Contusions (DBCOND0005359)

Identifiers

Synonyms

Bruises / Bruise / Bruising / Contusion / Other injury of unspecified body region / Contused wound / Contusion of unspecified site / Bruise - lesion (morphologic abnormality) / Contusion (disorder) / Ecchymosis / Ecchymosis NOS / Ecchymoses / Ecchymosis (morphologic abnormality) / Ecchymosis (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
2-(l-menthoxy)ethanol	Not Annotated	No drug targets
Arnica montana	Arnica montana is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.	No drug targets
Borneol	Not Annotated	Transient receptor potential cation channel subfamily V member 3target
Camphor	A compound used topically to help relieve pain and also as a topical antiseptic. May also be used in vaporizers to help suppress coughing. This medication should not be swallowed.	Camphor 5-monooxygenasetarget Transient receptor potential cation channel subfamily V member 1target Transient receptor potential cation channel subfamily V member 3target Transient receptor potential cation channel subfamily A member 1target Transient receptor potential cation channel subfamily M member 8target
Capsaicin	A topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain.	Cytochrome P450 3A4enzyme Prostaglandin G/H synthase 2enzyme Myeloperoxidaseenzyme Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme Amine oxidase [flavin-containing] Aenzyme Dopamine beta-hydroxylaseenzyme Glutamine synthetaseenzyme Cholinesteraseenzyme Transient receptor potential cation channel subfamily V member 1target Prohibitin-2target
Cinnamon oil	Not Annotated	No drug targets
Dexpanthenol	An alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN).	No drug targets
Diclofenac	An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Transthyretincarrier Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C8enzyme Albumincarrier ATP-binding cassette sub-family C member 4transporter Multidrug resistance-associated protein 1transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier family 22 member 11transporter UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2E1enzyme Solute carrier organic anion transporter family member 1B1transporter Bile salt export pumptransporter UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B4enzyme Polyunsaturated fatty acid 5-lipoxygenaseenzyme Sodium channel protein type 4 subunit alphatransporter Acid-sensing ion channel 1transporter Potassium voltage-gated channel subfamily KQT member 2transporter Potassium voltage-gated channel subfamily KQT member 3transporter Phospholipase A2, membrane associatedenzyme ATP-dependent translocase ABCB1transporter
Escin	An anti-inflammatory and vasoconstrictive agent indicated to treat minor muscle and joint trauma.	No drug targets
Eugenol	A phenol used for the temporary relief of toothaches.	Estrogen receptortarget Estrogen receptor betatarget Androgen receptortarget Transient receptor potential cation channel subfamily V member 3target Amine oxidase [flavin-containing] Btarget
Glycol salicylate	A salicylate used to treat mild to moderate muscle pain.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target
Heparin	An anticoagulant indicated for thromboprophylaxis and to treat thrombosis associated with a variety of conditions such as pulmonary embolism and atrial fibrillation.	Antithrombin-IIItarget Coagulation factor Xtarget P-selectintarget Heparanaseenzyme Fibroblast growth factor receptor 4target Fibroblast growth factor 4target Fibroblast growth factor 19target Fibroblast growth factor receptor 1target Fibroblast growth factor 1target Fibroblast growth factor receptor 2target Fibroblast growth factor 2target Platelet factor 4target Hepatocyte growth factortarget
Horse chestnut	A plant extract indicated in the treatment of venous insufficiency and other disorders caused by poor circulation.	No drug targets
Levomenthol	An organic compound used to treat mild to moderate muscle and joint pain.	Transient receptor potential cation channel subfamily A member 1target Transient receptor potential cation channel subfamily M member 8target Transient receptor potential cation channel subfamily V member 3target Kappa-type opioid receptortarget Voltage-dependent L-type calcium channeltarget Cytochrome P450 3A4enzyme
Menthyl salicylate	For the temporary relief of pain associated with rheumatism, arthritis, neuralgia, sprains and strains of joints and muscles, lumbago and fibrositis .	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target
Methyl salicylate	A topical counter-irritant used for the symptomatic relief of acute musculoskeletal pain in the muscles, joints, and tendons.	Transient receptor potential cation channel subfamily A member 1target
Mucopolysaccharide polysulphate	An anti-inflammatory and anticoagulant indicated in the treatment of bruising and varicose veins.	No drug targets
Myrtecaine	A local anesthetic used in topical products.	No drug targets
Nonivamide	Nonivamide is used as a topical analgesic and is also used as a flavoring ingredient , , .	Transient receptor potential cation channel subfamily V member 1target
Synthetic camphor	Not Annotated	No drug targets
Thymol	An essential oil found in various over-the-counter antibacterial and antifungal products.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04908748	Efficacy and Safety of Esflurbiprofen Hydrogel Patch in the Treatment of Local Acute Pain	Esflurbiprofen	treatment	2	completed
NCT00253396	Patients Preference With Self-Injection: The PRISM Study	Enoxaparin Heparin	treatment	4	completed
NCT03233321	Effectiveness of Dry Cold Application on Pain and Bruise at the Subcutaneous Injection Site Among Patients Admitted in ICU	No drug interventions	treatment	Not Available	completed
NCT03021096	Natural History of Pain After Shoulder Arthroplasty Conducted With Multimodal Analgesia	No drug interventions	Not Available	Not Available	completed
NCT06648265	EFFECTS of TRANEXAMIC ACID in TUMESCENT SOLUTION for LIPOSUCTION PROCEDURES	No drug interventions	prevention	4	completed
NCT00713596	Study Evaluating Benefit of Using Fibrin Glue in Septorhinoplasty	Fibrinogen human Human thrombin	treatment	Not Available	terminated
NCT04758728	Adrenaline Reduces Ecchymoses and Hematomas and Improves Quality of Life After Classic Saphenous Vein Stripping	Epinephrine	prevention	Not Available	completed
NCT05771285	Cold Application on the Subcutaneous Injection	No drug interventions	supportive_care	Not Available	completed
NCT01645774	Comparing Pain and Bruising of Subcutaneous Heparin Injection	No drug interventions	prevention	2 / 3	terminated
NCT06483204	Steroids for Rhinoplasty: Pain, Nausea, Edema and Ecchymosis	Methylprednisolone	prevention	4	not_yet_recruiting
NCT04724772	Use of Tranexamic Acid in Blepharoplasties	Tranexamic acid	prevention	3	withdrawn
NCT00940446	A Comparison of INSORB Staples With Metal Staples in Total Hip Replacement	No drug interventions	health_services_research	Not Available	completed
NCT01097798	To Evaluate the Efficacy and Safety Aliviador Compared to Gelol in Patients With Contusions, Sprains, Trauma and Muscle Injury.	No drug interventions	treatment	3	unknown_status
NCT00970658	Efficacy and Safety of Salonsip Compared to Sabiá Plaster	(+)-menthol Angelica archangelica root Carbomer Ginger Nicotinamide Safflower oil	treatment	3	unknown_status
NCT04533269	A Study of Topical Arnica & Ledum on Bruise Reduction in HNV	No drug interventions	treatment	Not Available	unknown_status
NCT00525993	Efficacy and Safety of Etoricoxib in Acute Ankle Sprain: A Double-Blind Comparative Study Among 2 Treatments Protocols	Etoricoxib	treatment	4	unknown_status
NCT04526275	Development of Validated Bruise Scale in HNV	No drug interventions	Not Available	Not Available	unknown_status
NCT05225714	Dermal Wound Closure Using Silkam®	No drug interventions	Not Available	Not Available	recruiting