Displaying drugs 551 - 575 of 8195 in total
Bacillus calmette-guerin substrain connaught live antigen
Bacillus calmette-guerin substrain connaught live antigen is intravesically administered for the treatment and prophylaxis of carcinoma in situ (CIS) of the urinary bladder and for the prophylaxis of primary or recurrent stage Ta and/or T1 papillary tumors following transurethral resection (TUR). The solution contains live, attenuated strain of Mycobacterium bovis....
Approved
Investigational
Matched Description: … carcinoma in situ (CIS) of the urinary bladder and for the prophylaxis of primary or recurrent stage ... The solution contains live, attenuated strain of Mycobacterium bovis. ... It is prepared from the Connaught strain of Bacillus Calmette and Guérin. …
Abatacept
Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it...
Approved
Matched Description: … 92,300 Da and it is a homodimer of two homologous polypeptide chains of 357 amino acids each. ... formulation of CTLA4-Ig into clinical trials (RG2077). ... antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin …
Ammonium lactate
Ammonium lactate is the ammonium salt of lactic acid.
Approved
Matched Description: … Ammonium lactate is the ammonium salt of lactic acid. …
Deflazacort
Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label]
Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dystrophin gene, which...
Approved
Investigational
Matched Description: … [L6694,FDA label]
Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of ... weakness and progressive breathing and cardiovascular disability, severely impacting patient quality of ... [A179449]
Deflazacort delays the onset of muscle related complications resulting from DMD[A179455] …
Alginic acid
Alginic acid, also referred to as algin or alginate, is a hydrophilic or anionic polysaccharide isolated from certain brown seaweed (Phacophycae) via alkaline extraction. It is present in cell walls of brown algae where it forms a viscous gel when binding with water. Alginic acid is a linear polymer consisted...
Approved
Investigational
Matched Description: … Available in different types of salt, alginic acid has been used in a variety of uses in food, cosmetics ... It is present in cell walls of brown algae where it forms a viscous gel when binding with water. ... Alginic acid is a linear polymer consisted of L-glucuronic acid and D-mannuronic acid residues connected …
Estradiol valerate
Estradiol Valerate (also known as E2V) is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol acetate therefore...
Approved
Investigational
Vet approved
Matched Description: … 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. ... Ester pro-drugs of estradiol are therefore considered to be bioidentical forms of estrogen [T84]. ... Administration of synthetic and bioidentical forms of estrogen, such as estradiol valerate, has shown …
Florbetapir (18F)
Florbetapir (18F) is a radiopharmaceutical compound containing the radionuclide fluorine-18 bound to the compound florbetapir, a molecule that binds with high affinity to beta amyloid plaque, a peptide that plays a key role in Alzheimer's Disease pathogenesis. Marketed as the product Amyvid, florbetapir 18F is indicated for positron emission tomography...
Approved
Investigational
Matched Description: … as the product Amyvid, florbetapir 18F is indicated for positron emission tomography (PET) imaging of ... The radionucleide fluorine-18 was chosen as it has a half life of 110 minutes allowing it to accumulate ... patients with cognitive impairment who are being evaluated for Alzheimer's Disease (AD) and other causes of …
Varicella zoster vaccine (live/attenuated)
Live attenuated zoster vaccine is available as two products: Zostavax for the prevention of shingles in immunocompetent people over the age of 50, and Varivax for the prevention of chickenpox in individuals 12 months of age and older. While the two vaccines contain the same immunological components and provide protection...
Approved
Matched Description: … 12 months of age and older. ... in immunocompetent people over the age of 50, and Varivax for the prevention of chickenpox in individuals ... of varicella-zoster virus. …
Propantheline
A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Approved
Matched Description: … muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of …
Certoparin
Certoparin is part of the heparins of low molecular weight that presents high activity against the coagulation factor Xa. It is normally used to prevent deep venous thrombosis.
Approved
Investigational
Matched Description: … Certoparin is part of the heparins of low molecular weight that presents high activity against the coagulation …
Ipecac
Ipecac is obtained from the plant Cephaelis ipecacuanha and contains a number of emetic alkaloids including emetine and cephaeline. Ipecac was approved by Health Canada as an OTC but all those products are now discontinued. The FDA does not have currently any approved product containing ipecac, however, ipecac as an...
Approved
Withdrawn
Matched Description: … Ipecac is obtained from the plant _Cephaelis ipecacuanha_ and contains a number of emetic alkaloids including ... containing ipecac, however, ipecac as an ingredient is accepted to be sold over the counter in packages of …
Glutethimide
Glutethimide is a hypnotic and sedative. Its use has been largely superseded by other drugs.
