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Displaying drugs 551 - 575 of 12824 in total

Thyroid, porcine

Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyroid extract is...
Approved
Matched Description: … [A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891[ ... [A190813] Thyroid extracts were never FDA approved as their use in the United States predates the …

Melphalan

Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem...
Approved
Matched Description: … [A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. ... [L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group …

Technetium Tc-99m pertechnetate

Technetium Tc-99m pertechnetate is a radiopharmaceutical diagnostic agent composed of an oxoanion with the chemical formula TcO4-. Pertechnetate has a wide variety of uses within nuclear medicine as it distributes within the body to a similar extent as iodine. It also concentrates in the thyroid gland, salivary glands, gastric mucosa,...
Approved
Investigational
Matched Description: … It also concentrates in the thyroid gland, salivary glands, gastric mucosa, and choroid plexus. ... However, in contrast to the iodide ion, the pertechnetate ion is released unchanged from the thyroid ... This is normally supplied in a hospital setting through the use of a technetium-99m generator, whereby …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Moxidectin

Moxidectin is a potent, broad-spectrum endectocide (antiparasitic that is active against endo- and ecto-parasites) with activity against nematodes, insects, and acari. It was first used in cattle followed by an approved use in general animals. It is a semi-synthetic methoxine derivative of nemadectin which is a 16-member pentacyclic lactone of...
Approved
Investigational
Vet approved
Matched Description: … It was first used in cattle followed by an approved use in general animals. ... [A33385] Moxidectin was developed by Medicines Development for Global Health and FDA approved in June …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Hexobendine

Hexobendine is a medication used to cause vasodilation, to treat several conditions including angina pectoris. It has not been approved in the United States or the United Kingdom, but has been used widely in Austria and Germany .
Approved
Matched Description: … It has not been approved in the United States or the United Kingdom, but has been used widely in Austria …
Matched Categories: … Vasodilators Used in Cardiac Diseases …

Polyethylene glycol 400

Polyethylene glycols (PEGs) are products made of condensed ethylene oxide and water that can contain various derivatives and have various functions. Because many PEG types are hydrophilic, they are favorably used as enhancers of penetration, and used heavily in topical dermatological preparations. PEGs, along with their many nonionic derivatives, are...
Approved
Matched Description: … many PEG types are hydrophilic, they are favorably used as enhancers of penetration, and used heavily in ... PEGs, along with their many nonionic derivatives, are widely utilized in cosmetic products as surfactants ... It is used in ophthalmic solutions for the relief of burning, irritation and/or discomfort that follows …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Amikacin

Amikacin is a semi-synthetic aminoglycoside antibiotic that is derived from kanamycin A.[FDA label] Amikacin is synthesized by acylation with the l-(-)-γ-amino-α-hydroxybutyryl side chain at the C-1 amino group of the deoxystreptamine moiety of kanamycin A. Amikacin's unique property is that it exerts activity against more resistant gram-negative bacilli such as...
Approved
Investigational
Vet approved
Matched Description: … label] Amikacin is synthesized by acylation with the l-(-)-γ-amino-α-hydroxybutyryl side chain at the C- ... M. avium-intracellulare (MAC) is a type of nontuberculous mycobacteria (NTM) found in water and soil. ... [F1949] In September 2018, a liposomal inhalation suspension of this drug was approved by the FDA for …

Tetryzoline

Tetryzoline, also known as tetrahydrozoline, is a derivative of imidazoline with central and peripheral alpha (α)-adrenergic properties. Available since the 1950s, tetryzoline is a selective α1-receptor agonist that is used as an ocular and nasal decongestant. Tetryzoline is found in a wide array of over-the-counter eye drops, including the most...
Approved
Matched Description: … , corticosteroids, and glucocorticoids in other countries. ... Tetryzoline is found in a wide array of over-the-counter eye drops, including the most common brand, ... [L32579] Tetryzoline is also found in combination products with other lubricants and anti-irritants, …
Matched Mixtures name: … Rohto All-In-One …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Compounds used in a research, industrial, or household setting …

Sparsentan

Sparsentan is a dual antagonist of the endothelin type A receptor (ETAR) and the angiotensin II (Ang II) type 1 receptor (AT1R) with a similar affinity for both (9.3 nM for ETAR and 0.8 nM for AT1R).[A257330,L45300] Sparsentan is first in its class and orally active, and was created by...
Approved
Investigational
Matched Description: … [A257330] In February 2023, the use of sparsentan to reduce proteinuria in adults with primary immunoglobulin ... the reduction of proteinuria in patients with IgAN and focal segmental glomerulosclerosis (FSGS). ... Furthermore, it is the first non-immunosuppressive therapy for the reduction of proteinuria in IgAN. …

