- Cardiotonic Agents
- Accession Number
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Drug Drug Description Milrinone A PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure. Digoxin A cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. Dexrazoxane A cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer. Phenylephrine An alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics. Carbamoylcholine A direct acting miotic agent administered ophthalmically to decrease intraocular pressure after cataract surgery, and to induce miosis during surgery. Acetyldigitoxin Used for fast digitalization in congestive heart failure. Lisinopril An ACE inhibitor used to treat hypertension, heart failure, and acute myocardial infarction. Dobutamine A beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery. Levosimendan A calcium sensitizer indicated to treat acutely decompensated severe chronic heart failure. Dopamine A catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. Isoprenaline A catecholamine non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block. Deslanoside For the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure. Ouabain For the treatment of atrial fibrillation and flutter and heart failure Arbutamine Used to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in... Aminophylline A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. Pirbuterol A beta-2 adrenergic agonist and bronchodilator used for the symptomatic treatment of asthma. Digitoxin A cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure. Amrinone A positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure. Colforsin Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities;... Enoximone A selective phosphodiesterase inhibitor indicated in the short term treatment of congestive heart failure. Canertinib Investigated for use/treatment in breast cancer and lung cancer. Tedisamil Investigated for use/treatment in arrhythmia, atrial fibrillation, and angina. Etilefrine An adrenergic agonist primarily of α1 and β1 receptors used as an anti-hypotensive. Pimobendan Not Annotated Vesnarinone Vesnarinone has been used in trials studying the treatment of HIV Infections and Sarcoma, Kaposi. Simendan Simendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure). Higenamine Higenamine is under investigation in clinical trial NCT01451229 (Pharmacokinetics and Pharmacodynamics of Higenamine in Chinese Healthy Subjects). Phosphocreatine A cardioprotective agent indicated for use in cardiac surgery. Cymarin Not Annotated Proscillaridin Proscillaridin is a cardiac glycoside that is derived from plants of the genus Scilla and in Drimia maritima (Scilla maritima). Studies suggest the potential cytotoxic and anticancer property of proscillaridin,... Ibopamine A sympathomimetic, indicated in the induction of mydriasis and treatment of pos-surgical ocular hypotonia. Oxyfedrine Not Annotated Metildigoxin A digitalis glycoside indicated in the treatment of acute and chronic heart failure. Prenalterol Not Annotated Peruvoside Not Annotated Acetyldigoxin Not Annotated Olprinone Not Annotated Plumbagin Plumbagin is a compound investigated for its anticancer activity. It has been found that it inactivates the Akt/NF-kB, MMP-9 and VEGF pathways.
- Drugs & Drug Targets