Metastatic Uveal Melanoma (DBCOND0051900)

Identifiers

Synonyms
Metastatic Malignant Uveal Melanoma / Metastatic Uveal Melanoma (UM) / Uveal Melanoma, Metastatic / Melanoma, Uveal Metastatic

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Tebentafusp
A bispecific gp100 peptide-HLA-directed CD3 T cell engager used to treat unresectable or metastatic uveal melanoma.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00506142
Safety and Efficacy of Marqibo in Metastatic Malignant Uveal Melanomatreatment2completed
NCT01773655
Clinical and Histopathologic Characteristics of BAP1 MutationsNo drug interventionsNot AvailableNot Availablecompleted
NCT04283890
PHP and Immunotherapy in Metastasized UMtreatment1 / 2recruiting
NCT04335890
IKKb-matured, RNA-loaded Dendritic Cells for Metastasised Uveal MelanomaNo drug interventionstreatment1unknown_status
NCT05047276
Phase I/II Study of AloCelyvir in Patients With Metastatic Uveal MelanomaNo drug interventionstreatment1 / 2not_yet_recruiting
NCT05987332
IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanomatreatment2 / 3recruiting
NCT06581406
A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanomatreatment2 / 3not_yet_recruiting
NCT00986661
A Study to Assess PV-10 Chemoablation of Cancer of the Livertreatment1active_not_recruiting
NCT05075993
Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid Tumorstreatment1recruiting
NCT01551459
A Phase II Study of Sunitinib Versus Dacarbazine in the Treatment of Patients With Metastatic Uveal Melanomatreatment2completed
NCT04879017
FHD-286 in Subjects With Metastatic Uveal MelanomaNo drug interventionstreatment1terminated
NCT05170334
Binimetinib Plus Belinostat for Subjects With Metastatic Uveal Melanomatreatment2recruiting
NCT02697630
Efficacy Study of Pembrolizumab With Entinostat to Treat Metastatic Melanoma of the Eyetreatment2completed
NCT05677373
Testing the Safety and Effectiveness of Combining Two Drugs, PLX2853 and Trametinib in the Treatment of Advanced Uveal Melanomatreatment1 / 2withdrawn
NCT01585194
Nivolumab and Ipilimumab in Treating Patients With Metastatic Uveal Melanomatreatment2completed
NCT04118062
Communicating With Patients on Cancer Resistance to Treatment: the Development of a Communication Tool. (HECTOR)No drug interventionsotherNot Availableactive_not_recruiting
NCT06121180
Study of Cemiplimab Plus Ziv-Aflibercept for Subjects With Metastatic Uveal Melanomatreatment2recruiting
NCT05282901
Efficacy and Safety of Pembrolizumab in Combination With Lenvatinib in Metastatic Uveal MElanoma Patients (PLUME)treatment2recruiting
NCT05415072
A Phase I/II Study of DYP688 in Patients With Metastatic Uveal Melanoma and Other GNAQ/11 Mutant MelanomasNo drug interventionstreatment1 / 2recruiting
NCT01814046
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Ocular Melanomatreatment2terminated
NCT04552223
Nivolumab Plus Relatlimab in Patients With Metastatic Uveal Melanomatreatment2active_not_recruiting
NCT02831933
Trial of Radiation and Gene Therapy Before Nivolumab for Metastatic Non-Small Cell Lung Carcinoma and Uveal Melanomatreatment2terminated
NCT04728633
Transarterial Chemoembolization for the Treatment of Uveal Melanoma With Liver Metastasestreatment2recruiting
NCT03025256
Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Diseasetreatment1active_not_recruiting
NCT03947385
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusionstreatment1 / 2recruiting
NCT01587352
Vorinostat in Treating Patients With Metastatic Melanoma of the Eyetreatment2active_not_recruiting
NCT04812470
Hepatic Arterial Infusion of Autologous Tumor Infiltrating Lymphocytes in Patients With Melanoma and Liver Metastasestreatment1recruiting
NCT01328106
Efficacy and Safety Study of GSK1120212, a MEK Inhibitor, in Subjects With Uveal Melanomatreatment2withdrawn
NCT04720417
Defactinib and VS-6766 for the Treatment of Patients With Metastatic Uveal Melanomatreatment2active_not_recruiting
NCT03068624
Autologous CD8+ SLC45A2-Specific T Lymphocytes With Cyclophosphamide, Aldesleukin, and Ipilimumab in Treating Patients With Metastatic Uveal Melanomatreatment1active_not_recruiting
NCT03472586
Ipilimumab and Nivolumab With Immunoembolization in Treating Participants With Metastatic Uveal Melanoma in the Livertreatment2active_not_recruiting
NCT05022901
An Open-Label Expanded Access Study of the Melphalan/Hepatic Delivery System (HDS) in Patients With Hepatic Dominant Ocular Melanomatreatment3active_not_recruiting
NCT03865212
Modified Virus VSV-IFNbetaTYRP1 in Treating Patients With Stage III-IV Melanomatreatment1active_not_recruiting
NCT05607095
Pilot Trial of Autologous Tumor Infiltrating Lymphocytes (LN-144) for Patients With Metastatic Uveal Melanomatreatment1recruiting