Atherosclerosis

Also known as: Atheromatosis / Atherosclerotic cardiovascular disease / Arteriosclerosis

Drug	Drug Name	Drug Description
DB01432	Cholestyramine	A bile acid sequestrant used as an adjunct in the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia, and for the relief of pruritus associated with partial biliary obstruction.
DB01095	Fluvastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DB13327	Picotamide	A platelet aggregation inhibitor indicated in the treatment of myocardial infarction, thrombosis, cerebrovascular disorders, pulmonary emboli, and atherosclerosis.
DB01098	Rosuvastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.

Drug	Drug Name	Target	Type
DB01432	Cholestyramine	Bile acids	target
DB01095	Fluvastatin	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
DB01095	Fluvastatin	Cytochrome P450 2C9	enzyme
DB01095	Fluvastatin	Cytochrome P450 3A4	enzyme
DB01095	Fluvastatin	Cytochrome P450 2C8	enzyme
DB01095	Fluvastatin	Cytochrome P450 2D6	enzyme
DB01095	Fluvastatin	Cytochrome P450 2C19	enzyme
DB01095	Fluvastatin	Cytochrome P450 1A1	enzyme
DB01095	Fluvastatin	Solute carrier organic anion transporter family member 1B1	transporter
DB01095	Fluvastatin	Solute carrier organic anion transporter family member 1B3	transporter
DB01095	Fluvastatin	Solute carrier organic anion transporter family member 2B1	transporter
DB01095	Fluvastatin	Solute carrier family 15 member 1	transporter
DB01095	Fluvastatin	Cytochrome P450 3A5	enzyme
DB01095	Fluvastatin	UDP-glucuronosyltransferase 1-1	enzyme
DB01095	Fluvastatin	UDP-glucuronosyltransferase 1-3	enzyme
DB01095	Fluvastatin	UDP-glucuronosyltransferase 2B7	enzyme
DB01095	Fluvastatin	Canalicular multispecific organic anion transporter 1	transporter
DB01095	Fluvastatin	Cytochrome P450 2B6	enzyme
DB01095	Fluvastatin	Histone deacetylase 2	target
DB01098	Rosuvastatin	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
DB01098	Rosuvastatin	Cytochrome P450 2C9	enzyme
DB01098	Rosuvastatin	Multidrug resistance-associated protein 4	transporter
DB01098	Rosuvastatin	Solute carrier organic anion transporter family member 1A2	transporter
DB01098	Rosuvastatin	Solute carrier organic anion transporter family member 1B3	transporter
DB01098	Rosuvastatin	Solute carrier organic anion transporter family member 2B1	transporter
DB01098	Rosuvastatin	Cystine/glutamate transporter	transporter
DB01098	Rosuvastatin	Solute carrier organic anion transporter family member 1B1	transporter
DB01098	Rosuvastatin	Bile salt export pump	transporter
DB01098	Rosuvastatin	ATP-binding cassette sub-family G member 2	transporter
DB01098	Rosuvastatin	Serum albumin	carrier
DB01098	Rosuvastatin	Canalicular multispecific organic anion transporter 1	transporter
DB01098	Rosuvastatin	Solute carrier family 22 member 8	transporter
