Adrenal Insufficiency (DBCOND0029087)

Identifiers

Synonyms
Adrenal insufficiency / Adrenal gland insufficiency / Hypoadrenalism / Hypoadrenalism (disorder) / Adrenal cortical hypofunction (disorder) / Adrenal insufficiency NOS / Insufficiency adrenal / Adrenal hypofunction / Hypofunction adrenal / Adrenal cortical hypofunctions / Adrenal cortical hypofunction / Adrenal cortical insufficiency / Hypoadrenocorticism / Corticoadrenal insufficiency / Insufficiency adrenal cortex / Adrenal cortex insufficiency / Adrenal cortex hypofunction

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Hydrocortisone
A glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.
Tetracosactide
A diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06637722
Self-management in Patients With Adrenal Insufficiency.No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00156767
Adrenal Function in Critical IllnessNo drug interventionsNot AvailableNot Availablecompleted
NCT06608433
Glucagon-like Peptide-1 Receptor Agnoists for the Assessment of Adrenal FunctionotherNot Availablenot_yet_recruiting
NCT03752190
Comparison of Intramuscular and Intravenous ACTH Stimulation Test in Normal Volunteersdiagnostic4withdrawn
NCT06148090
Screening for Adrenal Insufficiency During Dermocorticoid Reduction in Bullous Pemphigoid (BP)No drug interventionspreventionNot Availablerecruiting
NCT00005664
Evaluation of Patients With Endocrine-Related ConditionsNo drug interventionsNot AvailableNot Availableterminated
NCT06008184
Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological FluidsNo drug interventionsNot AvailableNot Availablerecruiting
NCT00552487
Isolated ACTH Deficiency in Patients With Hashimoto ThyroiditisdiagnosticNot Availablecompleted
NCT03282487
Optimising Steroid Replacement in Patients With Adrenal Insufficiencytreatment4unknown_status
NCT01822847
Physiological Response of Cortisol to Cardiac CatheterizationNo drug interventionsNot AvailableNot Availablecompleted
NCT03051893
A Two-part, Study to Compare the Pharmacokinetics and Dose Proportionality of up to 6 Chronocort FormulationsNo drug interventionstreatment1completed
NCT01452893
Counterregulatory Hormone Production in Adrenal Insufficiency and Diabetes Type INo drug interventionsNot AvailableNot Availablecompleted
NCT01052207
Pilot Study Assessing Oxidative Stress in ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT00974337
Relative Adrenal Insufficiency in Preterm Very Low Birth Weight Infants With ShockNo drug interventionsNot AvailableNot Availablecompleted
NCT02720952
Treatment of Adrenal Insufficiency in ChildrenNo drug interventionstreatment3completed
NCT00471900
Six Months DHEA Treatment in Female Adrenal FailuretreatmentNot Availablecompleted
NCT03615859
Objective Markers and New Indicators in AI Disease (OMNI-AID Study)No drug interventionsNot AvailableNot Availableunknown_status
NCT00851942
Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Testdiagnostic4completed
NCT02934399
Dynamic Hormone Diagnostics in Endocrine DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT00575341
Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiencytreatment3completed
NCT03936517
Safety and Efficacy of Prednisolone in Adrenal Insufficiency Disease (PRED-AID Study)treatment3active_not_recruiting
NCT01735617
Pilot Study to Characterize and Examine the Pharmacokinetics and Efficacy of Chronocort® in Adults With CAHtreatment2completed
NCT03083834
Salivary Free Cortisol Response to Cosyntropin Stimulation Test in Mitotane Treated PatientsNo drug interventionsdiagnosticNot Availableunknown_status
NCT00364624
Adrenal Function in Patients With Newly Diagnosed Lung CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT05457296
Salivary Cortisol Measurement in Corticotrope Deficiency Substitution With Hydrocortisone.treatment4completed
NCT02501486
Inhalation/Nasal Corticosteroids and Prevalence of Hypothalamic-pituitary-adrenal (HPA) Axis Suppression in Human Immunodeficiency Virus (HIV)-PatientsNo drug interventionsdiagnosticNot Availableunknown_status
NCT01960530
An Investigational Study of Hydrocortisoneother1completed
NCT02694926
National Education Programme for Patients With Chronic Adrenal InsufficiencyNo drug interventionspreventionNot Availablecompleted
