Uncoupling Agents

Uncoupling Agents
Accession Number

Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.

DrugDrug Description
DicoumarolFor decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis.
Picric acidUsed as antiseptic, astringent, and stimulant for epitheliazation.
2,4-DinitrophenolA toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman,...
GlyphosateNot Available
RotenoneRotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also...
MonensinMonensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds.
EllipticineEllipticine is a potent antineoplastic agent.
Drugs & Drug Targets
DicoumarolVitamin K epoxide reductase complex subunit 1target
DicoumarolNAD(P)H dehydrogenase [quinone] 1target
DicoumarolQuinone oxidoreductasetarget
DicoumarolCytochrome P450 2C9enzyme
DicoumarolSerum albumincarrier
DicoumarolCytochrome P450 2C6enzyme
DicoumarolCytochrome P450 2C11enzyme
Picric acidPentaerythritol tetranitrate reductasetarget
2,4-DinitrophenolPentaerythritol tetranitrate reductasetarget
Glyphosate3-phosphoshikimate 1-carboxyvinyltransferasetarget
Glyphosate3-phosphoshikimate 1-carboxyvinyltransferasetarget
GlyphosateCytochrome P450 19A1target
GlyphosateSerum albumincarrier
MonensinP-glycoprotein 1transporter