antibiotic pre-surgical prophylaxis (DBCOND0025348)

Identifiers

Synonyms

Preoperative Skin Preparation therapy / Antibiotic Prophylaxis Surgery / Antibiotic pre-surgical prophylaxis therapy / Pre-operative skin preparation therapy / Prophylaxis of surgical site infection / Surgical site prophylaxis therapy / Pre-surgical prophylaxis therapy / Pre-surgical prophylaxis / Surgical prophylaxis / Surgical scrub / Prophylaxis antibiotic pre-surgical / Prophylactic antibiotic therapy / Antibiotic prophylaxis / Antibiotic prophylaxis (procedure) / Prophylactic antibiotic therapy (procedure) / Prescription of prophylactic antibiotic (procedure) / Antibiotic prophylaxis (& [dental cover])

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cefazolin	A broad-spectrum cephalosporin antibiotic mainly used for the treatment of skin bacterial infections and other moderate to severe bacterial infections in the lung, bone, joint, stomach, blood, heart valve, and urinary tract.	Serum paraoxonase/arylesterase 1target Albumincarrier Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Penicillin-binding protein 1Ctarget Peptidoglycan synthase FtsItarget ATP-binding cassette sub-family C member 4transporter Thiopurine S-methyltransferaseenzyme Interleukin-15target Interleukin-2target
Cefotetan	An antibiotic medication used for the prophylaxis and treatment of various bacterial infections, including urinary tract infections, bone and joint infection, and lower respiratory tract infections.	Albumincarrier Penicillin-binding protein 3target
Cefoxitin	A semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection.	Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Peptidoglycan synthase FtsItarget D-alanyl-D-alanine carboxypeptidase DacAtarget D-alanyl-D-alanine carboxypeptidase DacBtarget D-alanyl-D-alanine carboxypeptidase DacCtarget D-alanyl-D-alanine endopeptidasetarget Beta-lactamaseenzyme Penicillin-binding protein 3target Penicillin-binding protein 1btarget Penicillin-binding protein 2atarget Penicillin-binding protein 1Atarget Penicillin-binding protein 2Btarget
Hexachlorophene	A chlorinated bisphenol antiseptic used as a surgical scrub and skin cleanser.	D-lactate dehydrogenasetarget Glutamate dehydrogenase 1, mitochondrialtarget Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialtarget Estrogen receptortarget
Iodine povacrylex	An antiseptic agent used for disinfection of the skin prior to surgical procedures to prevent bacterial skin infections.	No drug targets
Isopropyl alcohol	An antiseptic and disinfectant used in a variety of clinical and domestic settings.	Nitric oxide synthase 3target Oxysterols receptor LXR-betatarget Heme oxygenase 1target GTP cyclohydrolase 1target Phospholipase A2, membrane associatedtarget Tumor necrosis factortarget
Triclosan	An antimicrobial agent in clinical setting for disinfection, and prevention of spread and growth of bacteria, fungus, and mildew.	Enoyl-[acyl-carrier-protein] reductase [NADH] FabItarget Enoyl-[acyl-carrier-protein] reductase [NADH]target Enoyl-[acyl-carrier-protein] reductase [NADH] FabItarget Enoyl-[acyl-carrier-protein] reductase [NADH]target Enoyl-[acyl-carrier-protein] reductase [NADPH] FabItarget Nuclear receptor subfamily 1 group I member 2target Androgen receptortarget Nuclear receptor subfamily 1 group I member 3target Peroxisome proliferator-activated receptor gammatarget Thyroid peroxidasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02703857	Study of Repeated Cefoxitin Administration in Major Abdominal Surgery Using a Microdialysis Technique	Cefoxitin	other	4	completed
NCT05823155	Impact of Pre-operative Penicillin Allergy Evaluation on Surgical Prophylaxis	No drug interventions	treatment	Not Available	recruiting
NCT06005168	Comparison of a Morphomic-Based to the Standard-of-Care-Based Cefazolin Dose for Antimicrobial Prophylaxis	Cefazolin	other	4	recruiting