Benzenesulfonamides

Name
Benzenesulfonamides
Accession Number
DBCAT005891
Description

A group of compounds that contain sulfonamide group S-linked to a benzene ring. Many benzenesulfonamide derivatives are pharmaceuticals (e.g., BOSENTAN; SULFAPYRIDINE; and SULFADIAZINE; CELECOXIB) as their sulfonamide moiety target various enzymes (e.g., CARBONIC ANHYDRASES; ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; and CYCLOOXYNENASE 2).

Drugs
DrugDrug Description
AcetohexamideUsed in the management of diabetes mellitus type 2 (adult-onset).
Acetyl sulfisoxazoleAcute, recurrent or chronic urinary tract infections (primarily pyelonephritis, pyelitis and cystitis) due to susceptible organisms (usually Escherichia coli, Klebsiella-Enterobacter, staphylococcus, Proteus mirabilis and, less frequently, Proteus vulgaris) in the...
BosentanA dual endothelin receptor antagonist used to treat pulmonary arterial hypertension.
CarbutamideNot Annotated
CelecoxibAn NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis.
ChlorpropamideA sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
ChlorthalidoneA diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions.
GliclazideA sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.
MafenideAn antimicrobial topical agent indicated for use as an adjunctive treatment to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.
Silver sulfadiazineA topical sulfonamide antibiotic that acts on the bacterial cell wall and cell membrane; approved for the treatment of burns.
SulfachlorpyridazineA sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.
SulfadiazineA sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid.
SulfadimethoxineFor use in the treatment of infections.
SulfadoxineA long acting sulfonamide used for the treatment or prevention of malaria.
SulfaethoxypyridazineNot Annotated
SulfaguanidineSulfaguanidine is a sulfonamide antibiotic with antimicrobial and antibacterial activities.
SulfaisodimidineSulfaisodimidine also called sulfisomidine is an antibacterial product that has been studied for the treatment of urinary tract infections in the 1950s, however, it is unclear whether this drug has...
SulfamerazineAn antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections.
SulfameterLong acting sulfonamide used in leprosy, urinary, and respiratory tract infections.
SulfamethazineAn antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections.
SulfamethizoleA sulfonamide antibiotic used to treat a wide variety of susceptible bacterial infections.
SulfamethoxazoleAn oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract.
SulfamethoxypyridazineA sulphonamide antibiotic indicated in the treatment of gonorrhea, inflammation, urinary tract ulcers, and bronchitis.
SulfametopyrazineAn antibiotic used in the treatment or prevention of bacterial infections and malaria.
SulfamoxoleFor the treatment of bacterial infection.
SulfanilamideA sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans.
SulfaphenazoleFor the treatment bacterial infections.
SulfapyridineA sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum.
SulfaquinoxalineSulfaquinoxaline is a veterinary medicine which can be given to cattle and sheep to treat coccidiosis.It is available in Pakistan with Sanna Laboratories in combination with Amprolium and Vitamin K...
SulfathiazoleSulfathiazole is effective against a wide range of gram positive and gram negative pathogenic microorganisms. Although no longer used in humans, it is used in cattle.
SulfatolamideNot Annotated
SulfatroxazoleSulfatroxazole is a small molecule drug. Sulfatroxazole has a monoisotopic molecular weight of 267.07 Da.
SulfisoxazoleA sulfonamide antibiotic used with other antibiotics to prevent and treat a variety of bacterial infections.
TamsulosinAn alpha-1A and alpha-1B adrenergic receptor antagonist used to treat benign prostatic hyperplasia, ureteral stones, prostatitis, and female voiding dysfunction.
TolazamideA sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
TolbutamideA sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.
Drugs & Drug Targets
DrugTargetType
AcetohexamideATP-binding cassette sub-family C member 8target
AcetohexamideCytochrome P450 2C9enzyme
AcetohexamideAlbumincarrier
AcetohexamideATP-sensitive inward rectifier potassium channel 1target
AcetohexamideCarbonyl reductase [NADPH] 1enzyme
Acetyl sulfisoxazoleCytochrome P450 2C9enzyme
Acetyl sulfisoxazoleDihydropteroate synthasetarget
BosentanBile salt export pumptransporter
BosentanCytochrome P450 2C9enzyme
BosentanCytochrome P450 3A4enzyme
BosentanEndothelin-1 receptortarget
BosentanEndothelin receptor type Btarget
CarbutamideCytochrome P450 2C9enzyme
CarbutamideAlbumincarrier
CelecoxibSialidase-1target
CelecoxibSignal transducer and activator of transcription 3target
CelecoxibProstaglandin G/H synthase 2enzyme
CelecoxibProstaglandin G/H synthase 2target
