Displaying drugs 626 - 650 of 2959 in total
Megestrol acetate
17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Approved
Investigational
Vet approved
Matched Synonyms: … Megestrol acetate ... 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate ... 17α-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate …
Matched Name: … Megestrol acetate …
Matched Iupac: … ,11S,14R,15S)-14-acetyl-2,8,15-trimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-6,8-dien-14-yl acetate …
Matched Description: … As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor ... A progestational hormone used most commonly as the acetate ester. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... megestrol and estrogen ... megestrol and estrogen ... Hormones and Related Agents ... megestrol and ethinylestradiol …
Matched Products: … Megestrol Acetate ... Megestrol acetate ... MEGESTROL ACETATE …
Matched Name: … Megestrol acetate …
Matched Iupac: … ,11S,14R,15S)-14-acetyl-2,8,15-trimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-6,8-dien-14-yl acetate …
Matched Description: … As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor ... A progestational hormone used most commonly as the acetate ester. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... megestrol and estrogen ... megestrol and estrogen ... Hormones and Related Agents ... megestrol and ethinylestradiol …
Matched Products: … Megestrol Acetate ... Megestrol acetate ... MEGESTROL ACETATE …
Acyclovir
Acyclovir is a deoxynucleoside analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis.[L7303,L7315,L7318,L7321,L7324,L7327] Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA...
Approved
Matched Description: … analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and ... L7315,L7318,L7321,L7324,L7327] Acyclovir is generally used first line in the treatment of these viruses and …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... Acyclovir and prodrug ... Nucleosides and Nucleotides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Matched Products: … ACIC 200 ... ACIC 400 ... ACIC 800 …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... Acyclovir and prodrug ... Nucleosides and Nucleotides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …
Matched Products: … ACIC 200 ... ACIC 400 ... ACIC 800 …
Avalglucosidase alfa
Avalglucosidase alfa, or NeoGAA, is a drug for enzyme replacement therapy specifically designed for Pompe disease, a rare inherited neuromuscular disorder caused by the deficiency of the alpha-glucosidase (GAA) enzyme. GAA is an essential enzyme that hydrolyzes glycogen into free glucose for use in cellular functions. In Pompe disease, the...
Approved
Investigational
Matched Synonyms: … Neo-recombinant human acid alpha-glucosidase …
Matched Description: … designed for Pompe disease, a rare inherited neuromuscular disorder caused by the deficiency of the alpha-glucosidase ... , especially in smooth, cardiac, and skeletal muscle cells. ... In Pompe disease, the GAA enzyme is missing and patients are unable to properly break down glycogen, …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes …
Matched Description: … designed for Pompe disease, a rare inherited neuromuscular disorder caused by the deficiency of the alpha-glucosidase ... , especially in smooth, cardiac, and skeletal muscle cells. ... In Pompe disease, the GAA enzyme is missing and patients are unable to properly break down glycogen, …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes …
Fish oil
Fish oil is a component of SMOFLIPID, which was FDA approved in July 2016. It is indicated in adults as a source of calories and essential fatty acids for parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated.
More commonly, fish oil refers to the omega-3-fatty...
Approved
Nutraceutical
Matched Synonyms: … Fish oil containing omega-3 acids …
Matched Description: … More commonly, fish oil refers to the omega-3-fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic ... It is indicated in adults as a source of calories and essential fatty acids for parenteral nutrition ... EPA and DHA are ongoing. …
Matched Mixtures name: … Cleanse Gut And Colon …
Matched Products: … VASPRO OMEGA 3 Acid Ethyl Esters capsule …
Matched Description: … More commonly, fish oil refers to the omega-3-fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic ... It is indicated in adults as a source of calories and essential fatty acids for parenteral nutrition ... EPA and DHA are ongoing. …
Matched Mixtures name: … Cleanse Gut And Colon …
Matched Products: … VASPRO OMEGA 3 Acid Ethyl Esters capsule …
Oxothiazolidinecarboxylic acid
Procysteine has been used in trials studying the treatment of HIV Infections.
Investigational
Matched Synonyms: … (-)-2-OXO-4-THIAZOLIDINECARBOXYLIC ACID ... (R)-2-OXOTHIAZOLIDINE-4-CARBOXYLIC ACID ... 2-OXO-4-THIAZOLIDINECARBOXYLIC ACID, L- …
Matched Name: … Oxothiazolidinecarboxylic acid …
Matched Iupac: … (4R)-2-oxo-1,3-thiazolidine-4-carboxylic acid …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids, Acidic ... Amino Acids ... Imino Acids ... Amino Acids, Cyclic …
Matched Name: … Oxothiazolidinecarboxylic acid …
Matched Iupac: … (4R)-2-oxo-1,3-thiazolidine-4-carboxylic acid …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids, Acidic ... Amino Acids ... Imino Acids ... Amino Acids, Cyclic …
Histidine
An essential amino acid that is required for the production of histamine.
