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Displaying drugs 201 - 225 of 8055 in total

Chlorthalidone

Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. Chlorthalidone improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule...
Approved
Matched Description: … of edema caused by conditions such as heart failure or renal impairment. ... Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management ... improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of …
Matched Categories: … combinations of sulfonamides …

Stavudine

A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.
Approved
Investigational
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Naltrexone

Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Approved
Investigational
Vet approved
Matched Description: … Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. ... The FDA has approved naltrexone for the treatment of alcohol dependence. ... effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Dasabuvir

Dasabuvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Matched Description: … reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma ... Dasabuvir is a direct acting antiviral medication used as part of combination therapy to treat chronic ... nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of …
Matched Categories: … Antivirals for treatment of HCV infections …

Fluoxetine

Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies.
Approved
Vet approved
Matched Description: … [A181673] It gained FDA approval in 1987 and although it was initially intended for the treatment of …
Matched Categories: … Metabolic Side Effects of Drugs and Substances ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Miconazole

Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-based products are available.[L14021, L14024, L14027,...
Approved
Investigational
Vet approved
Matched Description: … oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of ... L14021, L14024, L14027, L14033, L14396] Miconazole is thought to act primarily through the inhibition of ... [A214523, L14021] It is currently available as a variety of prescription and over the counter products …
Matched Categories: … combinations of imidazole derivatives ... Metabolic Side Effects of Drugs and Substances …

Doxepin

Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to cidoxepin. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepressant but...
Approved
Investigational
Matched Description: … [L5971] However, in 2010 it was approved for the treatment of insomnia. ... properties with members of the drug family including [amitriptyline], [clomipramine], [desipramine], ... is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Dextrose, unspecified form

Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through...
Approved
Vet approved
Matched Description: … Glucose is listed on the World Health Organization's List of Essential Medicines. ... Its aldohexose stereoisomer, dextrose or D-glucose, is the most commonly occurring isomer of glucose ... The unspecified form of glucose is commonly supplied as an injection for nutritional supplementation …
Matched Mixtures name: … SOLUTION OF DEXTROSE 5 % IN NORMAL SALINE 0.9 % ... SOLUTION OF DEXTROSE 10 % IN NORMAL SALINE 0.9 % …

Acetaminophen

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA...
Approved
Matched Description: … [L5783] Confusion about dosing of this drug may be caused by the availability of different formulas, ... strengths, and dosage instructions for children of different ages. ... FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent …
Matched Mixtures name: … Hot Lemon Relief for Symptoms Of Cold and Flu ... Hot Lemon Relief for Symptoms Of Cold and Flu Forte ... Hot Lemon Relief for Symptoms Of Cough, Cold and Flu …

Desogestrel

Desogestrel, a prodrug, is a third generation progestogen and hence, a member of the gonane family which was largely used in Europe before being approved in the US and Canada. It was firstly generated from a study that showed that 11-beta and 11-alkylidene substituent in nortestosterone can enhance the biological...
Approved
Matched Description: … Desogestrel, a prodrug, is a third generation progestogen[A176315] and hence, a member of the gonane …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Palonosetron

Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first...
Approved
Investigational
Matched Description: … appear more than 24 hours after the first dose of a course of chemotherapy and is the only drug of its ... and treatment of chemotherapy-induced nausea and vomiting (CINV). ... As of 2008, it is the most recent 5-HT3 antagonist to enter clinical use. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Pergolide

Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian syndrome....
Approved
Investigational
Vet approved
Withdrawn
Matched Description: … It was later found that pergolide increased the risk of cardiac valvulopathy. ... Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease ... It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Hydromorphone

Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of morphine that has been available clinically since 1920. Structurally, hydromorphone derived from morphine in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and...
Approved
Illicit
Matched Description: … carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and 8. ... Hydromorphone is a pure opioid,[A176468] a semi-synthetic hydrogenated ketone derivative of [morphine ... Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Levonorgestrel

Levonorgestrel (LNG) is a synthetic progestogen similar to Progesterone used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices...
Approved
Investigational
Matched Description: … Some of these devices are known as Jaydess, Kyleena, and Mirena. ... A subdermal implant of levonorgestrel that slowly releases the hormone over a long-term period is also ... [L7823] In addition to the above uses, levonorgestrel is used as a component of long-term combination …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Bosentan

Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.
Approved
Investigational
Matched Description: … would otherwise promote narrowing of the blood vessels and lead to high blood pressure. ... Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that …
Matched Categories: … combinations of sulfonamides …

Granisetron

A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
Approved
Investigational
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sulfadiazine

One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Approved
Investigational
Vet approved
Matched Description: … One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in …
Matched Categories: … combinations of sulfonamides …

Clofazimine

Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as dapsone, for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloration of the skin...
Approved
Investigational
Matched Description: … antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of ... riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloration of …
Matched Categories: … Drugs for Treatment of Lepra …

Grazoprevir

Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Matched Description: … alter the affinity of the drug for NS3/4A or the activity of the enzyme itself. ... another class of DAAs [A19593]. ... The barrier for develoment of resistance to NS3/4A inhibitors is lower than that of NS5B inhibitors, …
Matched Categories: … Antivirals for treatment of HCV infections …

Velpatasvir

Velpatasvir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … ), after 12 weeks of daily therapy. ... reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma ... Epclusa is the first combination HCV product indicated for the treatment of all genotypes of Hepatitis …
Matched Categories: … Antivirals for treatment of HCV infections …

Conjugated estrogens

The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.[L5605,...
Approved
Matched Description: … , 3% of equilenin sulfate, 5% of 17-alpha and 17-beta-dihydroequilenin sulfate, 2% of 17-alpha-estradiolsulfate ... and 3% of 17-beta-estradiolsulfate. ... represented by estrone sulfate followed by 25% of equilin sulfate, 15% of 17-alpha-dehydroequilenin sulfate …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Secobarbital

Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom.
Approved
Vet approved
Matched Categories: … combinations of barbiturates …

Estrone

Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione....
Approved
Matched Description: … Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and ... in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Cyproterone acetate

An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.
Approved
Investigational
Matched Description: … in combination with estrogen, for the therapy of severe acne and hirsutism in females. ... An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties ... It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Lamivudine

A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Approved
Investigational
Matched Description: … reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …
Displaying drugs 201 - 225 of 8055 in total