Displaying drugs 726 - 750 of 8178 in total
Hexachlorophene
A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
Approved
Withdrawn
Matched Description: … It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders …
Glutamic acid
A peptide that is a homopolymer of glutamic acid.
Approved
Nutraceutical
Matched Description: … A peptide that is a homopolymer of glutamic acid. …
Cobimetinib
Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment of patients with unresectable or...
Approved
Investigational
Matched Description: … molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of ... It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment of …
Tetrofosmin
Tetrofosmin was developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines. Tetrofosmin is used in conjunction with technetium Tc-99m as a radiopharmaceutical.
Approved
Matched Description: … Tetrofosmin is part of the group of diphosphines. ... Tetrofosmin was developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic ... It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. …
Digoxin Immune Fab (Ovine)
Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin derivative Digoxindicarboxymethylamine. It is used as an antidote for overdose of digoxin.
Approved
Matched Description: … It is used as an antidote for overdose of digoxin. …
Isradipine
Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity...
Approved
Investigational
Matched Description: … used class of CCBs. ... the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells ... Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely …
Plazomicin
Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from DB12604. The structure of plazomicin was established via appending hydroxylaminobutyric acid to DB12604 at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglycoside-modifying enzymes, which contribute to the main...
Approved
Investigational
Matched Description: … However, acquired resistance of aminoglycosides may arise through over expression of efflux pumps and ... The structure of plazomicin was established via appending hydroxylaminobutyric acid to [DB12604] at position ... 28th, 2018, plazomicin sulfate was approved by the FDA for use in adult patients for the treatment of …
Soybean oil
Derived from soybeans, soybean oil is a common vegetable oil and a source of polyunsaturated and saturated fatty acids. It is a complex mixture of triglycerides where per 100 g, soybean oil has 16 g of saturated fat, 23 g of monounsaturated fat, and 58 g of polyunsaturated fat. The...
Approved
Matched Description: … of monounsaturated fat, and 58 g of polyunsaturated fat. ... It is a complex mixture of triglycerides where per 100 g, soybean oil has 16 g of saturated fat, 23 g ... Derived from soybeans, soybean oil is a common vegetable oil and a source of polyunsaturated and saturated …
Bacillus calmette-guerin substrain connaught live antigen
Bacillus calmette-guerin substrain connaught live antigen is intravesically administered for the treatment and prophylaxis of carcinoma in situ (CIS) of the urinary bladder and for the prophylaxis of primary or recurrent stage Ta and/or T1 papillary tumors following transurethral resection (TUR). The solution contains live, attenuated strain of Mycobacterium bovis....
Approved
Investigational
Matched Description: … carcinoma in situ (CIS) of the urinary bladder and for the prophylaxis of primary or recurrent stage ... The solution contains live, attenuated strain of Mycobacterium bovis. ... It is prepared from the Connaught strain of Bacillus Calmette and Guérin. …
Baloxavir marboxil
Baloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.[A39895, A251755] It is a prodrug of baloxavir with an improved absorption profile than its active metabolite due to the addition of a phenolic hydroxyl...
Approved
Investigational
Matched Description: … active metabolite due to the addition of a phenolic hydroxyl group to its structure. ... [A39895, A251755] It is a prodrug of [baloxavir] [L42855] with an improved absorption profile than its …
Pentostatin
A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Approved
Investigational
Matched Description: … A potent inhibitor of adenosine deaminase. ... The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell …
Trilostane
Trilostane is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. It was withdrawn from the United States market in April 1994.
Approved
Investigational
Vet approved
Withdrawn
Matched Description: … Trilostane is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's …
Pentastarch
Pentastarch is an artificial colloid (hydroxyethyl starch derivative). Pentastarch is characterized by presenting five hydroxyethyl groups, which signifies an approximate 50% hydroxyethylation. It is sold under the name Pentaspan by Bristol-Myers Squibb and is used for fluid resuscitation. When administered, pentastarch remains mainly in the circulatory system and hence, it...
Approved
Investigational
Bezafibrate
Antilipemic agent that lowers cholesterol and triglycerides. It decreases low density lipoproteins and increases high density lipoproteins.
Approved
Investigational
Varicella zoster vaccine (live/attenuated)
Live attenuated zoster vaccine is available as two products: Zostavax for the prevention of shingles in immunocompetent people over the age of 50, and Varivax for the prevention of chickenpox in individuals 12 months of age and older. While the two vaccines contain the same immunological components and provide protection...
Approved
Matched Description: … 12 months of age and older. ... in immunocompetent people over the age of 50, and Varivax for the prevention of chickenpox in individuals ... of varicella-zoster virus. …
Dofetilide
Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter.
Approved
Investigational
Matched Description: … antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of ... sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical …
Propantheline
A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Approved
Matched Description: … muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of …
Difenoxin
Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R)...
Approved
Illicit
Matched Description: … However, the antidiarrheal potency of difenoxin is much greater than its CNS effects, which makes it ... CNS). [3] Difenoxin is also closely related to loperamide, but unlike loperamide it is still capable of ... Difenoxin is an active metabolite of the anti-diarrheal drug, diphenoxylate, which is also used in combination …
Oxymetholone
Oxymetholone is a synthetic anabolic steroid marketed under the brand name Anapolon by Hoffmann La Roche Limitedand used in the treatment of osteoporosis, anaemia, and as an agent to stimulate muscle growth in malnourished or underdeveloped patients. Anabolic-androgenic steroids (AAS), such as oxymetholone, have been abused by bodybuilders and athletes....
Approved
Illicit
Matched Description: … The uncontrolled misuse of oxymetholone can lead to a large variety of detrimental effects, the most ... often reported of which are cardiovascular events. ... steroid marketed under the brand name Anapolon by Hoffmann La Roche Limitedand used in the treatment of …
Certoparin
Certoparin is part of the heparins of low molecular weight that presents high activity against the coagulation factor Xa. It is normally used to prevent deep venous thrombosis.
Approved
Investigational
Matched Description: … Certoparin is part of the heparins of low molecular weight that presents high activity against the coagulation …
Calcium glubionate anhydrous
Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
Approved
Mirikizumab
Mirikizumab is a monoclonal antibody developed by Eli Lilly intended to treat ulcerative colitis. It inhibits the actions of interleukin-23 (IL-23), a pro-inflammatory cytokine that activates pathways contributing to the development of inflammatory diseases.[L46237,L46257]
Mirikizumab is approved in Japan and received a positive opinion from the EMA's Committee for Medicinal...
Approved
Investigational
Matched Description: … on the basis of manufacturing concerns. ... contributing to the development of inflammatory diseases. ... It inhibits the actions of interleukin-23 (IL-23), a pro-inflammatory cytokine that activates pathways …
Quinine
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in...
Approved
Matched Description: … An alkaloid derived from the bark of the cinchona tree. ... The mechanisms of its antimalarial effects are not well understood. ... It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have …
Urea C-14
Urea 14C is a urea molecule radiolabelled with a radioactive carbon-14. It is currently used for the Urea Breath Test (UBT) and is available as a rapid diagnostic test (marketed as PyTest) for the detection of Helicobacter pylori infections. H pylori is a common stomach bacteria that has been linked...
Approved
Matched Description: … As the urease enzyme is not present in mammalian cells, the presence of urease (and the products of urea ... Exhaled breath samples can then be collected and measured for the presence of radioactivity. ... Breath Test (UBT) and is available as a rapid diagnostic test (marketed as PyTest) for the detection of …
Dexchlorpheniramine maleate
Dexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture.
Approved
Matched Description: … Dexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. …
Displaying drugs 726 - 750 of 8178 in total