Drugs for Treatment of Tuberculosis

Drugs for Treatment of Tuberculosis
Accession Number
DBCAT003667  (DBCAT000586, DBCAT002243)

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.

ATC Classification
DrugDrug Description
Aminosalicylic acidAn aminosalicylate drug used to induce remission in ulcerative colitis.
CycloserineA broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI).
CapreomycinAn aminoglycoside antibiotic used as an adjunct drug in tuberculosis.
EthionamideA second line antitubercular agent used to treat tuberculosis when other treatments have failed.
RifapentineAn antibiotic agent used in the treatment of pulmonary tuberculosis.
SparfloxacinA fluoroquinolone antibiotic used to treat bacterial respiratory infections and sinusitis.
PretomanidPart of a three-drug regimen used for the treatment of extensively drug-resistant and multidrug-resistant pulmonary tuberculosis.
BedaquilineA diarylquinoline antimycobacterial used in combination with other antibacterials to treat pulmonary multidrug resistant tuberculosis (MDR-TB).
EnviomycinCyclic basic peptide related to viomycin. It is isolated from an induced mutant of Streptomyces griseoverticillatus var. tuberacticus and acts as an antitubercular agent with less ototoxicity than tuberactinomycin.
PazufloxacinPazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol).
ProtionamideAn antitubercular thioamide-derivative used in the treatment of multi-drug resistant (MDR) tuberculosis and leprosy.
AmithiozoneAmithiozone has been used in trials studying the treatment of Mycobacterium Avium-intracellulare Infection.
DelamanidAn antibiotic used to treat multidrug resistant tuberculosis.
TerizidoneTerizidone has been used in trials studying the treatment of Tuberculosis, HIV Infections, Multidrug Resistant Tuberculosis, and Extensively-drug Resistant Tuberculosis.
MorinamideA second-line pyrazine anti-tuberculosis agent.
TiocarlideNot Annotated
EthambutolAn antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB).
PyrazinamideAn antituberculosis agent used as a component of tuberculosis (TB) treatment.
RifabutinAn antibiotic used to treat mycobacterium avium complex disease in patients with HIV.
IsoniazidAn antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis.
RifampinAn antibiotic used alone or in combination with other antimicrobial drugs to treat tuberculosis and asymptomatic carriers of Neisseria meningitidis.
StreptomycinAn aminoglycoside antibiotic indicated to treat multi-drug resistant mycobacterium tuberculosis and various non-tuberculosis infections.
RifamycinAn antibacterial used to treat traveler's diarrhea.
PyridoxineA vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.
SulfamethoxazoleAn oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract.
MacozinoneMacozinone is under investigation in clinical trial NCT03036163 (Phase 1 Study of PBTZ169).
AmprenavirA protease inhibitor used to treat HIV infection.
RifalazilInvestigated for use/treatment in atherosclerosis, bacterial infection, and peripheral vascular disease.
ViomycinViomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis.
