Displaying drugs 826 - 850 of 2055 in total
2-Methoxyestradiol
2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis.
Investigational
Matched Synonyms: … 2-Hydroxyestradiol 2-methyl ether ... 2-Hydroxyestradol 2-methyl ether …
Matched Iupac: … (1S,3aS,3bR,9bS,11aS)-8-methoxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene …
Matched Description: … It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Iupac: … (1S,3aS,3bR,9bS,11aS)-8-methoxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene …
Matched Description: … It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Thenalidine
Withdrawn from the Canadian, US, and UK markets in 1963 due to concerns involving neutropenia.
Approved
Withdrawn
Matched Synonyms: … 1-Methyl-4-N-2-thenylanilinopiperidine ... 1-Methyl-4-amino-N-phenyl-N-(2-thenyl)piperidine …
Matched Iupac: … 1-methyl-N-phenyl-N-[(thiophen-2-yl)methyl]piperidin-4-amine …
Matched Description: … Withdrawn from the Canadian, US, and UK markets in 1963 due to concerns involving neutropenia. …
Matched Iupac: … 1-methyl-N-phenyl-N-[(thiophen-2-yl)methyl]piperidin-4-amine …
Matched Description: … Withdrawn from the Canadian, US, and UK markets in 1963 due to concerns involving neutropenia. …
Flubendazole
Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.
Experimental
Withdrawn
Matched Synonyms: … methyl 5-(p-fluorobenzoyl)-2-benzimidazolecarbamate ... (5-(4-fluorobenzoyl)-1H-benzimidazole-2-yl)carbamic acid methyl ester …
Matched Iupac: … methyl N-[5-(4-fluorobenzoyl)-1H-1,3-benzodiazol-2-yl]carbamate …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …
Matched Iupac: … methyl N-[5-(4-fluorobenzoyl)-1H-1,3-benzodiazol-2-yl]carbamate …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents …
Defactinib
Defactinib has been investigated for the treatment of Malignant Pleural Mesothelioma.
Investigational
Matched Synonyms: … N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin …
Matched Iupac: … N-methyl-4-{[4-({[3-(N-methylmethanesulfonamido)pyrazin-2-yl]methyl}amino)-5-(trifluoromethyl)pyrimidin …
Matched Iupac: … N-methyl-4-{[4-({[3-(N-methylmethanesulfonamido)pyrazin-2-yl]methyl}amino)-5-(trifluoromethyl)pyrimidin …
Secnidazole
Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including DB00916 and DB00911, but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria as well as protozoa. Once...
Approved
Matched Synonyms: … 1-(2 hydroxypropyl)-2-methyl-5-nitroimidazole ... 1-(2-methyl-5-nitro-1H-imidazol-1-yl) propan-2 ol …
Matched Iupac: … 1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol …
Matched Description: … to form a radical anion, thereby damaging and killing the target pathogen. ... It is structurally related to other 5-nitroimidazoles, including [DB00916] and [DB00911], but displays ... improved oral absorption and a longer terminal elimination half-life than other drugs in this class. …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents ... azithromycin, fluconazole and secnidazole …
Matched Iupac: … 1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol …
Matched Description: … to form a radical anion, thereby damaging and killing the target pathogen. ... It is structurally related to other 5-nitroimidazoles, including [DB00916] and [DB00911], but displays ... improved oral absorption and a longer terminal elimination half-life than other drugs in this class. …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents ... azithromycin, fluconazole and secnidazole …
Alogabat
Investigational
Matched Synonyms: … 3-pyridazinecarboxamide, 6-((5-methyl-3-(6-methyl-3-pyridinyl)-4-isoxazolyl)methoxy)-n-(tetrahydro-2h-pyran …
Matched Iupac: … 6-{[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy}-N-(oxan-4-yl)pyridazine-3-carboxamide …
Matched Iupac: … 6-{[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy}-N-(oxan-4-yl)pyridazine-3-carboxamide …
Elimusertib
Elimusertib is under investigation in clinical trial NCT05071209 (Elimusertib for the Treatment of Relapsed or Refractory Solid Tumors).