Investigational
Nutraceutical
Matched Synonyms: … (S)-alpha-amino-1H-Imidazole-4-propanoic acid ... (S)-alpha-Amino-1H-imidazole-4-propionic acid ... (S)-a-Amino-1H-imidazole-4-propanoic acid …
Matched Iupac: … (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid …
Matched Description: … An essential amino acid that is required for the production of histamine. …
Matched Mixtures name: … Aminosyn II and Dextrose ... Aminosyn II and Dextrose ... Travasol Amino Acid Inj 8.5% …
Matched Salts name: … Copper histidine …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Cyclic ... Amino Acids, Essential ... Proteinogenic Amino Acids …
Matched Iupac: … (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid …
Matched Description: … An essential amino acid that is required for the production of histamine. …
Matched Mixtures name: … Aminosyn II and Dextrose ... Aminosyn II and Dextrose ... Travasol Amino Acid Inj 8.5% …
Matched Salts name: … Copper histidine …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Cyclic ... Amino Acids, Essential ... Proteinogenic Amino Acids …
Flunarizine
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Approved
Matched Description: … peripheral origin, and as an adjuvant in the therapy of epilepsy. ... Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 ... effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and …
Matched Categories: … Calcium-Regulating Hormones and Agents …
Matched Products: … FLUNARIZIN ACIS 5MG ... FLUNARIZIN ACIS 10MG …
Matched Categories: … Calcium-Regulating Hormones and Agents …
Matched Products: … FLUNARIZIN ACIS 5MG ... FLUNARIZIN ACIS 10MG …
Serine
A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids.
Investigational
Nutraceutical
Matched Synonyms: … alpha-Amino-beta-hydroxypropionic acid ... (S)-2-Amino-3-hydroxypropanoic acid …
Matched Iupac: … (2S)-2-amino-3-hydroxypropanoic acid …
Matched Description: … It is involved in the biosynthesis of purines; pyrimidines; and other amino acids. ... A non-essential amino acid occurring in natural form as the L-isomer. …
Matched Mixtures name: … Aminosyn II and Dextrose ... Aminosyn II and Dextrose ... Premasol - sulfite-free (Amino Acid) …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Neutral ... Proteinogenic Amino Acids …
Matched Iupac: … (2S)-2-amino-3-hydroxypropanoic acid …
Matched Description: … It is involved in the biosynthesis of purines; pyrimidines; and other amino acids. ... A non-essential amino acid occurring in natural form as the L-isomer. …
Matched Mixtures name: … Aminosyn II and Dextrose ... Aminosyn II and Dextrose ... Premasol - sulfite-free (Amino Acid) …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Neutral ... Proteinogenic Amino Acids …
Cinnamic acid
Investigational
Matched Synonyms: … Cinnamic acidum ... E-cinnamic acid ... 2-propenoic acid, 3-phenyl- …
Matched Name: … Cinnamic acid …
Matched Iupac: … (2E)-3-phenylprop-2-enoic acid …
Matched Categories: … Heparin and similars ... Acids, Carbocyclic ... Carboxylic Acids …
Matched Name: … Cinnamic acid …
Matched Iupac: … (2E)-3-phenylprop-2-enoic acid …
Matched Categories: … Heparin and similars ... Acids, Carbocyclic ... Carboxylic Acids …
Cystine
A covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
Approved
Nutraceutical
Matched Synonyms: … L-alpha-Diamino-beta-dithiolactic acid ... (R,R)-3,3'-dithiobis(2-aminopropanoic acid) …
Matched Iupac: … (2R)-2-amino-3-{[(2R)-2-amino-2-carboxyethyl]disulfanyl}propanoic acid …
Matched Description: … A covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Diamino ... Amino Acids, Sulfur ... Amino Acids, Dicarboxylic …
Matched Iupac: … (2R)-2-amino-3-{[(2R)-2-amino-2-carboxyethyl]disulfanyl}propanoic acid …
Matched Description: … A covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Diamino ... Amino Acids, Sulfur ... Amino Acids, Dicarboxylic …
Oxfendazole
Oxfendazole is a sulfoxide metabolite of fenbendazole. This benzimidazole antihelminthic protects livestock from roundworm. strongyles, and pinworn.