AconiazideNot Annotated
CPZEN-45Not Annotated
Drugs & Drug Targets
Aminosalicylic acidGroup IIE secretory phospholipase A2target
Aminosalicylic acidProstaglandin G/H synthase 2target
Aminosalicylic acidArachidonate 5-lipoxygenasetarget
Aminosalicylic acidInhibitor of nuclear factor kappa-B kinase subunit alphatarget
Aminosalicylic acidMyeloperoxidaseenzyme
CycloserineD-alanine--D-alanine ligase Atarget
CycloserineAlanine racemasetarget
CycloserineAromatic-L-amino-acid decarboxylaseenzyme
CycloserineProton-coupled amino acid transporter 2transporter
Capreomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
EthionamideEnoyl-[acyl-carrier-protein] reductase [NADH]target
RifapentineDNA-directed RNA polymerase subunit beta'target
RifapentineCytochrome P450 2C8enzyme
RifapentineCytochrome P450 2C9enzyme
RifapentineCytochrome P450 3A4enzyme
RifapentineCytochrome P450 2C19enzyme
RifapentineCytochrome P450 2B6enzyme
RifapentineCytochrome P450 3A Subfamilyenzyme
SparfloxacinDNA gyrase subunit Atarget
SparfloxacinDNA topoisomerase 4 subunit Atarget
SparfloxacinDNA topoisomerase 2-alphatarget
SparfloxacinSolute carrier family 22 member 5transporter
SparfloxacinCanalicular multispecific organic anion transporter 1transporter
SparfloxacinP-glycoprotein 1transporter
SparfloxacinCytochrome P450 1A2enzyme
PretomanidDeazaflavin-dependent nitroreductaseenzyme
PretomanidSolute carrier family 22 member 8transporter
PretomanidCytochrome P450 3A4enzyme
PretomanidFatty acid synthetasetarget
PretomanidUncharacterized MFS-type transporter EfpAtarget
PretomanidNucleoid-associated protein Lsr2target
PretomanidCyd operon, Mycobacterium tuberculosistarget
PretomanidEnoyl-[acyl-carrier-protein] reductase [NADH]target
BedaquilineCytochrome P450 3A4enzyme
BedaquilineATP synthase subunit ctarget
BedaquilineSerum albumincarrier
BedaquilineAlpha-1-acid glycoprotein 1carrier
PazufloxacinCytochrome P450 1A2enzyme
DelamanidDeazaflavin-dependent nitroreductaseenzyme
DelamanidCytochrome P450 3A4enzyme
DelamanidSerum albumincarrier
DelamanidAlpha-1-acid glycoprotein 1carrier
EthambutolProbable arabinosyltransferase Btarget
EthambutolProbable arabinosyltransferase Atarget
EthambutolProbable arabinosyltransferase Ctarget
EthambutolCytochrome P450 1A2enzyme
EthambutolCytochrome P450 2E1enzyme
EthambutolCytochrome P450 2C19enzyme
EthambutolCytochrome P450 2D6enzyme
EthambutolCytochrome P450 2A6enzyme
EthambutolCytochrome P450 2C9enzyme
EthambutolCytochrome P450 3A4enzyme
PyrazinamideXanthine dehydrogenase/oxidaseenzyme
PyrazinamideFatty acid synthetasetarget
PyrazinamideAldehyde oxidaseenzyme
RifabutinDNA-directed RNA polymerase subunit alphatarget
RifabutinHeat shock protein HSP 90-alphatarget
RifabutinCytochrome P450 3A4enzyme
RifabutinDNA-directed RNA polymerase subunit betatarget
RifabutinDNA-directed RNA polymerase subunit beta'target
RifabutinCytochrome P450 2C19enzyme
RifabutinCytochrome P450 2B6enzyme
RifabutinCytochrome P450 2C8enzyme
RifabutinCytochrome P450 2C9enzyme
RifabutinP-glycoprotein 1transporter
IsoniazidEnoyl-[acyl-carrier-protein] reductase [NADH]target
IsoniazidCytochrome P450 2E1enzyme
IsoniazidCytochrome P450 1A2enzyme
IsoniazidCytochrome P450 2C9enzyme
IsoniazidCytochrome P450 2D6enzyme
IsoniazidCytochrome P450 2C19enzyme
IsoniazidArylamine N-acetyltransferase 2enzyme
IsoniazidArylamine N-acetyltransferaseenzyme
IsoniazidCytochrome P450 2A6enzyme
IsoniazidCytochrome P450 2C8enzyme
IsoniazidCytochrome P450 2C8target
IsoniazidCytochrome P450 1A2target
IsoniazidCytochrome P450 3A4target
IsoniazidCytochrome P450 2C19target
IsoniazidDihydrofolate reductasetarget
IsoniazidSerum albumincarrier
IsoniazidCytochrome P450 3A4enzyme
RifampinNuclear receptor subfamily 1 group I member 2target
RifampinCytochrome P450 3A4enzyme
RifampinCytochrome P450 1A2enzyme
