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Displaying drugs 601 - 625 of 11064 in total

Desonide

A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.
Approved
Investigational

Turoctocog alfa pegol

Turoctocog alfa pegol is a pegylated version of turoctocog alfa. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019. Fundamentally, the N8-GP moiety is identical to turoctocog alfa, a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made...
Approved
Matched Description: … During secretion, some rFVIII molecules are cleaved at the C-terminal of the heavy chain (HC) at amino acid ... This modification to the general turoctocog alfa rFVIII structure makes N8-GP an extended half-life factor ... It was developed by Novo Nordisk and approved by the US FDA on October 16, 2013 [L1104]. …

Oxolamine

Oxolamine is not approved in the USA, it may be marketed elsewhere internationally as a cough suppressant . It is listed as a prescription drug in New Zealand legislation . Oxolamine is also approved in Taiwan for the treatment of respiratory tract inflamation .
Approved
Matched Description: … Oxolamine is also approved in Taiwan for the treatment of respiratory tract inflamation [L5422]. ... Oxolamine is not approved in the USA, it may be marketed elsewhere internationally as a cough suppressant …

Golodirsen

Golodirsen is a morpholino antisense oligomer designed to treat about 8% of patients with Duchenne Muscular Dystrophy (DMD). This is an X-linked condition leading to progressive muscle degeneration that begins in early childhood, rendering many patients wheelchair-bound by age 12. Often, patients succumb to this condition by age 30 or...
Approved
Matched Description: … This is an X-linked condition leading to progressive muscle degeneration that begins in early childhood …
Matched Categories: … Nucleic Acid Probes …

Chlorhexidine

Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of...
Approved
Vet approved
Withdrawn
Matched Mixtures name: … Disinfectant Spray(Speedy effect type) …

Etelcalcetide

Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis in February, 2017.
Approved
Investigational
Matched Iupac: … butyl]carbamoyl}butyl]carbamoyl}butyl]carbamoyl}ethyl]carbamoyl}-2-acetamidoethyl]disulfanyl}propanoic acid …
Matched Description: … Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism ( …

Faricimab

Retinal vascular diseases (RVDs) such as diabetic macular edema (DME), age-related macular degeneration (AMD), and retinal vein occlusion (RVO) are typically caused by retinal ischemia and subsequent neovascularization (NV).[A225985, A225990, A225995] Vascular endothelial growth factor A (VEGF-A) is a well-known mediator of retinal NV, and many currently approved RVD therapies...
Approved
Investigational
Matched Description: … [A225985, A225990, A225995] Faricimab is an IgG1-derived bispecific antibody capable of simultaneously ... [A225985, A225990, A225995, A226000, A226005, A226010] Faricimab was approved by the FDA on January ... Vascular endothelial growth factor A (VEGF-A) is a well-known mediator of retinal NV, and many currently approved …

Pirenzepine

An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also...
Approved
Matched Description: … An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal …
Matched Categories: … Drugs for Acid Related Disorders …

Influenza A virus A/Christchurch/16/2010 NIB-74XP (H1N1) antigen (formaldehyde inactivated)

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated …

Butaperazine

Butaperazine was approved in 1967 , and possibly discontinued in the 1980s .
Approved
Matched Description: … Butaperazine was approved in 1967 [L5143], and possibly discontinued in the 1980s [T397]. …

Turpentine

Turpentine, also known as spirit of turpentine, oil of turpentine, and wood turpentine, is a liquid extracted from live trees, mainly pine, through distillation of resin. It is used as a solvent and base material in organic synthesis reactions. Turpentine is composed of terpenes, mainly the monoterpenes alpha-pinene and beta-pinene...
Approved
Experimental

Chymotrypsin

Chymotrypsin (EC 3.4.21.1) is a digestive enzyme that promotes proteolysis, or the breakdown of proteins and polypeptides. It is a serine protease synthesized in the pancreas and is a vital component in the pancreatic juice. Like most proteolytic enzymes, chymotrypsin is activated from its inactive zymogen precursor, chymotrypsinogen, in presence...
Approved
Vet approved

Zopiclone

Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate-like properties.
Approved

Pregabalin

Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively characterized, there is evidence that pregabalin exerts its effects...
Approved
Investigational
Matched Iupac: … (3S)-3-(aminomethyl)-5-methylhexanoic acid …
Matched Description: … Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter …

Guanfacine

Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approval on 27 October 1986.
Approved
Investigational
Matched Description: … receptor agonist initially indicated for the treatment of hypertension[L11274] but is now indicated as an …

Amitriptyline

Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.
Approved
Matched Description: … ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961 …

Meperidine

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Approved
Matched Description: … Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than …

Dinutuximab

Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. It is composed of the variable heavy- and light-chain regions of the murine anti-GD2 mAb 14.18 and the constant regions...
Approved
Investigational
Matched Description: … Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed ... granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid …

Rilmenidine

Rilmenidine has been used in trials studying the treatment of Hypertension and Chronic Kidney Disease.
Approved
Investigational

Corifollitropin alfa

Corifollitropin alfa, also known as Elonva is used in women undergoing fertility treatment to stimulate the development of more than one mature egg (oocyte) at a time in the ovaries. This drug used together with a gonadotropin-releasing hormone (GnRH) antagonist, a type of medicine also used in fertility treatments. Elonva...
Approved
Investigational
Matched Description: … This drug used together with _a gonadotropin-releasing hormone (GnRH) antagonist_, a type of medicine ... the elevated effectiveness of this drug, however, warns at the same time against the possibility of an …

Nabilone

Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as...
Approved
Investigational
Matched Description: … (THCA-A) and cannabidiolic acid (CBDA), through decarboxylation reactions. ... DB00470]), THC and CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A ... It is also approved for use in treatment of anorexia and weight loss in patients with AIDS. …

Pentostatin

A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Approved
Investigational
Matched Categories: … Nucleic Acid Synthesis Inhibitors …

Disopyramide

A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
Approved

Clomifene

A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Approved
Investigational
Matched Description: … A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the …

Pramipexole

Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement) . It was first approved by the FDA in 1997 . Parkinson's Disease is...
Approved
Investigational
Matched Description: … It was first approved by the FDA in 1997 [L5882]. ... This increase may be attributed to an aging population along with other contributing factors [A176861 ... In addition to the above FDA approval for Parkinson's Disease, pramipexole was also approved by the FDA …
Displaying drugs 601 - 625 of 11064 in total