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Displaying drugs 1701 - 1725 of 15121 in total

Chlorpheniramine

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.
Approved
Matched Description: … A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. ... One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and …
Matched Mixtures name: … Top Value Effervescent Cold Relief ... Acetaminophen, Ascorbic acid, Chlorpheniramine Maleate ... Top Value Effervescent Cold Relief - Orange …

Triheptanoin

Triheptanoin is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid oxidation. In clinical trials, patients with long chain fatty acid oxidation disorders (lc-FAODs) treated with triheptanoin are less likely to develop hypoglycemia, cardiomyopathy, rhabdomyolysis, and hepatomegaly.[A214812,A214817] Complications in lc-FAOD patients...
Approved
Investigational
Matched Description: … with triheptanoin are less likely to develop hypoglycemia, cardiomyopathy, rhabdomyolysis, and hepatomegaly ... source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid ... [L14612] In clinical trials, patients with long chain fatty acid oxidation disorders (lc-FAODs) treated …
Matched Categories: … Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …

Thymol

A phenol obtained from thyme oil or other volatile oils. It is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a vermifuge. (Dorland, 28th ed)
Approved
Matched Description: … It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as …
Matched Mixtures name: … Salonpas - Pls Top ... Royal Mouthwash Fresh and Clean Original Mint ... Neo Medicated Plaster with Ginger and Lemongrass Oil Aroma …

Methantheline

Methantheline is a synthetic antispasmodic. Antispasmodics are used to relieve cramps or spasms of the stomach, intestines, and bladder. Methantheline is used to treat intestine or stomach ulcers (peptic ulcer disease), intestine problems (irritable bowel syndrome), pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, or urinary problems (reflex neurogenic bladder in children).
Approved
Investigational
Matched Description: … Antispasmodics are used to relieve cramps or spasms of the stomach, intestines, and bladder. …
Matched Categories: … Alimentary Tract and Metabolism ... Acid Reducers ... Gastric Acid Lowering Agents …

Cefiderocol

Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam antibiotics.[FDA Label] Unlike other agents in this category, cefiderocol is a siderophore able to undergo active transport into the bacterial cell through iron channels. It represents a significant addition to antibacterial treatment option as...
Approved
Investigational
Matched Description: … Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam ... Cefiderocol was granted designation as a Qualified Infectious Disease Product and granted priority review ... effective *in vitro* against multidrug resistant strains including extended spectrum β-lactamase producers and …

Rutin

A flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc. It has been used therapeutically to decrease capillary fragility.
Approved
Experimental
Investigational
Matched Mixtures name: … KORDEL`S C TIME ACID FREE C 1000MG TABLET …

Homatropine methylbromide

Homatropine methylbromide is a quaternary ammonium muscarinic acetylcholine receptor antagonist belonging to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be...
Approved
Matched Description: … It may also be used to prevent nausea, vomiting, and motion sickness. …
Matched Mixtures name: … Hydrocodone Bitartrate and Homatropine Methylbromide ... Hydrocodone Bitartrate and Homatropine Methylbromide ... Hydrocodone Bitartrate and Homatropine Methylbromide …
Matched Categories: … Alimentary Tract and Metabolism ... Belladonna and Derivatives, Plain ... homatropine methylbromide and psycholeptics …

Sodium tetradecyl sulfate

An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.
Approved
Investigational
Matched Description: … irritant and sclerosing agent for hemorrhoids and varicose veins. ... An anionic surface-active agent used for its wetting properties in industry and used in medicine as an …

Agomelatine

Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. Agomelatine was developed in Europe by Servier Laboratories Ltd. and submitted to the European Medicines Agency (EMA) in 2005. The Committee...
Approved
Investigational
Matched Description: … Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors ... Agomelatine was developed in Europe by Servier Laboratories Ltd. and submitted to the European Medicines …

Lapyrium

Lapyrium is a quaternary ammonium cation used as a surfactant, antistatic agent, and biocide in various cosmetic products . It is commonly found formulated as lapyrium chloride.
Approved
Matched Description: … Lapyrium is a quaternary ammonium cation used as a surfactant, antistatic agent, and biocide in various …

Givinostat

Givinostat is a small molecule histone deacetylase (HDAC) inhibitor. It has been investigated as a treatment for a variety of inflammatory diseases, like Crohn's disease and juvenile idiopathic arthritis, cancers like leukemia and lymphoma, as well as several muscular dystrophies. In the context of muscular dystrophy, inhibitors of HDAC appear...
Approved
Investigational
Matched Description: … It has been investigated as a treatment for a variety of inflammatory diseases, like Crohn's disease and ... appear to exert their therapeutic effects by targeting pathogenic processes that cause inflammation and ... juvenile idiopathic arthritis, cancers like leukemia and lymphoma, as well as several muscular dystrophies …

Nedaplatin

Nedaplatin is a second generation platinum analog . It is less nephrotoxic than DB00515 but has proven equally effective. It was approved for use in Japan in 1995.
Approved
Investigational

Ivermectin

Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of Streptomyces avermitilis. Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A1a (22,23-dihydroavermectin B1a) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A1a (22,23-dihydroavermectin B1b). Ivermectin is mainly used in...
Approved
Investigational
Vet approved
Matched Description: … use for the prophylaxis and treatment of COVID-19. ... roughly 90% 5-O-demethyl-22,23-dihydroavermectin A1a (22,23-dihydroavermectin B1a) and ... still ongoing, much of the evidence for ivermectin in COVID-19 relies on pre-print _in vitro_ data, and …
Matched Categories: … Scabicides and Pediculicides ... Antiparasitic Products, Insecticides and Repellents …
Matched Products: … IVOMEC Injection 1% w/v for Cattle and Sheep …

