Ethers, Cyclic

Name
Ethers, Cyclic
Accession Number
DBCAT000835
Description

Compounds of the general formula R-O-R arranged in a ring or crown formation.

Drugs
DrugDrug Description
MupirocinAn antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes.
DoxepinA psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
PPI-2458Investigated for use/treatment in lymphoma (non-hodgkin's) and solid tumors.
IcotinibIcotinib hydrochloride is a novel epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor, exhibits encouraging efficacy and tolerability in patients with advanced non-small-cell lung cancer (NSCLC) who failed previous chemotherapy.
TriptolideTriptolide has been used in trials studying the treatment of HIV, Crohn's Disease, Intestinal Diseases, Gastrointestinal Diseases, and Digestive System Diseases, among others.
SepetaprostSepetaprost has been used in trials studying the treatment of Open Angle-glaucoma, Ocular Hypertension, and Mild Open Angle-glaucoma (OAG).
BeloranibBeloranib has been used in trials studying the treatment of Obesity, Over-weight, Type 2 Diabetes, Craniopharyngioma, and Hypothalamic Injury, among others.
OmigapilOmigapil has been used in trials studying the treatment of Congenital Muscular Dystrophy.
EtoglucidNot Annotated
Bisphenol A diglycidyl etherNot Annotated
Minnelide free acidNot Annotated
MinnelideNot Annotated
EribulinA microtubule inhibitor used to treat metastatic breast cancer and metastatic or unresectable liposarcoma.
LasalocidLasalocid is an agent that presents antibacterial and coccidiostat activities. It is produced by strains of Streptomyces lasaliensis.
MonensinMonensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds.
SalinomycinNot Annotated
SemduramicinNot Annotated
Bryostatin 1Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease.
NigericinA polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed)
Drugs & Drug Targets
DrugTargetType
MupirocinIsoleucine--tRNA ligasetarget
DoxepinSodium-dependent serotonin transportertarget
DoxepinSodium-dependent noradrenaline transportertarget
DoxepinHistamine H1 receptortarget
DoxepinHistamine H2 receptortarget
DoxepinCytochrome P450 2D6enzyme
DoxepinMuscarinic acetylcholine receptor M1target
DoxepinMuscarinic acetylcholine receptor M2target
DoxepinMuscarinic acetylcholine receptor M3target
DoxepinMuscarinic acetylcholine receptor M4target
DoxepinMuscarinic acetylcholine receptor M5target
DoxepinAlpha-1A adrenergic receptortarget
Doxepin5-hydroxytryptamine receptor 1Atarget
Doxepin5-hydroxytryptamine receptor 2Atarget
DoxepinCytochrome P450 2C19enzyme
DoxepinCytochrome P450 2C9enzyme
DoxepinCytochrome P450 1A2enzyme
DoxepinP-glycoprotein 1transporter
Doxepin5-hydroxytryptamine receptor 2Btarget
Doxepin5-hydroxytryptamine receptor 2Ctarget
DoxepinAlpha-1B adrenergic receptortarget
DoxepinAlpha-1D adrenergic receptortarget
DoxepinCytochrome P450 3A4enzyme
Doxepin5-hydroxytryptamine receptor 6target
DoxepinHistamine H4 receptortarget
DoxepinPotassium voltage-gated channel subfamily H member 2target
DoxepinSerum albumincarrier
DoxepinAlpha-1-acid glycoprotein 1carrier
PPI-2458Methionine aminopeptidase 2target
IcotinibEpidermal growth factor receptortarget
IcotinibCytochrome P450 3A4enzyme
IcotinibCytochrome P450 1A2enzyme
IcotinibCytochrome P450 3A5enzyme
Bisphenol A diglycidyl etherCation channel sperm-associated protein 1target
EribulinApoptosis regulator Bcl-2target
EribulinTubulin beta-1 chaintarget
MonensinP-glycoprotein 1transporter
SalinomycinP-glycoprotein 1transporter
Bryostatin 1Cytochrome P450 3A4enzyme
Bryostatin 1Protein kinase C alpha typetarget
Bryostatin 1Protein kinase C epsilon typetarget
Bryostatin 1Caspase-8target
Bryostatin 1Protein unc-13 homolog Btarget
Bryostatin 1Serine/threonine-protein kinase D1target
Bryostatin 1T-lymphocyte activation antigen CD86target
Bryostatin 1Prostaglandin G/H synthase 2target
Bryostatin 1G1/S-specific cyclin-D1target
Bryostatin 1Tumor necrosis factortarget