Celecoxib3-phosphoinositide-dependent protein kinase 1target
CelecoxibCytochrome P450 2C9enzyme
CelecoxibCytochrome P450 2D6enzyme
CelecoxibATP-binding cassette sub-family C member 4transporter
CelecoxibCytochrome P450 3A4enzyme
CelecoxibCytochrome P450 2C8enzyme
CelecoxibCarbonic anhydrase 2target
CelecoxibCarbonic anhydrase 3target
CelecoxibBile salt export pumptransporter
CelecoxibCadherin-11target
CelecoxibATP-dependent translocase ABCB1transporter
CelecoxibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
ChlorpropamideSolute carrier family 22 member 6transporter
ChlorpropamideATP-sensitive inward rectifier potassium channel 10target
ChlorpropamideProstaglandin G/H synthase 1enzyme
ChlorpropamideCytochrome P450 2C19enzyme
ChlorpropamideCytochrome P450 2C9enzyme
ChlorpropamideATP-binding cassette sub-family C member 8target
ChlorpropamideSolute carrier family 15 member 1transporter
ChlorpropamideSolute carrier family 15 member 2transporter
ChlorthalidoneSolute carrier family 12 member 3target
ChlorthalidoneCarbonic anhydrase 1target
ChlorthalidoneAlbumincarrier
ChlorthalidoneSolute carrier family 12 member 1target
GliclazideATP-binding cassette sub-family C member 8target
GliclazideCytochrome P450 2C9enzyme
GliclazideAlbumincarrier
GliclazideCytochrome P450 2C19enzyme
GliclazideVascular endothelial growth factor A, long formtarget
MafenideCarbonic anhydrase 4target
MafenideCarbonic anhydrase 14target
MafenideCarbonic anhydrase 12target
MafenideCarbonic anhydrase 2target
MafenideCarbonic anhydrase 6target
MafenideDihydropteroate synthasetarget
Silver sulfadiazineDNAtarget
Silver sulfadiazineDihydropteroate synthasetarget
SulfadiazineCytochrome P450 2C9enzyme
Sulfadiazinedihydropteroate synthasetarget
SulfadiazineDihydropteroate synthasetarget
SulfadiazineCytochrome P450 2C8enzyme
SulfadiazineCytochrome P450 3A4enzyme
SulfadimethoxineDihydropteroate synthasetarget
SulfadimethoxineAlbumincarrier
SulfadimethoxineCytochrome P450 2C9enzyme
Sulfadoxinedihydropteroate synthasetarget
SulfadoxineAmine oxidase [flavin-containing] Btarget
SulfadoxineDihydropteroate synthasetarget
SulfadoxineBifunctional dihydrofolate reductase-thymidylate synthasetarget
SulfaguanidineDihydropteroate synthasetarget
SulfaisodimidineProtein argonaute-2target
SulfamerazineAlbumincarrier
SulfamerazineDihydropteroate synthasetarget
SulfameterDihydropteroate synthasetarget
SulfamethazineArylamine N-acetyltransferaseenzyme
SulfamethazineAlbumincarrier
SulfamethazineDihydropteroate synthasetarget
SulfamethizoleCytochrome P450 2C9enzyme
SulfamethizoleDihydropteroate synthasetarget
SulfamethizoleAlbumincarrier
SulfamethoxazoleCytochrome P450 2C9enzyme
SulfamethoxazoleBile salt export pumptransporter
SulfamethoxazoleCytochrome P450 3A4enzyme
SulfamethoxazoleDihydropteroate synthasetarget
SulfamethoxazoleArylamine N-acetyltransferase 2enzyme
SulfamethoxazoleArylamine N-acetyltransferase 1enzyme
SulfamethoxazoleAlbumincarrier
SulfamethoxypyridazineDihydropteroate synthasetarget
Sulfametopyrazinedihydropteroate synthasetarget
SulfametopyrazineDihydropteroate synthasetarget
SulfamoxoleCytochrome P450 2C9enzyme
Sulfamoxoledihydropteroate synthasetarget
SulfanilamideDihydropteroate synthasetarget
SulfaphenazoleCytochrome P450 2C9target
SulfaphenazoleDihydropteroate synthasetarget
SulfaphenazoleCytochrome P450 2D6enzyme
SulfaphenazoleCytochrome P450 2C8enzyme
SulfaphenazoleCytochrome P450 2B6enzyme
SulfaphenazoleCytochrome P450 2C9enzyme
SulfapyridineDihydropteroate synthase type-1target
SulfapyridineDihydropteroate synthasetarget
SulfapyridineCytochrome P450 2C9enzyme
Sulfathiazoledihydropteroate synthasetarget
SulfathiazoleAromataseenzyme
SulfathiazoleDihydropteroate synthasetarget
SulfisoxazoleCytochrome P450 2C9enzyme
SulfisoxazoleDihydropteroate synthasetarget
TamsulosinAlpha-1 adrenergic receptorstarget
TamsulosinCytochrome P450 3A4enzyme
TamsulosinCytochrome P450 2D6enzyme
TamsulosinAlpha-1-acid glycoprotein 1carrier
TamsulosinAlpha-1B adrenergic receptortarget
TamsulosinAlpha-1D adrenergic receptortarget
TamsulosinAlpha-1A adrenergic receptortarget
TolazamideATP-sensitive inward rectifier potassium channel 10target
TolazamideCytochrome P450 2C9enzyme
TolazamideSulfonylurea receptor 1, Kir6.2target
TolbutamideCytochrome P450 2C9enzyme
TolbutamideATP-sensitive inward rectifier potassium channel 1target
TolbutamideCytochrome P450 2C19enzyme
TolbutamideATP-binding cassette sub-family C member 9target
TolbutamideAlbumincarrier
TolbutamideCytochrome P450 2C18enzyme
TolbutamideSolute carrier organic anion transporter family member 2B1transporter
TolbutamideSolute carrier family 22 member 6transporter
TolbutamideSolute carrier family 15 member 2transporter
TolbutamideSolute carrier organic anion transporter family member 1A2transporter
TolbutamideSolute carrier family 15 member 1transporter
TolbutamideATP-binding cassette sub-family C member 8target
TolbutamideCytochrome P450 2C8enzyme