Investigational
Vet approved
Matched Synonyms: … Fenbendazole S-oxide ... 5-(phenylsulfinyl)-2-benzimidazolecarbamic acid methyl ester ... (5-(phenylsulfinyl)-1H-benzimidazol-2-yl)carbamic acid methyl ester …
Matched Description: … This benzimidazole antihelminthic protects livestock from roundworm. strongyles, and pinworn. …
Matched Description: … This benzimidazole antihelminthic protects livestock from roundworm. strongyles, and pinworn. …
Golexanolone
Investigational
Matched Synonyms: … Androstan-17-one, 3-ethynyl-3-hydroxy-, oxime, (3.beta.,5.alpha.,17e)- …
Magnesium
Magnesium is classified as an alkaline earth metal and has 2 hydration shells. The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate. Common dietary sources of magnesium include nuts (cashews, peanuts, almonds), beans, bananas, apples, carrots, broccoli, and leafy...
Approved
Experimental
Investigational
Matched Description: … and magnesium carbonate. ... [A32810] Further, the mineral helps regulate blood pressure and is necessary for RNA, DNA and protein ... Magnesium is classified as an alkaline earth metal and has 2 hydration shells. …
Matched Mixtures name: … Calcium Folic Acid Plus D Chewable ... Folet One ... Acti-cal/mag 2:1 + Zinc and D Caplet …
Matched Products: … Kordel’s Magnesium Amino Acid Chelate 750 Capsules …
Matched Mixtures name: … Calcium Folic Acid Plus D Chewable ... Folet One ... Acti-cal/mag 2:1 + Zinc and D Caplet …
Matched Products: … Kordel’s Magnesium Amino Acid Chelate 750 Capsules …
Oxybutynin
Overactive bladder (OAB) is a common condition negatively impacting the lives of millions of patients worldwide. Due to its urinary symptoms that include nocturia, urgency, and frequency, this condition causes social embarrassment and a poor quality of life.[A185996,A185999]
Oxybutynin, also marketed as Ditropan XL, is an anticholinergic medication used for...
Approved
Investigational
Matched Synonyms: … 4-(Diethylamino)-2-butynyl alpha-phenylcyclohexaneglycolic acid ester ... 4-Diethylamino-2-butinyl alpha-cyclohexylmandelat ... 4-Diethylamino-2-butynyl alpha-phenylcyclohexaneglycolate …
Matched Description: … embarrassment and a poor quality of life. ... Due to its urinary symptoms that include nocturia, urgency, and frequency, this condition causes social ... used for the relief of overactive bladder symptoms that has been optimized for high levels of safety and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Drugs for Urinary Frequency and Incontinence ... Acids, Carbocyclic ... Carboxylic Acids ... Hydroxy Acids …
Matched Description: … embarrassment and a poor quality of life. ... Due to its urinary symptoms that include nocturia, urgency, and frequency, this condition causes social ... used for the relief of overactive bladder symptoms that has been optimized for high levels of safety and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Drugs for Urinary Frequency and Incontinence ... Acids, Carbocyclic ... Carboxylic Acids ... Hydroxy Acids …
Paramethasone acetate
Approved
Matched Synonyms: … Paramethasone acetate ... Paramethasone 21-acetate …
Matched Name: … Paramethasone acetate …
Matched Iupac: … 11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl acetate …
Matched Name: … Paramethasone acetate …
Matched Iupac: … 11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl acetate …
Glatiramer
Glatiramer acetate is a mix of synthetic polypeptides that includes L-glutamic acid, L-alanine, L-tyrosine, and L-lysine at an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. Since glatiramer acetate is a heterogeneous drug, there is limited information about its physicochemical properties. Originally, glatiramer acetate was designed as a...
