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Displaying drugs 151 - 175 of 13330 in total
Durlobactam
Durlobactam is a diazabicyclooctane non-beta-lactam, beta-lactamase inhibitor. It is typically given in combination with sulbactam to protect it from degradation by certain serine-beta-lactamases. The combination product of durlobactam and sulbactam was first approved by the FDA in May 2023. It is used to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial...
Approved
Investigational
Matched Synonyms: … (2S,5R)-2-CARBAMOYL-3-METHYL-7-OXO-1,6-DIAZABICYCLO(3.2.1)OCT-3-EN-6-YL SULFATE ... SULFURIC ACID, MONO((2S,5R)-2-(AMINOCARBONYL)-3-METHYL-7-OXO-1,6-DIAZABICYCLO(3.2.1)OCT-3-EN-6-YL) ESTER …
Matched Iupac: … [(1R,2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxidanesulfonic acid …
Matched Iupac: … [(1R,2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl]oxidanesulfonic acid …
Ezogabine
Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients with refractory epilepsy....
Approved
Investigational
Matched Synonyms: … Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate ... ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate ... N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester …
Matched Iupac: … ethyl N-(2-amino-4-{[(4-fluorophenyl)methyl]amino}phenyl)carbamate …
Matched Description: … being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 …
Matched Iupac: … ethyl N-(2-amino-4-{[(4-fluorophenyl)methyl]amino}phenyl)carbamate …
Matched Description: … being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 …
Cefoxitin
Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. It is derived from cephamycin C, which is produced by Streptomyces lactamdurans.
Approved
Matched Synonyms: … (6R,7S)-4-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(thiophen-2-enyl)acetamido]-5-thia-1-azabicyclo[4.2.0 ... ]oct-2-ene-2-carboxylic acid …
Matched Iupac: … (6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0 ... ]oct-2-ene-2-carboxylic acid …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … (6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0 ... ]oct-2-ene-2-carboxylic acid …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Diflunisal
Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the...
Approved
Investigational
Matched Synonyms: … 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid ... 2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid …
Matched Iupac: … 2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid …
Matched Categories: … Non COX-2 selective NSAIDS …
Matched Iupac: … 2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid …
Matched Categories: … Non COX-2 selective NSAIDS …
Ethionamide
A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Approved
Matched Synonyms: … 2-ethyl-4-thiopyridylamide ... 2-ethylthioisonicotinamide …
Matched Iupac: … 2-ethylpyridine-4-carbothioamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 2-ethylpyridine-4-carbothioamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Cinnamyl alcohol
Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. Due to the low levels found in cinnamon, cinnamyl alcohol is usually supplied as DB14184 within commercial products.
Cinnamyl alcohol has been shown to be a skin sensitizer, with a NOEL (No Effect Level) of ~4% . Sensitivity...
Approved
Experimental
Matched Synonyms: … (2E)-3-phenylprop-2-en-1-ol …
Matched Iupac: … (2E)-3-phenylprop-2-en-1-ol …
Matched Iupac: … (2E)-3-phenylprop-2-en-1-ol …
Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of...
Approved
Illicit
Matched Synonyms: … methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate ... [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester ... 2-methyl-3β-hydroxy-1αH,5αH-tropane-2β-carboxylate benzoate (ester) …
Matched Iupac: … methyl (1R,2R,3S,5S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate …
Matched Iupac: … methyl (1R,2R,3S,5S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate …
Carbenicillin
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
Approved
Investigational
Matched Synonyms: … N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-2-phenylmalonamic acid ... (2S,5R,6R)-6-{[carboxy(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic …
Matched Iupac: … (2S,5R,6R)-6-(2-carboxy-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … (2S,5R,6R)-6-(2-carboxy-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
L-Lactic acid
Approved
Experimental
Matched Synonyms: … (S)-2-hydroxypropanoic acid ... (S)-2-hydroxypropionic acid …
Matched Iupac: … (2S)-2-hydroxypropanoic acid …
Matched Mixtures name: … Prismasol 2 …
Matched Iupac: … (2S)-2-hydroxypropanoic acid …
Matched Mixtures name: … Prismasol 2 …
Paromomycin
An oligosaccharide antibiotic produced by various streptomyces. [PubChem]
Approved
Investigational
Matched Synonyms: … ]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside ... (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl …
Matched Iupac: … -6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl ... (2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino ... ]oxy}-2-(hydroxymethyl)oxane-3,4-diol …
Matched Products: … GABROSIDIN 0.5 G ENJEKTABL FLAKON, 1 ADET …
Matched Iupac: … -6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl ... (2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino ... ]oxy}-2-(hydroxymethyl)oxane-3,4-diol …
Matched Products: … GABROSIDIN 0.5 G ENJEKTABL FLAKON, 1 ADET …
Chlorphenesin carbamate
Approved
Vet approved
Withdrawn
Matched Synonyms: … 3-(p-chlorophenoxy)-2-hydroxypropyl carbamate ... carbamic acid 3-(p-chlorophenoxy)-2-hydroxypropyl ester ... 1,2-propanediol-3-(p-chlorophenoxy)-1-carbamate …
Matched Iupac: … 3-(4-chlorophenoxy)-2-hydroxypropyl carbamate …
Matched Iupac: … 3-(4-chlorophenoxy)-2-hydroxypropyl carbamate …
Almotriptan
Almotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that...
