Displaying drugs 51 - 75 of 645 in total
Lactic acid
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed) Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste. It is produced by fermentation of a sugar source, such as...
Approved
Vet approved
Matched Description: … active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020 …
Dulaglutide
Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA in 2014, and...
Approved
Investigational
Matched Description: … [A236070] Dulaglutide was initially approved by the FDA in 2014, and in February 2020 was approved for …
Regdanvimab
Regdanvimab (CT-P59) is a recombinant human IgG1 monoclonal antibody directed at the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. It blocks the interaction between viral spike proteins and angiotensin-converting enzyme 2 (ACE2) that allows for viral entry into the cell, thereby inhibiting the virus' ability to replicate. Trials...
Approved
Investigational
Matched Description: … investigating the use of regdanvimab as a therapeutic candidate for the treatment of COVID-19 began in mid-2020 …
Dydrogesterone
A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.
Approved
Investigational
Withdrawn
Matched Products: … DUPHASTON 10 MG FİLM KAPLI TABLET, 20 ADET …
Dexamethasone
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone. Dexamethasone was granted FDA approval on 30 October 1958....
Approved
Investigational
Vet approved
Matched Description: … L10695] In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020 …
Matched Mixtures name: … NETILDEX GOZ DAMLASI %0,1 DEKSAMETAZON + %0,3 NETILMISIN 0,3 ML × 20 ADET …
Matched Products: … DEKORT 4 MG TABLET, 20 ADET ... DEKORT 8 MG TABLET, 20 ADET ... KORDEXA 4 MG TABLET, 20 ADET …
Matched Mixtures name: … NETILDEX GOZ DAMLASI %0,1 DEKSAMETAZON + %0,3 NETILMISIN 0,3 ML × 20 ADET …
Matched Products: … DEKORT 4 MG TABLET, 20 ADET ... DEKORT 8 MG TABLET, 20 ADET ... KORDEXA 4 MG TABLET, 20 ADET …
Flumethasone
Flumethasone is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.
Approved
Vet approved
Ouabain
A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase.
Approved
Matched Synonyms: … 3-(α-L-rhamnopyranosyloxy)-1β,5β,11α,14,19-pentahydroxy-5β-card-20(22)-enolide …
Clobetasol propionate
Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors. It has demonstrated superior activity compared to fluocinonide and was first described in the literature in 1974. Clobetasol Propionate was granted FDA approval on 27 December 1985.
Approved
Vibegron
Vibegron is a potent, selective beta-3 adrenergic receptor (β3) agonist that relaxes the detrusor smooth muscle of the bladder, thereby increasing bladder capacity. Vibegron was first approved in Japan in September 2018 for the treatment of overactive bladder, a condition associated with distressing symptoms of urge urinary incontinence, urgency, and...
Approved
Investigational
Matched Description: … On December 23, 2020, vibegron was approved for the same indication in adults. …
Cabazitaxel
Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more readily penetrate the blood–brain barrier compared to...
Approved
Matched Synonyms: … .,20-EPOXYTAX-11-ENE-2.ALPHA.,4,13.ALPHA. …
Matched Products: … Cabazitaxel G.L. 20 mg/ml-Konzentrat zur Herstellung einer Infusionslösung ... Cabazitaxel STADA 20 mg/ml Konzentrat zur Herstellung einer Infusionslösung ... Cabazitaxel Viatris 20 mg/ml Konzentrat zur Herstellung einer Infusionslösung …
Matched Products: … Cabazitaxel G.L. 20 mg/ml-Konzentrat zur Herstellung einer Infusionslösung ... Cabazitaxel STADA 20 mg/ml Konzentrat zur Herstellung einer Infusionslösung ... Cabazitaxel Viatris 20 mg/ml Konzentrat zur Herstellung einer Infusionslösung …
Deslanoside
Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.
Approved
Matched Synonyms: … 2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20 ... dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-3β,5β,12β-card-20 …
Hydroxychloroquine
Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like chloroquine. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is also used for the prophylaxis of malaria in...
Approved
Matched Description: … authorization for hydroxychloroquine and [chloroquine] in the treatment of COVID-19 was revoked on 15 June 2020 …
Mannitol
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a...
Approved
Investigational
Matched Description: … On October 30, 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of …
Matched Mixtures name: … OSMOFUNDIN INJECTION 20% …
Matched Products: … OSMOROL 20 ... BRAUN OSMOFUNDIN 20% ... Osmitrol Injection 20% …
Matched Mixtures name: … OSMOFUNDIN INJECTION 20% …
Matched Products: … OSMOROL 20 ... BRAUN OSMOFUNDIN 20% ... Osmitrol Injection 20% …
Lorcaserin
Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is...
Approved
Withdrawn
Matched Description: … hydrochloride tablets, 10 mg) and Belviq XR (lorcaserin hydrochloride extended-release tablets, 20 mg ... In February 2020, the FDA issued a Drug Safety Communication requesting the manufacturer of Belviq (lorcaserin …
Vibrio cholerae CVD 103-HgR strain live antigen
Vibrio cholerae CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against Vibrio cholerae serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by Vibrio cholerae, which is gram-negative bacteria. Two serogroups of V. cholerae, O1 and O139, are causative...
