Advanced Filter

Filter by Group

Filter by Market Availability

Clear
Displaying drugs 1901 - 1925 of 14984 in total

Dipyrithione

Dipyrithione, a bactericidal and fungicidal pyrithione derivate, was formulated as Crimanex anti-dandruff shampoo, but is no longer available. It is currently used as a pesticide, and not used in any FDA approved drug products. Interestingly, dipyrithione has been studied and shown to have cytotoxic and potent broad-spectrum antitumor activity, which...
Approved
Matched Description: … [A32829] Interestingly, dipyrithione has been studied and shown to have cytotoxic and potent broad-spectrum ... preservatives and as anti-dandruff agents in shampoos. ... be caused by fungi such as _Malassezia globosa_ and _M. restricta_. …

Birch bark extract

Birch bark extract is rich in triterpenoids with beneficial biological and pharmacological activities. Some of the compounds identified in it include betulin, lupeol, betulinic acid, oleanolic acid, and erythrodiol. Birch bark extract is obtained from the white part of the birch tree bark, and the main species of trees used...
Approved
Experimental
Matched Description: … Some of the compounds identified in it include betulin, [lupeol], [betulinic acid], oleanolic acid, and ... Birch bark extract is rich in triterpenoids with beneficial biological and pharmacological activities ... internal epithelial linings characterized by extreme skin fragility and blister development. …

Ganciclovir

An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Approved
Investigational
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... Ganciclovir and prodrug ... Nucleosides and Nucleotides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors …

Lactulose

Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929 , investigations regarding its possible use as a laxative for...
Approved
Matched Description: … possible use as a laxative for the treatment of chronic constipation did not occur until the 1960s and ... [L6202] Nevertheless, although lactulose received formal FDA approval in 1977 and has since become ... List of Essential Medicines as one of the most effective and safe medicines employed in a health system …
Matched Categories: … Alimentary Tract and Metabolism …

Alcaftadine

Alcaftadine is a H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis. This drug was approved in July 2010.
Approved
Matched Categories: … Decongestants and Antiallergics …

Interferon alfa-2a

Interferon a (human leukocyte protein moiety reduced). A type I interferon consisting of 165 amino acid residues with lysine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent. An oral form is...
Approved
Investigational
Matched Description: … A type I interferon consisting of 165 amino acid residues with lysine in position 23. ... This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …

Ferric sulfate

Ferric sulfate has the molecular formula of Fe2SO4, and it is a dark brown or yellow chemical agent with acidic properties. It is produced by the reaction of sulfuric acid and an oxidizing agent. It is used in different fields such as dermatology, dentistry and it is thought to present...
Approved
Matched Description: … It is produced by the reaction of sulfuric acid and an oxidizing agent. ... Ferric sulfate has the molecular formula of Fe2SO4, and it is a dark brown or yellow chemical agent with ... It is used in different fields such as dermatology, dentistry and it is thought to present hemostatic …

Aldesleukin

Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from...
Approved
Matched Description: … Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression ... because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid ... during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …

Fluvastatin

Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It...
Approved
Matched Iupac: … (6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid …
Matched Description: … HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol ... levels and prevent cardiovascular disease. ... Fluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. …

Vincristine

Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate...
Approved
Investigational
Matched Description: … several brand names, many of which have different formulations such as Marqibo (liposomal injection) and ... part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and ... indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Cisplatin

Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Approved
Matched Description: … ovarian cancer), lymphomas and germ cell tumors. ... It was the first member of its class, which now also includes carboplatin and oxaliplatin. ... to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and …
Matched Categories: … Medications that reduce magnesium levels ... Indicators and Reagents ... Antineoplastic and Immunomodulating Agents …

Zileuton

Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Zileuton relieves such symptoms through its...
Approved
Investigational
Withdrawn
Matched Description: … inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid ... , and smooth muscle contraction. ... Specifically, it inhibits leukotriene LTB4, LTC4, LTD4, and LTE4 formation. …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Lornoxicam

Lornoxicam (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug. Lornoxicam is approved for use in Japan.
Approved
Investigational
Matched Description: … new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Mepivacaine

A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Approved
Vet approved
Matched Description: … It is indicated for infiltration, nerve block, and epidural anesthesia. ... Mepivacaine is effective topically only in large doses and therefore should not be used by this route …
Matched Mixtures name: … Mepivacaine Hydrochloride and Levonordefrin …