Approved
Illicit
Erythrityl tetranitrate
A vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020)
Approved
Experimental
Investigational
Midodrine
An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.
Approved
Matched Description: … It is used as a vasoconstrictor agent in the treatment of hypotension. …
Meclizine
Meclizine is a histamine H1 antagonist with antiemetic and antivertigo properties. It is used in the symptomatic treatment of motion sickness and control of vertigo associated with vestibular system diseases. It also exhibits anticholinergic, central nervous system depressant, and local anesthetic effects. Commonly marketed under the brand name Antivert in...
Approved
Matched Description: … It is used in the symptomatic treatment of motion sickness and control of vertigo associated with vestibular …
Dofetilide
Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter.
Approved
Investigational
Matched Description: … antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of ... sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical …
Equine Botulinum Neurotoxin E Immune FAB2
Equine Botulinum Neurotoxin E Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype E. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes E in...
Approved
Experimental
Investigational
Matched Description: … Equine Botulinum Neurotoxin E Immune FAB2 is composed of a mixture of immune globulin fragments purified ... from plasma of horses that were previously immunized with botulinum toxin serotype E. ... It is intravenously administered for the treatment of symptomatic botulism following documented or suspected …
Equine Botulinum Neurotoxin C Immune FAB2
Equine Botulinum Neurotoxin C Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype C. It is intravenously administered for the treatment of symptomatic botulism following documented or suspected exposure to botulinum neurotoxin serotypes C in...
Approved
Experimental
Investigational
Matched Description: … Equine Botulinum Neurotoxin C Immune FAB2 is composed of a mixture of immune globulin fragments purified ... from plasma of horses that were previously immunized with botulinum toxin serotype C. ... It is intravenously administered for the treatment of symptomatic botulism following documented or suspected …
Botulinum toxin type B
Neurotoxin produced by fermentation of clostridium botulinum type B. The protein exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin complex. The neurotoxin complex is recovered from the fermentation process and purified through a series of precipitation and chromatography steps.
Approved
Investigational
Matched Description: … Neurotoxin produced by fermentation of clostridium botulinum type B. ... The neurotoxin complex is recovered from the fermentation process and purified through a series of precipitation …
Fluticasone
Fluticasone is a synthetic glucocorticoid available as 2 esters, DB08906 and DB00588[F4355,F4358,F4361,F4364][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358,F4361,F4364][FDA Label]. DB00588 was first approved in 1990 and DB08906 was approved in 2007 .
Approved
Experimental
Milrinone
Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. Often the result of long-term myocardial ischemia, cardiomyopathy, or other cardiac insults, heart failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and metabolites, resulting in complex systemic pathologies. Heart...
Approved
Matched Description: … Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. ... Often the result of long-term myocardial ischemia, cardiomyopathy, or other cardiac insults, heart failure ... second-generation bipyridine phosphodiesterase (PDE) inhibitor created through chemical modification of …
Erlotinib
Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)...
Approved
Investigational
Matched Description: … in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. ... This finding introduces the potential use of erlotinib in the treatment of JAK2V617F-positive PV and ... of patients with idiopathic myelofibrosis or essential thrombocythemia. …
Ceforanide
Ceforanide is administered parenterally. It has a longer elimination half-life than any currently available cephalosporin. Its activity is very similar to that of cefamandole, another second-generation cephalosporin antibiotic, except that ceforanide is less active against most gram-positive organisms. Many coliforms, including Escherichia coli, Klebsiella, Enterobacter, and Proteus, are susceptible to...
Approved
Matched Description: … Its activity is very similar to that of cefamandole, another second-generation cephalosporin antibiotic ... Escherichia coli, Klebsiella, Enterobacter, and Proteus, are susceptible to ceforanide, as are most strains of …
Phenyltoloxamine
Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the more common salt form...
Approved
Matched Description: … It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. ... It also potentiates the effects of other drugs, such as codeine and codeine derivatives. ... Phenyltoloxamine acts as an adjuvant analgesic, which augments the analgesic effect of acetaminophen. …
Mobocertinib
Mobocertinib is a kinase inhibitor targeted against human epidermal growth factor receptor (EGFR). It is used specifically in the treatment of non-small cell lung cancer (NSCLC) caused by exon 20 insertion mutations in the EGFR gene, which are typically associated with a poorer prognosis (as compared to "classical" EGFR mutants...
Approved
Investigational
Matched Description: … It is used specifically in the treatment of non-small cell lung cancer (NSCLC) caused by exon 20 insertion ... [A238828] Mobocertinib appears to be an effective means of treating this otherwise treatment-resistant ... Pharmaceuticals Inc.), was granted accelerated approval by the FDA in September 2021 for the treatment of …
Displaying drugs 551 - 575 of 8195 in total