Advanced Filter

Filter by Group

Filter by Market Availability

Clear
Did you mean amino and ferrous disulfide and sucrose?
Displaying drugs 801 - 825 of 14799 in total

Sulfasalazine

Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down into mesalazine and sulfapyridine, 2 compounds that carry out the main pharmacological...
Approved
Matched Description: … Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal ... It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis ... L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down into [mesalazine] and …
Matched Categories: … Alimentary Tract and Metabolism …

Baloxavir marboxil

Baloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.[A39895, A251755] It is a prodrug of baloxavir with an improved absorption profile than its active metabolite due to the addition of a phenolic hydroxyl...
Approved
Investigational
Matched Categories: … Baloxavir and prodrugs …

Balsalazide

Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. It is sold under the name "Colazal" in the US and "Colazide" in the UK. The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid. It is usually administered as the disodium salt. Balsalazide works by deliverying mesalazine...
Approved
Investigational
Matched Description: … It is sold under the name "Colazal" in the US and "Colazide" in the UK. …
Matched Categories: … Alimentary Tract and Metabolism …

Aclidinium

Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012.
Approved
Matched Categories: … formoterol and aclidinium bromide …

Apalutamide

Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resistant Prostate Cancer, and Prostatic...
Approved
Investigational
Matched Description: … It targets the AR ligand-binding domain and prevents AR nuclear translocation, DNA binding, and transcription ... risk for metastases and death [A31846]. ... Apalutamide displayed good tolerability and safety profile in clinical studies. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents …

Flunitrazepam

Flunitrazepam is a benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
Approved
Illicit
Matched Description: … Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepine hypnotics and sedatives ... Benzodiazepines and benzodiazepine derivatives …

Talbutal

Talbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. Talbutal is a schedule III drug in the U.S.
Approved
Illicit
Matched Categories: … Hypnotics and Sedatives …

Glutethimide

Glutethimide is a hypnotic and sedative. Its use has been largely superseded by other drugs.
Approved
Illicit
Matched Description: … Glutethimide is a hypnotic and sedative. Its use has been largely superseded by other drugs. …
Matched Categories: … Hypnotics and Sedatives …

Lucinactant

Lucinactant is a new synthetic peptide-containing surfactant for intratracheal use. It contains sinapultide, a novel, hydrophobic, 21-amino acid peptide (leucine and lysine repeating units, KL4 peptide) designed to mimic human surfactant protein-B (SB-P). More specifically, it mimics the C-terminal amphipathic helical domain of this protein. It also consists of phospholipids...
Approved
Investigational
Matched Description: … , POPG) and a fatty acid (palmitic acid). ... It contains sinapultide, a novel, hydrophobic, 21-amino acid peptide (leucine and lysine repeating units ... It also consists of phospholipids (dipalmitoylphosphatidylcholine, DPPC and palmitoyloleoyl phosphatidylglycerol …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Teriflunomide

Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of hepatoxicity and...
Approved
Matched Description: … Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting ... The FDA label states an important warning about the risk of hepatoxicity and teratogenicity for patients ... It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically …
Matched Categories: … Leflunomide and metabolite ... Antineoplastic and Immunomodulating Agents …

Clemastine

An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Approved
Investigational
Matched Description: … ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and …

Pentostatin

A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Approved
Investigational
Matched Description: … It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …

Fenoprofen

An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
Approved
Matched Description: … An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Niclosamide

Niclosamide is an antihelminthic used for the treatment of tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms....
Approved
Investigational
Vet approved
Matched Description: … nematodes, flukes, and tapeworms. ... Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad ... Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial …
Matched Categories: … Salicylanilide and Derivatives ... Antiparasitic Products, Insecticides and Repellents …

Belzutifan

Belzutifan is an inhibitor of hypoxia-inducible factor 2α (HIF-2α) used in the treatment of von Hippel-Lindau (VHL) disease-associated cancers. The HIF-2α protein was first identified in the 1990s by researchers at UT Southwestern Medical Center as a key player in the growth of certain cancers. Initially considered to be undruggable,...
Approved
Investigational
Matched Description: … binding pocket was eventually discovered in the HIF-2α molecule which allowed for compounds to bind and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Amikacin