Moderna COVID-19 Vaccine

The Moderna COVID-19 Vaccine (mRNA-1273) is a novel mRNA-based vaccine encapsulated in a lipid nanoparticle that encodes for a full-length pre-fusion stabilized spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) is a highly contagious infectious disease caused by the novel coronavirus, SARS-CoV-2, leading...
Approved
Investigational
Matched Description: … of age and older) study participants. ... [L12660] This trial was later followed by phase II and III trials, where the Moderna COVID-19 Vaccine ... as the second vaccine for the prevention of COVID-19 caused by SARS-CoV-2 in patients aged 18 years and …
Matched Categories: … Nucleic Acid-Based Vaccines …

Sulfinpyrazone

A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
Approved
Matched Description: … It lacks anti-inflammatory, analgesic, and diuretic properties. …
Matched Categories: … Preparations Increasing Uric Acid Excretion …

Benorilate

Approved
Matched Categories: … Salicylic Acid and Derivatives …

Sodium oxybate

Sodium oxybate (Xyrem) is a central nervous system (CNS) depressant used to treat cataplexy or excessive daytime sleepiness associated with narcolepsy. It is a sodium salt of gamma-Hydroxybutyric acid, an endogenous cerebral inhibitory neurotransmitter and a metabolite of the inhibitory neurotransmitter GABA. Due to its physiological effects, sodium oxybate is...
Approved
Matched Description: … [L30598] It is a sodium salt of [gamma-Hydroxybutyric acid], an endogenous cerebral inhibitory neurotransmitter ... Sodium oxybate has been misused to stimulate body growth and to induce euphoria, disinhibition, and sexual ... [A251445] and a metabolite of the inhibitory neurotransmitter GABA. …

Piracetam

Piracetam is a nootropic drug in the racetams group, with chemical name 2-oxo-1-pyrrolidine acetamide. It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative of the neurotransmitter γ-aminobutyric acid (GABA). However its mechanism of action differ from that of endogenous GABA. Piracetam has neuroprotective and...
Approved
Investigational
Matched Description: … It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative ... of the neurotransmitter γ-aminobutyric acid (GABA). ... Piracetam has neuroprotective and anticonvulsant properties and is reported to improve neural plasticity …
Matched Categories: … Psychostimulants, Agents Used for ADHD and Nootropics …

Lubiprostone

Lubiprostone is a medication used in the management of idiopathic chronic constipation. A prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of the gastrointestinal epithelial cells. Activation of these channels promotes the secretion of a chloride-rich fluid that soften...
Approved
Investigational
Matched Iupac: … -[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxo-octahydrocyclopenta[b]pyran-5-yl]heptanoic acid …
Matched Description: … A prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels ... promotes the secretion of a chloride-rich fluid that soften the stool, increase gastrointestinal motility, and …
Matched Categories: … Alimentary Tract and Metabolism …

Enzalutamide

Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line treatment of prostate cancer and remission can be...
Approved
Matched Description: … receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and ... A252667] Although androgen deprivation therapy (ADT) is the first-line treatment of prostate cancer and ... [A252667] Second-generation such as enzalutamide is more efficacious due to a higher affinity to AR and …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents …

Succinylcholine

Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter acetylcholine (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its...
Approved
Matched Description: … Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and ... A299] most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and …

Laronidase

Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical...
Approved
Matched Description: … The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …

Methyprylon

Methyprylon is a sedative of the piperidinedione derivative family that was previously used for the treatment of insomnia. However, with the introduction of newer drugs with fewer side effects, such as benzodiazepines, the clinical use of methyprylon is now limited. Methyprylon was withdrawn from the U.S. market in June 1965...
Approved
Illicit
Withdrawn
Matched Description: … Methyprylon was withdrawn from the U.S. market in June 1965 and the Canadian market in September 1990 …
Matched Categories: … Hypnotics and Sedatives …

AstraZeneca COVID-19 Vaccine

The AstraZeneca COVID-19 Vaccine (previously known as ChAdOx1 nCoV-19 or AZD1222) is one of several vaccines developed in 2020 for the prevention of COVID-19 caused by SARS-CoV-2.[L12669,L32649] The ChAdOx1 viral vector was developed at the University of Oxford and has been investigated as a potential vector for vaccines against another...
Approved
Investigational
Matched Description: … across the globe, including Canada, Mexico, the UK, the EU, and Australia, amongst others. ... [L12672] The University of Oxford struck a development and distribution deal with AstraZeneca in May ... 2020[L32659] which paved the way for the vaccine's subsequent approval and usage in dozens of regions …
Matched Categories: … Nucleic Acid-Based Vaccines …
Displaying drugs 1901 - 1925 of 14984 in total