DB01098	Rosuvastatin	Sodium/bile acid cotransporter	transporter
DB01098	Rosuvastatin	Integrin alpha-L	target

Drug	Drug Name	Phase	Status	Count
DB00973	Ezetimibe	0	Unknown Status	1
DB00635	Prednisone	0	Completed	1
DB01098	Rosuvastatin	0	Completed	2
DB00641	Simvastatin	0	Unknown Status	1
DB00945	Acetylsalicylic acid	1	Completed	1
DB09302	Alirocumab	1	Completed	1
DB00758	Clopidogrel	1	Completed	1
DB06311	Darapladib	1	Completed	13
DB00343	Diltiazem	1	Completed	1
DB00973	Ezetimibe	1	Completed	1
DB06705	Gadofosveset trisodium	1	Completed	1
DB16024	Indocyanine green	1	Completed	1
DB12270	Losmapimod	1	Completed	2
DB00683	Midazolam	1	Completed	1
DB14833	Recombinant human lecithin:cholesterol acyltransferase	1	Completed	1
DB05119	Rilapladib	1	Completed	3
DB01098	Rosuvastatin	1	Completed	2
DB09153	Sodium chloride	1	Terminated	1
DB12000	Apabetalone	1 / 2	Completed	1
DB00125	Arginine	1 / 2	Recruiting	1
DB00959	Methylprednisolone	1 / 2	Unknown Status	1
DB00860	Prednisolone	1 / 2	Unknown Status	1
DB14631	Prednisolone phosphate	1 / 2	Unknown Status	1
DB00945	Acetylsalicylic acid	2	Completed	1
DB12000	Apabetalone	2	Completed	1
DB00126	Ascorbic acid	2	Terminated	1
DB12758	Atreleuton	2	Completed	1
DB06401	Bazedoxifene	2	Recruiting	1
DB06168	Canakinumab	2	Completed	1
DB00608	Chloroquine	2	Recruiting	1
DB00169	Cholecalciferol	2	Completed	1
DB00758	Clopidogrel	2	Completed	2
DB00286	Conjugated estrogens	2	Recruiting	1
DB06311	Darapladib	2	Completed	4
DB00783	Estradiol	2	Completed	2
DB12469	Fasudil	2	Completed	1
DB01611	Hydroxychloroquine	2	Recruiting	1
DB12270	Losmapimod	2	Completed	1
DB00227	Lovastatin	2	Completed	1
DB15381	Menaquinone	2	Unknown Status	1
DB14936	Menaquinone 6	2	Unknown Status	1
DB09112	Nitrous acid	2	Recruiting	1
DB11062	Octisalate	2	Completed	1
DB09535	Octocrylene	2	Completed	1
DB16653	Orticumab	2	Completed	1
DB12971	Pactimibe	2	Completed	1
DB00806	Pentoxifylline	2	Completed	2
DB12520	Plozalizumab	2	Completed	1
DB00396	Progesterone	2	Completed	1
DB00178	Ramipril	2	Completed	1
DB14833	Recombinant human lecithin:cholesterol acyltransferase	2	Completed	1
DB05119	Rilapladib	2	Completed	1
DB06372	Rilonacept	2	Completed	1
DB01098	Rosuvastatin	2	Completed	1
DB00203	Sildenafil	2	Terminated	1
DB01261	Sitagliptin	2	Completed	1
DB09153	Sodium chloride	2	Recruiting	1
DB00177	Valsartan	2	Completed	1
DB00163	Vitamin E	2	Terminated	1
DB09030	Vorapaxar	2	Completed	1
DB09321	Zinc oxide	2	Completed	1
DB00945	Acetylsalicylic acid	2 / 3	Unknown Status	1
DB09026	Aliskiren	2 / 3	Terminated	1
DB00115	Cyanocobalamin	2 / 3	Completed	1
DB14476	DL-alpha-Tocopherol	2 / 3	Completed	1
DB00783	Estradiol	2 / 3	Completed	2
DB15058	Flutemetamol	2 / 3	Recruiting	1
DB00158	Folic acid	2 / 3	Completed	1
DB00227	Lovastatin	2 / 3	Completed	1
DB00563	Methotrexate	2 / 3	Recruiting	1