NCT03013166
THIN Database Study: Resource Use and Outcomes in Patients With Adrenal Insufficiency Prescribed Hydrocortisone: Immediate, or Modified Release, or PrednisoloneNo drug interventionsNot AvailableNot Availablecompleted
NCT05350982
Neonatal, Infant and Toddler Salivary Study (NITS Study)No drug interventionsNot AvailableNot Availablecompleted
NCT05639127
The Treatment of Adrenal Crisis With Inhaled Prednisolonetreatment0unknown_status
NCT01045876
The Effect of Dexamethasone on Cortisol Levels in Patients Undergoing Thyroid SurgeryNot Available4withdrawn
NCT02689960
Vaginal Prednisone Administration for Prevention of Adrenal Crisisprevention2completed
NCT02818660
Mass Spectrometry Based Cutoffs for Cortisol After Stimulation TestsdiagnosticNot Availablecompleted
NCT05070091
The Impact of Pituitary-thyroid and Pituitary-adrenal Axes Function on COVID-19 Clinical Course.No drug interventionsNot AvailableNot Availablecompleted
NCT06260462
Effects of Steroid Replacement Therapy on Metabolic, Cardiovascular and Bone Outcomes in Adrenal Insufficiencytreatment3completed
NCT03136562
Prevalence of Adrenal Insufficiency in Kidney Transplanted Patients in Glucocorticoid TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT05741762
Assessing Baseline Cortisol Levels in Patients Admitted With Septic Shock in Intensive Care UnitNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00575029
Adrenal Suppression and Adrenal Recovery Induced by Megestrol Acetatehealth_services_researchNot Availablecompleted
NCT00462644
Evaluation of Etomidate on Adrenal Function in Trauma PatientspreventionNot Availablecompleted
NCT02733367
Extension Study for Patients Entered Into Study Infacort 003No drug interventionstreatment3completed
NCT01859312
Comparison of Cortisol Pump With Standard Treatment for Congenital Adrenal Hyperplasiatreatment2completed
NCT03709381
Effect of Adrenocorticotropic Hormone on Vascular Endothelial Growth Factor Release in Children Studydiagnostic0completed
NCT06435481
Tolerability and Acceptance of Two Oral Hydrocortisone Compounding Formulation for Pediatricstreatment4not_yet_recruiting
NCT05435781
Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiencytreatment4recruiting
NCT00368381
Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsistreatment4withdrawn
NCT03019614
An Open Label Study in Healthy Volunteers to Compare Chronocort® to Hydrocortisonetreatment1completed
NCT06206655
Diagnosis of Adrenal Insufficiency in Liver Cirrhosis PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT03074123
Cortisol Response to Low Dose Cosyntropin Stimulation Test in the Late AfternoonNo drug interventionsdiagnosticNot Availablecompleted
NCT05149638
Updated Diagnostic Cortisol Values for Adrenal InsufficiencyNo drug interventionsdiagnosticNot Availablerecruiting
NCT00915343
Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiencytreatment2 / 3completed
NCT03499990
Study to Investigate Adrenal Crisis (Six-year Follow-up)No drug interventionsNot AvailableNot Availablecompleted
NCT05806190
Hypoglycaemia (Low Blood Sugar) in Adults With Diabetes and Adrenal FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT04374721
Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid DisordersNo drug interventionsotherNot Availablerecruiting
NCT02368379
Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi SyndromeNo drug interventionsdiagnosticNot Availablecompleted
NCT00562445
Adrenal Insufficiency in Critical Emergencies in Digestive DiseasesNo drug interventionsNot AvailableNot Availableunknown_status
NCT06309498
Residual Adrenal Function in Addison's DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT03399383
Adherence in Chronic Adrenal InsufficiencyNo drug interventionsotherNot Availableunknown_status
NCT03140761
The Prevalence of Secondary Adrenal Insufficiency in Patients With Exacerbation of COPD in Glucocorticoid Treatment Related to Differenct Gene Polymorphisms of the Glucocorticoid Receptor GeneNo drug interventionsNot AvailableNot Availablecompleted
NCT01093261
Corticosteroid Therapy for Glucocorticoid Insufficiency Related to Traumatic Brain Injurytreatment3completed
NCT06430528
A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid ReplacementNot AvailableNot Availablerecruiting
