Displaying drugs 676 - 700 of 14163 in total
Kappadione
Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not available in North America . It has been found to have carcinogenic potential in mammalian cells as...
Approved
Matched Description: … Studies involving the active metabolite of this formulation, menadione, showed oocyte toxicity in a study ... of mice [L1544]. ... It has been found to have carcinogenic potential in mammalian cells as well as cytotoxic properties [ …
Gilteritinib
Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression observed in other...
Approved
Investigational
Matched Iupac: … -2-carboxamide ... 6-ethyl-3-({3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-[(oxan-4-yl)amino]pyrazine …
Matched Description: … Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors ... derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression observed in …
Matched Description: … Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors ... derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression observed in …
Sodium phosphate, dibasic, unspecified form
Approved
Experimental
Matched Mixtures name: … Aminosyn II in Dextrose …
Propiolactone
Propiolactone is a lactone compound with a four-membered ring. It is a colorless liquid with a pungent slightly sweet odor. Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, surgical instruments, and enzymes. It has been used against bacteria, fungi, and virus. It is currently...
Approved
Withdrawn
Matched Iupac: … oxetan-2-one …
Matched Description: … Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, ... Propiolactone was first commercially available in the United States in 1958.[A32144] ... [A32144] It is currently FDA approved for its use as an indirect additive used in food contact substances …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Description: … Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, ... Propiolactone was first commercially available in the United States in 1958.[A32144] ... [A32144] It is currently FDA approved for its use as an indirect additive used in food contact substances …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Aclidinium
Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012.
Approved
Matched Iupac: … (3R)-3-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azabicyclo[2.2.2]octan-1-ium …
Matched Description: … Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease …
Matched Description: … Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease …
Chlorphenesin
Approved
Experimental
Regadenoson
Regadenoson is an A2A adenosine receptor agonist that causes coronary vasodilation and used for myocardial perfusion imagining. Manufactured by Astellas and FDA approved April 10, 2008.
Approved
Investigational
Matched Iupac: … 1-{6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-2-yl}-N-methyl-1H-pyrazole …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Methoxyflurane
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug...
Approved
Investigational
Vet approved
Withdrawn
Matched Description: … (From AMA Drug Evaluations Annual, 1994, p180)
In the US, methoxyflurane is one of the products that ... have been withdrawn or removed from the market for reasons of safety or effectiveness. ... , and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation …
Povidone
Povidone, also known as polyvinylpyrrolidone (PVP) or polyvidone, is a synthetic water-soluble polymer made from the monomer N-vinylpyrrolidone used as a binder in many pharmaceutical tablets and lubricant in eye drops. It is also used in many technical applications with various roles as an adhesive, additive, and emulsifier. When in...
Approved
Withdrawn
Matched Synonyms: … 1-vinyl-2-pyrrolidinone polymer ... 1-ethenyl-2-pyrrolidinone homopolymer …
Matched Description: … in a few clinical studies that the application of the compound in wounds was associated with impaired ... [L43942] Other formulations of povidone continue to be available. ... The FDA withdrew its approval for the use of all intravenous drug products containing povidone. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … VIDISEPT 2% …
Matched Description: … in a few clinical studies that the application of the compound in wounds was associated with impaired ... [L43942] Other formulations of povidone continue to be available. ... The FDA withdrew its approval for the use of all intravenous drug products containing povidone. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … VIDISEPT 2% …
Human varicella-zoster immune globulin
Human varicella-zoster immune globulin is a solvent/detergent-treated sterile liquid preparation of purified human immune globulin G (IgG) containing antibodies to varicella zoster virus (anti-VZV). It is prepared from pools of healthy human donors' plasma via anion-exchange column chromatography and was approved in 2012 under the name VariZIG to reduce the...
Approved
Matched Description: … was approved in 2012 under the name VariZIG to reduce the disease severity in high-risk patients who ... lack evidence of immunity to varicella and for whom varicella vaccine is contraindicated. ... Human varicella-zoster immune globulin is a solvent/detergent-treated sterile liquid preparation of purified …
Wormwood
Wormwood is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Wormwood is a plant/plant extract used in some OTC (over-the-counter) products. …
Buspirone
Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs. Unlike many drugs used to treat anxiety, buspirone does...
Approved
Investigational
Matched Synonyms: … 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione …
Matched Iupac: … 8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione …
Matched Description: … [L7375] The potential use of buspirone in combination with [melatonin] in depression and cognitive impairment ... , such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety. ... [A180985] First synthesized in 1968 then patented in 1975,[L7375] it is commonly marketed under the brand …
Matched Salts cas: … 33386-08-2 …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Iupac: … 8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione …
Matched Description: … [L7375] The potential use of buspirone in combination with [melatonin] in depression and cognitive impairment ... , such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety. ... [A180985] First synthesized in 1968 then patented in 1975,[L7375] it is commonly marketed under the brand …
Matched Salts cas: … 33386-08-2 …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Zinc
A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with anemia, short stature, hypogonadism, impaired wound...