DB01229	Paclitaxel	2 / 3	Active Not Recruiting	1
DB00635	Prednisone	2 / 3	Completed	1
DB00165	Pyridoxine	2 / 3	Completed	1
DB01399	Salsalate	2 / 3	Completed	2
DB00197	Troglitazone	2 / 3	Completed	1
DB00284	Acarbose	3	Completed	1
DB00945	Acetylsalicylic acid	3	Terminated	1
DB00945	Acetylsalicylic acid	3	Unknown Status	1
DB00381	Amlodipine	3	Completed	2
DB11842	Angiotensin II	3	Completed	2
DB01076	Atorvastatin	3	Completed	6
DB01076	Atorvastatin	3	Recruiting	1
DB11936	Bempedoic acid	3	Completed	1
DB00542	Benazepril	3	Completed	1
DB06168	Canakinumab	3	Completed	1
DB00796	Candesartan cilexetil	3	Completed	2
DB06441	Cangrelor	3	Completed	1
DB06441	Cangrelor	3	Terminated	1
DB01136	Carvedilol	3	Completed	1
DB00310	Chlorthalidone	3	Completed	1
DB01166	Cilostazol	3	Unknown Status	1
DB00758	Clopidogrel	3	Completed	1
DB00758	Clopidogrel	3	Terminated	1
DB00758	Clopidogrel	3	Unknown Status	1
DB01394	Colchicine	3	Recruiting	1
DB00375	Colestipol	3	Completed	1
DB06311	Darapladib	3	Completed	1
DB00343	Diltiazem	3	Completed	1
DB00973	Ezetimibe	3	Completed	7
DB00973	Ezetimibe	3	Terminated	1
DB01023	Felodipine	3	Completed	1
DB01039	Fenofibrate	3	Completed	1
DB01095	Fluvastatin	3	Completed	1
DB00695	Furosemide	3	Completed	1
DB00222	Glimepiride	3	Completed	1
DB01067	Glipizide	3	Completed	1
DB01275	Hydralazine	3	Completed	1
DB00999	Hydrochlorothiazide	3	Completed	1
DB01306	Insulin aspart	3	Completed	1
DB01307	Insulin detemir	3	Completed	1
DB00047	Insulin glargine	3	Completed	1
DB00030	Insulin human	3	Completed	1
DB01249	Iodixanol	3	Completed	1
DB00722	Lisinopril	3	Completed	1
DB00331	Metformin	3	Completed	1
DB00264	Metoprolol	3	Completed	1
DB05528	Mipomersen	3	Completed	1
DB00688	Mycophenolate mofetil	3	Terminated	1
DB00627	Niacin	3	Completed	2
DB00627	Niacin	3	Terminated	1
DB00275	Olmesartan	3	Completed	1
DB01229	Paclitaxel	3	Active Not Recruiting	1
DB01132	Pioglitazone	3	Completed	1
DB00175	Pravastatin	3	Completed	1
DB00635	Prednisone	3	Terminated	1
DB00178	Ramipril	3	Completed	2
DB00912	Repaglinide	3	Completed	1
DB00206	Reserpine	3	Completed	1
DB00412	Rosiglitazone	3	Completed	3
DB01098	Rosuvastatin	3	Completed	6
DB00641	Simvastatin	3	Completed	4
DB00641	Simvastatin	3	Terminated	2
DB00877	Sirolimus	3	Terminated	1
DB11104	Sulfur hexafluoride	3	Completed	1
DB00864	Tacrolimus	3	Terminated	1
DB01162	Terazosin	3	Completed	1
DB00384	Triamterene	3	Completed	1
DB00177	Valsartan	3	Completed	1
DB09030	Vorapaxar	3	Completed	2
DB05692	Vorapaxar	3	Terminated	1
DB09030	Vorapaxar	3	Terminated	1
DB00682	Warfarin	3	Terminated	1
DB06151	Acetylcysteine	4	Unknown Status	1
DB00945	Acetylsalicylic acid	4	Completed	7
DB00945	Acetylsalicylic acid	4	Recruiting	1
DB00945	Acetylsalicylic acid	4	Terminated	1
DB00945	Acetylsalicylic acid	4	Unknown Status	1
DB09302	Alirocumab	4	Active Not Recruiting	1