RifampinCytochrome P450 2C8enzyme
RifampinUDP-glucuronosyltransferase 1-1enzyme
RifampinCytochrome P450 2C9enzyme
RifampinCytochrome P450 2B6enzyme
RifampinCytochrome P450 2C19enzyme
RifampinCanalicular multispecific organic anion transporter 2transporter
RifampinMultidrug resistance-associated protein 5transporter
RifampinP-glycoprotein 1transporter
RifampinCanalicular multispecific organic anion transporter 1transporter
RifampinSolute carrier organic anion transporter family member 2B1transporter
RifampinBile salt export pumptransporter
RifampinMultidrug resistance-associated protein 1transporter
RifampinSolute carrier organic anion transporter family member 1A2transporter
RifampinSolute carrier organic anion transporter family member 1B3transporter
RifampinSolute carrier family 22 member 7transporter
RifampinSolute carrier organic anion transporter family member 1B1transporter
RifampinCytochrome P450 2A6enzyme
RifampinCytochrome P450 2E1enzyme
RifampinCytochrome P450 3A43enzyme
RifampinCytochrome P450 3A7enzyme
RifampinSolute carrier family 22 member 6transporter
RifampinSolute carrier family 22 member 8transporter
RifampinUDP-glucuronosyltransferase 1-9enzyme
RifampinCytochrome P450 3A5enzyme
RifampinSerum albumincarrier
Rifampinalpha1-acid glycoproteincarrier
RifampinDNA-directed RNA polymerase subunit betatarget
Streptomycin30S ribosomal protein S12target
Streptomycin16S ribosomal RNAtarget
StreptomycinProtein-arginine deiminase type-4target
Streptomycin23S ribosomal RNAtarget
StreptomycinBacterial outer membranetarget
StreptomycinCytoplasmic membranetarget
RifamycinCytochrome P450 3A4enzyme
RifamycinCytochrome P450 2C19enzyme
RifamycinCytochrome P450 2B6enzyme
RifamycinCytochrome P450 2C8enzyme
RifamycinCytochrome P450 2C9enzyme
RifamycinSolute carrier organic anion transporter family member 1A2transporter
RifamycinSolute carrier organic anion transporter family member 1B1transporter
RifamycinSolute carrier organic anion transporter family member 1B3transporter
RifamycinSolute carrier organic anion transporter family member 2A1transporter
RifamycinSolute carrier organic anion transporter family member 2B1transporter
RifamycinSerum albumincarrier
RifamycinDNA-directed RNA polymerase subunit betatarget
RifamycinDNA-directed RNA polymerase subunit alphatarget
RifamycinDNA-directed RNA polymerase subunit beta'target
RifamycinMultidrug and toxin extrusion protein 1transporter
RifamycinCytochrome P450 1A2enzyme
RifamycinP-glycoprotein 1transporter
RifamycinCytochrome P450 2D6enzyme
PyridoxinePyridoxal kinasetarget
PyridoxineCytochrome P450 1A1enzyme
PyridoxineSerum albumincarrier
PyridoxinePyridoxal kinaseenzyme
PyridoxinePyridoxal phosphate phosphataseenzyme
PyridoxineAlkaline phosphatase, tissue-nonspecific isozymetransporter
PyridoxineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
SulfamethoxazoleCytochrome P450 2C9enzyme
SulfamethoxazoleSerum albumincarrier
SulfamethoxazoleArylamine N-acetyltransferase 1enzyme
SulfamethoxazoleArylamine N-acetyltransferase 2enzyme
SulfamethoxazoleDihydropteroate synthasetarget
SulfamethoxazoleCytochrome P450 3A4enzyme
SulfamethoxazoleBile salt export pumptransporter
AmprenavirHuman immunodeficiency virus type 1 proteasetarget
AmprenavirCytochrome P450 3A4enzyme
AmprenavirP-glycoprotein 1transporter
AmprenavirMultidrug resistance-associated protein 1transporter
AmprenavirCytochrome P450 2B6enzyme
AmprenavirCytochrome P450 2C19enzyme
AmprenavirCytochrome P450 2C9enzyme
AmprenavirCytochrome P450 2D6enzyme
AmprenavirCytochrome P450 3A5enzyme
AmprenavirSolute carrier organic anion transporter family member 1B1transporter
RifalazilDNA-directed RNA polymerase subunit betatarget
RifalazilCytochrome P450 3A4enzyme
Viomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget