Antituberculosis Agents

Antituberculosis Agents
Accession Number
DBCAT003667  (DBCAT000586)

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.

DrugDrug Description
Aminosalicylic acidAn aminosalicylate drug used to induce remission in ulcerative colitis.
CycloserineA broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI).
CapreomycinAn aminoglycoside antibiotic used as an adjunct drug in tuberculosis.
EthionamideA second line antitubercular agent used to treat tuberculosis when other treatments have failed.
AmprenavirA protease inhibitor used to treat HIV infection.
RifapentineAn antibiotic agent used in the treatment of pulmonary tuberculosis.
SparfloxacinFor the treatment of adults with the following infections caused by susceptible strains microorganisms: community-acquired pneumonia (caused by Chlamydia pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, or Streptococcus...
RifalazilInvestigated for use/treatment in atherosclerosis, bacterial infection, and peripheral vascular disease.
PretomanidPart of a three-drug regimen used for the treatment of extensively drug-resistant and multidrug-resistant pulmonary tuberculosis.
ViomycinViomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis.
BedaquilineA diarylquinoline antimycobacterial used in combination with other antibacterials to treat pulmonary multidrug resistant tuberculosis (MDR-TB).
EnviomycinCyclic basic peptide related to viomycin. It is isolated from an induced mutant of Streptomyces griseoverticillatus var. tuberacticus and acts as an antitubercular agent with less ototoxicity than tuberactinomycin.
PazufloxacinPazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol).
ProtionamideProthionamide has been used in trials studying the treatment of MDR-TB and HIV Infections.
AmithiozoneAmithiozone has been used in trials studying the treatment of Mycobacterium Avium-intracellulare Infection.
EthambutolAn antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB).
PyrazinamideAn antituberculosis agent used as a component of tuberculosis (TB) treatment.
RifabutinAn antibiotic used to treat mycobacterium avium complex disease in patients with HIV.
IsoniazidAn antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis.
RifampicinAn antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis.
Drugs & Drug Targets
Aminosalicylic acidGroup IIE secretory phospholipase A2target
Aminosalicylic acidProstaglandin G/H synthase 2target
Aminosalicylic acidArachidonate 5-lipoxygenasetarget
Aminosalicylic acidInhibitor of nuclear factor kappa-B kinase subunit alphatarget
Aminosalicylic acidMyeloperoxidaseenzyme
CycloserineD-alanine--D-alanine ligase Atarget
CycloserineAlanine racemasetarget
CycloserineAromatic-L-amino-acid decarboxylaseenzyme
CycloserineProton-coupled amino acid transporter 2transporter
Capreomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
EthionamideEnoyl-[acyl-carrier-protein] reductase [NADH]target
AmprenavirHuman immunodeficiency virus type 1 proteasetarget
AmprenavirCytochrome P450 3A4enzyme
AmprenavirP-glycoprotein 1transporter
AmprenavirMultidrug resistance-associated protein 1transporter
AmprenavirCytochrome P450 2B6enzyme
AmprenavirCytochrome P450 2C19enzyme
AmprenavirCytochrome P450 2C9enzyme
AmprenavirCytochrome P450 2D6enzyme
AmprenavirCytochrome P450 3A5enzyme
AmprenavirSolute carrier organic anion transporter family member 1B1transporter
RifapentineDNA-directed RNA polymerase subunit beta'target
RifapentineCytochrome P450 2C8enzyme
RifapentineCytochrome P450 2C9enzyme
RifapentineCytochrome P450 3A4enzyme
RifapentineCytochrome P450 2C19enzyme
RifapentineCytochrome P450 2B6enzyme
RifapentineCytochrome P450 3A Subfamilyenzyme
SparfloxacinDNA gyrase subunit Atarget
SparfloxacinDNA topoisomerase 4 subunit Atarget
SparfloxacinDNA topoisomerase 2-alphatarget
SparfloxacinSolute carrier family 22 member 5transporter
