Displaying drugs 926 - 950 of 1099 in total
Priliximab
Investigational
Matched Synonyms: … Chimeric M-T412 (human-murine) IgG monoclonal anti-CD4 …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
INZ-701
INZ-701 is an enzyme replacement therapy under development with the intention to be used for the treatment of calcification disorders of the circulatory system, bones, and kidneys.
Investigational
Matched Synonyms: … Recombinant human ectonucleotide pyrophosphatase/phosphodiesterase 1 fused to the Fc fragment of IGG1 …
Matched Description: … intention to be used for the treatment of calcification disorders of the circulatory system, bones, and …
Matched Description: … intention to be used for the treatment of calcification disorders of the circulatory system, bones, and …
PRX-ASL
PRX-ASL is an intracellular enzyme replacement therapy designed to replace the missing or defective enzyme in patients with argininosuccinate lyase deficiency.
Investigational
Matched Synonyms: … Modified messenger ribonucleic acid encoding human argininosuccinate lyase enzyme encapsulated into lipid …
Inbakicept
Inbakicept is a dimeric human IL-15 receptor α (IL-15Rα) sushi domain/human IgG1 Fc fusion protein. It is one of the active ingredients in Anktiva, a combination product also containing nogapendekin alfa, where a single inbakicept is complexed with two nogapendekin alfa components. This combination product was approved by the FDA...
Investigational
Matched Synonyms: … CHAIN (HUMAN SUSHI DOMAIN-CONTAINING FRAGMENT) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN FC FRAGMENT ... INTERLEUKIN 15 RECEPTOR SUBUNIT ALPHA (HUMAN IL15R.ALPHA.) (1-65)-PEPTIDE (SUSHI DOMAIN-CONTAINING) FUSION ... PROTEIN WITH HUMAN IMMUNOGLOBULIN G1 FC FRAGMENT (232 C-TERMINAL RESIDUES) (66-297) (HOMO SAPIENS IGHG1 …
Matched Description: … Inbakicept is a dimeric human IL-15 receptor α (IL-15Rα) sushi domain/human IgG1 Fc fusion protein. ... 75% of all bladder tumours, is commonly treated with transurethral resection of the bladder tumour and ... proliferation of natural killer cells and CD8+ memory T cells, which also synergistically enhance BCG …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Inbakicept is a dimeric human IL-15 receptor α (IL-15Rα) sushi domain/human IgG1 Fc fusion protein. ... 75% of all bladder tumours, is commonly treated with transurethral resection of the bladder tumour and ... proliferation of natural killer cells and CD8+ memory T cells, which also synergistically enhance BCG …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Catridecacog
Coagulation Factor XIII A-Subunit (Recombinant), also known as catridecacog, is a recombinant form of the Factor XIII-A2 homodimer composed of two factor XIII (FXIII) A-subunits [FDA Label]. For people with congenital deficiency or mutation of Factor XIII, a rare bleeding disorder, exogenous replacement of this key coagulation factor is essential...
Approved
Matched Synonyms: … Blood Coagulation Factor XIII (Synthetic Human A-Chain Precursor) ... Human Factor XIII (A2) homodimer (allele F13A*1B), recombinant DNA origin …
Matched Description: … then isolated, the human form is isolated from pooled human plasma. ... ) include [DB12909], which is a purified endogenous (human) form of coagulation factor XIII. ... and maintenance of hemostasis [A18581]. …
Matched Categories: … Blood and Blood Forming Organs …
Matched Description: … then isolated, the human form is isolated from pooled human plasma. ... ) include [DB12909], which is a purified endogenous (human) form of coagulation factor XIII. ... and maintenance of hemostasis [A18581]. …
Matched Categories: … Blood and Blood Forming Organs …
Dazodalibep
Dazodalibep is under investigation in clinical trial NCT06104124 (A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity).
Investigational
Matched Synonyms: … PROTEIN VIB4920 (RECOMBINANT HUMAN TENASCIN C CD40 LIGAND-BINDING THIRD FIBRONECTIN TYPE III DOMAIN) ... ACID LINKER) FUSION PROTEIN WITH TENASCIN C CD40 LIGAND-BINDING THIRD FIBRONECTIN TYPE III DOMAIN (HUMAN …
Matched Description: … Dazodalibep is under investigation in clinical trial NCT06104124 (A Study to Evaluate the Efficacy and …
Matched Description: … Dazodalibep is under investigation in clinical trial NCT06104124 (A Study to Evaluate the Efficacy and …
Melphalan
Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem...
Approved
Matched Description: … [A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … ALKERAN TABLET 2 mg (Revised formula) …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … ALKERAN TABLET 2 mg (Revised formula) …
Tralesinidase alfa
Tralesinidase alfa is a chimeric fusion protein comprised of recombinant human NAGLU and a modified human insulin-like growth factor 2. It is being investigated for the treatment of mucopolysaccharidosis type IIIB (MPS IIIB), also known as Sanfilippo syndrome B.