Investigational
Matched Synonyms: … 1,7-naphthyridine, 2-((3r)-3-methyl-4-morpholinyl)-4-(1-methyl-1h-pyrazol-5-yl)-8-(1h-pyrazol-3-yl)- …
Encainide
All drug products containing encainide hydrochloride. Encainide hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack. The manufacturer of Enkaid capsules voluntarily withdrew the product from the US market on December 16, 1991.
Approved
Investigational
Withdrawn
Matched Synonyms: … (±)-2'-[2-(1-methyl-2-piperidyl)ethyl]-p-anisanilide ... 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide ... (±)-4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamide …
N-methylnicotinamide
N-methylnicotinamide is an experimental drug with no approved indication or marketed formulation. It is a metabolite of niacinamide/nicotinamide and niacin/nicotinic acid (vitamin B3), and as such N-methylnicotinamide is used to diagnose niacin deficiency by measuring N-methylnicotinamide in the urine.
Experimental
Matched Synonyms: … N-Methyl nicotineamide ... N-Methyl-3-pyridinecarboxamide …
Matched Description: … It is a metabolite of niacinamide/nicotinamide and niacin/nicotinic acid (vitamin B3), and as such N-methylnicotinamide …
Matched Categories: … Bile and Liver Therapy ... Alimentary Tract and Metabolism …
Matched Description: … It is a metabolite of niacinamide/nicotinamide and niacin/nicotinic acid (vitamin B3), and as such N-methylnicotinamide …
Matched Categories: … Bile and Liver Therapy ... Alimentary Tract and Metabolism …
IKT-001Pro
Investigational
Matched Synonyms: … Methanesulfonate-1-sec-butoxycarbonyloxymethyl-1-methyl-4-{4-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2- …
Befiradol
Befiradol is under investigation in clinical trial NCT05148884 (Study to Assess the Safety, Tolerability and Preliminary Efficacy of NLX-112 Versus Placebo in L-dopa-induced Dyskinesia).
Investigational
Matched Synonyms: … (3-chloro-4-fluorophenyl)(4-fluoro-4-((((5-methylpyridin-2-yl)methyl)amino)methyl)piperidin-1-yl)methanone …
Matched Description: … Befiradol is under investigation in clinical trial NCT05148884 (Study to Assess the Safety, Tolerability and …
Matched Description: … Befiradol is under investigation in clinical trial NCT05148884 (Study to Assess the Safety, Tolerability and …
Sodium tetradecyl sulfate
An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.
Approved
Investigational
Matched Synonyms: … Sodium 2-methyl-7-ethylundecanol-4-sulfate ... 7-Ethyl-2-methyl-4-undecanol sulfate sodium salt ... Sodium 7-ethyl-2-methyl-4-undecanol sulfate …
Matched Description: … irritant and sclerosing agent for hemorrhoids and varicose veins. ... An anionic surface-active agent used for its wetting properties in industry and used in medicine as an …
Matched Description: … irritant and sclerosing agent for hemorrhoids and varicose veins. ... An anionic surface-active agent used for its wetting properties in industry and used in medicine as an …
Coumaphos
This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a dip or wash. Coumaphos is widely used for both farm and domestic animals to control ticks, mites, flies and fleas.
Vet approved
Matched Synonyms: … 3-Chloro-4-methyl-7-coumarinyl diethyl phosphorothioate ... O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate ... 3-Chloro-7-hydroxy-4-methyl-coumarin O,O-diethyl phosphorothioate …
Matched Iupac: … O-3-chloro-4-methyl-2-oxo-2H-chromen-7-yl O,O-diethyl phosphorothioate …
Matched Description: … Coumaphos is widely used for both farm and domestic animals to control ticks, mites, flies and fleas. ... This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. ... It is non-volatile in nature and is well known by a variety of names as such a _dip_ or _wash_. …
Matched Iupac: … O-3-chloro-4-methyl-2-oxo-2H-chromen-7-yl O,O-diethyl phosphorothioate …
Matched Description: … Coumaphos is widely used for both farm and domestic animals to control ticks, mites, flies and fleas. ... This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. ... It is non-volatile in nature and is well known by a variety of names as such a _dip_ or _wash_. …
Medroxyprogesterone acetate
Medroxyprogesterone acetate (MPA) is a progesterone derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prevent pregnancy, manage pain in endometriosis, prevent pregnancy, and is also...