SparfloxacinCanalicular multispecific organic anion transporter 1transporter
SparfloxacinP-glycoprotein 1transporter
SparfloxacinCytochrome P450 1A2enzyme
RifalazilDNA-directed RNA polymerase subunit betatarget
RifalazilCytochrome P450 3A4enzyme
PretomanidDeazaflavin-dependent nitroreductaseenzyme
PretomanidSolute carrier family 22 member 8transporter
PretomanidCytochrome P450 3A4enzyme
PretomanidFatty acid synthetasetarget
PretomanidUncharacterized MFS-type transporter EfpAtarget
PretomanidNucleoid-associated protein Lsr2target
PretomanidCyd operon, Mycobacterium tuberculosistarget
PretomanidEnoyl-[acyl-carrier-protein] reductase [NADH]target
Viomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
BedaquilineCytochrome P450 3A4enzyme
BedaquilineATP synthase subunit ctarget
PazufloxacinCytochrome P450 1A2enzyme
EthambutolProbable arabinosyltransferase Btarget
EthambutolProbable arabinosyltransferase Atarget
EthambutolProbable arabinosyltransferase Ctarget
EthambutolCytochrome P450 1A2enzyme
EthambutolCytochrome P450 2E1enzyme
EthambutolCytochrome P450 2C19enzyme
EthambutolCytochrome P450 2D6enzyme
EthambutolCytochrome P450 2A6enzyme
EthambutolCytochrome P450 2C9enzyme
EthambutolCytochrome P450 3A4enzyme
PyrazinamideXanthine dehydrogenase/oxidaseenzyme
PyrazinamideFatty acid synthetasetarget
PyrazinamideAldehyde oxidaseenzyme
RifabutinDNA-directed RNA polymerase subunit alphatarget
RifabutinHeat shock protein HSP 90-alphatarget
RifabutinCytochrome P450 3A4enzyme
RifabutinDNA-directed RNA polymerase subunit betatarget
RifabutinDNA-directed RNA polymerase subunit beta'target
RifabutinCytochrome P450 2C19enzyme
RifabutinCytochrome P450 2B6enzyme
RifabutinCytochrome P450 2C8enzyme
RifabutinCytochrome P450 2C9enzyme
RifabutinP-glycoprotein 1transporter
IsoniazidEnoyl-[acyl-carrier-protein] reductase [NADH]target
IsoniazidCytochrome P450 2E1enzyme
IsoniazidCytochrome P450 1A2enzyme
IsoniazidCytochrome P450 2C9enzyme
IsoniazidCytochrome P450 2D6enzyme
IsoniazidCytochrome P450 2C19enzyme
IsoniazidArylamine N-acetyltransferase 2enzyme
IsoniazidArylamine N-acetyltransferaseenzyme
IsoniazidCytochrome P450 2A6enzyme
IsoniazidCytochrome P450 2C8enzyme
IsoniazidCytochrome P450 2C8target
IsoniazidCytochrome P450 1A2target
IsoniazidCytochrome P450 3A4target
IsoniazidCytochrome P450 2C19target
IsoniazidDihydrofolate reductasetarget
IsoniazidSerum albumincarrier
RifampicinDNA-directed RNA polymerase subunit betatarget
RifampicinNuclear receptor subfamily 1 group I member 2target
RifampicinCytochrome P450 3A4enzyme
RifampicinCytochrome P450 1A2enzyme
RifampicinCytochrome P450 2C8enzyme
RifampicinUDP-glucuronosyltransferase 1-1enzyme
RifampicinCytochrome P450 2C9enzyme
RifampicinCytochrome P450 2B6enzyme
RifampicinCytochrome P450 2C19enzyme
RifampicinCanalicular multispecific organic anion transporter 2transporter
RifampicinMultidrug resistance-associated protein 5transporter
RifampicinP-glycoprotein 1transporter
RifampicinCanalicular multispecific organic anion transporter 1transporter
RifampicinSolute carrier organic anion transporter family member 2B1transporter
RifampicinBile salt export pumptransporter
RifampicinMultidrug resistance-associated protein 1transporter
RifampicinSolute carrier organic anion transporter family member 1A2transporter
RifampicinSolute carrier organic anion transporter family member 1B3transporter
RifampicinSolute carrier family 22 member 7transporter
RifampicinSolute carrier organic anion transporter family member 1B1transporter
RifampicinCytochrome P450 2A6enzyme
RifampicinCytochrome P450 2E1enzyme
RifampicinCytochrome P450 3A43enzyme
RifampicinCytochrome P450 3A7enzyme
RifampicinSolute carrier family 22 member 6transporter
RifampicinSolute carrier family 22 member 8transporter
RifampicinUDP-glucuronosyltransferase 1-9enzyme
RifampicinCytochrome P450 3A5enzyme
RifampicinSerum albumincarrier
Rifampicinalpha1-acid glycoproteincarrier