Investigational
Matched Synonyms: … Recombinant human NAGLU-insulin-like growth factor II ... Recombinant human alpha-N-acetylglucosaminidase-insulin-like growth factor-2 …
Matched Description: … Tralesinidase alfa is a chimeric fusion protein comprised of recombinant human NAGLU and a modified human …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
Matched Description: … Tralesinidase alfa is a chimeric fusion protein comprised of recombinant human NAGLU and a modified human …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
MEDI3506
Tozorakimab (MEDI3506), developed by AstraZeneca, was investigated in multiple clinical trials to evaluate its safety, tolerability, efficacy, and pharmacokinetics across various conditions. These trials include NCT03096795 (completed; healthy participants, COPD patients, and healthy Japanese participants), NCT05070312 (completed; healthy Chinese participants), NCT04212169 (completed with results; atopic dermatitis), NCT04631016 (completed; COPD and...
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human interleukin 33) (human monoclonal MEDI3506 γ1-chain), disulfide with human …
Matched Description: … AstraZeneca, was investigated in multiple clinical trials to evaluate its safety, tolerability, efficacy, and ... These trials include NCT03096795 (completed; healthy participants, COPD patients, and healthy Japanese ... participants), NCT04212169 (completed with results; atopic dermatitis), NCT04631016 (completed; COPD and …
Matched Description: … AstraZeneca, was investigated in multiple clinical trials to evaluate its safety, tolerability, efficacy, and ... These trials include NCT03096795 (completed; healthy participants, COPD patients, and healthy Japanese ... participants), NCT04212169 (completed with results; atopic dermatitis), NCT04631016 (completed; COPD and …
Tisotumab vedotin
Tisotumab vedotin is a tissue factor-directed antibody-drug conjugate (ADC) comprised of an anti-tissue factor (TF) human IgG1-kappa antibody conjugated to monomethyl auristatin E (MMAE), a microtubule-disrupting agent, via a protease-cleavable valine-citrulline linker. Each monoclonal antibody molecule carries an average of four MMAE molecules. Tisotumab vedotin is the first TF-directed ADC...
Approved
Matched Synonyms: … HuMax-TF-ADC …
Matched Description: … vedotin is a tissue factor-directed antibody-drug conjugate (ADC) comprised of an anti-tissue factor (TF) human ... head and neck cancers. ... tumor-associated angiogenesis, progression, and metastasis for tumor survival. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Monoclonal antibodies and antibody drug conjugates …
Matched Description: … vedotin is a tissue factor-directed antibody-drug conjugate (ADC) comprised of an anti-tissue factor (TF) human ... head and neck cancers. ... tumor-associated angiogenesis, progression, and metastasis for tumor survival. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Monoclonal antibodies and antibody drug conjugates …
AMT-130
Investigational
Matched Synonyms: … Adeno-associated viral vector serotype 5 encoding a microRNA targeted to human Huntingtin gene …
CypCaps
Investigational
Matched Synonyms: … Cytochrome P450 isoform 2B1 gene transfected human embryonic kidney 293 cells encapsulated in polymeric …
Anvatabart opadotin
Investigational
Matched Synonyms: … Immunoglobulin G1 [121-(4-acetylphenylalanine),de-450-lysine], anti-(human epidermal growth factor receptor ... HER2) (human-Mus musculus monoclonal Amab788 γ1-chain), disulfide with human-Mus musculus monoclonal …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Botaretigene sparoparvovec
Investigational
Matched Synonyms: … DNA (RECOMBINANT PSEUDOTYPED ADENO-ASSOCIATED VIRUS 5 VECTOR AAV-RPGR HUMAN RHODOPSIN KINASE PROMOTER ... FRAGMENT-REGULATED HUMAN RETINITIS PIGMENTOSA GTPASE REGULATOR RPGR-ORF15 ISOFORM GENE VARIANT PLUS …
Rozibafusp Alfa
Rozibafusp Alfa is under investigation in clinical trial NCT04058028 (Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)).
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G2-KAPPA, ANTI-(HUMAN INDUCIBLE COSTIMULATOR (ICOS) LIGAND PROTEIN) HUMAN MONOCLONAL ANTIBODY …
Matched Description: … Rozibafusp Alfa is under investigation in clinical trial NCT04058028 (Efficacy and Safety of AMG 570 …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Rozibafusp Alfa is under investigation in clinical trial NCT04058028 (Efficacy and Safety of AMG 570 …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Pegvorhyaluronidase alfa
Pegvorhyaluronidase alfa is under investigation in clinical trial NCT02241187 (Two Stage Study Of Single Dose PEGPH20 And Cetuximab In Patients With Pancreatic Adenocarcinoma Prior To Surgical Resection).