Coagulation Factor IX Human

Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B.
Approved
Matched Mixtures name: … OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU ... Octaplex Powder and Solvent for Solution for Infusion …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins ... coagulation factor IX, II, VII and X in combination …
Matched Products: … IMMUNINE 120IU/ML Powder and solvent for solution for injection or infusion …

Sebelipase alfa

The lysosomal acid lipase (LAL) enzyme is found in lysosomes and is primarily responsible for the metabolism of lipids, and its absence or deficiency results in the accumulation of lipids in various organs. This lipid accumulation can lead to end-organ damage in the form of liver dysfunction or malabsorption secondary...
Approved
Investigational
Matched Description: … The lysosomal acid lipase (LAL) enzyme is found in lysosomes and is primarily responsible for the metabolism ... It was first approved by both the FDA and EMA in 2015 and is marketed under the brand name Kanuma (Alexion ... of lipids, and its absence or deficiency results in the accumulation of lipids in various organs. …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …

Olipudase alfa

Olipudase alfa is recombinant human acid sphingomyelinase. It is the first and only enzyme replacement therapy in the world for the treatment of Acid Sphingomyelinase Deficiency (ASMD), also known as Niemann–Pick disease. ASMD is a rare lysosomal storage disease caused by mutations in the SMPD1 gene, leading to a deficiency...
Approved
Investigational
Matched Description: … [A251590] It is the first and only enzyme replacement therapy in the world for the treatment of Acid ... Olipudase alfa is recombinant human acid sphingomyelinase. ... a rare lysosomal storage disease caused by mutations in the SMPD1 gene, leading to a deficiency in acid …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Phenelzine

Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name of Nardil.
Approved
Matched Description: … [A15753] It was developed by Parke Davis and originally FDA approved on June 9th, 1961. ... a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and …

Eladocagene exuparvovec

Eladocagene exuparvovec is a recombinant adeno-associated virus-2 (AAV2)-based gene therapy that expresses human aromatic L-amino acid decarboxylase (AADC), and it is used to treat AADC deficiency, a fatal and rare genetic disorder that causes severe disability in pediatric patients.[L43642,L43672] Patients with AADC have mutations in the dopa decarboxylase (DDC) gene...
Approved
Investigational
Matched Description: … recombinant adeno-associated virus-2 (AAV2)-based gene therapy that expresses human aromatic L-amino acid ... decarboxylase (AADC), and it is used to treat AADC deficiency, a fatal and rare genetic disorder that ... neurotransmitter production, decrease neurotransmitter catabolism via monoamine oxidase (MAO) inhibition and …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …

Dipyridamole

A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
Approved
Matched Description: … A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular …
Matched Mixtures name: … Aspirin and Dipyridamole ... Aspirin and Dipyridamole ... Aspirin and Dipyridamole …
Matched Categories: … Blood and Blood Forming Organs …

Pemetrexed

Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta. It is indicated for use in combination with cisplatin for the treatment of patients with malignant pleural mesothelioma whose disease is either unresectable or who are otherwise not candidates for...
Approved
Investigational
Matched Iupac: … )-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid …
Matched Description: … Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Folic Acid Analogues ... Folic Acid Antagonists ... Nucleic Acid Synthesis Inhibitors …

Dexlansoprazole

Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of DB00448, which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generation of PPIs (which includes...
Approved
Investigational
Matched Description: … [A19566, A19568, A178084, A174244] Dexlansoprazole inhibits the final step in gastric acid production ... Dexlansoprazole is the R-enantiomer of [DB00448], which is composed of a racemic mixture of the R- and ... Compared to the older generation of PPIs (which includes [DB00213], [DB00338], and [DB00448]),[A178084 …
Matched Categories: … Alimentary Tract and Metabolism ... Acid Reducers ... Gastric Acid Lowering Agents ... Drugs for Acid Related Disorders ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …

Pegloticase

Pegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in adult patients that do not respond to other types of therapies. Pegloticase has a similar activity to rasburicase, an enzyme that metabolizes uric acid to allantoin. In gout patients treated with pegloticase, the conversion of...
Approved
Investigational
Matched Description: … uric acid concentrations. ... of pegloticase and methotrexate. ... In gout patients treated with pegloticase, the conversion of uric acid to allantoin leads to lower plasma …
Matched Categories: … Enzymes and Coenzymes ... Uric Acid-specific Enzyme …

Fluorouracil

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Approved
Matched Description: … to thymidylic acid. ... It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... Fluorouracil and prodrugs ... Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …

Magnesium sulfate

A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual,...
Approved
Investigational
Vet approved
Matched Description: … Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. ... treatment of pre-eclampsia and eclampsia. ... A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the …
Matched Mixtures name: … Sodium Sulfate, Potassium Sulfate and Magnesium Sulfate ... Sodium Sulfate, Potassium Sulfate and Magnesium Sulfate ... Sodium Sulfate, Potassium Sulfate and Magnesium Sulfate …
Matched Categories: … Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Calcium-Regulating Hormones and Agents ... Blood Substitutes and Perfusion Solutions …
Matched Products: … Spearmint and Menthol scented Natural Epsom Salt …

Inosine pranobex

Inosine pranobex (Isoprinosine or Methisoprinol) is a combination of inosine, acetamidobenzoic acid, and dimethylaminoisopropanol used as an antiviral drug.
Approved
Matched Iupac: … tris((2R)-1-(dimethylamino)propan-2-ol); tris(4-acetamidobenzoic acid); 9-[(2R,3R,4S,5R)-3,4-dihydroxy …
Matched Description: … and dimethylaminoisopropanol used as an antiviral drug. ... Inosine pranobex (Isoprinosine or Methisoprinol) is a combination of inosine, acetamidobenzoic acid, …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Displaying drugs 1701 - 1725 of 15121 in total