Approved
Investigational
Matched Description: … [A244494] Vaxchora was later approved by the European Commission in April 2020. …
Imdevimab
Imdevimab is a monoclonal antibody combined with casirivimab in Regeneron's antibody cocktail known as REGEN-COV2 for the treatment of COVID-19. This drug is a combination of antibodies derived from humanized VelocImmune® mice in addition to blood samples from patients who have recovered from COVID-19. These antibodies have been formulated to...
Approved
Experimental
Matched Description: … [A221495]
On November 21, 2020, the FDA authorized emergency approval of REGN-COV2 to treat mild …
Clorazepic acid
Clorazepic acid (clorazepate) is a water-soluble benzodiazepine with muscle-relaxant and anticonvulsant actions effective in the treatment of anxiety.[A957,L44788] Following administration, clorazepate is rapidly converted to nordiazepam (N-desmethyldiazepam), its active metabolite, before entering systemic circulation. Similar to other benzodiazepines, the active metabolite of clorazepate enhances the binding of gamma-aminobutyric acid (GABA)...
Approved
Illicit
Matched Description: … In September 2020, a black box warning describing these risks was included on the product label of benzodiazepines …
Matched Products: … TRANXILIUM 20 …
Matched Products: … TRANXILIUM 20 …
Oxymetazoline
Oxymetazoline is an imidazole derivative and a potent, direct-acting alpha (α)-adrenergic agonist with affinity to both α1- and α2-adrenoceptors. Oxymetazoline is available in various formulations with a wide variety of clinical implications. The topical formulation of the drug is used to treat persistent facial redness in adults. As an effective...
Approved
Investigational
Matched Description: … [L15057] In July 2020, the FDA approved the use of an ophthalmic formulation of oxymetazoline (Upneeq …
Betamethasone
Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity.
Approved
Vet approved
Matched Salts cas: … 5593-20-4 …
Matched Mixtures name: … Fusicutan 20 mg/g + 1 mg/g Creme ... Fucibet Lipid 20 mg/g + 1 mg/g Creme ... FUCICORT 20 MG/G + 1 MG/G KREM, 30 G …
Matched Products: … NOVOVATE LOSYON, 20 ML ... BETNOVATE LOSYON, 20 ML …
Matched Mixtures name: … Fusicutan 20 mg/g + 1 mg/g Creme ... Fucibet Lipid 20 mg/g + 1 mg/g Creme ... FUCICORT 20 MG/G + 1 MG/G KREM, 30 G …
Matched Products: … NOVOVATE LOSYON, 20 ML ... BETNOVATE LOSYON, 20 ML …
Desoximetasone
A topical anti-inflammatory glucocorticoid used in dermatoses, skin allergies, psoriasis, etc.
Approved
Norethisterone
Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with levonorgestrel and its derivatives, and is the active form of several other progestins including norethynodrel and lynestrenol. Norethisterone mimics the actions of endogenous...
Approved
Matched Synonyms: … 17-hydroxy-19-nor-17-α-pregn-4-en-20-yn-3-one ... 17-hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one ... 17-β-hydroxy-19-norpregn-4-en-20-yn-3-one …
Matched Mixtures name: … Junel Fe 1/20 ... Larin 1/20 ... Gildess 1/20 …
Matched Mixtures name: … Junel Fe 1/20 ... Larin 1/20 ... Gildess 1/20 …
Mepolizumab
Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm3 or more) is associated with a spectrum of diseases, including severe asthma, eosinophilic granulomatosis with polyangiitis (EGPA), and hypereosinophilic syndrome (HES). The pathogenesis of eosinophilia is complex, but IL-5 is recognized as...
Approved
Investigational
Matched Description: … This indication was subsequently expanded to cover EGPA on December 12, 2017, and HES on September 25, 2020 …
Opicapone
Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine.[A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) inhibitor (eg carbidopa) experience motor complications over time, which calls for the management...
Approved
Investigational
Matched Description: … Opicapone was approved for use by the European Commission in June 2016 [L2339] and the FDA in April 2020 …
Inclisiran
Inclisiran is a long-acting, synthetic small interfering RNA (siRNA) directed against proprotein convertase subtilisin-kexin type 9 (PCSK9), which is a serine protease that regulates plasma low-density lipoprotein cholesterol (LDL-C) levels. By binding to PCSK9 messenger RNA, inclisiran prevents protein translation of PCSK9, leading to decreased concentrations of PCSK9 and plasma...
Approved
Investigational
Matched Description: … [A225953,A225958]
On December 11, 2020, the European Commission (EC) granted authorization for marketing …
Janssen COVID-19 Vaccine
The Janssen COVID-19 vaccine (Ad26.COV2.S) is a recombinant vaccine that contains an adenovirus serotype 26 (Ad26) vector expressing a stabilized SARS-CoV-2 spike protein. The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and the Beth Israel Deaconess Medical Center. A preclinical study in hamsters infected with...
Approved
Investigational
Matched Description: … As of June 2020, a Phase 1/2 clinical trial in adult humans was announced to evaluate the safety, immunogenicity …
Displaying drugs 51 - 75 of 645 in total