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Displaying drugs 551 - 575 of 13022 in total
Ceftobiprole is a fifth-generation semisynthetic cephalosporin antibacterial which is available commercially as the prodrug ceftobiprole medocaril. Ceftobiprole is a broad-spectrum agent with demonstrated activity against both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains of Staphylcoccus aureus (methicillin-resistant Staphylococcus aureus; MRSA). The EMA's Committee for Medicinal Products for Human Use (CHMP)...
Approved
Investigational
Matched Iupac: … -[1,3'-bipyrrolidin]-3-ylidene]methyl}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ... (6R,7R)-7-[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(N-hydroxyimino)acetamido]-8-oxo-3-{[(3E,3'R)-2-oxo …
Matched Description: … Ceftobiprole is a fifth-generation semisynthetic cephalosporin antibacterial which is available commercially ... Ceftobiprole is a broad-spectrum agent with demonstrated activity against both Gram-positive and Gram-negative ... The EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a negative opinion of ceftobiprole …
Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration.
Approved
Matched Iupac: … 6,7,8-trimethoxy-2-methyl-2-(3-{[4-oxo-4-(3-{6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl ... ]-1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl}propoxy)butanoyl]oxy}propyl)-1-[(3,4,5-trimethoxyphenyl)methyl …
Matched Description: … Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration …
Matched Salts cas: … 83348-52-1
Approved
Matched Name: … Cyd dengue virus serotype 1 live (attenuated) antigen …
Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients...
Approved
Investigational
Matched Iupac: … (2R,4R)-1-[(2S)-5-carbamimidamido-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl]-4- …
Matched Description: … Argatroban is a direct, selective thrombin inhibitor. ... Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT ... Parental anticoagulants must be stopped and a baseline activated partial thromboplastin time must be …
Matched Salts cas: … 141396-28-3
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …
Matched Products: … Argatra 1 mg/ml Infusionslösung ... Argatroban Accord 1 mg/ml Infusionslösung ... İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET …
Rozanolixizumab is a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P) targeting the immunoglobulin G (IgG). Rozonolixizumab itself is an IgG4P, an inactive isotype, to reduce the likelihood of unwanted chain exchange. It is investigated for use in autoimmune and alloimmune diseases with pathologic IgG, particularly generalized myasthenia...
Approved
Investigational
Matched Description: … [L47122] This is due to the efficacy demonstrated in the pivotal Phase 3 MycarinG study (NCT03971422) ... Rozanolixizumab is a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody ... [A260192] As a result, the main clinical manifestation of myasthenia gravis is easily fatigable or persistent …
Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.
Approved
Matched Synonyms: … 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine ... 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine ... 4-Dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidine …
Matched Iupac: … 1-methyl-4-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-ylidene}piperidine …
Matched Description: … Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Thiosulfuric acid is available in its salt forms sodium thiosulfate and sodium thiosulfate pentahydrate. Sodium thiosulfate is part of the World Health Organization’s list of essential medicines, and it has a variety of industrial uses, including food preservative, water de-chlorinator and paper pulp bleaching agent. Sodium thiosulfate is rapidly degraded...
Approved
Investigational
Matched Iupac: … dihydroxy-1lambda6-disulfen-1-one …
Matched Description: … Sodium thiosulfate is part of the World Health Organization’s list of essential medicines, and it has a ... [L43337] When administered 6 hours after cisplatin chemotherapy, Sodium thiosulfate leads to a lower ... cyanide poisoning[L310,L43332,A252832] and it is frequently used in conjunction with sodium nitrite (a
Matched Categories: … Compounds used in a research, industrial, or household setting …
Approved
Investigational
Estradiol Cypionate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol cypionate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Iupac: … -1-yl 3-cyclopentylpropanoate ... (1S,3aS,3bR,9bS,11aS)-7-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Estradiol Cypionate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously ... As a pro-drug of estradiol, estradiol cypionate therefore has the same downstream effects within the ... First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a
Estradiol Valerate (also known as E2V) is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol acetate therefore...
Approved
Investigational
Vet approved
Matched Iupac: … -1-yl pentanoate ... (1S,3aS,3bR,9bS,11aS)-7-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Estradiol Valerate (also known as E2V) is a pro-drug ester of [DB00783], a naturally occurring hormone ... As a pro-drug of estradiol, estradiol acetate therefore has the same downstream effects within the body ... First-pass metabolism by the gut and the liver quickly degrades the estradiol molecule before it gets a
Matched Mixtures name: … DIVICONT TABLETAS 1 MG/5 MG ... DIVICONT TABLETAS 1 MG/2.5 MG ... Velbienne 1 mg/2 mg Filmtabletten …
Matched Products: … โปรกีโนวา 1 มก. ... PROGYNOVA 1 MG. ... MERIESTRA ® 1 MG …
Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector therapy. Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of wounds associated with dystrophic epidermolysis bullosa (DEB). DEB is caused by mutations in the COL7A1 gene that...
Approved
Matched Synonyms: … Dna (recombinant herpes simplex virus type 1 strain kos plasmid vector kb103 human collagen col7a1-specifying …
Matched Description: … Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector ... [L46916] DEB is caused by mutations in the _COL7A1_ gene that encodes collagen VII (COL7), a major component …
Fluticasone is a synthetic glucocorticoid available as 2 esters, DB08906 and DB00588[F4355,F4358,F4361,F4364][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358,F4361,F4364][FDA Label]. DB00588 was first approved in 1990 and DB08906 was approved in 2007 .