Trichloroethylene

Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the similar 1,1,1-trichloroethane, also known as chlorothene. It has been sold under a variety of trade names including Trimar and Trilene and used as a volatile anesthetic and as an inhaled obstetrical analgesic. Environmental exposure,...
Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …

Tovorafenib

Tovorafenib is a selective type II RAF kinase inhibitor with anti-tumour activity. It was granted accelerated approval by the FDA, making it the first FDA approval of a systemic therapy for the treatment of pediatric low-grade glioma, with BRAF rearrangements. BRAF oncogenic mutations in cancers drive dysregulated cell growth, proliferation,...
Approved
Investigational
Matched Description: … [L50587] BRAF oncogenic mutations in cancers drive dysregulated cell growth, proliferation, and differentiation …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, Fused-Ring …

Chicken

Chicken allergenic extract is used in allergenic testing.
Approved
Matched Description: … Chicken allergenic extract is used in allergenic testing. …

Cocaine

An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of...
Approved
Illicit
Matched Description: … It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in …
Matched Categories: … Heterocyclic Compounds, Bridged-Ring …

Phenformin

A biguanide hypoglycemic agent with actions and uses similar to those of metformin. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
Approved
Investigational
Withdrawn
Matched Description: … associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in …
Matched Categories: … Drugs Used in Diabetes …

Technetium Tc-99m tetrofosmin

Technetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and which are referred to as tetrofosmin. It is a lipophilic technetium phosphine dioxo cation that was formulated into a freeze-dried kit...
Approved
Matched Description: … Technetium Tc-99m tetrofosmin is a drug used in nuclear myocardial perfusion imaging. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Fruquintinib

Fruquintinib is a novel small-molecule anti-VEGFR that targets VEGFR-1,-2, and -3 to inhibit angiogenesis. Tumor angiogenesis is one of the most critical biological processes for increasing oxygen and nutrient supply to cancer cells, and the VEGF/VEGFR pathway is one of the most critical pathways for this phenomenon.[A262102,A262107] Indeed, oncogenic activation,...
Approved
Investigational
Matched Description: … overall survival rate was observed in both trials. ... approval is based on favorable results obtained from the FRESCO and FRESCO-2 trials, where an increase in ... Although [bevacizumab] is successful in sustaining target inhibition, mandatory intravenous dosing, immunogenicity …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Heterocyclic Compounds, Fused-Ring …

Gemeprost

Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the cervix before surgical abortion. It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone for termination of 1st- and 2nd-trimester pregnancy . It is not FDA-approved but available in...
Approved
Withdrawn
Matched Description: … It is not FDA-approved but available in Japan marketed as Preglandin. ... It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone …

Berotralstat

Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat is strictly used to...
Approved
Matched Description: … Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary ... [L26661] It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the ... FDA on December 3, 2020, as the first once-daily oral therapy to prevent angioedema attacks of HAE in …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Drugs Used in Hereditary Angioedema …

Meglumine

Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …

Calcium glubionate anhydrous

Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
Approved
Matched Description: … glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in …

Nonacog beta pegol

Nonacog beta pegol is a recombinant coagulation factor IX derivative. It is produced without animal-derived materials and with an attached 40kDa polyethylene glycol (PEG) molecule for peptide activation by a site-directed glycoPEGylation. Once activated, the activation molecule with PEG is cleaved to leave the activated factor IX (Factor IXa). Nonacog...
Approved
Investigational
Matched Categories: … Compounds used in a research, industrial, or household setting …

Gadoversetamide

Gadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver.
Approved
Investigational
Matched Description: … Gadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast agent in …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Bioallethrin

Bioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an approximate ratio of 1:1, where both isomers are active ingredients. A mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin. A mixture containing only S-forms...
Approved
Experimental
Matched Description: … A mixture of the two same stereoisomers, but in an approximate ratio of R:S in 1:3, is called esbiothrin ... Bioallethrin refers to a mixture of two of the allethrin isomers (1R,trans;1R and 1R,trans;1S) in an …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Calcipotriol

Calcipotriol (INN) or calcipotriene (USAN) is a sythetic derivative of calcitriol or Vitamin D.
Approved
Matched Categories: … Fused-Ring Compounds …

Cyproheptadine

Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome.
Approved
Matched Description: … appetite stimulation[L32519] and its off-label use in the treatment of serotonin syndrome. ... L32474] It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Displaying drugs 551 - 575 of 12824 in total