DB00381	Amlodipine	4	Terminated	1
DB00335	Atenolol	4	Completed	2
DB01076	Atorvastatin	4	Active Not Recruiting	1
DB01076	Atorvastatin	4	Completed	5
DB01076	Atorvastatin	4	Terminated	3
DB01076	Atorvastatin	4	Unknown Status	3
DB01076	Atorvastatin	4	Withdrawn	1
DB13100	Biguanide	4	Recruiting	1
DB00201	Caffeine	4	Completed	1
DB01166	Cilostazol	4	Completed	1
DB00758	Clopidogrel	4	Completed	3
DB00758	Clopidogrel	4	Recruiting	1
DB00758	Clopidogrel	4	Unknown Status	1
DB00758	Clopidogrel	4	Withdrawn	1
DB01394	Colchicine	4	Recruiting	1
DB00930	Colesevelam	4	Active Not Recruiting	1
DB00115	Cyanocobalamin	4	Unknown Status	1
DB14726	Dabigatran	4	Terminated	1
DB00514	Dextromethorphan	4	Completed	1
DB00975	Dipyridamole	4	Completed	2
DB00584	Enalapril	4	Unknown Status	1
DB11827	Ertugliflozin	4	Not Yet Recruiting	1
DB00016	Erythropoietin	4	Terminated	1
DB00783	Estradiol	4	Recruiting	1
DB09303	Evolocumab	4	Recruiting	2
DB01276	Exenatide	4	Recruiting	1
DB00973	Ezetimibe	4	Active Not Recruiting	1
DB00973	Ezetimibe	4	Completed	7
DB00973	Ezetimibe	4	Terminated	3
DB09398	Fluoride ion F-18	4	Recruiting	1
DB01095	Fluvastatin	4	Unknown Status	1
DB00158	Folic acid	4	Unknown Status	1
DB01241	Gemfibrozil	4	Withdrawn	1
DB01067	Glipizide	4	Not Yet Recruiting	1
DB01611	Hydroxychloroquine	4	Recruiting	1
DB08887	Icosapent ethyl	4	Recruiting	1
DB01306	Insulin aspart	4	Completed	1
DB01306	Insulin aspart	4	Recruiting	1
DB01307	Insulin detemir	4	Completed	1
DB00030	Insulin human	4	Recruiting	1
DB11629	Laropiprant	4	Terminated	1
DB00451	Levothyroxine	4	Completed	2
DB00722	Lisinopril	4	Completed	1
DB00678	Losartan	4	Terminated	1
DB04835	Maraviroc	4	Completed	1
DB00331	Metformin	4	Active Not Recruiting	2
DB00331	Metformin	4	Completed	1
DB00331	Metformin	4	Recruiting	1
DB00264	Metoprolol	4	Completed	1
DB09282	Molsidomine	4	Completed	1
DB00688	Mycophenolate mofetil	4	Completed	1
DB00688	Mycophenolate mofetil	4	Unknown Status	1
DB04861	Nebivolol	4	Completed	1
DB00627	Niacin	4	Active Not Recruiting	1
DB00627	Niacin	4	Completed	1
DB00627	Niacin	4	Terminated	2
DB00627	Niacin	4	Unknown Status	1
DB09539	Omega-3-acid ethyl esters	4	Completed	1
DB00946	Phenprocoumon	4	Terminated	1
DB01132	Pioglitazone	4	Terminated	1
DB08860	Pitavastatin	4	Completed	1
DB00571	Propranolol	4	Completed	1
DB00165	Pyridoxine	4	Unknown Status	1
DB00178	Ramipril	4	Completed	1
DB06155	Rimonabant	4	Unknown Status	1
DB06228	Rivaroxaban	4	Completed	1
DB01098	Rosuvastatin	4	Completed	5
DB01098	Rosuvastatin	4	Recruiting	1
DB01098	Rosuvastatin	4	Terminated	3
DB01098	Rosuvastatin	4	Unknown Status	1
DB11767	Sarilumab	4	Not Yet Recruiting	1
DB00641	Simvastatin	4	Active Not Recruiting	1
DB00641	Simvastatin	4	Completed	5
DB00641	Simvastatin	4	Unknown Status	2
DB01261	Sitagliptin	4	Completed	2
