Multi-Drug Resistant Hiv-1 Infection (DBCOND0152283)

Identifiers

Synonyms

Multidrug resistant HIV-1 infection

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Fostemsavir	An antiretroviral HIV-1 attachment inhibitor targeted against the gp120 subunit within the HIV-1 gp160 envelope glycoprotein.	Cytochrome P450 3A4enzyme UDP-glucuronosyltransferases (UGTs)enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Albumincarrier Envelope glycoprotein gp160target
Ibalizumab	A CD4-specific antibody used to treat HIV infections.	T-cell surface glycoprotein CD4target C-C chemokine receptor type 5target C-X-C chemokine receptor type 4target
Lenacapavir	A first-in-class capsid inhibitor being investigated for use in HIV-1 treatment.	Gag-Pol polyproteintarget Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A1enzyme ATP-dependent translocase ABCB1transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05582694	A Trial of Anti-CD4 Antibody UB-421 in Combination With Optimized Background Antiretroviral Therapy in Patients With Multi-Drug Resistant HIV-1 Infection	Semzuvolimab	treatment	2	recruiting