Topoisomerase I Inhibitors

All categories
Name
Topoisomerase I Inhibitors
Accession Number
DBCAT001116
Description

Compounds that inhibit the activity of DNA TOPOISOMERASE I.

Drugs
DrugDrug Description
IrinotecanA topoisomerase inhibitor used to treat metastatic carcinoma of the colon or rectum and pancreatic adenocarcinoma.
TopotecanAn antineoplastic agent used to treat ovarian cancer, small cell lung cancer, or cervical cancer.
CamptothecinInvestigated for the treatment of cancer.
RubitecanInvestigated for use/treatment in pancreatic cancer, leukemia (unspecified), melanoma, ovarian cancer, and cancer/tumors (unspecified).
MLN576Investigated for use/treatment in solid tumors.
ExatecanExatecan has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Lung Cancer, and Liver Cancer, among others.
BelotecanBelotecan has been investigated for the treatment of Epithelial Ovarian Cancer.
SN-38Investigated for use/treatment in colorectal cancer.
Drugs & Drug Targets
DrugTargetType
IrinotecanDNA topoisomerase I, mitochondrialtarget
IrinotecanDNA topoisomerase 1target
IrinotecanCytochrome P450 3A4enzyme
IrinotecanCytochrome P450 3A5enzyme
IrinotecanUDP-glucuronosyltransferase 1A1enzyme
IrinotecanUDP-glucuronosyltransferase 1A9enzyme
IrinotecanCytochrome P450 3A7enzyme
IrinotecanSolute carrier family 22 member 3transporter
IrinotecanSolute carrier organic anion transporter family member 1B1transporter
IrinotecanMultidrug resistance-associated protein 1transporter
IrinotecanBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
IrinotecanAlbumincarrier
IrinotecanATP-dependent translocase ABCB1transporter
IrinotecanATP-binding cassette sub-family C member 2transporter
IrinotecanHuman Carboxylesterasesenzyme
TopotecanDNA topoisomerase I, mitochondrialtarget
TopotecanDNA topoisomerase 1target
TopotecanBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
TopotecanATP-dependent translocase ABCB1transporter
TopotecanDNAtarget
TopotecanMultidrug and toxin extrusion protein 1transporter
TopotecanMultidrug and toxin extrusion protein 2transporter
CamptothecinDNA topoisomerase 1target
CamptothecinATP-dependent translocase ABCB1transporter
CamptothecinBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
CamptothecinAlbumincarrier
RubitecanDNA topoisomerase 1target
ExatecanDNA topoisomerase 1target
BelotecanDNA topoisomerase 1target
SN-38DNA topoisomerase 1target
SN-38Cytochrome P450 3A4enzyme