Approved
Experimental
Matched Iupac: … (1R,2R,3aS,3bS,5S,9aS,9bR,10S,11aS)-5,9b-difluoro-1-{[(fluoromethyl)sulfanyl]carbonyl}-1,10-dihydroxy ... -2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one …
Matched Description: … Fluticasone is a synthetic glucocorticoid available as 2 esters, [DB08906] and [DB00588][F4355,F4358, …
A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval for the orphan...
Approved
Investigational
Matched Description: … It was formerly used as a war gas. ... A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … KOPAQ 350 MGI/ML ENJEKSIYONLUK ÇÖZELTI IÇEREN FLAKON ,50 ML -FLAKON, 1 ADET ... KOPAQ 350 MGI/ML ENJEKSIYONLUK ÇÖZELTI IÇEREN FLAKON ,100 ML -FLAKON, 1 ADET ... KOPAQ 350 MGI/ML ENJEKSIYONLUK ÇÖZELTI IÇEREN FLAKON ,200 ML -FLAKON, 1 ADET …
Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve the following group of developmentally...
Approved
Investigational
Matched Description: … Methylphenidate's beneficial effects in sustaining attention have also been shown to be mediated by alpha-1 ... biphasic concentration-time profile when given as a single dose. ... products and amphetamines, have a high potential for abuse and dependence. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 3-Ring …
Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs...
Approved
Matched Description: … Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, ... [A188514] It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... [L8791] Verapamil is administered as a racemic mixture containing equal amounts of the S- and R-enantiomer …
Matched Categories: … MATE 1 Inhibitors ... Adrenergic alpha-1 Receptor Antagonists …
Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dystrophin gene, which...
Approved
Investigational
Matched Description: … Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular …
Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.
Approved
Matched Iupac: … 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile …
Matched Description: … Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase ... Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (> …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Urea 14C is a urea molecule radiolabelled with a radioactive carbon-14. It is currently used for the Urea Breath Test (UBT) and is available as a rapid diagnostic test (marketed as PyTest) for the detection of Helicobacter pylori infections. H pylori is a common stomach bacteria that has been linked...
Approved
Matched Description: … Urea 14C is a urea molecule radiolabelled with a radioactive carbon-14. ... H pylori is a common stomach bacteria that has been linked to a variety of upper gastrointestinal disorders ... It is currently used for the Urea Breath Test (UBT) and is available as a rapid diagnostic test (marketed …
Approved
Experimental
Matched Iupac: … sodium 2-{7-[1,1-dimethyl-3-(4-sulfonatobutyl)-1H,2H,3H-benzo[e]indol-2-ylidene]hepta-1,3,5-trien-1-yl ... }-1,1-dimethyl-3-(4-sulfonatobutyl)-1H-benzo[e]indol-3-ium …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was developed by Pfizer Inc and approved by the FDA on...
Approved
Investigational
Matched Iupac: … (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide …
Matched Description: … Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Pholcodine formula is 3-o-morpholinoethylmorphine and it is classified as an antitussive which is defined as an opioid cough suppressant. It belongs to the opioid family of compounds and it is widely used. Pholcodine activity is the suppression of unproductive cough and it also has a mild sedative effect with little...
Approved
Illicit
Matched Description: … Pholcodine formula is 3-o-morpholinoethylmorphine and it is classified as an antitussive which is defined ... [A31738] Pholcodine activity is the suppression of unproductive cough and it also has a mild sedative ... [A31742] Pholcodine is not prescribed in the United States where it is classed as a Schedule I drug. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Renal cell carcinoma (RCC) is responsible for 3% of cancer cases and is one of the 10 most common cancers in adults. The average age of diagnosis is between age 65 to 74. Tivozanib, also known as FOTIVDA, is a kinase inhibitor developed to treat adult patients with relapsed or...
Approved
Investigational
Matched Iupac: … 1-{2-chloro-4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-3-(5-methyl-1,2-oxazol-3-yl)urea …
Matched Description: … Renal cell carcinoma (RCC) is responsible for 3% of cancer cases[A231314] and is one of the 10 most common ... [L32529] Tivozanib, also known as FOTIVDA, is a kinase inhibitor developed to treat adult patients with ... Marketed by Aveo Oncology, tivozanib is a promising therapy for individuals with RCC who have not been …
Matched Salts cas: … 682745-41-1
Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections. Dichlorobenzyl alcohol is considered as an active ingredient found in several marketed OTC products by Health Canada which has categorized this agent as an anatomical therapeutic chemical. On the other...
Approved
Matched Description: … Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated …
Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis in February, 2017.
Approved
Investigational
Matched Iupac: … (2R)-2-amino-3-{[(2S)-2-{[(1R)-1-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido-1-{[(1R)-4-carbamimidamido ... -1-{[(1R)-1-{[(1R)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}ethyl]carbamoyl}butyl]carbamoyl}butyl …
Matched Description: … Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing …
Matched Products: … PARSABİV 5 MG/1 ML I.V. ENJEKSİYONLUK ÇÖZELTİ, 1 ADET ... ENJEKSİYONLUK ÇÖZELTİ, 1 ADET ... ENJEKSİYONLUK ÇÖZELTİ, 1 ADET …
Displaying drugs 551 - 575 of 13022 in total