Investigational
Matched Synonyms: … PEGylated recombinant human hyaluronidase PH20 ... -METHOXY-, AMIDE WITH HYALURONOGLUCOSAMINIDASE (HUMAN ISOENZYME PH20) ... HUMAN HYALURONIDASE PH-20 (HYALURONOGLUCOSAMINIDASE PH-20, SPERM ADHESION MOLECULE 1, EC 3.2.1.35) PRECURSOR …
Matched Description: … Pegvorhyaluronidase alfa is under investigation in clinical trial NCT02241187 (Two Stage Study Of Single Dose PEGPH20 And …
Matched Categories: … Enzymes and Coenzymes …
Matched Description: … Pegvorhyaluronidase alfa is under investigation in clinical trial NCT02241187 (Two Stage Study Of Single Dose PEGPH20 And …
Matched Categories: … Enzymes and Coenzymes …
Obexelimab
Obexelimab is under investigation in clinical trial NCT02725515 (A Study of the Effect of XmAb®5871 in Patients With Systemic Lupus Erythematosus).
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human CD19 antigen) (human-mus musculus monoclonal XMAB5871 heavy chain), disulfide ... with human-mus musculus monoclonal XMAB5871 light chain, dimer …
Donanemab
Donanemab is a humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against insoluble N-truncated pyroglutamate amyloid beta (Aβ), which is found in the brain amyloid plaques that contribute to the pathophysiology of Alzheimer's Disease (AD). On July 2, 2024, donanemab was approved by the FDA for the treatment of AD...
Approved
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human pyroglutamyl Aβ (3-x) peptide)(human clone LY3002813 γ1-chain), disulfide ... with human clone LY3002813 κ-chain, dimer …
Matched Description: … [L50988] It works to reduce amyloid beta plaques and impede the progression of AD.[L50988] …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … [L50988] It works to reduce amyloid beta plaques and impede the progression of AD.[L50988] …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Dental Mesenchymal Pulp Stem Cells
Dental pulp is a soft, connective tissue present in the dental crown of both third molar and first premolar teeth. Dental pulp stem cells (DPSCs) exhibit fibro-blast like plasticity and adherent properties. They are harvested through surgical extraction of wisdom teeth from adults; this procedure is favoured as it is...
Investigational
Matched Synonyms: … Allogenic Human Dental Pulp Stem Cells …
Matched Description: … DPSCs can remain stable in media once extracted, and have a high proliferation and regeneration capacity ... DPSCs have multiple properties, and express surface antigens like CD90, CD29, and CD105 but not CD14 ... Dental pulp stem cells (DPSCs) exhibit fibro-blast like plasticity and adherent properties. …
Matched Description: … DPSCs can remain stable in media once extracted, and have a high proliferation and regeneration capacity ... DPSCs have multiple properties, and express surface antigens like CD90, CD29, and CD105 but not CD14 ... Dental pulp stem cells (DPSCs) exhibit fibro-blast like plasticity and adherent properties. …
TOL-101
Investigational
Matched Synonyms: … Murine IgM monoclonal antibody specific for the human alpha, beta T cell receptor …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
RGX-121
RGX-121 is designed to use the NAV AAV9 vector to deliver the human iduronate-2-sulfatase gene to the central nervous system.
Investigational
Matched Synonyms: … Non-replicating recombinant adeno-associated virus (AAV) vector of serotype 9 expressing human iduronate …
Matched Description: … RGX-121 is designed to use the NAV AAV9 vector to deliver the human iduronate-2-sulfatase gene to the …
Matched Description: … RGX-121 is designed to use the NAV AAV9 vector to deliver the human iduronate-2-sulfatase gene to the …
Rozrolimupab
Rozrolimupab is a recombinant polyclonal antibody consisting of 25 different anti-Rhesus D (RhD) antibodies to replace existing anti-RhD hyperimmune immunoglobulins for the treatment of Idiopathic Thrombocytopenic Purpura (ITP) and the prevention of Hemolytic Disease of Newborns (HDN).
Investigational
Matched Synonyms: … Recombinant human antigen-specific polyclonal antibody (pAb) against RhD antigen expressed in Chinese …
Matched Description: … anti-RhD hyperimmune immunoglobulins for the treatment of Idiopathic Thrombocytopenic Purpura (ITP) and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … anti-RhD hyperimmune immunoglobulins for the treatment of Idiopathic Thrombocytopenic Purpura (ITP) and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
AAV-AIPL
AAV-AIPL is an adenovirus-associated viral vector serotype 8 containing the human AIPL1 gene. Developed by MeiraGTx, it is being investigated for the treatment of inherited retinal dystrophy due to defects in AIPL1 gene.
Investigational
Matched Synonyms: … adenovirus associated viral vector serotype 8 containing the human AIPL1 gene …
Matched Description: … AAV-AIPL is an adenovirus-associated viral vector serotype 8 containing the human _AIPL1_ gene. …
Matched Description: … AAV-AIPL is an adenovirus-associated viral vector serotype 8 containing the human _AIPL1_ gene. …
PTR-01
Investigational
Matched Synonyms: … Recombinant human collagen alpha-1 (VII) chain homo-trimer (rC7) …
Displaying drugs 926 - 950 of 1099 in total