a genetic disease involving mitochondrial dysfunction, the Nrf2 pathway is impaired, and Nrf2 activity...
Approved
Investigational
Matched Description: … [A257529] In February 2023, omaveloxolone was approved by the FDA for the treatment of Friedreich's ataxia ... In patients with Friedreich's ataxia, a genetic disease involving mitochondrial dysfunction, the Nrf2 ... Therefore, the use of Nrf2 activators such as omaveloxolone represents a therapeutic advantage in this …

Sutimlimab

Cold agglutinin disease (CAD) is a type of autoimmune hemolytic anemia (AIHA) in which autoantibodies directed against red blood cell surface antigens cause hemolysis at low (3-4°C) temperatures.[A245154,L40114] This cold subtype accounts for approximately 15-25% of all AIHA and is more common in the elderly.[A245159,L40114] In approximately 90% of cases,...
Approved
Investigational
Matched Description: … [A245154,L40114] This cold subtype accounts for approximately 15-25% of all AIHA and is more common in ... Cold agglutinin disease (CAD) is a type of autoimmune hemolytic anemia (AIHA) in which autoantibodies ... [A245144] Hemolysis in patients with CAD is driven by complement activation, which initiates a cascade …

Setmelanotide

Setmelanotide is the first available treatment for patients with pro-opiomelanocortin, proprotein subilisin/kexin type 1, or leptin deficiencies. It is an agonist of the melanocortin 4 receptor. Earlier attempts at agonizing MC4R (such as LY2112688) lead to successful weight loss, but also an increase in blood pressure and heart rate. Other...
Approved
Investigational
Matched Description: … attempts at agonizing MC4R (such as LY2112688) lead to successful weight loss, but also an increase in ... [A224449] Other earlier treatments for these patients included gastric bypass surgery. ... Setmelanotide is the first available treatment for patients with pro-opiomelanocortin, proprotein subilisin …

Sulfathiazole

Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination with sulfabenzamide and sulfacetamide. Except for those formulated for vaginal use, the FDA withdrew its approval for the use of...
Approved
Vet approved
Withdrawn
Matched Description: … Except for those formulated for vaginal use, the FDA withdrew its approval for the use of all drug products ... Sulfathiazole is a short-acting sulfa drug. ... It is still occasionally used, sometimes in combination with sulfabenzamide and sulfacetamide. …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Bromocriptine

Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as the treatment of acromegaly. Bromocriptine has been...
Approved
Investigational
Withdrawn
Matched Description: … In 1995, the FDA withdrew the approval of bromocriptine mesylate for the prevention of physiological ... Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity ... pulmonary fibrosis, and can also cause sustained suppression of somatotropin (growth hormone) secretion in …

Potassium perchlorate

Potassium perchlorate is an inorganic salt with the chemical formula KClO4. It is a strong oxidizer with the lowest solubility of the alkali metal perchlorates. Potassium is most commonly used in flares and automobile airbags . The use of potassium perchlorate as a component in sealing gaskets for food containers...
Approved
Investigational
Matched Description: … The use of potassium perchlorate as a component in sealing gaskets for food containers has been revoked ... The therapeutic use of potassium perchlorate in thyroid disorders has been ceased due to a high risk ... for developing aplastic anemia and nephrotic syndrome [L2364]. …

Deflazacort

Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dystrophin gene, which...
Approved
Investigational
Matched Description: … Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular ... Dystrophy is an inherited disorder resulting from mutations of the dystrophin gene, which is important for ... It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA. …
Matched Categories: … Corticosteroids for Systemic Use ... Corticosteroids for Systemic Use, Plain …

Vaborbactam

Vaborbactam is a β-lactamase inhibitor based on a cyclic boronic acid pharmacophore. It has been used in trials investigating the treatment of bacterial infections in subjects with varying degrees of renal insufficiency. In August 2017, a combination antibacterial therapy under the market name Vabomere was approved by the FDA for...
Approved
Investigational
Matched Description: … In August 2017, a combination antibacterial therapy under the market name Vabomere was approved by the ... Vaborbactam is a β-lactamase inhibitor based on a cyclic boronic acid pharmacophore. ... [A32053] It has been used in trials investigating the treatment of bacterial infections in subjects with …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Norgestimate

Norgestimate was first described in the literature in 1977. It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects. It is commonly formulated with ethinylestradiol as a combined oral contraceptive that can also be used to treat moderate acne...
Approved
Investigational
Matched Iupac: … 11a-ethyl-1-ethynyl-7-(hydroxyimino)-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … Norgestimate was first described in the literature in 1977. ... [A191068] It is commonly formulated with [ethinylestradiol] as a combined oral contraceptive that can …
Matched Categories: … Hormonal Contraceptives for Systemic Use …

Propiolactone

Propiolactone is a lactone compound with a four-membered ring. It is a colorless liquid with a pungent slightly sweet odor. Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, surgical instruments, and enzymes. It has been used against bacteria, fungi, and virus. It is currently...
Approved
Withdrawn
Matched Description: … [A32144] It is currently FDA approved for its use as an indirect additive used in food contact substances ... Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, ... Propiolactone was first commercially available in the United States in 1958.[A32144] …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Fluticasone

Fluticasone is a synthetic glucocorticoid available as 2 esters, DB08906 and DB00588[F4355,F4358,F4361,F4364][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358,F4361,F4364][FDA Label]. DB00588 was first approved in 1990 and DB08906 was approved in 2007 .
Approved
Experimental
Matched Iupac: … carbonyl}-1,10-dihydroxy-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … [DB00588] was first approved in 1990[L5962] and [DB08906] was approved in 2007[L5965]. ... Fluticasone is a synthetic glucocorticoid available as 2 esters, [DB08906] and [DB00588][F4355,F4358, ... These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory …
Matched Categories: … Medications that reduce magnesium levels ... Corticosteroids for inhalation use ... Drugs for Obstructive Airway Diseases …

Tolbutamide

Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin...
Approved
Investigational
Matched Description: … Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes ... Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination ... Tolbutamide appears to be metabolized in the liver. …
Matched Categories: … Tests for Diabetes ... Drugs Used in Diabetes …
Displaying drugs 501 - 525 of 13963 in total