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Displaying drugs 151 - 175 of 8039 in total

Norelgestromin

Norelgestromin is a drug used in contraception. Norelgestromin is the active progestin responsible for the progestational activity that occurs in women after application of ORTHO EVRA patch.
Approved
Investigational
Matched Description: … active progestin responsible for the progestational activity that occurs in women after application of …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Chlortetracycline

Chlortetracycline is a tetracycline antibiotic, and historically the first member of this class to be identified. It was discovered in 1945 by the scientist, Benjamin Minge Duggar, working at Lederle Laboratories under the supervision of Yellapragada Subbarow. He discovered that this antibiotic was the product of an actinomycete strain he...
Approved
Investigational
Vet approved
Matched Description: … Chlortetracycline is a _tetracycline_ antibiotic, and historically the first member of this class to ... 1945 by the scientist, Benjamin Minge Duggar, working at Lederle Laboratories under the supervision of ... He discovered that this antibiotic was the product of an actinomycete strain he cultured and obtained …
Matched Categories: … combinations of tetracyclines …

Eluxadoline

Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system and peripherally in the gastrointestinal system. Agonism of peripheral...
Approved
Investigational
Matched Description: … Agonism of peripheral mu-opioid receptors results in reduced colonic motility, while antagonism of central ... both pain and diarrhea characteristic of IBS-D. ... delta-opioid receptors results in improved analgesia, making eluxadoline usable for the symptoms of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Lasmiditan

Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. sumatriptan) have seen preferential use...
Approved
Investigational
Matched Description: … to terminate migraines through neuronal inhibition has resulted in the creation of a new class of anti-migraine ... [L43997] Traditionally, the triptan class of anti-migraine medications (e.g. ... Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Diatrizoate

A commonly used x-ray contrast medium. As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.
Approved
Vet approved
Matched Categories: … Diagnostic Uses of Chemicals …

Piperacillin

Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics.
Approved
Matched Categories: … combinations of penicillins …

Isosorbide dinitrate

A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.
Approved
Investigational
Matched Description: … A vasodilator used in the treatment of angina pectoris. ... Its actions are similar to nitroglycerin but with a slower onset of action. …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Desvenlafaxine

Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of venlafaxine. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of adults with major depressive disorder (MDD).[L6016,A261271] MDD is a highly...
Approved
Investigational
Matched Description: … Although the exact mechanism of pathophysiology is still unknown, imbalances or deficiencies of monoamines ... Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. ... have been heavily implicated, thus the rationale behind the use of SNRI to treat MDD. …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Capreomycin

Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus.
Approved
Matched Categories: … Drugs for Treatment of Tuberculosis …

Norethynodrel

A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it has usually been administered in combination with MESTRANOL.
Approved
Matched Description: … It has been used in the treatment of functional uterine bleeding and endometriosis. ... A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Inclisiran

Inclisiran is a long-acting, synthetic small interfering RNA (siRNA) directed against proprotein convertase subtilisin-kexin type 9 (PCSK9), which is a serine protease that regulates plasma low-density lipoprotein cholesterol (LDL-C) levels. By binding to PCSK9 messenger RNA, inclisiran prevents protein translation of PCSK9, leading to decreased concentrations of PCSK9 and plasma...
Approved
Investigational
Matched Description: … concentrations of PCSK9 and plasma concentrations of LDL cholesterol. ... risk of cardiovascular disease (CVD) and improving cardiovascular outcomes, as hypercholesterolemia ... By binding to PCSK9 messenger RNA, inclisiran prevents protein translation of PCSK9, leading to decreased …
Matched Categories: … Diagnostic Uses of Chemicals …

Pentazocine

The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97)
Approved
Vet approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Mercaptopurine

An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Approved
Matched Description: … inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of …
Matched Categories: … combinations of xanthines …