DB00421	Spironolactone	4	Recruiting	1
DB00624	Testosterone	4	Completed	1
DB08816	Ticagrelor	4	Completed	1
DB08816	Ticagrelor	4	Recruiting	1
DB08816	Ticagrelor	4	Withdrawn	1
DB00162	Vitamin A	4	Unknown Status	2
DB00682	Warfarin	4	Completed	1
DB00054	Abciximab	Not Available	Completed	1
DB03128	Acetylcholine	Not Available	Unknown Status	1
DB00945	Acetylsalicylic acid	Not Available	Completed	3
DB00945	Acetylsalicylic acid	Not Available	Withdrawn	1
DB00051	Adalimumab	Not Available	Completed	1
DB00640	Adenosine	Not Available	Unknown Status	1
DB09302	Alirocumab	Not Available	Active Not Recruiting	1
DB09026	Aliskiren	Not Available	Unknown Status	1
DB11842	Angiotensin II	Not Available	Unknown Status	1
DB01076	Atorvastatin	Not Available	Active Not Recruiting	1
DB01076	Atorvastatin	Not Available	Completed	4
DB01076	Atorvastatin	Not Available	Unknown Status	1
DB01076	Atorvastatin	Not Available	Withdrawn	1
DB00169	Cholecalciferol	Not Available	Completed	1
DB00758	Clopidogrel	Not Available	Completed	1
DB00975	Dipyridamole	Not Available	Completed	1
DB00584	Enalapril	Not Available	Unknown Status	1
DB00005	Etanercept	Not Available	Completed	1
DB00973	Ezetimibe	Not Available	Active Not Recruiting	1
DB00973	Ezetimibe	Not Available	Withdrawn	1
DB01039	Fenofibrate	Not Available	Completed	1
DB00813	Fentanyl	Not Available	Unknown Status	1
DB13961	Fish oil	Not Available	Completed	1
DB01095	Fluvastatin	Not Available	Completed	1
DB00158	Folic acid	Not Available	Completed	1
DB00222	Glimepiride	Not Available	Completed	1
DB01109	Heparin	Not Available	Withdrawn	1
DB00065	Infliximab	Not Available	Completed	1
DB00678	Losartan	Not Available	Unknown Status	2
DB00563	Methotrexate	Not Available	Completed	1
DB00683	Midazolam	Not Available	Unknown Status	1
DB00627	Niacin	Not Available	Completed	3
DB00627	Niacin	Not Available	Terminated	1
DB00627	Niacin	Not Available	Unknown Status	1
DB01229	Paclitaxel	Not Available	Completed	1
DB01132	Pioglitazone	Not Available	Completed	2
DB14317	Pomegranate	Not Available	Unknown Status	1
DB06228	Rivaroxaban	Not Available	Completed	1
DB00412	Rosiglitazone	Not Available	Completed	1
DB01098	Rosuvastatin	Not Available	Active Not Recruiting	1
DB01098	Rosuvastatin	Not Available	Completed	2
DB01098	Rosuvastatin	Not Available	Suspended	1
DB12163	Sarpogrelate	Not Available	Unknown Status	1
DB00658	Sevelamer	Not Available	Terminated	1
DB00641	Simvastatin	Not Available	Active Not Recruiting	1
DB00641	Simvastatin	Not Available	Completed	4
DB00641	Simvastatin	Not Available	Withdrawn	1
DB11104	Sulfur hexafluoride	Not Available	Completed	1
DB05679	Ustekinumab	Not Available	Completed	1
DB00177	Valsartan	Not Available	Completed	1
DB11094	Vitamin D	Not Available	Completed	1
DB00163	Vitamin E	Not Available	Recruiting	1
DB14003	alpha-Tocopherol acetate	Not Available	Recruiting	1