Approved
Investigational
Matched Synonyms: … 6α-Methyl-17-acetoxy progesterone ... 6-alpha-Methyl-17-alpha-acetoxyprogesterone ... 6α-Methyl-17α-hydroxyprogesterone acetate …
Matched Description: … in palliative care for endometrial and renal carcinoma. ... vaginal atrophy, prevent pregnancy, manage pain in endometriosis, prevent pregnancy, and is also used ... endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and …
Matched Categories: … Contraceptives, Oral, Synthetic ... Antineoplastic and Immunomodulating Agents ... Hormones and Related Agents ... Progesterone and Derivatives ... medroxyprogesterone and estrogen …
Matched Description: … in palliative care for endometrial and renal carcinoma. ... vaginal atrophy, prevent pregnancy, manage pain in endometriosis, prevent pregnancy, and is also used ... endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and …
Matched Categories: … Contraceptives, Oral, Synthetic ... Antineoplastic and Immunomodulating Agents ... Hormones and Related Agents ... Progesterone and Derivatives ... medroxyprogesterone and estrogen …
Pabinafusp alfa
Pabinafusp alfa is under investigation in clinical trial NCT03568175 (A Study of JR-141 in Patients With Mucopolysaccharidosis II).
Investigational
Matched Synonyms: … TRANSFERRIN RECEPTOR) (HUMAN-MUS MUSCULUS MONOCLONAL JR-141 .GAMMA.1-CHAIN) FUSION PROTEIN WITH PEPTIDE (SYNTHETIC …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Traxoprodil
Investigational
Matched Synonyms: … -methyl-4-phenyl-, (s-(r*,r*))- ... -methyl-4-phenyl-1-piperidineethanol …
7-methyl-guanosine-5'-triphosphate
Experimental
Matched Synonyms: … 7-methyl-GTP(1+) …
Matched Name: … 7-methyl-guanosine-5'-triphosphate …
Matched Iupac: … )oxolan-2-yl]-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium ... amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-({[hydroxy({[hydroxy(phosphonooxy)phosphoryl]oxy})phosphoryl]oxy}methyl …
Matched Name: … 7-methyl-guanosine-5'-triphosphate …
Matched Iupac: … )oxolan-2-yl]-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium ... amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-({[hydroxy({[hydroxy(phosphonooxy)phosphoryl]oxy})phosphoryl]oxy}methyl …
(R)-methylmalonyl-CoA
Experimental
Matched Synonyms: … (R)-2-Methyl-3-oxopropanoyl-CoA ... (R)-2-Methyl-3-oxopropionyl-CoA …
Matched Iupac: … phosphoryl}oxy)-1,2-dihydroxy-3,3-dimethylbutylidene]amino}-1-hydroxypropylidene)amino]ethyl}sulfanyl)-2-methyl …
Matched Categories: … Enzymes and Coenzymes ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Iupac: … phosphoryl}oxy)-1,2-dihydroxy-3,3-dimethylbutylidene]amino}-1-hydroxypropylidene)amino]ethyl}sulfanyl)-2-methyl …
Matched Categories: … Enzymes and Coenzymes ... Nucleic Acids, Nucleotides, and Nucleosides …
Gemeprost
Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the cervix before surgical abortion. It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone for termination of 1st- and 2nd-trimester pregnancy . It is not FDA-approved but available in...