NCT05716607
Treatment Study in Patients Treated With Both Insulin & HydrocortisonetreatmentNot Availablenot_yet_recruiting
NCT01184209
Prospective Study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal InsufficiencyNo drug interventionsNot AvailableNot Availablecompleted
NCT03426332
Management of Adrenal Emergency in GermanyNo drug interventionsNot AvailableNot Availablecompleted
NCT03311932
A Study of Infacort® Versus Cortef® in Healthy Adult Male and Female Subjectstreatment1completed
NCT04488432
Endocrine, Bone And Metabolic Disorders In Adults After Allogeneic Stem-cell TransplantNo drug interventionsNot AvailableNot Availablecompleted
NCT03505775
Evaluation of the Muscular and Cutaneous Sodium Storage by 23Na MRI in Patients With Chronic Adrenal InsufficiencyNo drug interventionsdiagnosticNot Availablecompleted
NCT02769975
Evaluation of Children With Endocrine and Metabolic-Related ConditionsNo drug interventionsNot AvailableNot Availablerecruiting
NCT01428336
Value of 25 mcg Cortrosyn Stimulation TestNo drug interventionsdiagnosticNot Availablecompleted
NCT01703013
The Significance of Defensin Alpha 4 in the Pathophysiology of the Adrenal Insufficiency in Inflammatory Lung DiseasesNo drug interventionsNot AvailableNot Availableunknown_status
NCT03426319
Cardiovascular Status in Adrenal InsufficiencyNo drug interventionsNot AvailableNot Availablecompleted
NCT00444119
Survey in Patients With Chronic Adrenal Insufficiency in GermanyNo drug interventionsNot AvailableNot Availablecompleted
NCT05193396
Hydrocortisone and Placebo in Patients With Symptoms of Adrenal Insufficiency After Cessation of Glucocorticoid Treatmenttreatment4recruiting
NCT00773058
Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS)treatment4unknown_status
NCT00485186
Gene Polymorphisms Influencing Steroid Synthesis and ActionNo drug interventionsNot AvailableNot Availablewithdrawn
NCT01546922
Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT)treatment4completed
NCT00560625
Does Inhaled Busedonide or Fluticasone Impair Adrenal Function?No drug interventionsNot AvailableNot Availableterminated
NCT05302726
Impact of Exogenous Estrogens on Cotisol Levels During Synacthen StimulationdiagnosticNot Availableunknown_status
NCT05931926
Feasibility and Validation of the Fluispotter®, a Novel Intravenous System for Serial Blood SamplingNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03368066
Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients?diagnostic3completed
NCT01265966
Cortisol Response to Moderate and Deep Sedation in ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT04621565
Hydrocortisone Use During Peri-operation for Pituitary AdenomaspreventionNot Availableunknown_status
NCT03000231
Circadian Function and Cardio-metabolic Risk in Adrenal InsufficiencyNo drug interventionsNot AvailableNot Availablecompleted
NCT03343327
A Study of Chronocort® Versus Cortef ® in Healthy Adult Male Subjectstreatment1completed
NCT03294876
Rheumatoid Arthritis Adrenal Recovery StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT03410160
Predisposing Factors for the Incidence of Adrenal CrisisNo drug interventionsNot AvailableNot Availableunknown_status
NCT04642391
Defining the Mechanisms Underlying Adrenal Insufficiency in CirrhosisNot AvailableNot Availableactive_not_recruiting
NCT04519580
Improved Diagnostics and Monitoring of Polymyalgia RheumaticaNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04278404
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)Not AvailableNot Availablerecruiting
NCT04988269
Assessment of Diurnal Salivary Cortisol Production in COVID-19No drug interventionsNot AvailableNot Availablecompleted
NCT01652495
Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injectiontreatment4completed
NCT03178214
Bioavailability of Infacort When Administered Onto Food Compared to Direct Oral AdministrationNo drug interventionstreatment1completed
NCT02282150
Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalismtreatment4unknown_status
NCT05806723
Effects of High Intensity Statin Therapy on Steroid Hormones and Vitamin D in Type 2 Diabetic Mentreatment4completed
NCT03608943
Hydrocortisone Vs Prednisolone in AI (HYPER-AID)No drug interventionsNot AvailableNot Availablerecruiting