Proglumide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Proglumide
DrugBank Accession Number
DB13431
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 334.416
Monoisotopic: 334.189257325
Chemical Formula
C18H26N2O4
Synonyms
  • proglumida
  • Proglumide

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Symptomatic treatment ofGastric ulcer••••••••••••••••••
Treatment ofIntestinal inflammation••••••••••••••••••
Symptomatic treatment ofIntestinal ulcer••••••••••••••••••
Symptomatic treatment ofGastrointestinal ulceration••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Categories

ATC Codes
A02BX06 — Proglumide
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as glutamic acid and derivatives. These are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Glutamic acid and derivatives
Alternative Parents
N-acyl-alpha amino acids and derivatives / Hippuric acids and derivatives / Alpha amino acid amides / Benzoyl derivatives / N-acyl amines / Tertiary carboxylic acid amides / Secondary carboxylic acid amides / Monocarboxylic acids and derivatives / Carboxylic acids / Organopnictogen compounds
show 4 more
Substituents
Alpha-amino acid amide / Aromatic homomonocyclic compound / Benzamide / Benzenoid / Benzoic acid or derivatives / Benzoyl / Carbonyl group / Carboxamide group / Carboxylic acid / Glutamic acid or derivatives
show 14 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
racemate (CHEBI:32058)
Affected organisms
Not Available

Chemical Identifiers

UNII
EPL8W5565D
CAS number
6620-60-6
InChI Key
DGMKFQYCZXERLX-UHFFFAOYSA-N
InChI
InChI=1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)
IUPAC Name
4-(dipropylcarbamoyl)-4-(phenylformamido)butanoic acid
SMILES
CCCN(CCC)C(=O)C(CCC(O)=O)NC(=O)C1=CC=CC=C1

References

General References
  1. FDA Thailand Product Information: Milid (proglumide) oral tablets [Link]
ChemSpider
4753
BindingDB
50014888
RxNav
8730
ChEBI
32058
ChEMBL
CHEMBL316561
Wikipedia
Proglumide

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2RecruitingTreatmentPancreatic Metastatic Cancer1
1CompletedOtherNon Alcoholic Steatohepatitis (NASH)1
1WithdrawnTreatmentPancreatic Metastatic Cancer1
1, 2Active Not RecruitingTreatmentPain / Pancreas Fibrosis / Safety Issues1
0CompletedOtherCirrhosis of the Liver1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, solution
Tablet
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.145 mg/mLALOGPS
logP1.94ALOGPS
logP2.14Chemaxon
logS-3.4ALOGPS
pKa (Strongest Acidic)4.42Chemaxon
pKa (Strongest Basic)-1.2Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area86.71 Å2Chemaxon
Rotatable Bond Count10Chemaxon
Refractivity91.56 m3·mol-1Chemaxon
Polarizability36.7 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSsplash10-0a4i-5921100000-c874128dd39584e6e80b
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4i-5921100000-c874128dd39584e6e80b
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0ug0-2924000000-b17b16e444b0157c1f23
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-01q9-0869000000-8728b4710bd393507aa9
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-8920000000-f079815b5b7a377b950b
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-001j-1930000000-237743c732d6111b421d
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0pdl-9700000000-166a7a4c40d83207575f
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9340000000-3fd441fa5a28cf028b99
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-180.00911
predicted
DeepCCS 1.0 (2019)
[M+H]+182.36711
predicted
DeepCCS 1.0 (2019)
[M+Na]+188.91936
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:41 / Updated at February 21, 2021 18:54