Histiocytic Neoplasms (DBCOND0160647)
Identifiers
- Synonyms
- Histiocytic Neoplasm / Histiocytic neoplasm (disorder) / Histiocytic neoplasm (morphologic abnormality)
Associated Data
- Indicated Drugs and Targets
Drug Description Targets Cobimetinib An antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma.- Dual specificity mitogen-activated protein kinase kinase 1target
- Cytochrome P450 3A4enzyme
- Solute carrier organic anion transporter family member 1B1transporter
- Solute carrier organic anion transporter family member 1B3transporter
- Broad substrate specificity ATP-binding cassette transporter ABCG2transporter
- ATP-dependent translocase ABCB1transporter
- UDP-glucuronosyltransferase 2B7enzyme
- Cytochrome P450 2D6enzyme
- Cytochrome P450 3A5enzyme
- Alpha-1-acid glycoprotein 1carrier
- Clinical Trials
Identifier Title Drug(s) Purpose Phase Status NCT05786924 A Study of BDTX-4933 in Patients With KRAS, BRAF and Select RAS/MAPK Mutation-Positive Cancers No drug interventions treatment 1 active_not_recruiting NCT05028166 Individual Patient Compassionate Use of Mirdametinib Not Available Not Available available NCT06411821 Ulixertinib in People With Histiocytic Neoplasms treatment 2 recruiting NCT05093335 In-Human CXCR4 Imaging of Hematologic and Solid Tumors Using [68Ga]-Pentixafor-PET No drug interventions diagnostic 0 recruiting