Amikacin is a semi-synthetic aminoglycoside antibiotic that is derived from kanamycin A.[FDA label] Amikacin is synthesized by acylation with the l-(-)-γ-amino-α-hydroxybutyryl side chain at the C-1 amino group of the deoxystreptamine moiety of kanamycin A. Amikacin's unique property is that it exerts activity against more resistant gram-negative bacilli such as...
Approved
Investigational
Vet approved
Matched Description: … of breath and the coughing up of blood. ... some Mycobacterium (M. avium-intracellulare, M. chelonae, and M. fortuitum)[L4680]. ... that it exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and …
Matched Categories: … cefepime and amikacin …

Human vaccinia virus immune globulin

Human vaccinia immune globulin (VIG) is a sterile solution containing the purified gamma globulin (IgG) fraction of plasma taken from healthy donors previously vaccinated with live vaccinia virus vaccine who possess high titers of anti-vaccinia virus antibody [FDA Label, A33814]. The IgG fraction is purified by the anion-exchange column chromatography...
Approved
Matched Description: … The IgG fraction is purified by the anion-exchange column chromatography method and the solution is solvent ... is only available in very limited quantities - all factors that may intervene with its availability and ... Nevertheless, VIG by virtue of the way it is produced is a poorly characterized and highly variable human …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Guanadrel

Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent.
Approved
Matched Description: … Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent. …

Nabilone

Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as...
Approved
Investigational
Matched Description: … and emotional regulation. ... , and physiological effects. ... (via the Cannabinoid Receptors CB1 and CB2) and plays a role in many physiological processes such as …
Matched Categories: … Cannabinoids and similars ... Antiemetics and Antinauseants ... Alimentary Tract and Metabolism …

Osilodrostat

Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiologically elevated. Cushing's...
Approved
Investigational
Matched Description: … Cushing's disease),[A191850] and was granted FDA approval and Orphan Drug designation in the US in March ... Cushing's disease is often the result of ACTH hypersecretion secondary to a pituitary tumor, and surgical ... L12123] It has undergone phase II clinical trials for the treatment of solid tumours, hypertension, and …
Matched Categories: … Sex Hormones and Insulins …

Flupentixol

Flupentixol is an antipsychotic drug of the thioxanthene group. It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. Flupentixol decanoate is one of the active ingredients found in injectable drug formulations: it is produced by esterification of cis(Z)‐flupentixol with decanoic acid. Flupentixol is an antagonist of...
Approved
Investigational
Withdrawn
Matched Description: … [A229083] Flupentixol is an antagonist of both D1 and D2 dopamine receptors. ... It exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. ... It is approved for use in Canada and other countries around the world, but not in the US. …

Brigatinib

Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the EML4-ALK fusion gene, which is a...
Approved
Investigational
Matched Description: … Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and ... Brigatinib was developed by Ariad Pharmaceuticals, a subsidiary of Takeda Pharmaceutical Company Limited, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Penbutolol

Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high binding affinity to the...
Approved
Investigational
Matched Description: … Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker ... degree atrioventricular conduction block, bronchial asthma, and those with known hypersensitivity. ... Penbutolol is contraindicated in patients with cardiogenic shock, sinus bradycardia, second and third …
Matched Categories: … penbutolol and other diuretics …

Tezacaftor

Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator class. It was developed by Vertex Pharmaceuticals and FDA approved in combination with ivacaftor to manage cystic fibrosis. This drug was approved by the FDA on February 12, 2018. Cystic Fibrosis is an autosomal recessive disorder caused...
Approved
Investigational
Matched Description: … consequently abnormal fluid and ion transport across cell membranes. ... [L1595] It was developed by Vertex Pharmaceuticals and FDA approved in combination with [ivacaftor] to ... Alterations in the CFTR gene result in altered production, misfolding, or function of the protein and …
Matched Categories: … ivacaftor and tezacaftor ... ivacaftor, tezacaftor and elexacaftor …

Pralsetinib

Pralsetinib, similar to the previously approved selpercatinib, is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small cell lung cancer. Although multikinase inhibitors, including cabozantinib, ponatinib,...
Approved
Investigational
Matched Description: … Although multikinase inhibitors, including [cabozantinib], [ponatinib], [sorafenib], [sunitinib], and ... [A202055] Pralsetinib (BLU-667) and [selpercatinib] (LOXO-292) represent the first generation of specific …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Displaying drugs 801 - 825 of 14799 in total