Approved
Withdrawn
Matched Synonyms: … 16,16-Dimethyl-trans-delta-2-PGE1 methyl ester ... 16,16-Dimethyl-trans-delta(sup 2)-prostaglandin E1 methyl ester …
Matched Iupac: … methyl (2E)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4,4-dimethyloct-1-en-1-yl]-5-oxocyclopentyl] …
Matched Description: … It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone ... for termination of 1st- and 2nd-trimester pregnancy [A19726]. ... Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the …
Matched Categories: … Genito Urinary System and Sex Hormones ... Prostaglandins E, Synthetic …
Matched Iupac: … methyl (2E)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4,4-dimethyloct-1-en-1-yl]-5-oxocyclopentyl] …
Matched Description: … It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone ... for termination of 1st- and 2nd-trimester pregnancy [A19726]. ... Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the …
Matched Categories: … Genito Urinary System and Sex Hormones ... Prostaglandins E, Synthetic …
Fosmanogepix
Fosmanogepix is under investigation in clinical trial NCT03604705 (An Efficacy and Safety Study of APX001 in Non-Neutropenic Patients With Candidemia).
Investigational
Matched Synonyms: … [2-amino-3-[3-[[4-(2-pyridyloxymethyl)phenyl]methyl]isoxazol-5-yl]pyridin-1-ium-1-yl]methyl hydrogen …
Matched Iupac: … 2-amino-1-[(hydrogen phosphonatooxy)methyl]-3-[3-({4-[(pyridin-2-yloxy)methyl]phenyl}methyl)-1,2-oxazol …
Matched Description: … Fosmanogepix is under investigation in clinical trial NCT03604705 (An Efficacy and Safety Study of APX001 …
Matched Iupac: … 2-amino-1-[(hydrogen phosphonatooxy)methyl]-3-[3-({4-[(pyridin-2-yloxy)methyl]phenyl}methyl)-1,2-oxazol …
Matched Description: … Fosmanogepix is under investigation in clinical trial NCT03604705 (An Efficacy and Safety Study of APX001 …
Simufilam
Investigational
Matched Synonyms: … 1-benzyl-8-methyl-1,4,8-triazaspiro(4.5)decan-2-one ... 1,4,8-triazaspiro(4.5)decan-2-one, 8-methyl-1-(phenylmethyl)- …
Zeatin
An aminopurine factor in plant extracts that induces cell division. (Grant & Hackh's Chemical Dict, 5th ed)
Experimental
Matched Synonyms: … (E)-2-methyl-4-(1H-purin-6-ylamino)-2-buten-1-ol ... (E)-2-methyl-4-(purin-6-ylamino)-2-buten-1-ol ... (E)-2-methyl-4-(1H-purin-6-ylamino)but-2-en-1-ol …
Matched Iupac: … (2E)-2-methyl-4-[(7H-purin-6-yl)amino]but-2-en-1-ol …
Matched Iupac: … (2E)-2-methyl-4-[(7H-purin-6-yl)amino]but-2-en-1-ol …
MPT-0L055
Investigational
Matched Synonyms: … 4-(((3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino)methyl)-n-3-pyridinylbenzamide ... 4-(((3-chloro-1,4-dioxo-1,4 dihydronaphthalen-2-yl)amino)methyl)-n-(pyridine-3-yl)benzamide ... Benzamide, 4-(((3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino)methyl)-n-3-pyridinyl- …
Matched Iupac: … 4-{[(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino]methyl}-N-(pyridin-3-yl)benzamide …
Matched Iupac: … 4-{[(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino]methyl}-N-(pyridin-3-yl)benzamide …
{[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid
Experimental
Matched Name: … {[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid …
Matched Iupac: … ({7-[difluoro(phosphono)methyl]naphthalen-2-yl}difluoromethyl)phosphonic acid …
Matched Iupac: … ({7-[difluoro(phosphono)methyl]naphthalen-2-yl}difluoromethyl)phosphonic acid …
Displaying drugs 826 - 850 of 2055 in total