Approved
Investigational
Matched Description: … Glatiramer acetate is a mix of synthetic polypeptides that includes L-glutamic acid, L-alanine, L-tyrosine ... [A248870] Along with [human interferon beta], [teriflunomide], and [dimethyl fumarate], glatiramer acetate ... Glatiramer acetate exhibits several immunomodulatory effects and reduces the relapse rate of relapsing-remitting …
Matched Salts name: … Glatiramer acetate …
Matched Categories: … Amino Acids, Peptides, and Proteins ... glatiramer acetate ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Glatiramer Acetate ... Teva-glatiramer Acetate ... Glatiramer Acetate Injection …
Matched Salts name: … Glatiramer acetate …
Matched Categories: … Amino Acids, Peptides, and Proteins ... glatiramer acetate ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Glatiramer Acetate ... Teva-glatiramer Acetate ... Glatiramer Acetate Injection …
Ethyl 8-hydroxy-alpha-(2-propynylamino)-5-quinolinepropanoate
Experimental
Matched Synonyms: … 5-Quinolinepropanoic acid, 8-hydroxy-alpha-(2-propyn-1-ylamino)-, ethyl ester ... Ethyl 8-hydroxy-alpha-(2-propynylamino)-5-quinolinepropanoate …
Matched Name: … Ethyl 8-hydroxy-alpha-(2-propynylamino)-5-quinolinepropanoate …
Matched Name: … Ethyl 8-hydroxy-alpha-(2-propynylamino)-5-quinolinepropanoate …
Clostebol acetate
Experimental
Matched Synonyms: … Clostebol acetate ... Chlorotestosterone acetate ... 4-Chlorotestosterone acetate …
Matched Name: … Clostebol acetate …
Matched Iupac: … 11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Name: … Clostebol acetate …
Matched Iupac: … 11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Copper usnate
Experimental
Matched Name: … Copper usnate …
Matched Iupac: … copper(2+) 6,12-diacetyl-1,4-dimethyl-11,13-dioxo-8-oxatricyclo[7.4.0.0^{2,7}]trideca-2,4,6,9-tetraene …
Matched Categories: … copper usnate ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Matched Iupac: … copper(2+) 6,12-diacetyl-1,4-dimethyl-11,13-dioxo-8-oxatricyclo[7.4.0.0^{2,7}]trideca-2,4,6,9-tetraene …
Matched Categories: … copper usnate ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Clofibrate
A fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)
Approved
Investigational
Matched Synonyms: … alpha-(p-Chlorophenoxy)isobutyric acid, ethyl ester ... 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester ... 2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester …
Matched Description: … A fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia …
Matched Categories: … Acids, Acyclic ... Clofibric Acid ... Carboxylic Acids ... Fibric Acids …
Matched Description: … A fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia …
Matched Categories: … Acids, Acyclic ... Clofibric Acid ... Carboxylic Acids ... Fibric Acids …
Vinblastine N-oxide
Investigational
Matched Synonyms: … Vinblastine N-oxide …
Matched Name: … Vinblastine N-oxide …
Matched Name: … Vinblastine N-oxide …
Segesterone acetate
Segesterone acetate is a steroidal progestin or synthetic progesterone and a 19-norprogesterone derivative with no CH3 group radical in position 6 . In animal studies, segesterone acetate was shown to be one of the most potent progestins . It mediates progestational activity 100 times higher than that of progesterone ....
Approved
Experimental
Investigational
Matched Synonyms: … 16-Methylene-17-alpha-acetoxy-19-nor-4-pregnene-3,20-dione ... Segesterone acetate ... 17-Hydroxy-16-methylene-19-norpregn-4-ene-3,20-dione acetate …
Matched Name: … Segesterone acetate …
Matched Iupac: … methylidene-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate …
Matched Description: … Segesterone acetate is a steroidal progestin or synthetic progesterone and a 19-norprogesterone derivative ... Segesterone acetate binds selectively to progesterone receptors and not androgen receptors [A37083]. ... On August 10, 2018, Annovera™ containing segesterone acetate and [ethinyl estradiol] was granted approval …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Name: … Segesterone acetate …
Matched Iupac: … methylidene-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl acetate …
Matched Description: … Segesterone acetate is a steroidal progestin or synthetic progesterone and a 19-norprogesterone derivative ... Segesterone acetate binds selectively to progesterone receptors and not androgen receptors [A37083]. ... On August 10, 2018, Annovera™ containing segesterone acetate and [ethinyl estradiol] was granted approval …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Octreotide
Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also occur. Acromegaly is...
Approved
Investigational
Matched Description: … Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also ... Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and ... , including carcinoid tumors and vasoactive intestinal tumors (VIPomas). …
Matched Salts name: … Octreotide acetate …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Pituitary and Hypothalamic Hormones and Analogues ... Somatostatin and Analogues ... Sex Hormones and Insulins …
Matched Products: … Octreotide acetate ... Octreotide Acetate ... OCTREOTIDE ACETATE …
Matched Salts name: … Octreotide acetate …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Pituitary and Hypothalamic Hormones and Analogues ... Somatostatin and Analogues ... Sex Hormones and Insulins …
Matched Products: … Octreotide acetate ... Octreotide Acetate ... OCTREOTIDE ACETATE …
Acetyl simvastatin
Experimental
Matched Synonyms: … Simvastatin acetate ... Simvastatin acetate ester …
Heptanoic acid
Experimental
Investigational
Matched Synonyms: … Enanthic acid ... Heptoic acid ... Enanthylic acid …
Matched Name: … Heptanoic acid …
Matched Iupac: … heptanoic acid …
Matched Name: … Heptanoic acid …
Matched Iupac: … heptanoic acid …
Displaying drugs 626 - 650 of 2959 in total