Approved
Investigational
Matched Description: … /ZnT8_ may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in ... in the pathophysiology and treatment of affective disorders, plus discussed the potential value of zinc ... It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an …
Matched Mixtures name: … Micro+6 Concentrate ... For-2 ... Zinc Lozenges With Vitamin C In A Nonmedicinal Base With Echinacea Lozenge …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …
Matched Mixtures name: … Micro+6 Concentrate ... For-2 ... Zinc Lozenges With Vitamin C In A Nonmedicinal Base With Echinacea Lozenge …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …
Dutasteride
Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestosterone (DHT), a primary hormonal...
Approved
Investigational
Matched Synonyms: … α,α,α,α',α',α'-hexafluoro-3-oxo-4-aza-5α-androst-1-ene-17β-carboxy-2',5'-xylidide …
Matched Iupac: … (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-1H,2H,4aH,4bH,5H …
Matched Description: … Its clinical efficacy against benign prostate hyperplasia in male patients is comparable to that of [ ... Dutasteride was approved by the FDA in 2001 for the treatment of symptomatic benign prostatic hyperplasia ... the development and enlargement of the prostate gland. …
Matched Categories: … Drugs Used in Benign Prostatic Hypertrophy …
Matched Iupac: … (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-1H,2H,4aH,4bH,5H …
Matched Description: … Its clinical efficacy against benign prostate hyperplasia in male patients is comparable to that of [ ... Dutasteride was approved by the FDA in 2001 for the treatment of symptomatic benign prostatic hyperplasia ... the development and enlargement of the prostate gland. …
Matched Categories: … Drugs Used in Benign Prostatic Hypertrophy …
Fenoprofen
An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Approved
Matched Synonyms: … 2-(3-phenoxyphenyl)propionic acid ... 2-(m-phenoxyphenyl)propionic acid ... (±)-2-(3-phenoxyphenyl)propionic acid …
Matched Iupac: … 2-(3-phenoxyphenyl)propanoic acid …
Matched Categories: … Non COX-2 selective NSAIDS …
Matched Iupac: … 2-(3-phenoxyphenyl)propanoic acid …
Matched Categories: … Non COX-2 selective NSAIDS …
Erythrityl tetranitrate
A vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020)
Approved
Experimental
Investigational
Matched Iupac: … (2R,3S)-1,3,4-tris(nitrooxy)butan-2-yl nitrate …
Matched Categories: … Vasodilators Used in Cardiac Diseases …
Matched Categories: … Vasodilators Used in Cardiac Diseases …
Flunisolide
Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid with anti-inflammatory actions. It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves activation of glucocorticoid receptors.
Approved
Investigational
Matched Iupac: … (1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo …
Matched Description: … activation of glucocorticoid receptors. ... It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves …
Matched Salts cas: … 77326-96-6 …
Matched Description: … activation of glucocorticoid receptors. ... It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves …
Matched Salts cas: … 77326-96-6 …
Flurandrenolide
A corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733)
Approved
Matched Iupac: … (1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo …
Matched Description: … A corticosteroid used topically in the treatment of various skin disorders. …
Matched Description: … A corticosteroid used topically in the treatment of various skin disorders. …
Memantine
Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism than the cholinesterase enzyme inhibitors normally employed in the management of Alzheimer's...
Approved
Investigational
Matched Description: … used in the management of Alzheimer's Disease (AD). ... Memantine blocks the effects of glutamate, a neurotransmitter in the brain that leads to neuronal excitability ... the management of Alzheimer's disease [A1639]. …
Chlorambucil
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Approved
Matched Synonyms: … 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid ... γ-[p-di(2-chloroethyl)aminophenyl]butyric acid ... N,N-di-2-chloroethyl-γ-p-aminophenylbutyric acid …
Matched Iupac: … 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoic acid …
Matched Description: … A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant ... Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in …
Matched Products: … ลูเคอแรน (เม็ด 2 มก.) ... Leukeran 2 mg - Filmtabletten ... LEUKERAN 2 MG TABLET, 25 ADET …
Matched Iupac: … 4-{4-[bis(2-chloroethyl)amino]phenyl}butanoic acid …
Matched Description: … A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant ... Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in …
Matched Products: … ลูเคอแรน (เม็ด 2 มก.) ... Leukeran 2 mg - Filmtabletten ... LEUKERAN 2 MG TABLET, 25 ADET …
Nalbuphine
A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States.
Approved
Matched Description: … Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. …
Matched Salts cas: … 23277-43-2 …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Salts cas: … 23277-43-2 …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Tolbutamide
Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin...
Approved
Investigational
Matched Description: … Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination ... The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. ... Tolbutamide appears to be metabolized in the liver. …
Matched Salts cas: … 473-41-6 …
Matched Categories: … Drugs Used in Diabetes ... combinations of sulfonamides …
Matched Salts cas: … 473-41-6 …
Matched Categories: … Drugs Used in Diabetes ... combinations of sulfonamides …
Clozapine
Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical". . This low affinity to dopamine receptors results in fewer extrapyramidal side effects,...
Approved
Matched Iupac: … 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,9,11,13-heptaene …
Matched Description: … Despite its effectiveness in treating both positive and negative symptoms of schizophrenia, clozapine ... was briefly removed from the market in various jurisdictions in 1970 due to severe agranulocytosis. ... various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of …
Matched Description: … Despite its effectiveness in treating both positive and negative symptoms of schizophrenia, clozapine ... was briefly removed from the market in various jurisdictions in 1970 due to severe agranulocytosis. ... various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of …
Displaying drugs 676 - 700 of 14163 in total