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Displaying drugs 1026 - 1050 of 15720 in total

Vilazodone

Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. Vilazodone may also be associated with less sexual dysfunction and weight gain . Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Approved
Matched Description: … (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. ... Vilazodone may also be associated with less sexual dysfunction and weight gain[A6947]. ... Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine …
Matched Categories: … Serotonin antagonist and reuptake inhibitors (SARIs) …

Micronomicin

Micronomicin is an aminoglycoside antibiotic which is marketed in Japan, and sold under the brand names Sagamicin and Luxomicina.
Approved
Matched Iupac: … ]oxy}-2-hydroxycyclohexyl]oxy}-5-methyl-4-(methylamino)oxane-3,5-diol ... (2R,3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,6S)-3-amino-6-[(methylamino)methyl]oxan-2-yl …
Matched Description: … Sagamicin and Luxomicina. ... Micronomicin is an aminoglycoside antibiotic which is marketed in Japan, and sold under the brand names …

Human thrombin

Human thrombin is a sterile solution, pH 6.8-7.2, containing highly purified human thrombin for the activation of clotting. Thrombin is a highly specific serine protease encoded by the F2 gene that transforms soluble fibrinogen into insoluble fibrin. This transformation mimics the final coagulation cascade step which involves the clotting mass...
Approved
Matched Description: … achieves hemostasis and sealing of open tissues. ... the final coagulation cascade step which involves the clotting mass that adheres to the wound surface and …

Ramelteon

Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse.
Approved
Investigational
Matched Description: … Ramelteon has not been shown to produce dependence and has shown no potential for abuse. …
Matched Categories: … Hypnotics and Sedatives …

Disulfiram

A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms...
Approved
Matched Description: … increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and …
Matched Categories: … Scabicides, Insecticides and Repellents ... Antiparasitic Products, Insecticides and Repellents …

Sotagliflozin

Sotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind, which is approved for use in the EU, in combination with insulin, to improve glycemic control in patients with type 1 diabetes mellitus (T1DM) and a BMI ≥27 kg/m2. Its potency in inhibiting SGLT2 is similar...
Approved
Investigational
Matched Iupac: … (2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(methylsulfanyl)oxane-3,4,5-triol …
Matched Description: … Sotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind,[A244499] which is approved ... combination with insulin, to improve glycemic control in patients with type 1 diabetes mellitus (T1DM) and ... Its potency in inhibiting SGLT2 is similar to that of other SGLT2 inhibitors, such as [canagliflozin] and …
Matched Categories: … Alimentary Tract and Metabolism …

Ipecac

Ipecac is obtained from the plant Cephaelis ipecacuanha and contains a number of emetic alkaloids including emetine and cephaeline. Ipecac was approved by Health Canada as an OTC but all those products are now discontinued. The FDA does not have currently any approved product containing ipecac, however, ipecac as an...
Approved
Withdrawn
Matched Description: … emetine and cephaeline. ... Ipecac is obtained from the plant _Cephaelis ipecacuanha_ and contains a number of emetic alkaloids including …
Matched Categories: … Cough and Cold Preparations …

Propiomazine

Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds...
Approved
Matched Description: … H1, muscarinic, and serotonin type 2 (5-HT2) receptors. ... Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of ... schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. …
Matched Categories: … Hypnotics and Sedatives …

Bisphenol A diglycidyl ether

Approved
Experimental
Matched Iupac: … 2-{[4-(2-{4-[(oxiran-2-yl)methoxy]phenyl}propan-2-yl)phenoxy]methyl}oxirane …

Polyquaternium-10 (400 cps at 2%)

Polyquaternium-10 is a quaternized hydroxyethyl cellulose and a polycationic polymer. It is commonly found in cosmetics and personal care products to mainly reduce static electricity and form films.
Approved
Matched Description: … It is commonly found in cosmetics and personal care products to mainly reduce static electricity and ... Polyquaternium-10 is a quaternized hydroxyethyl cellulose and a polycationic polymer. …

Tecovirimat

The World Health Organization declared smallpox, a contagious and sometimes fatal infectious disease, eradicated in 1980. However, there have been longstanding concerns that smallpox may be used as a bioweapon.[A35133,L3614] Tecovirimat is an antiviral drug that was identified via a high-throughput screen in 2002. It is effective against all orthopoxviruses,...
Approved
Investigational
Matched Description: … to treat monkeypox and cowpox in adults and children. ... [L40154] Tecovirimat is available as both oral and intravenous formulations.[L41835] ... The World Health Organization declared smallpox, a contagious and sometimes fatal infectious disease, …

Ethyl macadamiate

Ethyl macadamiate is derived from Macadamia terifolia seed oil. It is a non-volatile ester of ethyl alcohol and the fatty acids. Ethyl macadamiate is used in cosmetics and personal care products such as sunscreen, hair care products and skin care products as an emollient and skin conditioning agent.
Approved
Matched Description: … and skin care products as an emollient and skin conditioning agent. ... It is a non-volatile ester of ethyl alcohol and the fatty acids. ... Ethyl macadamiate is used in cosmetics and personal care products such as sunscreen, hair care products …

Sodium zirconium cyclosilicate

Sodium zirconium cyclosilicate is approved as the trade product Lokelma developed by AstraZeneca - an insoluble, non-absorbed sodium zirconium silicate, formulated as a powder for oral suspension that acts as a highly selective potassium removing agent. It is administered orally and is odorless, tasteless, and stable at room temperature. Approval...
Approved
Investigational
Matched Description: … [L2933] It is administered orally and is odorless, tasteless, and stable at room temperature. ... Approval of the medication is supported by data from three double-blind, placebo-controlled trials and ... two open-label trials which showed that the onset of action was approximately 1.0 hour and the median …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …

