Penicillin-binding protein 2B

BE0003624ProteinStreptococcus pneumoniae (strain ATCC BAA-255 / R6)penA

A transpeptidase that forms peptide cross-links between adjacent glycan strands in cell wall peptidoglycan (PG). It is acted on by 19 drugs in DrugBank.

Gene name
penA
UniProtKB entry
P0A3M6Swiss-Prot
Cellular location
Cell membrane
Residues / weight
680 residues · 73,872 Da
Also known as
pbp2b · Peptidoglycan transpeptidase

Resolves to

Protein
UniProtP0A3M6UniProt namePBP2_STRR6
Gene
NCBI Gene933948GenBank984233
Pharmacology
KEGGspr:spr1517
Structure
PDB2WADPDB2WAEPDB2WAF
Drugs

What you can answer from here — as of September 07, 2019

19DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Penicillin-binding protein 2B, how selective are they, and which programs against it are still in active trials?

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