Approved
Investigational
Matched Synonyms: … 1-(((3-(2-(Dimethylamino)ethyl)indol-5-yl)methyl)sulfonyl)pyrrolidine …
Matched Iupac: … dimethyl(2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}ethyl)amine …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … dimethyl(2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}ethyl)amine …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Omaveloxolone
Omaveloxolone (RTA-408) is a semisynthetic oleanane triterpenoid with antioxidant and anti-inflammatory properties.[A257534,A257539] Omaveloxolone acts as an activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor that mitigates oxidative stress. In patients with Friedreich's ataxia, a genetic disease involving mitochondrial dysfunction, the Nrf2 pathway is impaired, and Nrf2 activity...
Approved
Investigational
Matched Synonyms: … Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro- …
Matched Description: … [A257534,A257539] Omaveloxolone acts as an activator of nuclear factor (erythroid-derived 2)-like 2 ( …
Matched Description: … [A257534,A257539] Omaveloxolone acts as an activator of nuclear factor (erythroid-derived 2)-like 2 ( …
Cinoxate
Approved
Matched Synonyms: … 2-Ethoxyethyl-p-methoxycinnamate …
Matched Iupac: … 2-ethoxyethyl (2E)-3-(4-methoxyphenyl)prop-2-enoate …
Matched Iupac: … 2-ethoxyethyl (2E)-3-(4-methoxyphenyl)prop-2-enoate …
Nifedipine
Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to nicardipine.[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development, second and third generation dihydropyridines have been developed with slower onsets and longer...
Approved
Matched Synonyms: … 4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsäuredimethylester …
Matched Iupac: … 3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Carboxin
A systemic agricultural fungicide and seed treatment agent.
Approved
Experimental
Matched Synonyms: … 5,6-Dihydro-2-methyl-1,4-oxathiin-3-carboxanilide ... 5,6-Dihydro-2-methyl-3-carboxanilido-1,4-oxathiin ... 5,6-Dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide …
Matched Iupac: … 2-methyl-N-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 2-methyl-N-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Dexibuprofen
Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID). It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties. It is proposed to be more pharmacologically active and tolerable with a better safety profile than ibuprofen due to higher concentration of active S enantiomer. Dexibuprofen has a...
Approved
Investigational
Matched Synonyms: … (2S)-2-(4-isobutylphenyl)propanoic acid ... (S)-α-methyl-4-(2-methylpropyl)benzeneacetic acid …
Matched Iupac: … (2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid …
Matched Categories: … Non COX-2 selective NSAIDS …
Matched Products: … EXER® 1% SUSPENSION …
Matched Iupac: … (2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid …
Matched Categories: … Non COX-2 selective NSAIDS …
Matched Products: … EXER® 1% SUSPENSION …
Citric acid
A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium-chelating ability.
Citric acid is one of the active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA...
Approved
Nutraceutical
Vet approved
Matched Synonyms: … 3-carboxy-3-hydroxypentane-1,5-dioic acid ... 2-Hydroxytricarballylic acid ... 2-hydroxy-1,2,3-propanetricarboxyic acid …
Matched Iupac: … 2-hydroxypropane-1,2,3-tricarboxylic acid …
Matched Salts cas: … 5949-29-1 …
Matched Mixtures name: … Cytra-2 ... Cytra-2 ... Virtrate-2 …
Matched Iupac: … 2-hydroxypropane-1,2,3-tricarboxylic acid …
Matched Salts cas: … 5949-29-1 …
Matched Mixtures name: … Cytra-2 ... Cytra-2 ... Virtrate-2 …
Ciclopirox
Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. In particular, the agent is especially effective in treating Tinea versicolor.
Approved
Investigational
Matched Synonyms: … 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone …
Matched Iupac: … 6-cyclohexyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one …
Matched Salts cas: … 41621-49-2 …
Matched Mixtures name: … Ciclopirox Olamine 1% / Salicylic Acid 2% ... Ciclopirox 0.77% / Salicylic Acid 2% ... Ciclopirox 3% / Itraconazole 5% / Urea 20% …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Products: … Ciclopirox 3% ... NIBULEN 80 MG/G TIRNAK CILASI SETİ, 3 G ... SİROKSİL 80 MG/G TIRNAK CİLASI SETİ, 3 G …
Matched Iupac: … 6-cyclohexyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one …
Matched Salts cas: … 41621-49-2 …
Matched Mixtures name: … Ciclopirox Olamine 1% / Salicylic Acid 2% ... Ciclopirox 0.77% / Salicylic Acid 2% ... Ciclopirox 3% / Itraconazole 5% / Urea 20% …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Products: … Ciclopirox 3% ... NIBULEN 80 MG/G TIRNAK CILASI SETİ, 3 G ... SİROKSİL 80 MG/G TIRNAK CİLASI SETİ, 3 G …
Milrinone
Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. Often the result of long-term myocardial ischemia, cardiomyopathy, or other cardiac insults, heart failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and metabolites, resulting in complex systemic pathologies. Heart...