Brinzolamide

Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase II (CA-II) inhibitor indicated to reduce ocular pressure in patients with ocular hypertension or open-angle glaucoma. Although the exact pathophysiology of glaucoma is still unknown, one of the main hallmarks of this disease is vascular dysregulation and abnormalities.[A2049,A2051] The resulting vascular...
Approved
Matched Description: … [L35310] Although the exact pathophysiology of glaucoma is still unknown, one of the main hallmarks of ... success, systemic administration results in an increase in incidences of adverse effects. ... systemic anti-carbonic anhydrase (CA) therapy has been used for almost 50 years with varying degrees of …
Matched Categories: … combinations of sulfonamides …

Oxtriphylline

Oxtriphylline is the choline salt form of theophylline. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Its main physiological reponse is to dilate the bronchioles. As such, oxytriphylline is indicated mainly for asthma, bronchospasm, and COPD (i.e. all...
Approved
Matched Description: … Oxtriphylline is the choline salt form of [theophylline]. ... It is marketed under the name Choledyl SA, and several forms of oxytriphylline have been discontinued …
Matched Categories: … combinations of xanthines …

Danazol

A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Approved
Matched Description: … Danazol has been used in the treatment of endometriosis and some benign breast disorders. ... anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Ulipristal

Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocorticoid receptor, however compared to...
Approved
Matched Description: … (Ella) and for the treatment of uterine fibroids (Fibristal). ... Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception ... It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Levomenthol

Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. Forming clear or white waxy, crystalline substance, menthol is typically solid at room temperature. (-)-Menthol is the naturally-occurring and main form of menthol, and is assigned the (1R,2S,5R) configuration. Menthol mediates anesthetic properties and...
Approved
Matched Description: … . (-)-Menthol is the naturally-occurring and main form of menthol, and is assigned the (1R,2S,5R) configuration …
Matched Mixtures name: … GLYCERIN OF THYMOL …

Bendroflumethiazide

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
Approved
Matched Description: … A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. ... It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders …
Matched Categories: … combinations of sulfonamides …

Streptomycin

Streptomycin, an antibiotic derived from Streptomyces griseus, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activity.[A233325,A232294] Although streptomycin was the first antibiotic...
Approved
Vet approved
Matched Description: … the first antibiotic determined to be effective against mycobacterium tuberculosis, it has fallen out of ... Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of ... favor due to resistance and is now primarily used as adjunctive treatment in cases of multi-drug resistant …
Matched Categories: … Drugs for Treatment of Tuberculosis …

Zinc chloride

Zinc chloride is a solution of ions indicated for use in total parenteral nutrition to maintain zinc levels and prevent deficiency syndromes. Zinc chloride was granted FDA approval before 26 June 1986.
Approved
Investigational
Matched Description: … Zinc chloride is a solution of ions indicated for use in total parenteral nutrition to maintain zinc …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Levodopa

Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent...
Approved
Matched Description: … dopamine to treat symptoms of Parkinson's[Label]. ... Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability ... Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Isocarboxazid

Isocarboxazid has the formula 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine-isocarboxazid. It is a monoamine oxidase inhibitor. It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic disorder and the phobic disorders. It was first introduced by Roche pharmaceuticals, further developed by Validus pharms Inc and first FDA approved as a prescription...
Approved
Matched Description: … [A31930] It is used in the treatment of major depression, dysthymic disorder, atypical disorder, panic …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Zimelidine

Zimelidine has been banned worldwide due to serious, sometimes fatal, cases of central and/or peripheral neuropathy known as Guillain-Barré syndrome and due to a peculiar hypersensitivity reaction involving many organs including skin exanthema, flu-like symptoms, arthralgias, and sometimes eosinophilia. Additionally, zimelidine was charged to cause an increase in suicidal ideation...
Approved
Withdrawn
Matched Description: … Zimelidine has been banned worldwide due to serious, sometimes fatal, cases of central and/or peripheral …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Ospemifene

Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013.
Approved
Investigational
Matched Description: … moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. ... Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of …
Matched Categories: … Sex Hormones and Modulators of the Genital System …
Displaying drugs 151 - 175 of 8039 in total