Pentastarch

Pentastarch is an artificial colloid (hydroxyethyl starch derivative). Pentastarch is characterized by presenting five hydroxyethyl groups, which signifies an approximate 50% hydroxyethylation. It is sold under the name Pentaspan by Bristol-Myers Squibb and is used for fluid resuscitation. When administered, pentastarch remains mainly in the circulatory system and hence, it...
Approved
Investigational
Matched Description: … It is sold under the name Pentaspan by Bristol-Myers Squibb and is used for fluid resuscitation. ... When administered, pentastarch remains mainly in the circulatory system and hence, it is considered a …

Thalidomide

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha...
Approved
Investigational
Withdrawn
Matched Description: … It has been reintroduced and used for a number of inflammatory disorders and cancers. ... inflammatory mediators like tumor necrosis factor-alpha (TNF-a) and other cytokine action. ... Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Tannic acid

Tannic acid is a polyphenolic compound. It is a type of the commercially available tannins. It acts as a weak acid. Tannic acid is found in the nutgalls formed by insects on twigs of certain oak trees (Quercus infectoria and other Quercus species). It is removed and used as medicine....
Approved
Matched Iupac: … -(3,4,5-trihydroxybenzoyloxy)benzoyloxy]-2-{[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyloxy)benzoyloxy]methyl …
Matched Description: … It is removed and used as medicine. ... urine, painful joints, persistent coughs, and cancer. ... Tannic acid is found in the nutgalls formed by insects on twigs of certain oak trees (Quercus infectoria and …

Lomitapide

Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).
Approved
Investigational

Ethylhexyl methoxycrylene

Ethylhexyl methoxycrylene is a photostabilizer that preserves the effectiveness of UV filters by interacting with both the singlet and triplet states . It returns UV filters to their ground states without absorbing sunlight . It is used as a solvent for crystalline UV filters and is easily emulsified and suitable...
Approved
Experimental
Matched Description: … It is used as a solvent for crystalline UV filters and is easily emulsified and suitable for use in various ... lotions, creams, sprays, sticks, and gel formulations [F104]. ... It currently enjoys regional approvals in Canada, the EU, and the US [L2847]. …

Imiquimod

Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. Imiquimod does not cure warts, and new warts may appear during treatment. Imiquimod does not fight the viruses that...
Approved
Investigational
Matched Description: … Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain ... Imiquimod does not cure warts, and new warts may appear during treatment. ... Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. …
Matched Categories: … Skin and Mucous Membrane Agents …

Bepotastine

Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor. Bepotastine was approved in Japan for use in the treatment of allergic rhinitis and uriticaria/puritus in July 2000 and January 2002, respectively, and is marketed by Tanabe Seiyaku Co., Ltd. under the brand name Talion. It is available...
Approved
Matched Description: … in July 2000 and January 2002, respectively, and is marketed by Tanabe Seiyaku Co., Ltd. under the brand ... It is available in oral and opthalmic dosage forms in Japan. ... The opthalmic solution is FDA approved since Sept 8, 2009 and is under the brand name Bepreve. …

Samarium (153Sm) lexidronam

Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium...
Approved
Investigational
Matched Iupac: … hydrogen {[(hydrogen phosphonomethyl)({2-[(hydrogen phosphonomethyl)(phosphonomethyl)amino]ethyl})amino]methyl …
Matched Description: … The radioactive samarium is taken up in the bone cancer area and gives off radiation that helps provide …

Pizotifen

Pizotifen belongs to the class of antamines and is related to cyproheptadine. It is a potent serotonin and tryptamine antagonist that has been used for migraine prevention for many years. It exhibits weak anticholinergic, antihistamine, and antikinin actions in addition to sedative and appetite-stimulating properties . Some patients receiving pizotifen...
Approved
Matched Iupac: … 1-methyl-4-{6-thiatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3(7),4,10,12-pentaen-2-ylidene}piperidine …
Matched Description: … It exhibits weak anticholinergic, antihistamine, and antikinin actions in addition to sedative and appetite-stimulating ... Pizotifen belongs to the class of antamines and is related to [cyproheptadine]. ... [A32532] It is a potent serotonin and tryptamine antagonist that has been used for migraine prevention …

Hydroxypropyl cellulose

Hydroxypropyl cellulose is an ether of cellulose where some of the hydroxyl groups of the cellulose have been hydroxypropylated forming -OCH2CH(OH)CH3 groups. Lacrisertis a formulation of hydroxypropyl cellulose that is used for artificial tears. It is used to treat syndromes characterized by insufficient tear production (keratoconjunctivitis sicca), recurrent corneal erosions,...
Approved
Matched Description: … neuroparalytic keratitis, and as a lubricant for artificial eyes. ... As a food additive, hydroxypropyl cellulose is used as a thickener and as an emulsion stabilizer. ... production (keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and …

Imipramine

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, imipramine exerts...
Approved
Matched Description: … and clomipramine. ... than secondary amine TCAs, such as nortriptyline and desipramine. ... TCAs are potent inhibitors of serotonin and norepinephrine reuptake. …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …

Ethotoin

Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent the spread...
Approved
Matched Description: … Ethotoin is a hydantoin derivative and anticonvulsant. ... The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to prevent …
Displaying drugs 1026 - 1050 of 15720 in total