Approved
Matched Synonyms: … 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile …
Matched Iupac: … 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carbonitrile …
Matched Description: … Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. …
Matched Salts cas: … 100286-97-3 …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Phosphodiesterase 3 Inhibitors …
Matched Products: … Milrinon Hikma 1 mg/ml Injektionslösung ... Milrinon Tillomed 1 mg/ml Injektions-/Infusionslösung ... Milrinon Carino 1 mg/ml Injektions- oder Infusionslösung …
Matched Iupac: … 2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carbonitrile …
Matched Description: … Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. …
Matched Salts cas: … 100286-97-3 …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Phosphodiesterase 3 Inhibitors …
Matched Products: … Milrinon Hikma 1 mg/ml Injektionslösung ... Milrinon Tillomed 1 mg/ml Injektions-/Infusionslösung ... Milrinon Carino 1 mg/ml Injektions- oder Infusionslösung …
Cefmetazole
A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.
Approved
Investigational
Matched Synonyms: … }-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ... (6R,7S)-7-({[(cyanomethyl)sulfanyl]acetyl}amino)-7-methoxy-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl …
Matched Iupac: … (6R,7S)-7-{2-[(cyanomethyl)sulfanyl]acetamido}-7-methoxy-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl ... ]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … (6R,7S)-7-{2-[(cyanomethyl)sulfanyl]acetamido}-7-methoxy-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl ... ]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Trofinetide
Trofinetide is a novel synthetic analog of glypromate, also known as glycine–proline–glutamate (GPE), a naturally occurring protein in the brain and the N-terminal tripeptide of insulin-like growth factor 1 (IGF-1). Trofinetide was approved by the FDA on March 10, 2023, for the treatment of Rett syndrome,[L45718,L45748] which is an X-linked...
Approved
Investigational
Matched Synonyms: … glycyl-L-2-methylprolyl-L-glutamic acid …
Matched Iupac: … (2S)-2-{[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidin-2-yl]formamido}pentanedioic acid …
Matched Description: … (IGF-1). ... naturally occurring protein in the brain and the N-terminal tripeptide of insulin-like growth factor 1 …
Matched Iupac: … (2S)-2-{[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidin-2-yl]formamido}pentanedioic acid …
Matched Description: … (IGF-1). ... naturally occurring protein in the brain and the N-terminal tripeptide of insulin-like growth factor 1 …
Mianserin
A tetracyclic compound with antidepressant effects. Mianserin was previously available internationally, however in most markets it has been phased out in favour of mirtazapine.
Approved
Investigational
Matched Synonyms: … 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine …
Matched Iupac: … 5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(19),8,10,12,15,17-hexaene …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Matched Iupac: … 5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(19),8,10,12,15,17-hexaene …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Betaine
Betaine is a methyl group donor that functions in the normal metabolic cycle of methionine. It is a naturally occurring choline derivative commonly ingested through diet, with a role in regulating cellular hydration and maintaining cell function.[A252235,A252240] Homocystinuria is an inherited disorder that leads to the accumulation of homocysteine in...
Approved
Investigational
Nutraceutical
Matched Synonyms: … 2-(Trimethylammonio)Acetate ... 2-trimethylammonioacetate ... 2-N,N,N-trimethylammonio acetate …
Matched Iupac: … 2-(trimethylazaniumyl)acetate …
Matched Products: … CYSTADANE® 1 G ... HOMOSİSTİNEX 1 G ORAL TOZ, 180 GRAM …
Matched Iupac: … 2-(trimethylazaniumyl)acetate …
Matched Products: … CYSTADANE® 1 G ... HOMOSİSTİNEX 1 G ORAL TOZ, 180 GRAM …
Oxymetholone
Oxymetholone is a synthetic anabolic steroid marketed under the brand name Anapolon by Hoffmann La Roche Limitedand used in the treatment of osteoporosis, anaemia, and as an agent to stimulate muscle growth in malnourished or underdeveloped patients. Anabolic-androgenic steroids (AAS), such as oxymetholone, have been abused by bodybuilders and athletes....
Approved
Illicit
Matched Synonyms: … 17β-Hydroxy-2-hydroxymethylidene-17α-methyl-3-androstanone …
Displaying drugs 151 - 175 of 13330 in total